[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cholecystectomy-laparoscopic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cholecystectomy-laparoscopic":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,49,74,107,134,153,183,209,238,266,291,314,343,372,397,427],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641300","effects-of-vr-on-preanesthetic-anxiety-100641300",false,"NCT07656246","Effects of VR on Preanesthetic Anxiety","Effects of Virtual Reality Intervention on Anxiety and Uncertainty Before General Anesthesia Among Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Able to communicate in Mandarin Chinese or Taiwanese and complete questionnaires.\n* ASA Physical Status I-II.\n* Hospitalized one day before surgery.\n* No previous experience with general anesthesia.\n* Scheduled for laparoscopic cholecystectomy under general anesthesia with endotracheal intubation.\n\nExclusion Criteria:\n\n* Psychiatric disorders.\n* Emergency surgery.\n* Visual or hearing impairment.","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","In today's medical environment, laparoscopic cholecystectomy is a common procedure for treating gallbladder diseases, offering advantages such as smaller incisions and faster recovery. However, patients often experience significant preoperative anxiety and uncertainty when facing general anesthesia. This is mainly due to unfamiliarity with the anesthesia process, concerns about potential risks, and uncertainty regarding the overall experience. Excessive anxiety and uncertainty can not only affect the patient's emotional stability and cooperation but may also prolong postoperative recovery time and negatively impact the overall quality of medical care. Virtual Reality (VR) is an emerging innovative technology characterized by its immersive, interactive, and highly realistic features. It has been widely applied in fields such as education, psychotherapy, and healthcare education. By simulating the surgical environment and anesthesia process through VR technology, patients can gain visual and psychological adaptation before undergoing anesthesia. This helps enhance their understanding and sense of control over the medical procedure, thereby reducing feelings of unease and anxiety. The purpose of this study is to explore the effects of a virtual reality (VR) intervention on preoperative anxiety and uncertainty in patients undergoing laparoscopic cholecystectomy under general anesthesia. This experimental study recruited a total of 142 patients scheduled for surgery at a medical center, who were randomly assigned to either the experimental group or the control group. Patients in the experimental group, in addition to receiving standard printed preoperative education materials, experienced a VR video the day before surgery. The video introduced the operating room environment and anesthesia procedures. The control group received only the printed educational materials. Research instruments included measures of anxiety (Amsterdam Preoperative Anxiety and Information Scale \\[APAIS\\], Anxiety Visual Analogue Scale \\[VAS\\]), uncertainty (Uncertainty Visual Analogue Scale, Intolerance of Uncertainty Scale), and neuro-autonomic feedback indicators. Assessments were conducted before and after the intervention to evaluate its effectiveness. This study anticipates that the virtual reality (VR) intervention will effectively reduce patients' pre-anesthesia anxiety and uncertainty, thereby enhancing their adaptation to the general anesthesia process and improving psychological stability. The findings may provide clinical anesthesia nursing staff with evidence-based support for incorporating emerging technologies into pre-anesthesia education. Furthermore, the results can serve as a reference for developing diversified patient education models in the future.",[26,27,28,29],"Cholecystectomy, Laparoscopic","Anxiety","Uncertainty","Perioperative Period",[31,32,33,34,35],"Virtual Reality (VR)","Preoperative Anxiety","General Anesthesia","Patient Education","Physiological Feedback","NOT_YET_RECRUITING","2026-06-30",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":20},"2026-06-09",{"date":44,"type":20},"2028-12-31",{"name":46,"class":47},"Mackay Memorial Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100641076","opiranserin-for-minimally-invasive-cholecystectomy-100641076","NCT07620665","Opiranserin for Minimally Invasive Cholecystectomy","Comparison of Opiranserin\u002FAcetaminophen Versus Ibuprofen\u002FAcetaminophen for Postoperative Pain Management After Minimally Invasive Cholecystectomy: A Randomized, Controlled, Non-inferiority Trial","Inclusion Criteria:\n\n* Adult patient undergoing minimally invasive cholecystectomy\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to acetaminophen, NSAIDs, opiranserin, or fentanyl.\n* pre-existing chronic pain,\n* clinically significant ECG findings (QRS \\> 200 msec, QTcF \\>450 msec)\n* severe renal impairment\n* severe hepatic impairment","19 Years",{"count":58,"type":20},88,[23],"The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative pain management after minimally invasive cholecystectomy.\n\nThis is a single-center, randomized, controlled, non-inferiority clinical trial in adult patients undergoing minimally invasive cholecystectomy. Participants will be randomly assigned to either the Treatement group (opiranserin + acetaminophen) or the control group (NSAIDs + acetaminophen) in a 1:1 ratio to compare the analgesic efficacy and safety between the two analgesic regimens.",[26,62],"Cholecystectomy, Robotic","RECRUITING","2026-06-16",{"date":66,"type":40},"2026-06-18",{"date":68,"type":40},"2026-06-10",{"date":70,"type":20},"2028-05-30",{"name":72,"class":47},"Gangnam Severance Hospital",2,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":48},"100636387","internal-jugular-vein-collapsibility-index-for-predicting-post-induction-hypotension-100636387","NCT07565025","Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension","The Value of Internal Jugular Vein Collapsibility Index in Predicting Hypotension Following General Anesthesia Induction in Patients Undergoing Elective Laparoscopic Cholecystectomy","IJV-CI","Inclusion Criteria:\n\n* Patients aged 18-65 years.\n* Patients with ASA (American Society of Anesthesiologists) physical status I, II, or III.\n* Patients scheduled to receive general anesthesia.\n* Patients scheduled for elective laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with obesity (Body Mass Index \\> 35 kg\u002Fm²).\n* Patients with Atrial Fibrillation or other serious cardiac arrhythmias.\n* Patients with a history of neck surgery or any pathology preventing Internal Jugular Vein (IJV) measurement.\n* Patients with advanced heart failure (Ejection Fraction \\\u003C 40%).\n* Patients with severe valvular heart disease.\n* Patients with peripheral vascular disease.\n* Patients undergoing emergency surgery.\n* Patients who are unwilling to participate in the study.","65 Years",{"count":84,"type":20},42,"OBSERVATIONAL","This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.",[88,89,26],"Hypotension","Anesthesia, General",[91,92,80,93,94,95,96,97],"Internal Jugular Vein","Collapsibility Index","Ultrasonography","Post-induction Hypotension","Anesthesia Induction","Laparoscopic Cholecystectomy","Fluid Responsiveness","2026-04-27",{"date":100,"type":40},"2026-05-04",{"date":102,"type":20},"2026-05-01",{"date":104,"type":20},"2027-02",{"name":106,"class":47},"University of Gaziantep",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":114,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":48},"100627899","bis-variability-and-change-in-quality-of-recovery-after-surgery-100627899","NCT07454629","BIS Variability and Change in Quality of Recovery After Surgery","Association Between Intraoperative Bispectral Index Variability and Change in Quality of Recovery-15 Score: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Planned general anesthesia with routine bispectral index (BIS) monitoring\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* History of neurological disease\n* Use of neuropsychiatric medications\n* Cognitive impairment or mental retardation\n* Inability to complete the Quality of Recovery-15 (QoR-15) questionnaire",{"count":115,"type":20},126,"This prospective observational study aims to examine the relationship between fluctuations in anesthesia depth, measured by bispectral index (BIS) monitoring during surgery, and changes in patients' postoperative recovery quality.\n\nBIS monitoring is routinely used during general anesthesia to assess the depth of anesthesia, but BIS values often fluctuate over time rather than remaining stable. The clinical significance of this variability is not well understood. In this study, BIS variability during anesthesia induction and maintenance will be evaluated and compared with changes in postoperative recovery quality.\n\nRecovery quality will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, which will be administered before surgery and again on the first postoperative day. The primary outcome of the study will be the change in QoR-15 score from the preoperative baseline to postoperative day one (ΔQoR-15). Delirium screening and routine perioperative clinical data will also be collected.\n\nNo additional interventions beyond standard anesthesia care will be performed. The results of this study may help improve understanding of how intraoperative anesthesia stability relates to patient recovery after surgery.",[118,26],"Bispectral Index Variability During General Anesthesia and Postoperative Recovery",[120,121,122,33,123,124],"Bispectral Index","Anesthesia Depth","Quality of Recovery","Postoperative Recovery","Bispectral Index Variability","2026-04-02",{"date":127,"type":40},"2026-04-08",{"date":129,"type":40},"2026-01-01",{"date":131,"type":20},"2026-12-30",{"name":133,"class":47},"Sakarya University",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":142,"studyType":85,"phases":4,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":151,"locationsCount":48},"100628151","the-relationship-between-pain-anxiety-and-post-operative-pain-in-patients-undergoing-cholecystectomy-surgery-100628151","NCT07457905","THE RELATIONSHIP BETWEEN PAIN ANXIETY AND POST-OPERATIVE PAIN IN PATIENTS UNDERGOING CHOLECYSTECTOMY SURGERY","Inclusion Criteria:\n\n* Adults aged 18 years and older Scheduled for elective cholecystectomy Able to speak and understand Turkish Conscious and able to complete questionnaires independently Voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Use of anxiolytic medication Diagnosed psychiatric disorder that may affect pain perception Cognitive impairment preventing completion of study forms Emergency cholecystectomy Development of major postoperative complications requiring intensive care",{"count":141,"type":20},106,"106 Years","This descriptive observational study aims to examine the relationship between preoperative fear of postoperative pain and postoperative pain intensity in patients undergoing cholecystectomy.\n\nPostoperative pain is one of the most common and significant clinical problems following surgical procedures. Psychological factors such as anxiety and fear of pain are known to influence pain perception and recovery outcomes. Preoperative fear related to postoperative pain may increase perceived pain intensity and negatively affect the postoperative recovery process.\n\nThe study will be conducted in the general surgery clinics of a tertiary care hospital. A total of 106 adult patients scheduled for cholecystectomy will be included. Preoperative fear of postoperative pain will be assessed one day before surgery using the Postoperative Pain Fear Scale. Postoperative pain intensity will be evaluated using the Numeric Rating Scale at the 4th, 12th, and 24th hours after surgery.\n\nThe findings of this study are expected to contribute to a better understanding of the relationship between preoperative pain-related fear and postoperative pain severity, and to provide evidence to improve perioperative nursing care and pain management strategies.",[26],"2026-03-03",{"date":147,"type":40},"2026-03-09",{"date":149,"type":20},"2026-02-15",{"date":131,"type":20},{"name":152,"class":47},"Okan University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":160,"targetDuration":4,"studyType":21,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":4},"100623980","m-tapa-vs-espb-for-postoperative-analgesia-after-laparoscopic-cholecystectomy-100623980","NCT07403682","M-TAPA vs ESPB for Postoperative Analgesia After Laparoscopic Cholecystectomy","Comparison of M-TAPA and ESPB Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective surgery under general anesthesia\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Known allergy to local anesthetics\n* Coagulation disorders or anticoagulant therapy\n* Infection at the injection site\n* Severe hepatic, renal, or cardiac disease\n* Chronic opioid use",{"count":161,"type":20},124,[23],"Postoperative pain after laparoscopic cholecystectomy can negatively affect patient comfort, recovery, and opioid consumption. Regional abdominal wall blocks are commonly used as part of multimodal analgesia to improve postoperative pain control and reduce opioid-related side effects.\n\nThe modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) and the erector spinae plane block (ESPB) are two ultrasound-guided regional anesthesia techniques that have been shown to provide effective postoperative analgesia in abdominal surgery. However, comparative clinical data between these two techniques in laparoscopic cholecystectomy are limited.\n\nThis randomized, single-blind clinical trial aims to compare the postoperative analgesic effectiveness of M-TAPA and ESPB in adult patients undergoing elective laparoscopic cholecystectomy. Postoperative pain scores, opioid consumption, time to first analgesic requirement, and patient satisfaction will be evaluated.",[165,26],"Postoperative Pain",[167,168,169,170,171,172],"Laparoscopic cholecystectomy","M-TAPA block","Erector spinae plane block (ESPB)","Regional anesthesia","Postoperative analgesia","Opioid consumption","2026-02-11",{"date":175,"type":40},"2026-02-13",{"date":177,"type":20},"2026-03-01",{"date":179,"type":20},"2026-09-01",{"name":181,"class":182},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":191,"targetDuration":4,"studyType":21,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":48},"100618308","dexamethasone-dexmedetomidine-and-their-combination-on-post-op-git-function-measured-by-i-ffed-score-post-laparoscopic-cholecystectomy-100618308","NCT07329933","Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy","Effect of Dexamethasone, Dexmedetomidine and Their Combination on Postoperative Gastrointestinal Function Measured by I-FEED Score After Elective Laparoscopic Cholecystectomy Surgery: a Randomized Controlled Trial","GIT","Inclusion Criteria:\n\n\\- . Age 18-65 years. 2. American Society of Anesthesiologists (ASA) physical status I or II. 3. Scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia.\n\n4\\. Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or contraindication to any study drug (dexamethasone, dexmedetomidine, or placebo).\n\n  2\\. Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).\n\n  3\\. Chronic use of opioids, steroids, or antiemetics. 4. History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).\n\n  5\\. Uncontrolled diabetes mellitus (HbA1c \\> 8.0%). 6. Emergency surgery or conversion to open surgery. 7. Pregnancy or breastfeeding. 8. Morbid obesity (BMI \\>40). 9. Severe hepatic or renal dysfunction.",{"count":192,"type":20},160,[23],"The goal of this clinical trial is to learn the effect of Dexamethasone and Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy\n\nWhat medical problems do participants have when taking Dexamethasone and Dexmedetomidine? Researchers will compare Dexamethasone and Dexmedetomidine and Their Combination to a placebo (a look-alike substance that contains no drug) to see the effect on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.\n\nParticipants will receive Dexmedetomidine 0.5 mcg \u002Fkg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.\n\nParticipants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg\u002Fkg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.\n\nParticipants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia",[196,26,197,198,199],"GIT Function","Dexamethasone","Dexmedetomidine","I-FEED Score","2025-12-29",{"date":202,"type":40},"2026-01-09",{"date":204,"type":20},"2025-12-15",{"date":206,"type":20},"2026-06-01",{"name":208,"class":47},"Benha University",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":225,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":236,"locationsCount":48},"100602107","surgical-techniques-robotic-versus-conventional-laparoscopic-cholecystectomy-in-benign-gallbladder-disease-100602107","NCT07119203","Surgical Techniques: Robotic Versus Conventional Laparoscopic Cholecystectomy IN Benign Gallbladder Disease","Surgical Techniques: Robotic Versus Conventional Laparoscopic Cholecystectomy IN Benign Gallbladder Disease: A Randomized Controlled, Open, Parallel, Non-inferiority, Single-center Trial (STaRLING Trial)","STaRLING","Inclusion Criteria:\n\n* Age equal or above 18 years;\n* Benign gallbladder disease: diagnosis of gallbladder polyps or symptomatic gallstones proven on imaging (ultrasound, computed tomography (CT) scan or magnetic resonance cholangiopancreatography (MRCP));\n* Capacity to give informed consent.\n\nExclusion Criteria:\n\n* Minimally invasive procedure is not deemed possible by the operating surgeon;\n* Evidence of acute cholecystitis;\n* Known stones in the common bile duct (CBD);\n* Suspicion of possible malignancy;\n* Pregnancy;\n* Diagnosis of liver cirrhosis (stage III or IV);\n* Insufficient language skills to be able to perform the quality-of-life questionnaires.",{"count":218,"type":20},276,[23],"This is a single-center, randomized controlled, parallel, non-inferiority trial. All adult patients with benign gallbladder disease with an indication for cholecystectomy will be assessed for eligibility and included after obtaining informed consent. A total of 276 patients will be randomized to undergo either robotic cholecystectomy (RC) or laparoscopic cholecystectomy (LC). The primary endpoint will be the incidence and severity of postoperative complications within 30 days after surgery. Secondary endpoints include perioperative outcomes, total health care utilization, health-related quality of life (HR-QoL) as assessed by patient-reported outcome measures, and cost-effectiveness. Follow-up assessments will be conducted at 7 and 30 days postoperatively.\n\nThis is the first randomized controlled trial designed to compare RC with LC in the treatment of benign gallbladder disease. The trial aims to evaluate the safety and non-inferiority of RC relative to LC, providing important evidence to guide the progress and adoption of robotic surgery in clinical practice.",[62,26,222,223,224],"Cholecystectomy","Gallstones","Benign Gallbladder Disease",[226,167,227,228,229],"Robotic cholecystectomy","Benign gallbladder disease","Randomized controlled trial","Cost-effectiveness","2025-12-16",{"date":232,"type":40},"2025-12-23",{"date":234,"type":40},"2025-09-12",{"date":206,"type":20},{"name":237,"class":182},"Portsmouth Hospitals NHS Trust",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":246,"targetDuration":4,"studyType":21,"phases":248,"briefSummary":249,"conditions":250,"keywords":252,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":264,"locationsCount":48},"100608610","analgesic-efficacy-of-bupivacaine-infiltration-erector-spinae-plane-block-and-intrathecal-morphine-in-laparoscopic-cholecystectomy-100608610","NCT07203794","Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy","A Prospective, Randomized Controlled Study Comparing the Analgesic Efficacy of Bupivacaine Infiltration of the Gallbladder Bed and Trocar Sites, Erector Spinae Plane Block, and Intrathecal Morphine in Patients Undergoing Laparoscopic Cholecystectomy","ITM-ESP-IPLA","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\> 35 kg\u002Fm²\n* History of coagulopathy or bleeding disorders\n* Known allergy or hypersensitivity to opioids or local anesthetics\n* Chronic pain or regular analgesic use\n* History of neurological or psychiatric disease\n* Pregnancy\n* Refusal to participate in the study",{"count":247,"type":20},132,[23],"This study is designed to compare three different methods of pain control after laparoscopic gallbladder surgery (laparoscopic cholecystectomy). Although this surgery is minimally invasive, participants often experience different types of pain after the operation, such as pain at the incision site, pain inside the abdomen, and shoulder pain caused by the gas used during surgery.\n\nThe investigators will compare three commonly used pain relief techniques:\n\nLocal infiltration - injecting a numbing medicine (bupivacaine) into the gallbladder bed and at the sites where the surgical instruments are placed.\n\nErector spinae plane (ESP) block - an ultrasound-guided nerve block performed in the back to reduce both abdominal and incisional pain.\n\nIntrathecal morphine - a very small dose of morphine given into the spinal fluid before surgery to provide long-lasting pain relief.\n\nThe goal is to determine which method provides the best pain control, reduces the need for opioid medications, and improves recovery after surgery.",[251,26],"Postoperative Pain Management",[96,165,253,254,255,256,257],"Bupivacaine Infiltration","Erector Spinae Plane Block","Intrathecal Morphine","Analgesia","Opioid Consumption","2025-11-20",{"date":260,"type":40},"2025-11-25",{"date":262,"type":20},"2025-12-01",{"date":125,"type":20},{"name":265,"class":47},"Ataturk University",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":16,"minAge":273,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":21,"phases":276,"briefSummary":277,"conditions":278,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":290},"100593052","cholecystectomy-after-successful-endoscopic-common-bile-duct-stone-extraction-in-elderly-100593052","NCT07001423","ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly","COFFEE","Inclusion Criteria:\n\n* Common bile duct stones cleared after Endoscopic Retrograde Cholangio Pancreatography (ERCP)\n* Age \\>= 80 years or age 75-79 years with a Charlson Comorbidity index \\>=2\n* gallbladder in situ\n\nExclusion Criteria:\n\n* Acute Cholecystitis\n* Biliary Pancreatitis\n* Severe or moderately severe post-ERCP pancreatitis\n* Chronic pancreatitis\n* Bile duct pathology\n* Widespread malignancy\n* Unable to give consent","75 Years",{"count":275,"type":20},400,[23],"The goal of this study is to compare safety and efficacy of laparoscopic cholecystectomy versus wait-and-see policy after endoscopic removal of common bile duct stones in elderly. The primary endpoint is a composite outcome: Death or major postoperative complications or recurrent biliary disease within 1 year after randomization.",[26,279,280],"Choledocholithiasis","Cholelithiasis","2025-10-02",{"date":283,"type":40},"2025-10-07",{"date":285,"type":20},"2025-10-03",{"date":287,"type":20},"2032-08-31",{"name":289,"class":47},"Helsinki University Central Hospital",12,{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":21,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":48},"100591122","deep-rectus-sheath-block-for-laparoscopic-cholecystectomy-100591122","NCT06976320","Deep Rectus Sheath Block for Laparoscopic Cholecystectomy","Deep Rectus Sheath Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Patients with American Society of Anesthesiology (ASA) physical status I-II\n* Patients scheduled for a laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Coagulopathy\n* Skin infection at the deep rectus sheath block area\n* Advanced hepatic or renal failure\n* Chronic pain syndromes\n* Alcohol or drug abuse\n* Severe pulmonary and\u002For cardiovascular disease\n* Psychiatric disorders","80 Years",{"count":300,"type":20},60,[23],"Postoperative pain after laparoscopic cholecystectomy can be considerable. Regional techniques such as erector spinae plane (ESP) block or transversus abdominis plane (TAP) block may be suitable for patients at increased risk of postoperative pain. The deep rectus sheath block is a novel block which is a modified version of the conventional rectus sheath block. It was reported in a few case reports that, it may be used for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. The aim of this study is to investigate the postoperative analgesic efficacy of deep rectus sheath block in patients undergoing laparoscopic cholecystectomy.",[26,304,165],"Anesthesia","2025-09-17",{"date":307,"type":40},"2025-09-22",{"date":309,"type":40},"2025-09-09",{"date":311,"type":20},"2026-01",{"name":313,"class":47},"Istinye University",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":21,"phases":322,"briefSummary":323,"conditions":324,"keywords":332,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":48},"100564856","the-effect-of-patient-education-and-in-the-operating-room-family-interview-practices-on-patient-outcomes-using-virtual-reality-in-cholecystectomy-patients-100564856","NCT06634615","The Effect of Patient Education and in the Operating Room Family Interview Practices on Patient Outcomes Using Virtual Reality in Cholecystectomy Patients","The Effect of Patient Education and in the Operating Room Family Interview Practices on Patient Outcomes Using Virtual Reality in Cholecystectomy Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who volunteered to participate in the study,\n* who were 18 years of age or older,\n* who would undergo elective laparoscopic cholecystectomy surgery,\n* who had no vision, hearing and communication problems,\n* whose relatives had a smartphone and internet connection,\n* whose stress intensity was higher than 3 points (between 1-10 points) met the inclusion criteria.\n\nExclusion Criteria:\n\n* Patients with complaints of dizziness,\n* psychiatric disorders,\n* persistent sleep problems were excluded from the study.\n* Patients who voluntarily left the study,\n* interrupted the family video call with VR,\n* felt discomfort during VR application,\n* developed any allergy to the goggle material,\n* filled out the data collection forms incompletely and\u002For incorrectly will be excluded from the study.",{"count":300,"type":20},[23],"This study was planned to be a randomized controlled experimental study to determine the effect of patient education and family interview practices using virtual reality on stress intensity, anxiety and information need levels, sleep quality and satisfaction with the preparation process for surgery in cholecystectomy patients. The main questions it aims to answer are:\n\n* Is there a significant difference in stress intensity, anxiety, and information need levels between patients who received and did not receive patient education with VR glasses in the ward before cholecystectomy surgery?\n* Is there a significant difference in stress intensity and anxiety levels between patients who received and did not receive video family interviews with VR glasses in the operative waiting area before cholecystectomy surgery?\n* Is there a significant difference in stress intensity, anxiety, and sleep quality levels at discharge of groups that received different VR interventions?\n* What is the postoperative sleep quality of patients with low preoperative anxiety levels?\n* What is the satisfaction of patients who received VR with the surgery preparation process? The patients participating in the study will be numbered according to the order of hospitalization and assigned to one of the control, education, education+interview groups in accordance with the randomization list. Face-to-face communication will be established with each patient in the ward on the day of hospitalization, in the preoperative waiting area when they come to the operating room and in the ward on the day of discharge. Depending on the groups in which the patients are included, they will be shown an educational video using virtual reality goggles and\u002For will be allowed to meet with their families. No application will be made to the control group and the ward routine will continue.",[26,325,34,326,327,27,328,329,330,331],"Virtual Reality","Family Interviews","Operating Room","Stress","Sleep Quality","Patient Satisfaction","Patient Outcomes",[222,325,34,333,331,27,328,329,330],"Operating Room Family Interview","2025-05-08",{"date":336,"type":40},"2025-05-09",{"date":338,"type":40},"2025-01-05",{"date":340,"type":20},"2025-08",{"name":342,"class":47},"Marmara University",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":351,"targetDuration":4,"studyType":21,"phases":353,"briefSummary":354,"conditions":355,"keywords":356,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":48},"100584887","smart-intraoperative-reminder-to-implement-safety-principles-in-laparoscopic-cholecystectomy-100584887","NCT06895200","Smart Intraoperative Reminder to Implement Safety Principles in Laparoscopic Cholecystectomy","CVS-Notifier - Smart Intraoperative Reminder to Implement Safety Principles in Laparoscopic Cholecystectomy","CVS-Notifier","Inclusion Criteria:\n\n* Man or woman over 18 years old.\n* Patient presenting with benign gallbladder disease requiring an elective laparoscopic cholecystectomy.\n* Patient without contraindications to anaesthesia or laparoscopic cholecystectomy surgery.\n* Patients capable of understanding and providing their written consent to the study.\n* Patient affiliated to the French social security system.\n\nExclusion Criteria:\n\n* Patients presenting with malignant gallbladder disease requiring an elective laparoscopic cholecystectomy.\n* Pregnant or lactating patient.\n* Patient in exclusion period (determined by a previous or a current study).\n* Patient under guardianship or trusteeship.\n* Patient under the protection of justice or deprived of liberty.\n* Patient in situation of emergency.",{"count":352,"type":20},40,[23],"The Critical View of Safety (CVS) is universally recommended to prevent bile duct injuries in laparoscopic cholecystectomy. However, CVS is underutilized and bile duct injuries are not decreasing. The CVS-Notifier SaMD (Software as a Medical Device) reminds surgeons to verify the CVS before dividing the cystic duct, as recommended by guidelines. It is hypothesized that this systematic and timely reminder could improve the implementation of CVS without disturbing surgical workflows.",[26],[167,357,358,359,360,361,362],"Gallbladder","Safety","Critical View of Safety","CVS","Bile Duct Injuries","BDI","2025-04-29",{"date":365,"type":40},"2025-04-30",{"date":367,"type":40},"2025-04-03",{"date":369,"type":20},"2026-05",{"name":371,"class":47},"IHU Strasbourg",{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":379,"sex":16,"minAge":17,"maxAge":380,"enrollmentInfo":381,"targetDuration":4,"studyType":21,"phases":383,"briefSummary":384,"conditions":385,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":48},"100579088","efficacy-and-safety-of-cocktail-of-ropivacaine-for-local-infiltration-analgesia-in-patients-undergoing-laparoscopic-cholecystectomy-100579088","NCT06819748","Efficacy and Safety of Cocktail of Ropivacaine for Local Infiltration Analgesia in Patients Undergoing Laparoscopic Cholecystectomy","Efficacy and Safety of Cocktail of Ropivacaine,sodium Bicarbonate and Dexamethasone for Incision Local Infiltration Analgesia in Patients Undergoing Ambulatory Laparoscopic Cholecystectomy:A Prospective Randomized Control Trial","Inclusion Criteria:\n\n* Patients undergoing daytime laparoscopic cholecystectomy in Sichuan Provincial People's hospital ② Age: 18-70 years\n\n  * American society of Anesthesiologists physical status classification system I-II ④ 18 kg\u002F㎡≤ BMI ≤ 30 kg\u002F㎡ ⑤ No communication barriers, able to understand the research process and the use of pain scale.\n\n    * Signed informed consent\n\nExclusion Criteria:\n\n* Drug allergy related to this study\n\n  * History of chronic pain, long-term use of analgesic drugs (equivalent to ≥ 10mg oxycodone per day), alcohol abuse, gastrointestinal bleeding or perforation after application of non steroidal anti-inflammatory drugs\n\n    * Patients with ischemic heart disease, peripheral arterial vascular or cerebrovascular disease, or patients with pulmonary heart disease, active peptic ulcer or gastrointestinal bleeding, or patients with inflammatory bowel disease\n\n      * Patients taking monoamine oxidase inhibitors or within 2 weeks after discontinuation ⑤ Preoperative pain score (NRS ) was greater than or equal to 4 points ⑥ Participated in other clinical studies within three months",true,"70 Years",{"count":382,"type":20},210,[23],"The goal of this clinical trial is to learn if the use of cocktail of ropivacaine,sodium bicarbonate and dexamethasone for incision local infiltration analgesia in patients undergoing ambulatory laparoscopic cholecystectomy is safe and effective. The main questions it aims to answer are:\n\nDoes the cocktail lower the The incidence of moderate to severe pain during movement stages within six hours after surgery.\n\nResearchers will compare the cocktail to ropivacaine for incision local infiltration analgesia to see if the cocktail works to moderate the postoperative pain of ambulatory laparoscopic cholecystectomy patients.\n\nParticipants will:\n\nReceive the cocktail or ropivacaine for incision local infiltration analgesia at the end of the surgery.\n\nAnswer the questions about postsurgical pain at rest or during motion(using a Numeric Rating Scale (NRS) of 0 to 10. Pain measurements were performed at 2, 6, 12, 24 hours,3,7,30 days and 3 months postoperatively.",[26,386,387],"Ambulatory Surgical Procedures","Multimodal Analgesia","2025-02-16",{"date":390,"type":40},"2025-02-19",{"date":392,"type":40},"2025-02-14",{"date":394,"type":20},"2025-09-01",{"name":396,"class":47},"Sichuan Provincial People's Hospital",{"id":398,"slug":399,"hasResults":11,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":405,"targetDuration":4,"studyType":21,"phases":406,"briefSummary":407,"conditions":408,"keywords":412,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":4},"100569905","intraoperative-hyperspectral-imaging-for-laparoscopic-surgery-100569905","NCT06700317","Intraoperative Hyperspectral Imaging for Laparoscopic Surgery","Intraoperative Hyperspectral Imaging for Laparoscopic Surgery (LapHSI): a Multicentre Post-market Clinical Study","LapHSI","Inclusion Criteria:\n\nA) Cholelithiasis or cholecystitis with indications for laparoscopic surgery (cholecystectomy)\n\n* Adult patients aged 18 years and over\n* Common bile duct diameter \\\u003C 8mm as assessed using ultrasound\n* Patients able to provide written informed consent\n\nB) Colorectal cancer requiring elective bowel resection via a laparoscopic approach.\n\n* Adult patients aged 18 years and over\n* Patients who are scheduled for elective laparoscopic colon cancer resection\n* Patients able to provide written informed consent\n\nExclusion Criteria:\n\nA) Cholelithiasis or cholecystitis with indications for laparoscopic surgery (cholecystectomy)\n\n* Patients under 18 years of age\n* Patients with a history of previous abdominal surgery and multiply scarred abdomen\n* Common bile duct diameter ≥ 8mm as assessed using ultrasound\n* Patients unable to provide written informed consent\n* Patients who are pregnant\n\nB) Colorectal cancer requiring elective bowel resection via a laparoscopic approach.\n\n* Patients under 18 years of age\n* Patients with a history of previous abdominal surgery and multiply scarred abdomen\n* Patients unable to provide written informed consent\n* Patients undergoing emergency surgery\n* Patients who are pregnant",{"count":352,"type":20},[23],"The study aims to evaluate the use of the HyperSnap Surgical System (HSS1) during laparoscopic surgeries, specifically in bowel resections and cholecystectomies.",[409,410,411,26],"Colorectal Neoplasms","Colorectal Surgery","Cholecystitis",[413,414,415,416,417],"hyperspectral imaging","surgery","laparoscopic surgery","colorectal cancer","cholecystitis","2024-11-20",{"date":420,"type":40},"2024-11-21",{"date":422,"type":20},"2025-02-01",{"date":424,"type":20},"2025-08-01",{"name":426,"class":47},"King's College London",{"id":428,"slug":429,"hasResults":11,"nctId":430,"briefTitle":431,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":380,"enrollmentInfo":433,"targetDuration":4,"studyType":21,"phases":435,"briefSummary":436,"conditions":437,"keywords":438,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":449},"100521829","clinical-study-of-single-incision-laparoscopic-cholecystectomy-in-the-treatment-of-patients-with-acute-cholecystitis-100521829","NCT06074679","Clinical Study of Single Incision Laparoscopic Cholecystectomy in the Treatment of Patients With Acute Cholecystitis","Inclusion Criteria:\n\n* Acute cholecystitis（GradeⅠ，II）\n\nExclusion Criteria:\n\n* Combined with liver cirrhosis (Child grade B and above)\n* Upper abdominal surgical history;\n* Changes in surgical plan (conversion to laparotomy,cholangiography, bile duct exploration, bile duct injury repair, abscess clearance, multivisceral resection.)\n* Patients and their families do not agree with the treatment lost follow-up",{"count":434,"type":20},600,[23],"Gallstone is a common disease in China.At present, the prevalence of gallstones in China is 15 %, and about 210 million people are sick. Acute cholecystitis is acute gallbladder inflammation, is one of the main complications of cholelithiasis or gallstones. The removal of gallbladder and gallstones in patients with acute cholecystitis in the presence of biliary pain will prevent the recurrence of gallbladder and reduce the risk of cholecystitis progression. If gallbladder perforation is not treated in time, the mortality rate is 30 %. Acute acalculous cholecystitis without treatment will be life-threatening, with a mortality rate of up to 50 %. At present, the vast majority of patients with acute cholecystitis are treated with 4-hole traditional laparoscopic cholecystectomy and open cholecystectomy. Their postoperative quality of life, pain and scar-related complications, remain major factors for patients.In recent years, with the renewal of the concept of minimally invasive surgery and the continuous advancement of instruments and technology, single-incision laparoscopic cholecystectomy has also maximized the quality of life after surgery and reduced postoperative pain and scar-related complications. At present, there are few reports on randomized controlled clinical trials of SILC in patients with acute cholecystitis, and there is a lack of large sample size studies.Due to the difficulty of SILC operation, the longer learning curve, the different equipment conditions and technical characteristics of each center, and the lack of standardized training, there is no effective consensus on the application indications and operation procedures of SILC in acute cholecystitis surgery. Based on the current status, the purpose of this study was to investigate the effect of SILC on postoperative quality of life, postoperative pain, scar assessment and postoperative complications in patients with acute cholecystitis, so as to propose a standardized single incision laparoscopic operation procedure in the treatment of acute cholecystitis.",[26],[439,440],"Single-incision laparoscopic cholecystectomy","Conventional laparoscopic cholecystectomy","2024-11-18",{"date":420,"type":40},{"date":444,"type":40},"2023-10-01",{"date":446,"type":20},"2026-09-30",{"name":448,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University",5]