[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chlordecone-kepone-toxicity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chlordecone-kepone-toxicity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100518106","effects-of-probiotic-oral-intake-on-plasma-chlordecone-kepone-concentrations-in-individuals-environmentally-exposed-to-pesticide-in-martinique-100518106",false,"NCT06026228","Effects of Probiotic Oral Intake on Plasma Chlordecone (Kepone) Concentrations in Individuals Environmentally Exposed to Pesticide in Martinique.","Effects of Oral Intake of the Probiotic Limosilactobacillus Reuteri on Plasma Chlordecone (Kepone) Concentrations (Chlordeconemia) in Individuals Environmentally Exposed to the Organochlorine Pesticide in Martinique : an Exploratory Pilot Study","CHLOR-DETOX","Inclusion Criteria:\n\n* Male or female, 18 years of age or older\n* Seen in clinical toxicology consultation at the CHU of Martinique during the study period\n* With an initial chlordeconemia \\> 1μg\u002FL on a test less than 1 month old at the time of study inclusion\n* Affiliated to a social security scheme\n* Having received informed information on research\n* Having freely given written and informed consent to participate in the research\n\nExclusion Criteria:\n\n* History of cancer\n* Recent infections less than 6 months old\n* Known digestive diseases: chronic diarrhoea, ulcerative colitis, Crohn's disease, pancreatitis\n* Digestive procedures less than 6 months old.\n* Intrahepatic cholestasis less than 6 months old\n* Extrahepatic cholestasis less than 6 months old\n* Use of cholestyramine or ursodeoxycholic acid in the previous 3 months\n* Consumption of food (non-ordinary yoghurt, etc.) or supplements (tablets, drops, capsules, etc.) containing L. reuteri or any other probiotic within the previous 2 weeks.\n* Antibiotics taken in the previous 4 weeks.\n* Immune deficiency secondary to a pathology (lymphoma, leukaemia) or medical treatment (immunosuppressant, corticoid, chemotherapy).\n* Women who are unable to obtain contraception during the trial\n* Persons referred to in articles L.1121-5, L.1121-7, L. 1121-8 of the Public Health Code:\n\n  * Pregnant woman, parturient or breastfeeding mother\n  * Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)\n  * Persons deprived of their liberty by a judicial or administrative decision,\n  * Persons staying in a health or social care institution for purposes other than research\n* Persons subject to psychiatric care under Articles L. 3212-1 and L. 3213-1 of the Public Health Code.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The CHLOR-DETOX study is a single-centre, double-blind, prospective, interventional, controlled, exploratory pilot study on subjects environmentally exposed to the organochlorine pesticide (kepone or chlordecone, CLD) in the French Caribbean (Martinique island). To our best knowledge, it is the first clinical trial in such subjects evaluating the potential effect of oral probiotic intake (Limosilactobacillus reuteri) on the reduction of CLD plasma levels (chlordeconemia) and fecal excretion, thus concurring to the reduction of CLD toxicity in study subjects.",[27],"Chlordecone (Kepone) Toxicity",[29,30,31,32,33],"Chlordecone toxicity","Probiotics","Gut elimination","entero-hepatic cycle","plasma level concentration","NOT_YET_RECRUITING","2024-02-19",{"date":37,"type":38},"2024-02-21","ACTUAL",{"date":40,"type":21},"2024-04",{"date":42,"type":21},"2026-10",{"name":44,"class":45},"University Hospital Center of Martinique","OTHER"]