[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cholecystitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cholecystitis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,81,116,141,166,194,223,251,274,308],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100638697","ultrasound-guided-rectus-sheath-block-versus-local-infiltration-100638697",false,"NCT07582029","Ultrasound-Guided Rectus Sheath Block Versus Local Infiltration","Comparison of the Analgesic Effects of Local Anesthetic Infiltration and Ultrasound-Guided Rectus Sheath Block in Laparoscopic Cholecystectomy Operations: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) class I-II patients\n* Patients aged between 18 and 65 years\n* Patients undergoing laparoscopic cholecystectomy surgery\n\nExclusion Criteria:\n\n* ASA class III-IV patients\n* Patients undergoing emergency surgery\n* Relatives of patients who do not provide consent\n* Presence of chronic pain\n* Chronic opioid use\n* Presence of local anesthetic allergy\n* Ibuprofen allergy\n* Paracetamol allergy\n* Presence of infection at the block site\n* Coagulopathy\n* Increased intracranial pressure\n* Pre-existing neurological deficit\n* Severe organ failure\n* Mental retardation\n* Anatomical deformity","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Laparoscopic cholecystectomy is associated with significant postoperative pain originating from trocar sites, pneumoperitoneum, and visceral irritation. Both local anesthetic infiltration and ultrasound-guided rectus sheath block are commonly used regional analgesic techniques to reduce postoperative pain and opioid consumption. This prospective randomized controlled study aims to compare the effects of these two techniques on postoperative pain scores, opioid requirements, and analgesia-related adverse effects following laparoscopic cholecystectomy.",[26,27,28],"Cholelithiases","Cholecystitis","Postoperative Pain",[30,31,32,33],"Cholecystectomy, Laparoscopic","Rectus Sheath Block","Anesthesia, Local","Pain, Postoperative","NOT_YET_RECRUITING","2026-05-06",{"date":37,"type":38},"2026-05-12","ACTUAL",{"date":37,"type":20},{"date":41,"type":20},"2026-12-12",{"name":43,"class":44},"Sisli Hamidiye Etfal Training and Research Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100629362","feasibility-study-of-non-contact-imaging-based-physiological-monitoring-in-the-operating-room-100629362","NCT07473687","Feasibility Study of Non-Contact Imaging-Based Physiological Monitoring in the Operating Room","IBPM","Inclusion Criteria:\n\n1. Patients aged \\>18 years.\n2. Patients scheduled to undergo surgical procedures under general anesthesia.\n3. American Society of Anesthesiologists (ASA) Physical Status I, II, or III.\n\nExclusion Criteria:\n\n1. Patients aged \\\u003C 18 years.\n2. Pregnant patients.\n3. Patients whose facial images cannot be captured or recognized (e.g., due to surgical drapes, severe edema, or major trauma).\n4. Patients who refuse to participate or have not signed the informed consent form.\n5. Other cases deemed unsuitable for the study by the clinical physician or anesthesiologist.",{"count":54,"type":20},315,"1 Day","OBSERVATIONAL","This study aims to evaluate the feasibility and accuracy of a non-contact, camera-based physiological monitoring technology in a perioperative setting (including anesthesia induction, surgery, and recovery).Conventional vital sign monitoring tools-such as ECG leads, blood pressure cuffs, and pulse oximeters-require direct skin contact, which may pose risks of cross-infection or skin injury in vulnerable populations (e.g., newborns or elderly patients). This research utilizes remote Photoplethysmography (rPPG) technology to estimate vital signs, including heart rate, blood pressure, and blood oxygen saturation (SpO2), by analyzing facial video captured via standard camera devices (Logitech C930, iPhone 16 Pro Max, and Samsung Galaxy S24 Ultra).The primary goal is to assess the consistency and stability of this non-contact system compared to clinical gold-standard monitors (Masimo Root, SedLine O3, and Radical-7) during actual surgical procedures. The findings will serve as a foundation for developing non-invasive, supplementary monitoring tools in dynamic clinical environments.",[27,59,60,61],"Liver Neoplasms","Cholelithiasis","Inguinal Hernia",[63,64,65,66,67,68,69],"General anesthesia","Intraoperative monitoring","Camera-based monitor","Non-contact Physiological Monitoring","Total Extraperitoneal Approach (TEP)","Remote Sensing","Perioperative Care","RECRUITING","2026-03-10",{"date":73,"type":38},"2026-03-16",{"date":75,"type":38},"2026-01-08",{"date":77,"type":20},"2030-06-30",{"name":79,"class":80},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":45},"100610049","one-vs-two-stents-for-gallbladder-disease-100610049","NCT07222527","One vs. Two Stents for Gallbladder Disease","A Randomized Trial of One vs. Two Transpapillary Cystic Duct Stents to Prevent Recurrent Symptomatic Gallbladder Disease in Non-Cholecystectomy Candidates","Inclusion Criteria:\n\n1. Males or non-pregnant females presenting with cholecystitis, biliary colic or gallstone pancreatitis.\n2. Age 18-95.\n3. Participants must be willing and able to provide informed consent\n4. Referred for ERCP for management of 1) suspected choledocholithiasis 2) acute biliary pancreatitis and\u002For 3) acute cholangitis in whom cholecystectomy is expected to be delayed \\> 30 days or are deemed to not be surgical candidates for cholecystectomy.\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. History of surgically altered upper gastrointestinal anatomy (e.g. Roux-en-Y gastric bypass, Billroth I\u002FII) precluding standard ERCP\n3. History of primary sclerosing cholangitis\n4. History of gallbladder cancer\n5. History of cholecystectomy\n6. Unsuccessful biliary cannulation during ERCP -","95 Years",{"count":90,"type":20},30,[23],"This randomized trial will look at whether placing two cystic duct stents is more effective than one cystic duct stent in preventing recurrent gallbladder disease (cholecystitis, gallstone pancreatitis, or biliary colic) among patients who are not immediate surgical candidates for removal of their gallbladder.\n\nThe study will evaluate the safety profile, including rates of recurrent cholecystitis, biliary colic, and procedure-related complications, and technical success, defined as successful placement of stents into the gallbladder.\n\nThe main questions it aims to answer are:\n\n1. Does placement of two transpapillary cystic duct stents reduce the risk of recurrent symptomatic gallbladder disease compared to one stent?\n2. Is there a difference in procedure-related adverse events (post-ERCP pancreatitis, cholangitis, stent migration) between the two strategies?\n\nResearchers will compare outcomes between patients randomized to one stent versus two stents to determine which approach provides better long-term gallbladder drainage and fewer recurrent events.\n\nParticipants will:\n\nBe evaluated for eligibility and provide informed consent prior to undergoing an endoscopic retrograde cholangiopancreatography (ERCP), an endoscopy where a guidewire is placed into the bile duct from the small intestine.\n\nThey will then undergo ERCP with transpapillary cystic duct stent placement, randomized to one or two stents.\n\nAll participants will receive standard post-procedure care and follow-up assessments for recurrence, adverse events, and need for reintervention.",[94,27,95,96],"Recurrent Cholecystitis","Symptomatic Gallbladder Disease","Biliary Colic",[98,99,100,101,102,103,104,105,106,107],"gallbladder disease","symptomatic gallbladder disease","Recurrent cholecystitis","biliary colic","cystic duct stent","transpapillary gallbladder stents","high surgical risk patient","nonsurgical management gallbladder disease","gallbladder decompression","acute cholecystitis in non-cholecystectomy candidate","2025-12-12",{"date":110,"type":38},"2025-12-16",{"date":108,"type":38},{"date":113,"type":20},"2028-05-27",{"name":115,"class":44},"Mayo Clinic",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100525544","stall-vs-sole-local-wound-infiltration-in-laparoscopic-cholecystectomy-100525544","NCT06123117","STALL vs Sole Local Wound Infiltration in Laparoscopic Cholecystectomy","Single Transversus Abdominis Laparoscopy-guided Plane Block Combined With Local Trocar Site Ropivacaine Infiltration (STALL) vs Sole Local Wound Infiltration in LCC (Laparoscopic CholeCystectomy) - Double-blinded Randomized Controlled Trial.","STALL","Inclusion Criteria:\n\n* All patients scheduled for elective or emergency LCC, aged over 18 and able to give an informed consent.\n\nExclusion Criteria:\n\n* Age under 18 years, chronic daily opioid and\u002For pain tolerance \u002F pain threshold -modifying medication use (abuse), pregnancy, known allergy to local anesthetics, diagnosed severe coagulopathy and incapability to give informed consent for whatever reason.",{"count":125,"type":20},850,[23],"This trial is a prospective randomized superiority trial comparing sole ropivacaine based local trocar site infiltration to local infiltration combined with laparoscopic ropivacaine TAP block (STALL) in LCC.\n\nThere are only a few randomized trials comparing sole local anesthesia to additional laparoscopic TAP block in laparoscopic cholecystectomy and they have yet failed to show evidence in favor of TAP block.\n\nWe hypothesize STALL (Single Transversus Abdominis Laparoscopy-guided plane block combined with Local trocar site ropivacaine infiltration) is superior to local port site infiltration, provided that the sample size is sufficiently big.\n\nThe aim of this randomized study is to compare the efficacy of sole local anesthesia of trocar sites to STALL in LCC.",[60,27,129],"Gallbladder Cancer",[131],"laparoscopic transversus abdominis plane block","2025-09-10",{"date":134,"type":38},"2025-09-11",{"date":136,"type":38},"2024-01-16",{"date":138,"type":20},"2027-10",{"name":140,"class":44},"Helsinki University Central Hospital",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":16,"minAge":148,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":45},"100575459","desflurane-potentially-induces-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-perioperative-procedures-by-modulating-cdc42-and-clock-proteins-100575459","NCT06772558","Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins","The Potential Mechanism by Which Desflurane Induces Postoperative Cognitive Dysfunction in Elderly Perioperative Patients Involves the Modulation of Cdc42 and Clock Proteins, and Their Related Signaling Pathways.","Inclusion Criteria:\n\n* Age \\> 70 years\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled to undergo elective surgery requiring general anesthesia with desflurane\n* Able and willing to provide voluntary written informed consent\n* Able to understand the study procedures and complete follow-up assessments\n\nExclusion Criteria:\n\n* Pre-existing diagnosis of dementia or any other neurodegenerative disease that could affect cognitive function\n* Preoperative Montreal Cognitive Assessment (MoCA) score \\\u003C 20\n* History of severe psychiatric disorders, including psychosis, severe depression, or bipolar disorder\n* Unstable angina, uncontrolled hypertension, or a history of myocardial infarction within the past 6 months\n* Severe chronic obstructive pulmonary disease (COPD) with significant respiratory compromise, or other significant respiratory disease\n* Severe hepatic or renal impairment, defined as Child-Pugh class C for liver disease, or glomerular filtration rate (GFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m2 for kidney disease\n* History of stroke, transient ischemic attack (TIA), or other significant neurological disorders\n* History of alcohol or drug abuse\n* Patients with visual, auditory, or language impairments that would interfere with cognitive testing.\n* Known allergy or contraindication to any of the study drugs\n* Other conditions at the discretion of the investigator that could interfere with the conduct of the study or the interpretation of the results","70 Years",{"count":19,"type":20},[23],"This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins. The primary research questions are: (1) Does desflurane administration contribute to POCD in this patient population? and (2) Are alterations in Cdc42 and Clock protein levels associated with desflurane-induced POCD in elderly patients? To address these questions, elderly patients will be administered desflurane for anesthesia maintenance. Postoperative assessments will then compare blood levels of Cdc42 and Clock proteins, and examine related signaling pathways, between a control group and a POCD group.\n\nStudy participants will receive desflurane anesthesia maintained at a Bispectral Index (BIS) value of 40-60. Postoperative cognitive function will be assessed on the second day using the Montreal Cognitive Assessment (MoCA), and participants will be categorized into either a control group or a POCD group based on MoCA performance. Cognitive function and blood levels of Cdc42 and Clock proteins will be recorded. Furthermore, the study will also investigate associated signaling pathways.",[153,154,155,27,156],"Avascular Necrosis of the Femoral Head","Coronary Artery Disease (CAD)","Benign Prostatic Hyperplasia (BPH)","Knee Osteoarthritis","2025-01-12",{"date":159,"type":38},"2025-01-14",{"date":161,"type":20},"2025-02-01",{"date":163,"type":20},"2025-05-10",{"name":165,"class":44},"Xiaguang Duan",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":173,"sex":16,"minAge":174,"maxAge":148,"enrollmentInfo":175,"targetDuration":4,"studyType":21,"phases":177,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":45},"100573025","phase-2-evaluating-perioperative-outcomes-dexmedetomidine-vs-lignocaine-in-laparoscopic-chlolecystectomy-100573025","NCT06740903","Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy","Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n1. Patients of age 20-70 years\n2. Both gender\n3. Laparoscopic cholecystectomy under general Anaesthesia\n4. ASA I-II.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Patients with history of allergic reaction to trial drugs\n* Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record)\n* Anemia\n* Patient on TCA or Beta blocker drugs.\n* Uncontrolled hypertension (P≥160\u002F100 mmHg)\n* Uncontrolled diabetes mellitus\n* Obesity BMI \\> 35",true,"20 Years",{"count":176,"type":20},140,[178,179],"PHASE2","PHASE3","Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications. To minimize these side effects associated with the use of opioids, various methods have been adopted. Recently, different trials have highlighted the possible role of dexmedetomidine and lignocaine in providing postoperative analgesia and attenuating hemodynamic response. Literature showed conflicting results regarding both these drugs. So, we want to find the evidence for local setting. This Randomized Controlled Trial will be done at Department of Anesthesia, Sahiwal teaching hospital, Sahiwal for 12 months. Sample size of 140 cases; 70 cases in each group will be included through non-probability consecutive sampling. Then patients will be divided in two groups by using computer generated random number table. In group A, patients will be given dexmedetomidine infusion. In group B, patients will be given lignocaine infusion. All anesthesia procedures will be done by researcher. Heart rate and mean arterial pressure will be assessed before induction of anesthesia, after every 10 mins every 30 mins till completion of surgery. Total operative time will be noted. After procedure, patients will be assessed for postoperative pain score. when pain will be ≥4 on visual analogue scale rescue analgesia will be given and time will be noted. Total duration from time of surgery till need for rescue analgesia will be noted. Duration of postoperative analgesia opioid consumption \u002F24 hrs.) will be presented by using mean± SD.",[182,183,184,27],"Hemodynamics Instability","Post Operative Pain","Gastrointestinal Dysfunction","2024-12-14",{"date":187,"type":38},"2024-12-18",{"date":189,"type":38},"2024-08-06",{"date":191,"type":20},"2025-09-06",{"name":193,"class":80},"Sahiwal medical college sahiwal",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":21,"phases":204,"briefSummary":205,"conditions":206,"keywords":209,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":219,"leadSponsor":221,"locationsCount":4},"100569905","intraoperative-hyperspectral-imaging-for-laparoscopic-surgery-100569905","NCT06700317","Intraoperative Hyperspectral Imaging for Laparoscopic Surgery","Intraoperative Hyperspectral Imaging for Laparoscopic Surgery (LapHSI): a Multicentre Post-market Clinical Study","LapHSI","Inclusion Criteria:\n\nA) Cholelithiasis or cholecystitis with indications for laparoscopic surgery (cholecystectomy)\n\n* Adult patients aged 18 years and over\n* Common bile duct diameter \\\u003C 8mm as assessed using ultrasound\n* Patients able to provide written informed consent\n\nB) Colorectal cancer requiring elective bowel resection via a laparoscopic approach.\n\n* Adult patients aged 18 years and over\n* Patients who are scheduled for elective laparoscopic colon cancer resection\n* Patients able to provide written informed consent\n\nExclusion Criteria:\n\nA) Cholelithiasis or cholecystitis with indications for laparoscopic surgery (cholecystectomy)\n\n* Patients under 18 years of age\n* Patients with a history of previous abdominal surgery and multiply scarred abdomen\n* Common bile duct diameter ≥ 8mm as assessed using ultrasound\n* Patients unable to provide written informed consent\n* Patients who are pregnant\n\nB) Colorectal cancer requiring elective bowel resection via a laparoscopic approach.\n\n* Patients under 18 years of age\n* Patients with a history of previous abdominal surgery and multiply scarred abdomen\n* Patients unable to provide written informed consent\n* Patients undergoing emergency surgery\n* Patients who are pregnant",{"count":203,"type":20},40,[23],"The study aims to evaluate the use of the HyperSnap Surgical System (HSS1) during laparoscopic surgeries, specifically in bowel resections and cholecystectomies.",[207,208,27,30],"Colorectal Neoplasms","Colorectal Surgery",[210,211,212,213,214],"hyperspectral imaging","surgery","laparoscopic surgery","colorectal cancer","cholecystitis","2024-11-20",{"date":217,"type":38},"2024-11-21",{"date":161,"type":20},{"date":220,"type":20},"2025-08-01",{"name":222,"class":44},"King's College London",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":238,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":247,"leadSponsor":249,"locationsCount":45},"100566524","eoib-for-laparoscopic-cholecystectomy-100566524","NCT06656299","EOIB for Laparoscopic Cholecystectomy","Evaluation of Post-Operative Analgesic Efficacy of Bilateral External Oblique Intercostal Plane Block Versus Wound Site Infiltration Control Group in Patients Underwent Laparoscopic Cholecystectomy Surgery","Inclusion Criteria:\n\n* Patients aged 18 to 65 who will be scheduled for an elective laparoscopic cholecystectomy under general anesthesia\n* ASA (American Society of Anesthesiologists) I-II-III\n\nExclusion Criteria:\n\n* presence of coagulation disorder\n* infection at the injection site of the block\n* known allergy to local anesthetics\n* advanced hepatic, heart or renal failure\n* history of abdominal surgery or trauma\n* conversion of laparoscopic to open surgery\n* consumption of any pain killers within the 24 h before the operation\n* chronic opioid consumption\n* pregnancy\n* alcohol or drug abuse\n* body mass index (BMI) ≥ 35 kg m-2\n* Impairment of the patient's cognitive functions (such as Alzheimer's disease, dementia, etc.).\n* Cholecystectomy cases performed under emergency conditions.","65 Years",{"count":19,"type":20},[23],"Laparoscopic cholecystectomy, while less painful compared to conventional methods, is still a surgery that can cause significant pain for patients. Preventing postoperative pain is crucial for reducing respiratory complications, shortening hospital stays, and increasing patient satisfaction. Interfascial plane blocks have been widely used for postoperative analgesia in recent years worldwide. The External Oblique Intercostal Plane Block is one of the interfascial plane blocks used in abdominal surgeries. In our study, we aimed to compare the postoperative pain scores of patients who underwent laparoscopic cholecystectomy under general anesthesia, specifically between those who received the external oblique intercostal plane block and those who had trocar entry site infiltration.",[27,235,236,237],"Cholecystitis, Acute","Cholecystitis, Chronic","Cholecystitis; Gallstone",[239,240,241,242],"External Oblique Intercostal Plan Block","Wound Infiltration","Laparoscopic Cholecystectomy","Postoperative pain","2024-10-30",{"date":245,"type":38},"2024-11-01",{"date":243,"type":38},{"date":248,"type":20},"2025-11-01",{"name":250,"class":44},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":259,"enrollmentInfo":260,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":45},"100542976","dutch-cholecystitis-snapshot-study-100542976","NCT06349863","Dutch Cholecystitis Snapshot Study","Variation in Cholecystitis Treatment and Outcome in the Netherlands; a Nation-wide Cohort Study","Dutch CHESS","All patients \\>18 years with a calculous cholecystitis as primary reason for their hospital admittance. Location of diagnosis may the emergency department, the ward during admittance for diagnostics, or during diagnostic laparoscopy. Cholecystitis is defined according to the TG18 diagnostic criteria for a definitive diagnosis of cholecystitis: A. Local signs of inflammation (Murphy's sign and or RUQ mass\u002Fpain\u002Ftenderness) + B. Systemic signs of inflammation (Fever, elevated CRP and\u002For elevated WBC count) + C. Imaging findings characteristic of acute cholecystitis. Patients with a suspected diagnosis (one item in A + one item in B + C), of which the diagnosis is confirmed by peroperative findings, are also included. Patients will be identified by a local study investigator, e.g. a surgeon or surgeon in training.","120 Years",{"count":261,"type":20},3000,"Background: Cholecystitis is treated by in various types of hospitals by different specialists, and treatment strategy is influenced by logistical and medical reasons and personal preference. This may significantly impact hospital stay and other outcomes.\n\nPurpose: To determine the variation in treatment of cholecystitis in the Netherlands and its impact on outcome.\n\nMethods: Nation-wide cohort study of all patients diagnosed and treated for cholecystitis during a 6 month period. The primary outcome will be the proportion of patients with an acute cholecystitis in which the guideline is followed. This group will be compared to those in which the guideline is not followed, focussing on total hospital stay and complications. Secondary aims are to determine: factors related to guideline compliance; the best method of cystic duct closure; the best treatment strategy for a \\>7-day existing cholecystitis; factors predictive for concomitant common bile duct stones; strategies following gallbladder drainage. Multivariable analysis and propensity score matching will be used when appropriate for the etiological study aims. The TRIPOD guideline for prediction modelling will be used for the predictive study aims. Hospitals will receive their own results, set out against the national average and best practices, thereafter subsequent changes in hospital practice will be recorded.\n\nConclusion: This study will determine the variation in treatment of cholecystitis in the Netherlands and its impact on clinical outcome. Its results will serve as an important incentive to create optimal, uniform cholecystitis treatment in the Netherlands.",[27,237,264],"Cholecystitis; Choledocholithiasis","2024-08-08",{"date":267,"type":38},"2024-08-12",{"date":269,"type":38},"2024-04-01",{"date":271,"type":20},"2025-10-30",{"name":273,"class":44},"St. Antonius Hospital",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":282,"targetDuration":284,"studyType":56,"phases":4,"briefSummary":285,"conditions":286,"keywords":293,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":4},"100553047","algerian-cholecystectomy-outcomes-and-determinants-study-al-cods-100553047","NCT06481007","ALgerian Cholecystectomy Outcomes and Determinants Study (AL-CODS)","Algerian Cholecystectomy Outcomes and Determinants Study","AL-CODS","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Undergoing cholecystectomy.\n* Surgery performed in public or private hospitals in Algeria.\n* Surgery performed from January 1, 2025, to June 30, 2025.\n\nExclusion Criteria:\n\n* Patients younger than 18 years.\n* Patients refusing to participate.\n* Cholecystectomy performed for Gallbladder cancer.\n* Cholecystectomy performed outside the inclusion period.\n* Cholecystectomies performed in conjunction with other major surgeries.",{"count":283,"type":20},500,"1 Month","Cholecystectomy, the surgical removal of the gallbladder, is a common procedure performed to treat benign gallbladder diseases such as cholelithiasis (gallstones), cholecystitis (inflammation of the gallbladder), and biliary dyskinesia. While generally considered safe, this surgery can be associated with significant morbidity and mortality, particularly in certain populations or healthcare settings. Understanding these outcomes and the factors influencing them is crucial for improving patient care and surgical practices.\n\nIn Algeria, the healthcare landscape presents unique challenges and opportunities for evaluating surgical outcomes. Limited studies have specifically focused on the morbidity and mortality associated with cholecystectomy in this context. This study aims to fill that gap by providing comprehensive data on 30-day postoperative outcomes following cholecystectomy for benign gallbladder diseases in Algeria. Such data is essential for benchmarking current practices, identifying areas for improvement, and ultimately enhancing patient safety and surgical efficacy.",[287,288,289,290,291,292,27],"Cholecystectomy","Adults","Gall Stone","Polyps","Pancreatitis Biliary","Gallbladder Dyskinesia",[294,287,295,296,297,298],"Algeria","mortality","morbidity","30 days","determinants","2024-06-26",{"date":301,"type":38},"2024-07-01",{"date":303,"type":20},"2025-01-01",{"date":305,"type":20},"2025-07-02",{"name":307,"class":44},"University of Oran 1",{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":314,"targetDuration":316,"studyType":56,"phases":4,"briefSummary":317,"conditions":318,"keywords":319,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":45},"100541501","prospective-evaluation-of-ultrasound-guided-percutaneous-cholecystostomy-with-the-trocar-technique-100541501","NCT06330688","Prospective Evaluation of Ultrasound-guided Percutaneous Cholecystostomy With the Trocar Technique","Inclusion Criteria:\n\n* All patients requiring PC, irrespective of the underlying cause and indication, are suitable for inclusion in the study.\n\nExclusion Criteria:\n\n* Patients are going to be excluded from the study if they are younger than 18 years, if they require PC catheter placement under CT guidance (according to the operator's judgement), or if they suffer from severe uncontrollable coagulopathy.",{"count":315,"type":20},100,"3 Months","The purpose of this study is to further evaluate and investigate the safety and efficacy of ultrasound (US)-guided percutaneous cholecystostomy (PC) with the trocar technique by the patient's bedside.",[235,27],[320,321,322,323,324,325,326,327,328,329,330,331,332,333],"cholecystostomy","percutaneous","trocar","ultrasound","guided","technique","Seldinger","transhepatic","transperitoneal","subcostal","intercostal","technical","success","complications","2024-03-19",{"date":336,"type":38},"2024-03-26",{"date":338,"type":20},"2024-03",{"date":340,"type":20},"2026-06",{"name":342,"class":44},"Attikon Hospital"]