[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cholesteatoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cholesteatoma":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100510069","short--and-medium-term-evaluation-of-mastoid-filling-using-bioactive-glass-100510069",false,"NCT05921643","Short- and Medium-term Evaluation of Mastoid Filling Using Bioactive Glass\"","GLASS-BONA","Inclusion Criteria:\n\n* Patients at least 18 years old\n* Patients with proven cholesteatoma\n* Patient requiring and agreeing to surgery with filling of the mastoid or tympanic epi (closed technique with filling)\n* Patient having a surgery with filling in first intention\n\nExclusion Criteria:\n\n* Background:\n* Known outer, middle or inner ear malformation\n* Congenital cholesteatoma\n* Previously operated cholesteatoma\n* Cholesteatoma requiring an open technique or presenting with chronic non-cholesteatomatous otitis\n* Contraindications to the use of GlassBONE™ or Bonalive™\n* Pregnant, parturient or nursing mothers\n* Persons deprived of their liberty by a judicial or administrative decision, persons subject to psychiatric care, adults subject to a measure of legal protection or unable to express themselves\n* Patient participating in interventional research excluding routine care research (old regulations) and category 2 research that does not interfere with the analysis of the primary endpoint\n* Patient objecting to the use of their data","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","OBSERVATIONAL","Adult patients referred to the ENT surgery department of the Hospices Civils de Lyon with cholesteatoma that had never been operated on.\n\nAll patients will benefit from surgical management for cholesteatoma initially in the operating room under general anesthesia. The surgical technique (closed technique) is the reference technique for the management of cholesteatoma in adults. It involves a cartilaginous removal to reconstruct the attical region. Then a filling material is used to fill the mastoid (GlassBONE™ or Bonalive™), and above all to stabilize the cartilaginous fragment to prevent a recurrence.",[24],"Cholesteatoma","RECRUITING","2026-06-15",{"date":28,"type":29},"2026-06-16","ACTUAL",{"date":31,"type":29},"2023-09-29",{"date":33,"type":20},"2030-04",{"name":35,"class":36},"Centre Hospitalier Intercommunal Creteil","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":49,"conditions":50,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":70,"locationsCount":37},"100572873","otological-study-of-facial-cleft-patients-over-10-years-of-age-excluding-isolated-cleft-lip-efeof-100572873","NCT06738927","Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF)","Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip)","EFEOF","Inclusion Criteria:\n\nPresence of a facial cleft between 2004 and 2014 Minor and adult patients Followed up by ENT services at the University Hospital of Brest or Marseille\n\nExclusion Criteria:\n\nPatients under legal protection (guardianship, curatorship, etc.) Refusal to participate Objection from one of the parents Isolated cleft lip No ENT follow-up","10 Years",{"count":48,"type":20},500,"Studies published on the placement of transtympanic ventilatory tubes in children with cleft palate show heterogeneous results, highlighting the need for a new study with strong statistical power and long-term follow-up to clarify the real benefits of this intervention.\n\nMirashrafi (2022) and Maina (2022), for example, emphasize the current uncertainties regarding the management of otitis media with effusion in children with cleft palate. Mirashrafi conducted a study on 40 children and found no significant difference between those with a complete cleft palate and those with an incomplete cleft palate in terms of middle ear status after the placement of transtympanic ventilatory tubes. Maina, in an ongoing review, identified a lack of consensus on the optimal management of chronic otitis media with effusion, with outcomes being varied and often of low methodological quality.\n\nThe absence of convincing evidence justifies the need for further research to establish clear guidelines. The objective is to study the otological status of patients based on the presence or absence of ENT surgical management involving the placement of transtympanic ventilatory tubes.",[51,52,53,24,54,55,56,57],"Serous Otitis","Tympanic Membrane Perforation","Retraction Pocket","Otorrhea","Myringosclerosis","Tympanosclerosis","Audiometric Tests",[59,60,61,62],"Serous otitis Tympanic membrane perforation Retraction pocket Cholesteatoma otorrhea Myringosclerosis Tympanosclerosis Audiometric tests","ENT","transtympanic ventilatory tubes.","cleft palate","NOT_YET_RECRUITING","2024-12-13",{"date":66,"type":29},"2024-12-18",{"date":68,"type":20},"2024-12-12",{"date":68,"type":20},{"name":71,"class":36},"University Hospital, Brest"]