[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cholesterol-ldl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cholesterol-ldl":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100634461","evaluation-of-a-novel-indoor-air-pollution-intervention-among-older-adults-100634461",false,"NCT07539987","Evaluation of a Novel Indoor Air Pollution Intervention Among Older Adults","Inclusion Criteria:\n\n* 55-79 years of age one primary residence (5+ days per week)\n* have an electronic device, email address, and reliable internet at home for survey submission\n\nExclusion Criteria:\n\n* current smoking of any kind or living in a household with someone who currently smokes\n* current use of a portable air cleaner unit at home\n* plans to move in the next year\n* previous physician-diagnosed cardiovascular disease (coronary heart disease \\[myocardial infarction\\], stroke, or heart failure)","ALL","55 Years","79 Years",{"count":19,"type":20},154,"ESTIMATED","INTERVENTIONAL",[23],"NA","Particulate matter air pollution is the leading environmental risk factor of cardiovascular disease and is increasing in the Western United States due to more frequent and severe wildfires. Older adults are particularly susceptible to both air pollution exposures and the development of cardiovascular disease, and the older adult population in the United States is rapidly growing. Given the converging threats of worsening air quality and an aging population, this clinical trial will evaluate a novel, multifaceted indoor air quality intervention to improve cardiovascular health outcomes among older adults in the wildfire-impacted state of Montana.",[26,27,28,29,30,31,32,33,34],"Cardiovascular Diseases","Blood Pressure","Glycated Hemoglobin (HbA1c)","Cholesterol","Cholesterol, HDL","Cholesterol, LDL","Indoor Air Quality","Particulate Matter","Health Behavior","NOT_YET_RECRUITING","2026-04-13",{"date":38,"type":39},"2026-04-20","ACTUAL",{"date":41,"type":20},"2026-08",{"date":43,"type":20},"2030-07",{"name":45,"class":46},"University of Montana","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100565981","optimal-target-low-density-lipoprotein-cholesterol-level-for-small-vessel-occlusion-stroke-100565981","NCT06649240","Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke","Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke (SVO70)","SVO70","Inclusion Criteria:\n\n1. Age 19 years or older\n2. Patients with objectively confirmed small vessel occlusive infarctions in the subcortical or brainstem regions, identified through neuroimaging (MRI or CT)\n3. Patients with a history of symptomatic ischemic stroke caused by the lesion described in 2), occurring within 180 days prior to enrollment\n4. Patients or guardians who agree to the study protocol and sign with informed consent\n\nExclusion Criteria:\n\n1. Patients requiring intensive LDL cholesterol management (LDL-C \\\u003C70 mg\u002FdL) due to another condition, with LDL cholesterol targets specified in the guidelines for that condition\n2. Patients contraindicated for statin use (e.g., active liver disease, serum transaminase levels elevated more than three times the normal limit, muscle disorders, hypersensitivity to statins, or taking medications contraindicated for use with statins)\n3. Women who are pregnant, breastfeeding, or intending to become pregnant during the study period\n4. Deemed unsuitable for participation in the study for more than four years, as per the investigators' discretion","19 Years",{"count":58,"type":20},4016,[23],"Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels tailored to the stroke subtypes. Most clinical trials on LDL-cholesterol management have not differentiated between stroke subtypes or have primarily focused on large artery atherosclerosis (LAA) stroke, leaving a gap in evidence for managing LDL-cholesterol in other stroke subtypes, e.g., small vessel occlusion (SVO) stroke. While hypertension is the leading risk factor for SVO strokes, the link between elevated LDL-cholesterol and SVO stroke is also recognized. Establishing optimal LDL-cholesterol targets for SVO stroke would significantly enhance secondary prevention strategies and improve patient outcome. Thus, the investigators aim to compare intensive versus standard lipid-lowering in patients with SVO stroke. SVO70 is a multicenter, prospective, randomized, open, blinded-endpoint clinical trial. Adult participants with objectively confirmed SVO stroke within 180 days of randomization will be included. Exclusion criteria include those with predefined LDL-cholesterol targets for other conditions, statin contraindications, or women who are pregnant, breastfeeding, or planning pregnancy during the study period. Eligible participants will be randomized 1:1 to target LDL-cholesterol \\\u003C70 mg\u002FdL (intensive group) or 90-110 mg\u002FdL (standard group). The trial plans to enroll 4,016 participants, with the primary outcome being major adverse cardiovascular events-cardiovascular death, stroke, and acute coronary syndrome-during a follow-up period of at least 4 years. This study would provide valuable information for determining the optimal LDL-cholesterol target for patients with SVO stroke.",[62,63,31,64,26],"Ischemic Stroke","Small Vessel Cerebrovascular Disease","Secondary Prevention",[66,62,64,31,67],"Cerebral Small Vessel Diseases","Statins","RECRUITING","2025-05-17",{"date":71,"type":39},"2025-05-21",{"date":73,"type":39},"2024-10-04",{"date":75,"type":20},"2030-09",{"name":77,"class":46},"Seoul National University Hospital",46]