[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-ankle-instability-cai\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-ankle-instability-cai":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,45,76,98,124,144,168,195,221,243,273],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":13,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643309","effects-of-cervical-and-oculomotor-exercises-on-functional-status-balance-and-proprioception-in-chronic-ankle-instability-100643309",false,"NCT07581535","Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability","Effects of Cervical and Oculomotor Exercises Added to Conventional Treatment on Ankle Functional Status, Balance, and Proprioception in Individuals With Chronic Ankle Instability: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosed with unilateral chronic ankle instability (CAI) in accordance with the International Ankle Consortium recommendations\n* A history of at least one significant lateral ankle sprain that occurred at least 12 months prior to participation, resulting in inflammatory symptoms such as pain and swelling and causing at least one day of interruption in physical activity\n* A history of \"giving way\" and\u002For recurrent ankle sprains and\u002For a feeling of instability in the affected ankle within the past 6 months\n* A Cumberland Ankle Instability Tool (CAIT) score of ≤ 25\n\nExclusion Criteria:\n\n* History of surgery or fracture in the lower extremities or spine\n* Acute musculoskeletal injury affecting other joints of the lower extremity within the past 3 months (e.g., sprains, fractures) that impaired joint integrity and function and caused at least one day of interruption in physical activity\n* History of injection in the affected ankle\n* History of ankle sprain in the affected extremity within the past 4 weeks\n* Presence of systemic musculoskeletal disorders, neurological disorders, vestibular disorders, or any other condition that may affect balance or sensory function\n* Previous participation in any rehabilitation program for the ankle or cervical region\n* History of head or neck trauma or diagnosed pathology within the past 12 months\n* History of neck pain greater than 3\u002F10 in severity within the past 12 months","ALL","18 Years","45 Years",{"count":20,"type":21},38,"ESTIMATED","INTERVENTIONAL",[24],"NA",[26],"Chronic Ankle Instability, CAI",[28,29,30,31],"Postural Balance","Proprioception","Rehabilitation","Ankle Instability","RECRUITING","2026-06-04",{"date":35,"type":36},"2026-06-08","ACTUAL",{"date":38,"type":21},"2026-06-07",{"date":40,"type":21},"2027-06-07",{"name":42,"class":43},"Izmir Katip Celebi University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100638420","ankle-vs-hip-vs-combined-strengthening-in-chronic-ankle-instability-100638420","NCT07606534","Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability","Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability: A Randomized Controlled Trial","SHAC","Inclusion Criteria:\n\n* Have a history of at least one major ankle sprain that occurred at least 12 months prior to enrolment in the study, was associated with inflammatory symptoms (pain, swelling, etc), created at least one interrupted day of desired physical activity.\n* Have had at least two episodes of feeling like an \"unstable\" ankle in the six months preceding the study.\n* The Cumberland Ankle Instability Tool (CAIT) with a score of less than 24.\n* The Foot and Ankle Ability Measure (FAAM) Sport scale with a score below 80%.\n* Between 18 and 35 years old\n* Must be able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Have had a recent injury of less than three months prior to enrolment in the study.\n* A history of surgery on the musculoskeletal structures of the lower limbs.\n* Have a history of fracture of one of the lower limbs requiring realignment.\n* Being diagnosed with a neuromuscular disease.\n* The appearance of swelling or pain in the lower limb during the experiment.","35 Years",{"count":55,"type":21},45,[24],"Chronic ankle instability (CAI) is a common condition that can develop after a lateral ankle sprain. Up to 40% of people who sprain their ankle experience a recurrence within a year, and as many as 30% develop persistent symptoms such as ankle \"giving way,\" weakness, or instability. These symptoms can limit daily activities, sports participation, and increase the risk of future sprains. Muscle weakness in both the ankle and hip has been identified as an important factor contributing to CAI. Strengthening these muscles may therefore help improve stability and function.\n\nThe SHAC study is a randomized controlled trial designed to compare three different strengthening programs in people with chronic ankle instability: (1) an ankle-focused strengthening program, (2) a hip-focused strengthening program, and (3) a combined ankle-hip strengthening program. The goal is to determine which approach leads to the greatest improvement in functional ability, muscle strength, balance, and ankle mobility.\n\nA total of 45 participants aged 18 to 35 years with documented chronic ankle instability will be recruited from local sports clubs and the University of Liège. All participants must have a history of at least one ankle sprain that occurred more than 12 months before entering the study, report episodes of ankle instability in the previous six months, and meet specific questionnaire criteria (CAIT \\\u003C 24 and FAAM Sport \\\u003C 80%). People with recent injuries, previous lower-limb surgery, fractures requiring realignment, neuromuscular conditions, or current pain or swelling will not be able to participate.\n\nAfter the first assessment (T1), participants will be randomly assigned to one of the three groups. Each intervention lasts four weeks and includes three supervised sessions per week. All strengthening exercises are isometric, performed using a handheld dynamometer to measure force accurately. The ankle program includes plantarflexion, dorsiflexion, inversion, and eversion exercises. The hip program includes clamshells, hip external rotation, abduction, and extension. The combined group alternates between hip and ankle exercises. A warm-up and standardized familiarization are performed before each session.\n\nAll participants will attend two additional assessment sessions: one immediately after the four-week program (T2) and one at a later follow-up time point (T3). During each visit, they will complete functional questionnaires, report their sports participation, and undergo several strength and performance tests. These include hip and ankle muscle strength measurements using a dynamometer, the Heel Rise Test, the modified Y-Balance Test, the Side Hop Test, and a dorsiflexion mobility test.\n\nThe study aims to identify whether one of the strengthening approaches leads to better functional outcomes for individuals with chronic ankle instability. Understanding these effects may help clinicians design more effective rehabilitation programs for people recovering from ankle sprains and for those experiencing ongoing instability.\n\nParticipant data will be kept confidential and stored securely in anonymized form for 20 years. Participation is voluntary, and individuals may withdraw at any time without consequences. Results will be presented anonymously in scientific publications and conferences.",[26,59],"Ankle Sprain",[61,62,63,64,65,30,66],"chronic ankle instability","Ankle strengthening","Hip strengthening","Isometric exercise","Physiotherapy","Randomized controlled trial","2026-05-18",{"date":69,"type":36},"2026-05-26",{"date":71,"type":36},"2026-03-02",{"date":73,"type":21},"2027-09",{"name":75,"class":43},"University of Liege",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100638940","lower-extremity-mobility-for-cai-100638940","NCT07584746","Lower Extremity Mobility for CAI","Effects of Targeted Mobility Interventions at the Ankle Versus Hip on Clinical and Functional Outcomes in Chronic Ankle Instability","Inclusion Criteria:\n\n* Adults (18-30 years old) with chronic ankle instability\n* Patient's Body mass index (BMI) will range from 18.5- 29.9 kg\u002Fm2\n* A history of at least one ankle sprain with the initial sprain occurring 12 months prior to study\n* Most recent injury 3 months prior to start of treatment with at least one day of interrupted desired physical activity and associated inflammatory symptoms (pain, swelling, etc.).\n* A history of previous giving way and\u002For recurrent sprain, and\u002For feeling of instability to injured ankle.\n* Cumberland Ankle Instability Tool: score of ≤ 24.\n\nExclusion Criteria:\n\n* Other lower extremity injury surgery 6 months before testing\n* Patient suffered an acute sprain in the previous 6 weeks to the start of the study.\n* History of neuromuscular disorders.\n* Systemic diseases that affect balance.","30 Years",{"count":85,"type":21},40,[24],"This study will be conducted to determine the effect of addition of ankle mobility versus hip mobility exercises to traditional rehabilitation to patients with chronic ankle instability. the main purpose is to answer the following question:\n\n* out of these interventions which would better improve lower limb flexibility, range of motion, severity of functional instability and dynamic postural control?\n\nResearcher will compare between ankle mobility versus hip mobility exercises\n\nParticipants will be allocated in 2 experimental groups:\n\n* group A will include 20 patients receiving conventional physiotherapy in addition to ankle mobility exercises\n* group B will include 20 patients receiving conventional physiotherapy in addition to hip mobility exercises\n\nPatients will receive 3 sessions per week for 6 weeks in a physiotherapy outpatient facility for both groups",[26],"NOT_YET_RECRUITING","2026-05-15",{"date":67,"type":36},{"date":93,"type":21},"2026-06",{"date":95,"type":21},"2026-10",{"name":97,"class":43},"Cairo University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":105,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":44},"100612333","effects-of-ankle-evertor-fatigue-on-force-sense-and-neuromuscular-activation-in-subjects-with-chronic-ankle-instability-100612333","NCT07252219","Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation in Subjects With Chronic Ankle Instability","Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation During Submaximal Isometric Contractions in Individuals With and Without Chronic Ankle Instability","Inclusion criteria for the healthy control group (no CAI):\n\n* Age between 18 and 45 years,\n* No history of injuries or surgical procedures to the lower limbs,\n* No peripheral or central neurological impairments.\n\nInclusion criteria for the chronic ankle instability (CAI) group:\n\n* Age between 18 and 45 years,\n* No history of major surgical procedures on the lower limbs\n* No peripheral or central neurological impairments,\n* Diagnosed chronic ankle instability:\n\n  * First ankle sprain occurred at least one year prior to testing,\n  * At least three months since the most recent ankle sprain,\n  * Subjective feeling of ankle instability - CAIT (Cumberland Ankle Instability Tool) score \\\u003C 24.\n\nExclusion criteria for the CAI group:\n\n\\- Other pathologies of the ankle joint.",true,{"count":107,"type":21},50,"OBSERVATIONAL","The goal of this observational study is to investigate whether ankle evertor muscle fatigue impairs force perception and alters neuromuscular activation patterns during submaximal isometric contractions, and whether these effects differ between individuals with chronic ankle instability (CAI) and individuals without CAI.",[26],[61,112,113,114],"force sense","muscle fatigue","proprioception","2026-04-28",{"date":117,"type":36},"2026-04-29",{"date":119,"type":36},"2025-05-15",{"date":121,"type":21},"2026-05-04",{"name":123,"class":43},"University of Ljubljana",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":105,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":131,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":138,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":44},"100613938","effects-of-ankle-evertor-fatigue-on-perturbed-gait-100613938","NCT07273097","Effects of Ankle Evertor Fatigue on Perturbed Gait","Effects of Ankle Evertor Fatigue on Gait Perturbation Responses in Individuals With and Without Chronic Ankle Instability","Inclusion criteria for the healthy control group (no CAI):\n\n* Age between 18 and 45 years,\n* No history of injuries or surgical procedures to the lower limbs,\n* No peripheral or central neurological impairments.\n\nInclusion criteria for the chronic ankle instability (CAI) group:\n\n* Age between 18 and 45 years,\n* No history of major surgical procedures on the lower limbs\n* No peripheral or central neurological impairments,\n* Diagnosed chronic ankle instability:\n\n  * First ankle sprain occurred at least one year prior to testing,\n  * At least three months since the most recent ankle sprain,\n  * Subjective feeling of ankle instability - CAIT (Cumberland Ankle Instability Tool) score \\\u003C 24.\n\nExclusion criteria for the CAI group:\n\n* Other pathologies of the ankle joint.\n* Acute pain",{"count":85,"type":21},"This study will investigate the effects of ankle evertor muscle fatigue on gait stability during treadmill walking with mechanical perturbations. Participants will walk at two speeds (0.4 m\u002Fs and 1.0 m\u002Fs) while random medial and lateral perturbations (\\\u003C10% body weight) are applied to the pelvis. Surface EMG from ankle muscles and center of pressure (COP)-based gait parameters (e.g., step length, step width, single support duration, COP trajectory) will be analyzed before and immediately after an isotonic fatigue protocol of the ankle evertors.",[26],[135,136,137],"perturbed walking","fatigue","treadmill",{"date":117,"type":36},{"date":140,"type":36},"2025-05-05",{"date":142,"type":21},"2026-05-06",{"name":123,"class":43},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":105,"sex":16,"minAge":17,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100626763","the-effect-of-cognitive-dual-task-on-athletic-performance-parameters-in-volleyball-players-with-and-without-chronic-ankle-instability-100626763","NCT07439861","The Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankle Instability","Investigation of the Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankle Instability","Inclusion Criteria for players with CAI:\n\n* Chronic Ankle Instability Group Patients who meet all of the following criteria will be included in the study. The inclusion criteria defined by the International Ankle Consortium will be accepted.\n\n  1. Individuals must have been actively participating in the sport of volleyball for at least 5 years,\n  2. Individuals' first ankle sprain history must have occurred at least 1 year prior to the study and must have been associated with inflammatory symptoms (pain, swelling),\n  3. The most recent ankle sprain must have occurred 3 months or more before the start date of the study,\n  4. Athletes must have experienced a sensation of giving way at least twice within the past 6 months,\n  5. Athletes must have no history of ankle fracture,\n  6. Athletes must not have undergone any surgical procedures affecting sensorimotor function in the lower extremity and must have no internal diseases,\n  7. The score of the Identification of Functional Ankle Instability questionnaire must be greater than 11,\n  8. The Foot and Ankle Ability Measure score must be less than 90%,\n  9. The Foot and Ankle Ability Measure Sports subscale score must be less than 80%,\n  10. The Cumberland Ankle Instability Tool (CAIT) score must be less than 24,\n  11. The Foot and Ankle Outcome Score must be less than 75% in three or more categories.\n\nInclusion Criteria for players without CAI:\n\n1. Participation in volleyball training at least 3 days per week for 1 hour for a minimum of 5 years,\n2. A Cumberland Ankle Instability Tool score of 25 or higher,\n3. A Tegner activity level of 4 or higher,\n4. Absence of any systemic disease that could interfere with measurements.\n\nExclusion Criteria:\n\n1. Presence of rheumatic, neurological, or cardiovascular disease,\n2. History of ankle surgery,\n3. Musculoskeletal injury affecting the lower extremity within the last 6 months,\n4. Individuals who do not agree to participate in the study.","25 Years",{"count":153,"type":21},60,"The aim of this study is to investigate the effect of the cognitive dual-task on athletic performance parameters in volleyball players with and without chronic ankle instability. In addition, it will examine how a pathology in the lower extremity affects upper extremity function.",[156,26,157,158],"Chronic Ankle Instability","Volleyball","Volleyball Players","2026-02-23",{"date":161,"type":36},"2026-02-27",{"date":163,"type":21},"2026-03-23",{"date":165,"type":21},"2028-02-05",{"name":167,"class":43},"Hacettepe University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":175,"minAge":176,"maxAge":53,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":184,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100613442","effects-of-pilates-training-on-ankle-proprioception-postural-control-and-performance-in-footballers-with-chronic-ankle-instability-100613442","NCT07266649","Effects of Pilates Training on Ankle Proprioception, Postural Control and Performance in Footballers With Chronic Ankle Instability","CAI","Inclusion Criteria:\n\nMale footballers aged 22-35\n\n* History of unilateral ankle sprain in past 12 months\n* Inability to bear weight post-injury\n* CAIT score \\\u003C 24\n* Minimum of 1-year experience in football\n\nExclusion Criteria:\n\n* Bilateral ankle sprains\n* Lower limb fractures or surgeries\n* Neurological conditions (e.g., MS, CMT, Stroke)","MALE","22 Years",{"count":178,"type":21},88,[24],"This study aims to contribute to the effects of Pilates training on ankle proprioception, postural control, and performance in football players with chronic ankle instability. Eighty eight participants will be randomly allocated into two groups and will receive both Pilates and balance training for eight weeks. it is hypothesized that the group that will receive Pilates taring will produce greater improvements as compared to other group.",[182,183,26],"Proprioception, Postural Balance","Performance",[156,114,185,183],"Postural Control","2025-11-24",{"date":188,"type":36},"2025-12-05",{"date":190,"type":21},"2025-11-25",{"date":192,"type":21},"2026-05-30",{"name":194,"class":43},"Lahore University of Biological and Applied Sciences",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":105,"sex":16,"minAge":17,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":44},"100605544","validation-of-a-portable-ankle-arthrometer-100605544","NCT07163897","Validation of a Portable Ankle Arthrometer","Aim 1:\n\nInclusion Criteria:\n\n* Young adults between the ages of 18 and 40.\n* Willingness and ability to comply with scheduled visits and study procedures.\n* Fit one of the three groups: 1. Healthy - no history of ankle sprain, 2. Copers - one previous ankle sprain with no residual problems, 3. Chronic Ankle Instability.\n* Ability to sign consent.\n\nAim 2:\n\nInclusion Criteria:\n\n* Young adults between the ages of 18 and 40.\n* Willingness and ability to comply with scheduled visits and study procedures.\n* Acute ankle sprain within the last 48-96 hours.\n* Ability to sign consent.\n\nAim 1:\n\nExclusion Criteria:\n\n* Previous history of ankle fracture.\n* Diagnosis of Ehlers-Danlos Syndrome\n\nAim 2:\n\nExclusion Criteria:\n\n* Previous history of ankle fracture.\n* Diagnosis of Ehlers-Danlos Syndrome.","40 Years",{"count":203,"type":21},62,"The purpose of this study is to assess the validity and reliability of a prototype portable ankle arthrometer in various populations. There are two aims to this study. Aim 1 will look to determine the reliability and validity of a prototype portable ankle arthrometer on young adults with no history of ankle sprain, copers, and young adults with chronic ankle instability. It is hypothesized that the prototype portable ankle arthrometer will be a valid and reliable tool to assess joint laxity across the three different populations. Aim 2 will look to determine the validity of a prototype portable ankle arthrometer in young adults with an acute ankle sprain across multiple timepoints in their first month post injury. It is hypothesized that the prototype portable ankle arthrometer will be a valid tool to assess joint laxity at three different timepoints for the same individual.",[26,59,206],"Healthy",[208,209,210,211],"Arthrometer","Ankle","Validity","Reliability","2025-09-04",{"date":214,"type":36},"2025-09-09",{"date":216,"type":21},"2025-10-01",{"date":218,"type":21},"2026-10-01",{"name":220,"class":43},"University of Virginia",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":227,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":44},"100603651","extracorporeal-shock-wave-versus-photobiomodulation-therapy-for-chronic-ankle-instability-100603651","NCT07139288","Extracorporeal Shock Wave Versus Photobiomodulation Therapy for Chronic Ankle Instability","Inclusion Criteria:\n\n\\- 60 participants ranging in age from 18 to 65 years from both gender with a diagnosis of Chronic lateral ankle instability stage (II) (Schurz et al., 2023).\n\nPatients body mass index (BMI) are ranged from 18,5 to 25 (lee et al., 2022). The main presenting symptoms were ankle pain with restricted ROM that compromised activities of daily living (Schurz et al., 2023).\n\nAll ankle sprains occurring more than four weeks before inclusion both recurrent sprain and CAI patients are included (Schurz et al., 2023).\n\nMild to moderate severity of pain measured by NPRS scale (Srinivas, 2022). no wounds in the ankle joint and calf (lee et al., 2022). Participants had no history of ankle joint injuries or surgical procedures within the last year and injection treatment around the ankle joint within six months (lee et al., 2022).\n\nExclusion Criteria:\n\n* they had any medical condition that could cause ankle pain (arthritis, fracture, rheumatiod arthritis, any deformity of ankle and neurological condition).\n\nAny individual who had previously suffered a musculoskeletal injury or surgery that could have influenced the measurement was also eliminated.\n\nAny individual who had diagnosed a Chronic lateral ankle instability stage (I, III).\n\nAcute foot trauma occurring from 7 days of injury (Srinivas, 2022).","20 Years","65 Years",{"count":20,"type":21},[24],"PURPOSE:\n\nTo Compare between the effect of extra corporeal shock wave and Photobiomodulation on pain level, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability.\n\nBACKGROUND:\n\nLateral ankle sprains are the most common lower limb musculoskeletal injury incurred by individuals who participate in sports and recreational physical activities Approximately 40% of individuals who sustain a LAS develop a condition known as chronic ankle instability (CAI) (Miklovic et al., 2018), The lateral ligamentous complex is the main structure affected in 80-85% of these injuries, which are originated from a sudden inversion or supination trauma (Mansur et al., 2021).\n\nThe ligament system plays a fundamental role in the ankle's stability and includes a talocrural complex and a subtalar complex that are functionally related. For the talocrural joint, three lateral collateral ligaments are present and one medial collateral ligament (Bonnel et al., 2010).\n\nPhysical examination is mostly the first diagnostic step in the assessment of ankle injuries. Imaging modalities such as ultrasonography (US) and magnetic resonance imaging (MRI) play a major role in providing a detailed depiction of ankle tendons and ligaments (Hosseinian et al., 2022).\n\nThe effect of ESWT is Higher multiplication of collagen fibers; faster organization of muscle fibers and vascularization by treatment with radial shockwaves (Schnurrer-Luke-Vrbanic et al., 2018), ESWT could improve pain, ankle instability, ankle function, dorsiflexion ROM, and dynamic balance in patients with CAI (Le et al., 2022).\n\nPhotobiomodulation Therapy (PBMT) is effective for patients with an ankle sprain. PBMT showed high effect size with a moderate level of evidence on pain intensity and is related to the PBMT intensity and frequency (Alayat et al., 2024).\n\nHYPOTHESES:\n\nThere is no statistically significant effect of extra corporeal shock wave versus photobiomodulation on level of pain, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability.\n\nRESEARCH QUESTION:\n\nIs there any effect of extra corporeal shock wave versus Photobiomodulation on pain level, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability?",[26],[234],"extracorporeal shock wave, photobiomodulation, chronic ankle instability","2025-08-17",{"date":237,"type":36},"2025-08-24",{"date":239,"type":21},"2025-08-29",{"date":241,"type":21},"2026-01-10",{"name":97,"class":43},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":253,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":44},"100599009","motor-training-versus-motor-cognitive-training-in-athletes-with-chronic-ankle-instability-100599009","NCT07078916","MOTOR TRAINING VERSUS MOTOR COGNITIVE TRAINING IN ATHLETES WITH CHRONIC ANKLE INSTABILITY","Inclusion Criteria:\n\n* Young adult basketball athletes aged between (18 - 30) years.\n* A history of unilateral one or more significant ankle inversion injury occurred at least 1 year before participation in the study.\n* Interruption of physical activity or cessation from training for at least 24 hours following injury.\n* Report episodes of giving way and sense of instability of the affected ankle.\n* Two episodes of giving way or\u002F recurrent inversion injury should be reported by the patient before study enrollment at least two times in the last 6 months.\n* Cumberland Ankle Instability Tool (CAIT) patient scores \\\u003C 24.\n\nExclusion Criteria:\n\n* A history of previous surgery or fracture to musculoskeletal structure (bone, joint, etc.) in the limb of the affected ankle.\n* Acute lower limb sprain in the last 3 months before enrollment in the study resulting in interruption of physical activity for 1 day.\n* Any disorder or disease that could affect the balance as vestibular disorders, eye injury, and so on.\n* Any athlete who participates in any formal or informal rehabilitation.\n* Participants who will not commit to two successive sessions will also be considered for exclusion.\n* If they received NSAID 2 weeks before enrollment in the study.",{"count":153,"type":21},[24],"This study aims to evaluate the effect of one-leg balance activity (OLBA) combined with visual feedback using BlazePod™ as a dual motor-cognitive rehabilitation task in basketball players with Chronic Ankle Instability (CAI). The intervention will be compared to OLBA alone as a motor task. Outcomes measured include dynamic balance, sense of instability, response time, athletic performance, and self-reported physical function. This study will help improve rehabilitation strategies for athletes suffering from ankle instability.",[26],[254,59,156,255,256,257,258,259,260,261,262,263,264],"Ankle Injuries [MeSH]","Basketball Players","Balance Rehabilitation [MeSH]","Motor Skills [MeSH]","Cognitive Training [MeSH]","Visual Feedback","BlazePod","Dual-task Training","Dynamic Balance","Motor-Cognitive Training","Reaction Time","2025-07-14",{"date":267,"type":36},"2025-07-22",{"date":269,"type":21},"2025-08-01",{"date":271,"type":21},"2026-04-01",{"name":97,"class":43},{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":279,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":280,"conditions":281,"keywords":282,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":4},"100596864","radiological-and-clinical-measures-as-predictors-of-dynamic-postural-control-deficits-in-chronic-ankle-instability-100596864","NCT07051018","Radiological and Clinical Measures as Predictors of Dynamic Postural Control Deficits in Chronic Ankle Instability","Inclusion Criteria:\n\n* Participants will be screened for eligibility and only those who meet the inclusion criteria according to Delahunt et al. (2010) and Gribble et al. (2013) will be enrolled in our study, i.e., they will participate if they have:\n\n  1. At least one significant unilateral lateral ankle sprain in which the subject was unable to walk independently without the aid of crutches (the first sprain occurred more than 12 months ago).\n  2. Repeated bouts of lateral ankle injury (last injury had to be more than three months prior to inclusion in the study).\n  3. Feeling of ankle instability \"giving way\", at least 2 episodes in the last 6 months (Terada et al., 2014).\n  4. Pain during intense loading.\n  5. The Cumberland Ankle Instability Tool (CAIT) ≤ 24.\n  6. Age range of 18-30 years (Delahunt et al., 2010).\n\nExclusion Criteria:\n\n* \\*Patients will be excluded if they didn't meet the inclusion criteria mentioned above, such as:\n\n  1. A previous trauma or surgery to the trunk or lower extremities other than an ankle sprain.\n  2. Neurological or vestibular impairments with remaining deficits.\n  3. No participant with CAI had acutely sprained his or her ankle in the 3 months prior to the testing.\n  4. Participants will be excluded if they have participated in any rehabilitation in the past 6 months.\n  5. Concussion or head injury or lower back pain in the past 6 months.",{"count":107,"type":21},"The purpose of this study is to investigate the association between dynamic postural control and clinical measures of (ankle and hip strength, ankle DFROM and position sense) and radiological measures in patients with unilateral CAI.",[26],[283,61,284,285],"postural control","talar tilt","tibiotalar contact ratio","2025-07-02",{"date":288,"type":36},"2025-07-03",{"date":290,"type":21},"2025-07-15",{"date":292,"type":21},"2025-09-20",{"name":97,"class":43}]