[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chlamydia-trachomatis-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chlamydia-trachomatis-infection":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,64,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":63},"100628220","healthy-expectancy-through-routine-antenatal-sti-screening-100628220",false,"NCT07458802","Healthy Expectancy Through Routine Antenatal STI Screening","Screening and Treatment for Chlamydia Trachomatis Infection to Prevent Preterm Birth","HERA","Inclusion Criteria:\n\n1. Asymptomatic for cervicovaginitis at first ANC (i.e., not syndromically treated for an STI by clinic midwives at first ANC)\n2. Age ≥ 15 years\n3. Currently pregnant\n4. ≤20 weeks gestation (based on gestational age in obstetric record or last menstrual period if gestational age missing from record)\n5. Attending first ANC visit\n6. Residence in Gaborone, Bostwana or surrounding villages through the time of delivery\n7. Mentally competent to understand study procedures or give informed consent",true,"FEMALE","15 Years",{"count":21,"type":22},2000,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and whether this approach is affordable and cost-effective for the health system.\n\nAbout 2,000 pregnant women attending their first antenatal care visit at up to 10 government clinics in Botswana will be invited to join the study. All women will first receive the usual antenatal care services provided in Botswana, including routine health checks and HIV and syphilis testing. Women who enroll in the study will be randomly assigned to one of two groups:\n\n1. Standard of care group: Women receive routine antenatal care only.\n2. Intervention group: In addition to routine antenatal care, women are screened for chlamydia and gonorrhoea using self-collected vaginal swabs at their first antenatal care visit and again in the third trimester.\n\nThe main outcome of the study is whether screening and treating chlamydia and gonorrhoeae reduces preterm birth (before 37 weeks). Other outcomes include low birth weight, very preterm birth, and maternal health conditions.",[28,29,30,31,32,33,34,35],"Antenatal Health","Antenatal Care","STI","Chlamydia Trachomatis Infection in Pregnancy","Chlamydia","Chlamydia Trachomatis","Chlamydia Trachomatis Infection","Preterm Birth",[37,38,39,40,41,42,43,30,44,45,46,47,48,49,50],"antenatal health","antenatal screening","chlamydia","chlamydia trachomatis","chlamydia screening","chlamydia treatment","pregnancy screening","STI screening","STI in pregnancy","preterm delivery","Botswana","CT infection","chlamydia in pregnancy","birth outcomes","RECRUITING","2026-06-30",{"date":54,"type":55},"2026-07-02","ACTUAL",{"date":57,"type":55},"2026-05-25",{"date":59,"type":22},"2030-07-01",{"name":61,"class":62},"Adriane Wynn","OTHER",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":17,"sex":71,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100623687","outcomes-from-point-of-care-sexually-transmitted-infection-sti-testing-in-an-urban-sexual-health-clinic-a-randomized-trial-100623687","NCT07399873","Outcomes From Point-of-Care Sexually Transmitted Infection (STI) Testing in an Urban Sexual Health Clinic: A Randomized Trial","Outcomes From Point-of-Care STI Testing in an Urban Sexual Health Clinic: A Randomized Trial","Inclusion Criteria:\n\n* At least 18 years of age\n* Willing and able to provide informed consent\n* Asymptomatic at the urogenital site\n* Being screened for urogenital C. trachomatis and\u002For N. gonorrhoeae as part of routine clinical care\n\nExclusion Criteria:\n\n* Indication for antimicrobial therapy for C. trachomatis or N. gonorrhoeae at the time of the visit, regardless of test results","ALL","18 Years",{"count":74,"type":22},400,[25],"The goal of this clinical trial is to learn about the impact of a point-of-care test for gonorrhea and chlamydia in people without symptoms who are seeking sexually transmitted infection testing. The main questions it aims to answer are:\n\nDoes the point of care test reduce the time to antibiotic treatment? Does the point of care test increase the number of people who have completed treatment by day 7?\n\nResearchers will compare the point-of-care test to a standard laboratory-based test for gonorrhea and chlamydia.\n\nParticipants will be asked to provide a urine sample or vaginal swab for testing. They will also complete surveys about their experiences with the testing.",[78,34],"Neisseria Gonorrhoeae Infection",[80,39,81,30,82],"gonorrhea","sexually transmitted infection","point-of-care testing","NOT_YET_RECRUITING","2026-04-16",{"date":86,"type":55},"2026-04-17",{"date":88,"type":22},"2026-06",{"date":90,"type":22},"2027-02",{"name":92,"class":62},"Massachusetts General Hospital",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":23,"phases":103,"briefSummary":104,"conditions":105,"keywords":110,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":63},"100615271","improving-maternal-and-child-health-through-point-of-care-sti-testing-100615271","NCT07290439","Improving Maternal and Child Health Through Point-of-care STI Testing","Improving Maternal and Child Health Through Point-of-care STI Testing (MATCH-POINT)","MATCH-POINT","Inclusion Criteria:\n\n* Pregnant and clinically indicated for STI testing (syphilis and\u002For Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) at a prenatal care (PNC ) or labor and delivery (L\\&D) triage visit at Grady Memorial Hospital (GMH). Indications for STI testing in pregnancy at GMH:\n\n  * Syphilis, CT, NG, and TV indicated at first PNC visit\n  * Syphilis serologic testing additionally indicated in 3rd trimester and at delivery\n  * CT\u002FNG\u002FTV additionally indicated in the 3rd trimester for those \\\u003C25 or with increased risk \\[1\\]\n  * Additional testing recommended based on clinical signs or symptoms (e.g., genital lesion or vaginal discharge, new exposure history)\n* English or Spanish-speaking\n* If \\\u003C16 years of age, has a parent or legal guardian present\n* Have STI risk factor:\n\n  * \\\u003C25 years of age\n  * Reports current substance use\n  * Reported or documented history of a positive STI\n  * More than one current sex partner\n  * A current sex partner who has concurrent partners\n  * A new sex partner (\\\u003C6 months )\n  * A current sex partner who has an STI\n  * Exchange of sex for money or drugs\n  * Incarceration\n  * No previous prenatal care during the current pregnancy\n* Able to follow study procedures and provide written informed consent or assent, as appropriate\n\nExclusion Criteria:\n\n* Indicated for syphilis test: negative RPR test during this pregnancy\n* Indicated for syphilis test: ever had a previous syphilis diagnosis (lifetime history)\n* Indicated for CT\u002FNG\u002FTV test: negative for all three of CT, NG, and TV within the previous 1 month\n* Indicated for CT\u002FNG\u002FTV test: positive for any of CT, NG, and\u002For TV and completed treatment \\\u003C3 weeks prior\n\nStakeholders:\n\n* GMH PNC or L\\&D providers, GMH leadership, Georgia Dept of Health leadership\n* \\>=18 years of age\n* Able to follow study procedures and provide verbal informed consent",{"count":102,"type":22},756,[25],"The goal of this clinical trial is to learn if point-of-care tests (POCTs) for sexually transmitted infections (STIs) improve the timely treatment of syphilis, chlamydia, gonorrhea, and trichomonas in pregnant women. It will also learn about the feasibility, acceptability, and cost-effectiveness of implementing POCTs in a large safety-net hospital setting.\n\nThe main questions it aims to answer are:\n\n* Do POCTs reduce delays in STI treatment compared with standard laboratory-based testing?\n* What barriers, facilitators, and processes affect POCT implementation in prenatal and obstetric care?\n* What are the costs and cost-effectiveness of POCTs compared with standard testing?\n\nParticipants will:\n\n* Complete a baseline survey and receive either POCTs (fingerstick blood draw or vaginal swab) or standard laboratory STI testing.\n* If diagnosed with an STI, complete a follow-up survey approximately one month later.\n* Stakeholders (providers, hospital leadership, and public health officials) will complete interviews to inform implementation strategies.",[106,34,107,108,109],"Treponema Pallidum Infection","Neisseria Gonorrheae Infection","Trichomonas Vaginalis Vaginitis","Sexually Transmitted Infection",[111,112],"Prenatal care","Point of care test","2025-12-16",{"date":115,"type":55},"2025-12-18",{"date":117,"type":22},"2026-05",{"date":119,"type":22},"2030-06",{"name":121,"class":62},"Emory University"]