[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cholecystolithiasis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cholecystolithiasis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100348126","comparison-of-anaesthesia-requirement-for-ventilation-with-endotracheal-tube-versus-proseal-laryngeal-mask-airway-100348126",false,"NCT03812718","Comparison of Anaesthesia Requirement for Ventilation With Endotracheal Tube Versus Proseal Laryngeal Mask Airway","Anaesthesia Requirements for Ventilation With Endotracheal Tube Versus ProSeal Laryngeal Mask Airway During Automated Feedback-Loop Controlled Total Intravenous Anaesthesia in Patients Undergoing Laparoscopic Cholecystectomy: A Randomised Controlled Study","Inclusion Criteria:\n\n1. ASA physical status I\u002FII\n2. Undergoing elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n1. Anticipated difficult airway\n2. Body mass index \\> 30-kg\u002Fm2\n3. Uncompensated cardiovascular disease (e.g. uncontrolled hypertension, atrio-ventricular block, sinus bradycardia, congenital heart disease, reduced LV compliance, diastolic dysfunction)\n4. Hepato-renal insufficiency\n5. Uncontrolled endocrinology disease (e.g. diabetes mellitus, hypothyroidism)\n6. Known allergy\u002Fhypersensitivity to the study drug (propofol)\n7. Drug dependence\u002Fsubstance abuse\u002Fpsychiatric illness\n8. Requirement of postoperative ventilation\n9. Refusal to informed consent","ALL","18 Years","65 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","Endotracheal tube (ETT) is the gold standard conduit for providing controlled ventilation during general anaesthesia (GA). however, the supra-glottic airway (SGA) devices in particular the laryngeal mask airway (LMA) and its variants have become a reliable alternative to ETT for carrying out controlled ventilation. Of the several variants of LMA available today, the proseal LMA (PLMA) is preferred for controlled ventilation. The various advantages of LMA includes, a lower incidence of postoperative sore throat and superior haemodynamic profile during surgery. However, one aspect of providing anaesthesia with LMA compared to ETT is the ability of LMA to maintain equivalent depth of anaesthesia with lower anaesthetic requirement, is quiet intriguing and evidence to this regard is very limited.\n\nBy measuring the anaesthesia requirement using a robust computerised delivery system such as the closed loop anaesthesia delivery system (CLADS) we can establish for sure the anaesthesia required for maintaining intraoperative mechanical ventilation with the use of these two (ETT and PLMA) airway management devices.\n\nThis randomised controlled study aims to calculate the anaesthesia requirement as determined by the total amount of propofol consumed for maintaining anaesthesia with ETT versus PLMA",[27,28],"Cholelithiases","Cholecystolithiasis","RECRUITING","2026-04-22",{"date":32,"type":33},"2026-04-27","ACTUAL",{"date":35,"type":33},"2019-03-04",{"date":37,"type":21},"2026-12",{"name":39,"class":40},"Sir Ganga Ram Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100611786","the-pro-chol-study-100611786","NCT07245108","The Pro-Chol Study","The ProChol Study - Prospective Assessment of Symptoms Following Cholecystectomy in Patients With Symptomatic Uncomplicated Gallstones","ProChol","Inclusion Criteria:\n\n* Ultrasound examination with presence of gallstones and description of size, number and presence of stones in infundibulum or cystic duct\n* Abdominal symptoms believed to be caused by symptomatic uncomplicated gallstones\n* Indication and candidate for elective laparoscopic cholecystectomy\n* Above 18 years of age\n* Ability to give oral and written consent\n* Ability to understand, speak and read Danish\n* Ability to receive digital post\n\nExclusion Criteria:\n\n* History of complicated gallstone disease including acute cholecystitis, pancreatitis, common bile duct stones, or cholangitis\n* Previous sphincterotomy\n* Abnormal liver function test (ALAT\u002FASAT, alkaline phosphatase, bilirubin) without magnetic resonance cholangio-pancreatography or endoscopic ultrasound to rule out common bile duct pathology\n* Indication for urgent cholecystectomy\n* Current pregnancy",{"count":51,"type":21},800,"OBSERVATIONAL","This prospective clinical cohort study will include patients with gallstones and abdominal pain scheduled for surgery (laparoscopic cholecystectomy). Data on quality of life, abdominal pain, gallstone disease, and patient characteristics will be collected before surgery. The outcomes will be assessed three months following surgery and will primarily be determinants for resolution of pain. The aim is to make a prediction score that may aid clinicians and patients in decision making about surgery.",[55,56,57,28],"Gallstones","Gallstone Attack","Uncomplicated Cholelithiasis",[59,60,61,62,63],"Cohort study","Prospective clinical study","Cholecystectomy","Laparoscopic cholecystectomy","Pain relief","2025-11-20",{"date":66,"type":33},"2025-11-24",{"date":68,"type":33},"2024-01-22",{"date":70,"type":21},"2027-04",{"name":72,"class":40},"Nordsjaellands Hospital",7,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100593144","cholangiography-performed-routinely-versus-selectively-during-cholecystectomy-a-national-registry-based-randomized-controlled-trial-100593144","NCT07002619","ChOlanGiography Performed Routinely Versus Selectively During Cholecystectomy: A NAtional Registry-based Randomized Controlled Trial","COGNAC","Inclusion Criteria:\n\n* Patients undergoing cholecystectomy\n\nExclusion Criteria:\n\n* Preoperative suspicion of common bile duct stone\n* Pregnancy\n* Age \\\u003C18 years\n* Preoperative suspicion of malignancy in the gallbladder or bile ducts",{"count":82,"type":21},6000,[24],"Common bile duct stones (CBDS) may be asymptomatic but can cause pancreatitis, obstructive jaundice, and\u002For cholangitis. In Sweden, intraoperative cholangiography (IOC) is usually performed during gallstone surgery in order to detect CBDS and proactively extract them. The intervention to extract them may, however, cause complications by itself such as pancreatitis, bleeding, or perforation. In many countries, IOC is performed selectively when CBDS are suspected preoperatively (by patient history, imaging, or blood tests), or if the anatomy is unclear. There is a knowledge gap regarding the relation between risks associated with refraining from IOC and, thus, leaving undetected CBDS in situ, or actively diagnosing and removing the stones.\n\nTo compare these risks, we propose a national multicenter randomized controlled trial. The study will be embedded in the Swedish Registry for Gallstone Surgery (GallRiks), which will include all variables for inclusion and follow-up.\n\nPopulation: Patients undergoing gallstone surgery without suspicion of CBDS Intervention: IOC Control: No IOC Outcome: Readmission or reintervention (Clavien-Dindo grade ≥IIIa) related to the cholecystectomy within 12 months after the operation.\n\nA total of 6000 patients will be recruited. The results will have the potential to provide level A evidence for routines used in gallstone surgery not only in Sweden, but also internationally.",[28,86],"Common Bile Duct Gall Stones",[61,88],"Intraoperative cholangiography","2025-05-25",{"date":91,"type":33},"2025-06-03",{"date":93,"type":33},"2023-05-01",{"date":95,"type":21},"2028-12",{"name":97,"class":40},"Karolinska Institutet"]