[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"choledocholithiasis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:choledocholithiasis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,39,69,99,131,151,168,192,215,246,272,298,320,347],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100450163","optimizing-the-evaluation-and-management-of-patients-with-suspected-choledocholithiasis-100450163",false,"NCT05141916","Optimizing the Evaluation and Management of Patients With Suspected Choledocholithiasis","Inclusion Criteria:\n\n* Patients with suspected choledocholithiasis, regardless of probability\n* age 18 years old or older\n* able to give informed consent to involvement (in the prospective validation phase).\n\nExclusion Criteria:\n\n* Unable or unwilling to provide informed consent;\n* age \\\u003C 18 years;\n* suspected or proven cholangitis;\n* previous ERCP with sphincterotomy;\n* prior diagnosis or management of choledocholithiasis;\n* outpatient status;\n* out-of-province status (prohibiting full medical record access).","ALL","18 Years",{"count":18,"type":19},2000,"ESTIMATED","6 Months","OBSERVATIONAL","Choledocholithiasis (stone(s) in the common bile duct) is common. Untreated or missed, choledocholithiasis has high morbidity and mortality. Endoscopic retrograde cholangio-pancreatography (ERCP) is recognized as the first-line modality for management. While effective, ERCP is associated with adverse events. Thus, the selection of patients for ERCP should be accompanied by a high pre-test suspicion of choledocholithiasis.\n\nCholedocholithiasis is suspected based on clinical, biochemical and radiographic findings. The most relied-upon strategy for risk stratification of choledocholithiasis is based on guidelines from The American Society for Gastrointestinal Endoscopy (ASGE). In it, clinical predictors are defined as \"very strong\", \"strong\" or \"moderate\", and the presence of one or more of these is meant to suggest \"high\" or \"intermediate\" probability of choledocholithiasis.\n\nA knowledge gap exists in the performance characteristics of intermediate-probability criteria, where overall accuracy is \\\u003C50% from limited data. Patients in this group are recommended to a) undergo endoscopic ultrasound (EUS) or magnetic resonance cholangio-pancreatography (MRCP), b) undergo cholecystectomy with intra-operative cholangiography (IOC), or c) proceed directly to ERCP. At centres where EUS and MRCP are readily available, these are preferred options, as they are least invasive and sensitive; however, they are often unavailable. Thus, in clinical practice, a high proportion of intermediate-risk patients ultimately proceed directly to ERCP, where likelihood of benefit is only moderate, while procedural risk remains.\n\nThe role of liver enzyme changes has not been evaluated; however, dynamic changes may offer another method for evaluating patients at intermediate risk of CBD stones that is safe and available. Incorporation of dynamic liver enzymes may improve the test-performance characteristics of the existing framework.",[24,25],"Biliary Disease","Choledocholithiasis","RECRUITING","2026-04-28",{"date":29,"type":30},"2026-04-29","ACTUAL",{"date":32,"type":30},"2019-02-25",{"date":34,"type":19},"2029-06-30",{"name":36,"class":37},"University of Calgary","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":38},"100625090","phase-4-comparing-the-efficacy-and-safety-of-holmium-laser-lithotripsy-versus-electrohydraulic-lithotripsy-for-the-treatment-of-difficult-choledocholithiasis-and-pancreatic-duct-stones-100625090","NCT07418112","Comparing the Efficacy and Safety of Holmium Laser Lithotripsy Versus Electrohydraulic Lithotripsy for the Treatment of Difficult Choledocholithiasis and Pancreatic Duct Stones","Comparing the Efficacy and Safety of Holmium Laser Lithotripsy Versus Electrohydraulic Lithotripsy for the Treatment of Difficult Choledocholithiasis and Pancreatic Duct Stones: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 19-85 years\n* Signed written informed consent.\n* Presence of one or more biliary (common bile duct or intrahepatic) or pancreatic duct stones that are deemed \"difficult\" based on at least one of the following criteria:\n\n  * Stone diameter ≥ 15 mm in any single dimension as measured on prior cross-sectional imaging (CT, MRCP, or EUS).\n  * Presence of an impacted stone that cannot be dislodged with a standard balloon or basket.\n  * Stone located proximal to a benign biliary or pancreatic duct stricture.\n  * Documented failure of stone extraction during a prior ERCP attempt using standard techniques (e.g., sphincterotomy with balloon\u002Fbasket extraction).\n\nExclusion Criteria:\n\n* Pregnancy: Repeated ERCP would be delayed until after delivery if possible\n* Clinically significant, uncorrectable coagulopathy (defined as INR \\> 1.5 or platelet count \\\u003C 50,000\u002FμL).\n* Surgically altered upper gastrointestinal anatomy that precludes conventional ERCP access (e.g., Roux-en-Y gastric bypass), unless an alternative access route (e.g., laparoscopy-assisted or EUS-directed) is planned as the standard of care.\n* Known or highly suspected malignant biliary or pancreatic stricture associated with the stone.\n* Acute pancreatitis at the time of screening, unless it is gallstone pancreatitis with persistent biliary obstruction, for which ERCP is therapeutically indicated.\n* Severe cardiopulmonary disease or other comorbidities that, in the judgment of the investigator, would make the patient an unsuitable candidate for a prolonged endoscopic procedure under general anesthesia.\n* Known life expectancy of less than 6 months.\n* Inability or unwillingness to comply with study procedures or follow-up requirements.","19 Years","85 Years",{"count":49,"type":19},40,"INTERVENTIONAL",[52],"PHASE4","The goal of this clinical trial is to learn if a low-power holmium laser works to treat large and\u002For difficult bile duct or pancreatic duct stones in adults. It will also learn about the safety of the low-wattage holmium laser. The main questions it aims to answer are:\n\nIs the low-power holmium laser effective at treating large and\u002For difficult bile duct or pancreatic duct stones? Is the low-power holmium laser effective safe to use in adults? How does the low-power holmium laser compare to electrohydraulic lithotripsy for the management of large and\u002For difficult bile duct or pancreatic duct stones.\n\nParticipants will:\n\nUndergo ERCP procedure and their bile duct or pancreatic duct stone will either be broken up with the low-power holmium laser lithotripsy device or the electrohydraulic lithotripsy lithotripsy device.\n\nAnswer a call 30 days after the procedure to document symptoms and\u002For any side effects.",[25,55],"Pancreatic Duct Stone",[57,58,59],"Laser lithotripsy","choledocholithiasis","pancreaticolithiasis","2026-02-17",{"date":62,"type":30},"2026-02-18",{"date":64,"type":30},"2026-01-15",{"date":66,"type":19},"2027-12",{"name":68,"class":37},"Rush University Medical Center",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":50,"phases":78,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":38},"100624273","phase-2-comparative-efficacy-of-intraductal-antibiotic-during-ercp-in-acute-cholangitis-100624273","NCT07407491","Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis","Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The patients diagnosed with mild and moderate acute cholangitis based on TG 18\n* Planned for ERCP within 48 hours\n* 18 years old and above\n\nExclusion Criteria:\n\n* Severe acute cholangitis\n* History of antibiotic hypersensitivity\n* Receiving cancer chemotherapy, steroids, or immunosuppressive agents\n* Concomitant infections\n* Recent biliary interventions such as percutaneous transhepatic biliary drainage (PTBD) within last 3 months\n* Known or suspected perforated tympanic membrane, myasthenia gravis",{"count":77,"type":19},172,[79],"PHASE2","Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis compared with standard systemic antibiotic therapy alone?",[82,83,84,25,85],"Acute Cholangitis","Biliary Tract Infection","Biliary Obstruction","Malignant Biliary Stricture",[82,87,88,89,25],"ERCP","Intraductal antibiotics","Biliary tract infection","2026-02-05",{"date":92,"type":30},"2026-02-12",{"date":94,"type":30},"2024-07-09",{"date":96,"type":19},"2026-07-08",{"name":98,"class":37},"National University of Malaysia",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":50,"phases":109,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100618298","pre-cut-versus-intentional-double-guidewire-for-ercp-cannulation-prospective-randomized-controlled-trial-100618298","NCT07329803","Pre-cut Versus Intentional Double Guidewire for ERCP Cannulation: Prospective, Randomized Controlled Trial","PRIDE","Inclusion Criteria:\n\n\\- Age \\> 18 years.\n\n* Valid indication for ERCP (benign or malignant obstruction).\n* Native papilla (no prior sphincterotomy).\n* Difficult Biliary Cannulation (DBC) defined by ESGE \"5-5-2\" criteria:\n* \\> 5 minutes of cannulation attempts.\n* \\> 5 contacts with the papilla.\n* \\> 1 inadvertent pancreatic duct cannulation.\n\nExclusion Criteria:\n\n* Ampullary mass or tumor preventing standard cannulation view.\n\n  * Surgically altered anatomy (e.g., Billroth II, Roux-en-Y).\n  * Uncorrectable coagulopathy (INR \\> 1.5 or Platelets \\\u003C 50,000).\n  * Acute pancreatitis present prior to ERCP.","75 Years",{"count":108,"type":19},840,[110],"NA","Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable therapeutic procedure in the management of a wide spectrum of pancreaticobiliary disorders, including choledocholithiasis, benign and malignant biliary strictures, pancreatic ductal obstructions, and postoperative bile leaks. The procedure has revolutionized the management of these conditions, often obviating the need for surgery.Precut papillotomy and Double Guidewire Technique (DGT) are both salvage techniques used in ERCP when standard biliary cannulation fails.\n\nPrecut (Needle-Knife Precut): An endoscopic incision made into the papilla to gain access to the bile duct when conventional methods fail.\n\nIntentional Double Guidewire Technique (DGT): A technique where a guidewire is intentionally placed into the pancreatic duct to act as a \"guide\" or anchor, straightening the biliary axis and allowing a second guidewire to be inserted into the bile duct.",[87,25,113,114,115],"Biliary Drainage","Biliary Strictures Caused by Malignant Neoplasms","Biliary Stricture",[117,118,119,120],"Selective CBD cannulation","Post ERCP Pancreatitis","Precut Sphincterotomy","Double Guidewire Technique","NOT_YET_RECRUITING","2026-01-09",{"date":124,"type":30},"2026-01-12",{"date":126,"type":19},"2026-01-25",{"date":128,"type":19},"2027-02-28",{"name":130,"class":37},"Asian Institute of Gastroenterology, India",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":38},"100614714","prospective-comparison-of-the-carbon-footprint-of-eus-vs-mrcp-for-evaluation-of-suspected-choledocholithiasis-100614714","NCT07283185","Prospective Comparison of the Carbon Footprint of EUS vs MRCP for Evaluation of Suspected Choledocholithiasis","Prospective Comparison of the Carbon Footprint of Endoscopic Ultrasound (EUS) vs Magnetic Resonance Cholangiopancreatography (MRCP) for Evaluation of Suspected Choledocholithiasis","Inclusion Criteria:\n\n* Age ≥18 years\n* Intermediate likelihood of CBD stone (per ESGE)\n* Undergoing either MRCP or EUS for evaluation\n\nExclusion Criteria:\n\n* High or low likelihood category (per ESGE)\n* Undergoing both MRCP and EUS simultaneously\n* Contraindications to either modality","80 Years",{"count":140,"type":19},200,"MRCP and EUS are diagnostically equivalent in detecting CBD stones among patients with intermediate risk, as shown in a landmark RCT. However, MRI-based imaging is power-intensive, requiring large infrastructure and long scan durations. EUS, a less energy-consuming and portable procedure, has the added advantage of enabling same-session ERCP, reducing the need for repeat procedures.",[25],"2026-01-04",{"date":145,"type":30},"2026-01-06",{"date":147,"type":30},"2025-12-01",{"date":149,"type":19},"2026-11",{"name":130,"class":37},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":138,"enrollmentInfo":158,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":38},"100521190","application-of-machine-learning-models-to-reduce-need-for-diagnostic-eus-or-mrcp-in-patients-with-intermediate-likelihood-of-choledocholithiasis-100521190","NCT06066372","Application of Machine Learning Models to Reduce Need for Diagnostic EUS or MRCP in Patients With Intermediate Likelihood of Choledocholithiasis","Application of Machine Learning Models to Reduce Need for Diagnostic EUS or MRCP in Patients With Intermediate Likelihood of Choledocholithiasis- A Prospective, Open Label, Diagnostic Study","Inclusion Criteria:\n\n• Individual 18 years or older with a suspected choledocholithiasis satisfying either ASGE or ESGE risk stratification criteria of intermediate likelihood undergoing EUS or MRCP\n\nExclusion Criteria:\n\n* Patients having co-exiting disease of pancreato biliary system other than gall stones and choledocholithiasis which include chronic pancreatitis, biliary stricture, pancreatobiliary malignancy, portal biliopathy\n* Patients having underlying chronic liver diseases\n* Pregnancy and breast feeding\n* Previous history of cholecystectomy",{"count":159,"type":19},1000,"Machine learning predictive model can help in stratifying heterogenous intermediate likelihood group to reduce need for EUS or MRCP in selected subgroup of patients.",[25],{"date":145,"type":30},{"date":164,"type":30},"2023-10-01",{"date":166,"type":19},"2026-10-30",{"name":130,"class":37},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":15,"minAge":106,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":50,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":191},"100593052","cholecystectomy-after-successful-endoscopic-common-bile-duct-stone-extraction-in-elderly-100593052","NCT07001423","ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly","COFFEE","Inclusion Criteria:\n\n* Common bile duct stones cleared after Endoscopic Retrograde Cholangio Pancreatography (ERCP)\n* Age \\>= 80 years or age 75-79 years with a Charlson Comorbidity index \\>=2\n* gallbladder in situ\n\nExclusion Criteria:\n\n* Acute Cholecystitis\n* Biliary Pancreatitis\n* Severe or moderately severe post-ERCP pancreatitis\n* Chronic pancreatitis\n* Bile duct pathology\n* Widespread malignancy\n* Unable to give consent",{"count":176,"type":19},400,[110],"The goal of this study is to compare safety and efficacy of laparoscopic cholecystectomy versus wait-and-see policy after endoscopic removal of common bile duct stones in elderly. The primary endpoint is a composite outcome: Death or major postoperative complications or recurrent biliary disease within 1 year after randomization.",[180,25,181],"Cholecystectomy, Laparoscopic","Cholelithiasis","2025-10-02",{"date":184,"type":30},"2025-10-07",{"date":186,"type":19},"2025-10-03",{"date":188,"type":19},"2032-08-31",{"name":190,"class":37},"Helsinki University Central Hospital",12,{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":50,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":38},"100603003","early-vs-late-laparoscopic-cholecystectomy-after-common-bile-duct-stones-clearance-through-ercp-100603003","NCT07130864","Early vs Late Laparoscopic Cholecystectomy After Common Bile Duct Stones Clearance Through Ercp.","Early Vs Late Laparoscopic Cholecystectomy After Ercp For Choledocholithiasis, A Randomised Control Trial.","Inclusion criteria :\n\n.All patients undergoing laparoscopic cholecystectomy who had concomitant choledocholithiasis for which ercp is done.\n\nexclusion criteria:\n\n.Non consenting indviduals",{"count":200,"type":19},136,[110],"There is controversy about timing of cholecystectomy after the common bile duct is cleared of stones. our study aims to compare the results of early vs late cholecystectomy.",[204,25,87,205],"Laparoscopic Cholecystectomy","Bile Duct Injury","2025-08-18",{"date":208,"type":30},"2025-08-19",{"date":210,"type":30},"2025-05-23",{"date":212,"type":19},"2025-12-31",{"name":214,"class":37},"Khyber Teaching Hospital",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":222,"targetDuration":224,"studyType":21,"phases":4,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":4},"100597896","spanish-registry-of-direct-cholangiopancreatoscopy-by-single-operator-100597896","NCT07064447","Spanish Registry of Direct Cholangiopancreatoscopy by Single Operator","National Prospective Registry of Direct Cholangiopancreatoscopy by Single Operator","Inclusion Criteria:\n\n* Patients undergoing cholangiopancreatoscopy at the participating centers from 1 June 2025 will be included.\n* Be over 18 years of age.\n* Provide signed informed consent.\n\nExclusion Criteria:\n\n* Age under 18 years.\n* Lack of availability of signed informed consent.\n* Impossibility of follow-up.",{"count":223,"type":19},260,"1 Year","Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) remain fundamental tools for the diagnosis and treatment of many pancreatobiliary diseases.\n\nHowever, there are situations in which these procedures face limitations, such as the evaluation of indeterminate ductal strictures or the management of complex choledocholithiasis.\n\nDirect visualization of the biliary and pancreatic ducts has proven to be a useful and effective alternative in such cases. It also has a safety profile comparable to conventional ERCP, with only a slight increase in the incidence of adverse events.\n\nNevertheless, due to the associated increase in costs, most centers have adopted a stepwise approach in their diagnostic and therapeutic algorithms, using this technique only after multiple ERCPs.\n\nAlthough the evidence is still limited, recent studies suggest that early use of direct cholangiopancreatoscopy could be a cost-effective strategy due to its increased efficacy.\n\nIn this regard, collecting data on direct cholangiopancreatoscopy would be of interest to generate robust conclusions on cost-effectiveness in routine clinical practice.\n\nThis study aims to objectively assess the real-world use of direct cholangiopancreatoscopy in our setting, with the goal of confirming technical aspects, efficacy, and safety, and ultimately conducting cost-effectiveness evaluations to determine the optimal point in the algorithm at which this technique should be introduced.",[227,228,115,25,229],"Cholangiocarcinoma","Cholangiopathy","Pancreatic Cancer",[231,232,233,234,235,236],"Cholangiopancreatoscopy","indeterminate biliary stricture","choledocholitiasis","pancreatic cancer","cost-effectiveness","algorithm","2025-07-03",{"date":239,"type":30},"2025-07-14",{"date":241,"type":19},"2025-09-01",{"date":243,"type":19},"2026-06-30",{"name":245,"class":37},"Germans Trias i Pujol Hospital",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":106,"enrollmentInfo":254,"targetDuration":4,"studyType":50,"phases":256,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":38},"100593571","laparoendoscopic-rendezvous-for-concomitant-gall-bladder-stones-and-common-bile-duct-stones-100593571","NCT07008170","Laparoendoscopic Rendezvous for Concomitant Gall Bladder Stones and Common Bile Duct Stones","Laparoendoscopic Rendezvous for Difficult Cholecystocholedocholithiasis.","LERV","Inclusion Criteria:\n\n* Patients having stone(s) in the gallbladder and concurrent common bile duct , as determined by MRCP(magnetic resonance cholangiopancreatography) or US.\n* Patients with acute cholecystitis, acute cholangitis, obstructive jaundice, and those with highly suspicious criteria for common bile duct stones, such as dilated CBD( common bile duct ) on US examination \\> 7 mm in diameter without obvious common bile duct stones, high serum bilirubin level, and\u002For high serum alkaline phosphatase level, were also included in this study. (high risk for cholecystocholedocholithiasis)\n* Previous failed ERCP attempt\n* Patients fit for general anesthesia and tolerant of pneumoperitoneum and endoscopic procedures.\n\nExclusion Criteria:\n\n* History of hepatobiliary surgery as choledochoduodenal anastomosis\n* A Previous upper abdominal surgery as total or partial gastric resection.\n* Morbid obesity.\n* Uncorrectable coagulopathy.\n* Patients who refused to give consent.\n* Pregnancy.\n* Suspected malignant biliary stricture or cholangiocarcinoma\n* Severe acute cholangitis with hemodynamic instability or septic shock requiring immediate biliary drainage (may necessitate emergent ERCP or percutaneous drainage first)\n* Impacted CBD stones or stones deemed too large for endoscopic extraction (e.g., \\> 1.5 cm)\n* Severe cardiopulmonary disease significantly increasing operative risk.\n* Intrahepatic bile duct stones with indications for surgery.\n* Patients with choledocholithiasis \\>2 cm or a large number of stones were difficult to remove.",{"count":255,"type":19},80,[110],"Chronic calculous cholecystitis in pediatric patients leads to choledocholithiasis in about 12% of cases. These patients require removal of stones from the common bile duct. The most common method of cleaning the common bile duct is endoscopic retrograde cholangiopancreatography, and the standard technique for removing the gallbladder is laparoscopic cholecystectomy. There are different approaches to the treatment of this category of patients: laparoscopic common bile duct exploration (LCBDE), laparoendoscopic rendezvous method (LERV) and one-stage LC( laparoscopic cholecystectomy) after ERCP( endoscopic retrograde cholangiopancreatography).\n\nThe aim of this prospective study is to evaluate the efficacy and safety Laparoendoscopic rendezvous for difficult cholecystocholedocholithiasis.",[259,260,261,25,262],"Gall Stone","Common Bile Duct Calculi","Cholecystitis, Chronic","Periampullary Diverticula","2025-06-16",{"date":265,"type":30},"2025-06-19",{"date":267,"type":30},"2025-06-15",{"date":269,"type":19},"2026-07-15",{"name":271,"class":37},"Minia University",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":15,"minAge":106,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":50,"phases":282,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":38},"100356476","clinical-trial-comparing-ercp-vs-ercp-and-transmural-gall-bladder-drainage-100356476","NCT03921502","Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage","Randomized Multicentre Double-blind Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage in Non-surgical Patients With Symptomatic Choledocholithiasis","PECAS","Inclusion Criteria:\n\n* Symptomatic choledocholithiasis (choledocholithiasis demonstrated radiologically or highly suspected by clinical data (acute cholangitis or obstructive jaundice), analytical and imaging according to the criteria of high probability of choledocholithiasis established in the clinical guidelines (ASGE Guide).\n* Discarded for surgical treatment due to age, comorbidity or refusal of the patient.\n* Age\\>75 years\n\nExclusion Criteria:\n\n* Charlson comorbidity scale adjusted to age \\\u003C4.\n* Hepatobiliary surgery or previous superior digestive tract.\n* Ascitis.\n* Inability to tolerate sedation of endoscopy, perforation of the digestive tract or other contraindication to endoscopy.\n* Coagulopathy with INR (international normalized ratio) \\> 1.5 not correctable or thrombocytopenia \\\u003C50000 \u002F mm3 not correctable.\n* Other diagnoses at admission (acute cholecystitis, acute pancreatitis, biliopancreatic neoplasia).\n* Hemodynamic instability.\n* Urgent procedure performed after hours\n* No availability of expert material \u002F endoscopist in drainage.\n* Anatomical impossibility of performing biliary drainage (absence of vesicular distension, contact between gallbladder and stomach or duodenum, contact area \\\u003C10 mm).\n* Baseline ECOG (Easthern Cooperative Oncology Group) \\> = 4\n* Expectancy of survival \\\u003C6 months.\n* Refusal to participate.\n* Distance between the gallbladder and upper digestive tract\\> 1cm, scleroatrophic vesicle, lack of stable acoustic window for drainage\n* ERCP failed (inhability to dain common bile duct)",{"count":281,"type":19},150,[110],"Cholelithiasis occurs in 10-20% of the general population. Up to 18% of these subjects will present symptoms. In patients with symptomatic choledocholithiasis who are not candidates for surgery with indication for ERCP, transmural drainage of the gallbladder reduces the risk of recurrence.\n\nThe investigators propose a multicentric double-blind randomized trial. Our primary objective is to assess whether ERCP associated with transmural gallbladder drainage is able to reduce biliary disease income compared with ERCP in patients not candidates for surgery with symptomatic choledocholithiasis and cholelithiasis during one year of follow-up. Also the investigators will analyze the proportion of technical success and complications.\n\nThe study population includes all patients older than 75 years with symptomatic choledocholithiasis. An estimated 75 subjects per group (ERCP alone and ERCP and transmural drainage) are needed.",[285,25],"Bile Duct; Obstruction, With Calculus",[25,287,288],"Gall Bladder drainage","LAMS","2025-03-10",{"date":291,"type":30},"2025-03-11",{"date":293,"type":30},"2019-08-01",{"date":295,"type":19},"2026-05-01",{"name":297,"class":37},"Hospital del Rio Hortega",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":15,"minAge":305,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":50,"phases":308,"briefSummary":309,"conditions":310,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":38},"100581640","using-da-vinci-sp-system-for-patients-with-cholelithiasis-and-choledocholithiasis-100581640","NCT06852937","Using da Vinci SP System for Patients With Cholelithiasis and Choledocholithiasis","Pilot Study of Single-Port Robot-Assisted Surgery Using Da Vinci SP Surgical System for Patients With Complex Cholelithiasis and Choledocholithiasis","Inclusion Criteria:\n\n1. Age 20 years or more\n2. Symptomatic cholelithiasis with or without choledocholithiasis, symptomatic chronic cholecystitis with or without biliary tract injury or stricture\n3. Indication of cholecystectomy with or without common bile duct exploration and deemed feasible for robotic surgery\n4. Patient not feasible or have failed stone extraction or intervention for choledocholithiasis by endoscopic retrograde cholangiopancreatography for patients with choledocholithiasis could be included\n5. ASA physical status classification 1-2 and adequate organ function\n6. Patients willing and able to comply with study protocol requirements and follow-up\n7. Patients who are taking anti-platelet or anti-coagulation medications are eligible for this trial, but the associated agents should be discontinued 5 days prior to the operation day. Patients who are taking Wafarin should be admitted two days earlier for bridging to Heparin. Other medications for underlying diseases can be taken as usual.\n8. With informed consent\n\nExclusion Criteria:\n\n1. Severe acute cholecystitis\n2. Suspected biliary tract cancer or untreated biliary tract cancer\n3. BMI ≥35 or BMI \\\u003C18.5\n4. Unable to tolerate robotic surgery position\n5. Severe adhesion due to prior abdominopelvic surgery\n6. Prior major upper abdominal surgery judged by the investigator as not feasible for robotic surgery\n7. Active infectious disease\n8. Severe concomitant illness that drastically shortens life expectancy or increases risk of therapeutic interventions, such as: severe heart disease (NYHA functional class III-IV) or severe lung disease (GOLD Group C-D)\n9. Cannot follow trial-required procedures\n10. Concomitant systemic or pelvic disease that increases the risk of surgery\n11. Patients with coagulopathy\n12. Emergency surgery","20 Years",{"count":307,"type":19},25,[110],"A prospective, interventional, single arm study to investigate clinical feasibility of single-stage cholecystectomy and common bile duct exploration using da Vinci SP Surgical System (robotic surgery)",[181,25],"2025-02-25",{"date":313,"type":30},"2025-02-28",{"date":315,"type":30},"2024-12-21",{"date":317,"type":19},"2026-12",{"name":319,"class":37},"National Taiwan University Hospital",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":327,"targetDuration":329,"studyType":21,"phases":4,"briefSummary":330,"conditions":331,"keywords":337,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":344,"leadSponsor":346,"locationsCount":4},"100567619","spanish-registry-of-quality-indicators-and-adverse-events-of-endoscopic-retrograde-cholangiopancreatography-100567619","NCT06670547","Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography","Prospective and Multicenter Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography","Inclusion Criteria:\n\nAll consecutive patients who have undergone an ERCP at participating centres from 1 November 2024 will be included. An ERCP will be considered to have been performed when an endoscope is introduced to access the duodenal papilla.\n\nThese included patients must meet all of the following criteria:\n\n* Over 18 years of age\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Unavailability of informed consent\n* Impossibility of follow-up.",{"count":328,"type":19},3000,"30 Days","Endoscopic retrograde cholangiopancreatography (ERCP) is a technique which combines endoscopic and radiological vision and allows for therapeutic procedures on pathologies of the pancreas and bile duct.\n\nERCP is a generally well tolerated procedure, nonetheless it is a complex technique that has a higher frequency of complications compared to most endoscopic procedures that can even be life-threatening. These complications are related to patient characteristics, experience of the endoscopist performing the procedure, and specific factors to the technique. Due to its complexity, quality assurance, operator training and auditing are required to increase success and minimize complications.\n\nThere are quality indicators suggested by the main scientific societies in relation to technical aspects and complications, recommending their monitoring and auditing. Most endoscopy units lack records to monitor quality and complications, which prevents the assessment of quality and the identification of areas for improvement.\n\nGiven the lack of evidence of the quality of ERCP in the Spanish population, the investigators will be conducting a multicenter, national prospective study that will include subjects who undergo ERCP.\n\nPatient data and technical aspects of the procedure will be recorded and all included patients will be monitored to identify complications. The quality indicators obtained within the registry will be compared with those established by scientific societies and the relationship between complications and technical factors will be analyzed.",[25,332,227,333,334,335,336],"Choledocholithiasis With Acute Cholangitis","Sclerosing Cholangitis","Pancreatic Cancer Resectable","Pancreatic Cancer Non-resectable","Biliary Fistula",[338,339],"ERCP ADVERSE EVENTS","PERFORMANCE MEASURES","2024-10-31",{"date":342,"type":30},"2024-11-01",{"date":342,"type":19},{"date":345,"type":19},"2028-10-30",{"name":245,"class":37},{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":354,"sex":15,"minAge":16,"maxAge":47,"enrollmentInfo":355,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":357,"conditions":358,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":38},"100532610","the-treatment-effect-for-asymptomatic-common-bile-duct-stone-100532610","NCT06215040","The Treatment Effect for Asymptomatic Common Bile Duct Stone","Multicenter Prospective Study for Efficacy of Asymptomatic Common Bile Duct Stone Treatment","Inclusion Criteria:\n\n* diagnosed as common bile duct stone by image modality examination\n* agreement for this study enrollment\n\nExclusion Criteria:\n\n* no definite common bile duct stone by image modality examination\n* symptomatic patients who complain with fever\u002Fabdominal pain that compatible with common bile duct stone related symptom\n* previously diagnosed as pancreatobiliary malignancy\n* previously treated by endoscopic or percutaneous treatment for bile duct stones\n* severe cardio or pulmonary disease\n* pregnancy or possibility of pregnancy\n* who do not agree with study enrollment",true,{"count":356,"type":19},120,"This study is prospective, multicenter study for identify the characteristics of asymptomatic common bile duct stones and effectiveness of treatment.",[25,359,360],"Asymptomatic Condition","Quality of Life","2024-01-10",{"date":363,"type":30},"2024-01-22",{"date":365,"type":30},"2024-01-02",{"date":367,"type":19},"2028-12-31",{"name":369,"class":37},"Kyungpook National University Hospital"]