[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-ankle-instability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-ankle-instability":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,78,105,129,156,181,212,238,261,284],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644057","different-pressure-tissue-flossing-combined-with-exercise-for-chronic-ankle-instability-100644057",false,"NCT07667816","Different Pressure Tissue Flossing Combined With Exercise for Chronic Ankle Instability","Effects of Different Tissue Flossing Pressures Combined With Exercise Training on Ankle Function in Patients With Chronic Ankle Instability: A Three-Arm Randomized Controlled Trial","CAI-FLOSS","Inclusion Criteria:\n\n* Young adults aged 18 to 30 years.\n* History of at least one recurrent ankle sprain or repeated episodes of ankle giving way in the affected limb.\n* Subjective ankle instability, with or without pain, swelling, or activity limitation.\n* Reduced balance ability, movement ability, or foot and ankle function on screening assessment.\n* Symptoms lasting at least 6 months.\n* No recent structured ankle rehabilitation before enrollment.\n* No plan for vigorous additional exercise during the intervention period.\n* Willing to participate and able to provide informed consent.\n\nExclusion Criteria:\n\n* Latex allergy or intolerance to floss band material.\n* Previous ankle dislocation, fracture, complete ligament rupture, or other severe structural injury.\n* Most recent ankle sprain within 1 month before enrollment.\n* Recent ankle surgery or acute ankle injury.\n* Receipt of other ankle-related treatment, rehabilitation, or additional training during the study period.\n* Diabetes, hyperlipidemia, or other conditions that may affect vascular status.\n* Neurological disease, major musculoskeletal disease, vestibular disorder, visual disorder, or other lower-limb conditions that could affect assessment.\n* Determined by the study physician or investigator to be unsuitable for participation.","ALL","18 Years","30 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will evaluate whether tissue flossing with different pressure levels, when combined with exercise training, improves ankle function in young adults with chronic ankle instability. Forty-eight participants will be randomly assigned to one of three groups: a control exercise group, a 150 mmHg tissue flossing plus exercise group, or a 200 mmHg tissue flossing plus exercise group. All groups will complete the same 6-week rehabilitation program, three times per week. Outcomes will be assessed at baseline and after the intervention, and long-term follow-up data will also be collected.",[28,29],"Chronic Ankle Instability","Ankle Instability",[31,32,28,33,34],"Tissue Flossing","Floss Band","Ankle Rehabilitation","Exercise Therapy","NOT_YET_RECRUITING","2026-06-21",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-07",{"date":43,"type":22},"2027-05",{"name":45,"class":46},"Chengdu Sport University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100637448","pelvic-parameters-in-males-with-and-without-ankle-instability-100637448","NCT07594210","Pelvic Parameters in Males With and Without Ankle Instability","Pelvic Parameters in Male Athletes With and Without Chronic Ankle Instability: A Cross Sectional Study","Inclusion Criteria:\n\n* Male football players aged between 18 and 35 years (Herzog et al., 2019; Jiang et al., 2022).\n* A documented history of lateral ankle sprain (LAS) for at least 12 months before the study, with the initial injury resulting in a minimum of one day of weight-bearing restriction.\n* Self-reported episodes of ankle \"giving way\" occurring at least twice within the 6-12 months preceding enrollment.\n* The most recent injury must have occurred more than 3 months before study enrollment.\n* A perceived sense of the injured ankle being chronically weaker and\u002For less functional than the contralateral side before the first LAS episode.\n* A Cumberland Ankle Instability Tool (CAIT) score of less than 24 indicates chronic ankle instability.\n* For group B: participants with no previous history of ankle sprain.\n\nExclusion Criteria:\n\n* Bilateral LAS (Tahoon et al., 2022).\n* Previous injury, fracture, or surgical intervention involving the spine, pelvis, or lower extremity.\n* History of low back pain requiring medical or surgical intervention.\n* Engagement in supervised or unsupervised ankle rehabilitation within one month before the study.\n* Any LAS occurring within three months before participation.\n* Leg length discrepancy exceeding 0.5 cm.",true,"MALE","35 Years",{"count":59,"type":22},38,"OBSERVATIONAL","This study aims to investigate the relationship between pelvic alignment and ankle stability in male athletes with and without a history of ankle sprain.\n\nChronic ankle instability is a common condition that may affect not only the ankle joint but also the alignment and function of other body segments, including the pelvis. Understanding this relationship may help improve injury prevention and rehabilitation strategies.\n\nParticipants will undergo clinical assessments, functional tests, and radiographic evaluation of pelvic parameters to compare findings between injured and non-injured groups.\n\nThe objective of this study is to determine whether differences in pelvic sagittal parameters are associated with ankle instability in male athletes.",[28],[64,65,66,67,68],"chronic ankle instability","ankle sprain","dynamic balance","pelvic alignment","athletes","2026-05-14",{"date":71,"type":39},"2026-05-18",{"date":73,"type":22},"2026-05-07",{"date":75,"type":22},"2026-07-07",{"name":77,"class":46},"Ahmed Korany Abdallah Ahmed",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":104},"100556606","neurocognitive-ankle-training-for-instability-to-optimize-neuromusculoskeletal-outcomes-nation-100556606","NCT06527287","Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)","NATION","Inclusion Criteria:\n\n* Physically active and engage in regular exercise\u002Ftraining\n* 18-44 years old (accounts for 86% of the individuals deployed in recent military conflicts)\n* Answer \"yes\" to Question 1 (i.e., have you ever sprained an ankle?) on the Ankle Instability Instrument\n* Answer \"yes\" to any four of the remaining Ankle Instability Instrument questions\n* Score \\\u003C24 on the Cumberland Ankle Instability Tool\n* Report at least two episodes of the ankle \"giving way\" in the last six months\n* Access to a functional email address and internet for completion of health and Service member outcomes\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Unable to read or comprehend the English language.\n* An ankle sprain within the last six (≤6) weeks that resulted in altered or missed physical activity for one or more (≥1) consecutive days.\n* History of ankle surgery.\n* History of lower extremity fracture in the last year or history of fracture that required fixation.\n* Any peripheral neuropathies or other health conditions\u002Fcurrent musculoskeletal injuries that may influence balance.\n* Pregnant females (will be eligible for participation in the study after delivery of the baby and medical clearance by a qualified and licensed healthcare provider).","44 Years",{"count":87,"type":22},180,[25],"The purpose of this study is to examine the effectiveness of a novel ankle rehabilitation protocol on improving clinical and health outcomes in physically active individuals with chronic ankle instability (CAI). Our central hypothesis is NATION, a novel rehabilitation intervention that includes neurocognitive tasks, will improve overall health and function, and reduce lower extremity musculoskeletal injury in physically active individuals with CAI.",[28],[92],"Chronic Ankle Instability; neurocognition; evidence-based rehabilitation; musculoskeletal outcomes; dual tasks","RECRUITING","2026-04-16",{"date":96,"type":39},"2026-04-22",{"date":98,"type":39},"2025-10-13",{"date":100,"type":22},"2027-06-14",{"name":102,"class":103},"Womack Army Medical Center","FED",2,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":47},"100626763","the-effect-of-cognitive-dual-task-on-athletic-performance-parameters-in-volleyball-players-with-and-without-chronic-ankle-instability-100626763","NCT07439861","The Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankle Instability","Investigation of the Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankle Instability","Inclusion Criteria for players with CAI:\n\n* Chronic Ankle Instability Group Patients who meet all of the following criteria will be included in the study. The inclusion criteria defined by the International Ankle Consortium will be accepted.\n\n  1. Individuals must have been actively participating in the sport of volleyball for at least 5 years,\n  2. Individuals' first ankle sprain history must have occurred at least 1 year prior to the study and must have been associated with inflammatory symptoms (pain, swelling),\n  3. The most recent ankle sprain must have occurred 3 months or more before the start date of the study,\n  4. Athletes must have experienced a sensation of giving way at least twice within the past 6 months,\n  5. Athletes must have no history of ankle fracture,\n  6. Athletes must not have undergone any surgical procedures affecting sensorimotor function in the lower extremity and must have no internal diseases,\n  7. The score of the Identification of Functional Ankle Instability questionnaire must be greater than 11,\n  8. The Foot and Ankle Ability Measure score must be less than 90%,\n  9. The Foot and Ankle Ability Measure Sports subscale score must be less than 80%,\n  10. The Cumberland Ankle Instability Tool (CAIT) score must be less than 24,\n  11. The Foot and Ankle Outcome Score must be less than 75% in three or more categories.\n\nInclusion Criteria for players without CAI:\n\n1. Participation in volleyball training at least 3 days per week for 1 hour for a minimum of 5 years,\n2. A Cumberland Ankle Instability Tool score of 25 or higher,\n3. A Tegner activity level of 4 or higher,\n4. Absence of any systemic disease that could interfere with measurements.\n\nExclusion Criteria:\n\n1. Presence of rheumatic, neurological, or cardiovascular disease,\n2. History of ankle surgery,\n3. Musculoskeletal injury affecting the lower extremity within the last 6 months,\n4. Individuals who do not agree to participate in the study.","25 Years",{"count":114,"type":22},60,"The aim of this study is to investigate the effect of the cognitive dual-task on athletic performance parameters in volleyball players with and without chronic ankle instability. In addition, it will examine how a pathology in the lower extremity affects upper extremity function.",[28,117,118,119],"Chronic Ankle Instability, CAI","Volleyball","Volleyball Players","2026-02-23",{"date":122,"type":39},"2026-02-27",{"date":124,"type":22},"2026-03-23",{"date":126,"type":22},"2028-02-05",{"name":128,"class":46},"Hacettepe University",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":145,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100619806","dilute-epinephrine-vs-tourniquet-for-visualization-in-ankle-arthroscopy-a-rct-100619806","NCT07349407","Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT","The Effect of Dilute Epinephrine Saline Irrigation on Field Clarity in Ankle Arthroscopic Surgery Compared to a Tourniquet: a Double-blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Able to understand the procedures and methods of the clinical trial\n* voluntarily provide written informed consent\n* Aged from 15 to 65 years old , regardless of sex\n* Diagnosed with a condition requiring ankle surgery\n* Be scheduled to undergo unilateral ankle arthroscopy\n\nExclusion Criteria:\n\n* Patients who decline to participate in the study\n* Known history of heart disease (e.g., coronary artery disease, cardiac conduction abnormalities), diabetes, or asthma\n* Poorly controlled hypertension\n* Age under 15 years or above 65 years old\n* Intellectual disability\n* Pregnant or breastfeeding women\n* Known allergy to sulfites\n\nContraindications to ISBPB (including planned injection site infection, pre-existing neurological deficits, allergy to local anesthetics, severe chronic obstructive pulmonary disease, or contralateral phrenic nerve dysfunction)","15 Years","65 Years",{"count":139,"type":22},88,[25],"This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy. Patients are randomized into an epinephrine group (normal saline with 1 mL of 1:1000 epinephrine per 3 L bag; tourniquet placed but not inflated unless needed) or a standard tourniquet group. The primary outcome is arthroscopic visual field clarity assessed using a 4-point Likert-style numeric rating scale. Secondary outcomes include postoperative pain intensity at 2 and 24 hours (VAS), and the incidence of hypotension, bradycardia, and cardiovascular adverse events.",[28,143,144],"Ankle Ligament Injury","Ankle Arthroscopy",[146],"Arthroscopic visual field","2026-01-11",{"date":149,"type":39},"2026-01-16",{"date":151,"type":22},"2025-12-30",{"date":153,"type":22},"2026-12-30",{"name":155,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":165,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":47},"100614721","effect-of-functional-core-stability-training-or-cognitive-training-on-balance-and-postural-control-in-chronic-ankle-instability-100614721","NCT07283276","Effect of Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Chronic Ankle Instability","Effect of Adding Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Rehabilitation of Chronic Ankle Instability","Inclusion Criteria:\n\nInclusion criteria will be based on the standard criteria outlined by the International Ankle Consortium\n\n1. History of chronic lateral ankle sprain and\u002For recurrent sprain and\u002For \"feelings of instability or giving way\" for 6 months or more before the study, with at least 2 episodes.\n2. Patients are between 18 and 30 years old. 3- Body mass index less than 30\n\n4\\. The patient has a history of at least one significant ankle sprain with associated inflammatory symptoms and at least one day of interrupted physical activity.\n\n5\\. Patients who have unilateral chronic ankle instability. 6. Self-reported ankle instability should be confirmed using a validated ankle instability questionnaire (greater than 24).\n\nExclusion Criteria:\n\nThose with a history of spine, pelvis, and lower extremity injury, fracture, or surgery 2- Those with low back pain that require medical or surgical intervention. 3- Having a history of an acute lower extremity injury or lower extremity surgery or fracture in the 3 months before the Study 4. Participation in formal ankle rehabilitation in the 3 months before the study.\n\n5\\. Being diagnosed with neurologic dysfunction, such as multiple sclerosis, Parkinson's disease, or head injury",{"count":164,"type":22},45,[25],"The purpose of the study is to investigate dynamic core stability training versus cognitive training on balance, functional performance, postural control, ankle instability scores, ankle dorsiflexion range of motion, and mental workload in chronic ankle instability",[168,169,170,171,28],"Cognitive Training","Functional Core Stability Training","Balance; Distorted","Postural Control","2025-12-02",{"date":174,"type":39},"2025-12-15",{"date":176,"type":39},"2025-08-15",{"date":178,"type":22},"2026-03-01",{"name":180,"class":46},"Cairo University",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":4},"100605354","fus-subcutaneous-needling-for-postacute-lateral-ankle-sprain-and-prevention-of-chronic-ankle-instability-100605354","NCT07161427","Fu's Subcutaneous Needling for Postacute Lateral Ankle Sprain and Prevention of Chronic Ankle Instability","Biomechanics-based Fu's Subcutaneous Needling Versus Bracing Combined With Resistance Training in the Treatment of Postacute Lateral Ankle Sprain and the Prevention of Chronic Ankle Instability: A Randomized Controlled Trial Protocol","Inclusion Criteria:\n\n1. Patients with first-time lateral ankle sprains\n2. The patient presents with symptoms of swelling and aching and weakness in the ankle joint. There may be a feeling of friction during joint movement, and the symptoms are aggravated after long - distance walking or on rainy and overcast days.\n3. The patient presents with swelling and tenderness in the anteroinferior aspect of the lateral malleolus and the anterolateral aspect of the medial malleolus, and has limited mobility during inversion and flexion-extension.\n4. Auxiliary examinations: No fracture or dislocation was found in the patient during the examination, and no fracture was detected by X-ray examination.\n5. The patient's sprain time is more than 3 weeks and within 6 months.\n6. Those who have not received surgical treatment at other medical institutions before coming to our hospital for treatment, can complete the treatment and accept follow - up.\n7. The patients' ages range from 18 to 60 years old.\n8. The patient voluntarily and is capable of signing the Informed Consent Form.\n\nExclusion Criteria:\n\n1. Those with complete rupture of fractures or soft tissues such as muscles, tendons, and ligaments\n2. Patients with severe primary diseases such as heart, liver, kidney, hematopoietic system diseases and mental diseases\n3. Patients with tumors or tuberculosis in the ankle joint\n4. Patients with rheumatic and rheumatoid arthritis, or gout.\n5. Patients with acute inflammatory reactions such as redness, swelling, heat and pain and signs of infection in the ankle joint, or those accompanied by severe osteoarthritis.\n6. Patients with abnormal coagulation function or bleeding tendency, such as those with thrombocytopenia and severe diabetes.\n7. Patients during pregnancy and lactation\n8. Patients with damaged skin at the necessary needle insertion sites.","60 Years",{"count":190,"type":22},62,[25],"Introduction: Fu's Subcutaneous Needling (FSN) is a new type of acupuncture treatment method based on the subcutaneous tissue sweeping technique, and it has been proven to have a good therapeutic effect on ankle sprain. However, at present, the difference between its curative effect and the ankle joint orthosis and exercise therapy recommended by the Guidelines remains unclear. Therefore, this study aims to explore the improvement effects of FSN on pain relief, joint function improvement, and ankle balance ability by comparing with ankle orthosis combined with exercise therapy. Verify whether it is more helpful in preventing the progression of lateral ankle sprain (LAS) to chronic ankle instability (CAI) and provide evidence-based basis for clinical decision-making.\n\nMethods and analysis: This study is a randomized, parallel - controlled, single - center prospective clinical study. This study will include 60 subjects with postacute lateral ankle sprain and divide them into the FSN group and the combined treatment group. There are 30 cases in each group. The FSN group will be treated with Fu's subcutaneous needling three times a week for a total of two weeks. The Combined treatment group will wear ankle orthotics from 9:00 to 20:00, and complete resistance exercise training every day for a total of two weeks.Patients will be followed up for 6 months after the treatment. The main efficacy index is the change value of the Visual Analog Scale (VAS) compared to the baseline after 2 weeks of treatment. The secondary indicators include active range of motion (ROM) of the ankle joint, Star Excursion Balance Test (SEBT), and the Foot and Ankle Ability Measure (FAAM) to prove the clinical efficacy.\n\nEthics and dissemination: This study strictly adheres to the ethical guidelines of the Declaration of Helsinki.This study has passed the review of the Ethics Committee of Guangdong Provincial Hospital of Chinese Medicine. Approval No.: YF 2025 - 158 - 01. All subjects will sign a written informed consent form. The research results will be publicly published in journals indexed by SCI.\n\nKeywords: Fu's subcutaneous needling, Ankle sprain, Postacute lateral ankle sprain, Chronic ankle instability, Functional rehabilitation, Balance, Non-surgical therapy",[28,194],"Lateral Ankle Sprain",[196,197,198,199,200,201,202],"Fu's subcutaneous needling","Ankle sprain","Postacute lateral ankle sprain","Chronic ankle instability","Functional rehabilitation","Balance","Non-surgical therapy","2025-09-14",{"date":205,"type":39},"2025-09-16",{"date":207,"type":22},"2025-10-01",{"date":209,"type":22},"2027-09-01",{"name":211,"class":46},"Guangzhou University of Chinese Medicine",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":23,"phases":221,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":47},"100603308","the-effects-of-stroboscopic-visual-conditions-on-gait-and-lower-limb-muscle-activity-in-individuals-with-chronic-ankle-instability-100603308","NCT07134829","The Effects of Stroboscopic Visual Conditions on Gait and Lower Limb Muscle Activity in Individuals With Chronic Ankle Instability","Inclusion Criteria:\n\n* Individuals with a Cumberland Ankle Instability Tool (CAIT) score of less than 24\n* Individuals diagnosed with ankle sprain or instability within the past 6 months\n\nExclusion Criteria:\n\n* Individuals who have undergone lower limb surgery or experienced a fracture due to ankle trauma within the past 6 months\n* Individuals with systemic diseases, such as cardiovascular disorders, that may affect balance\n* Individuals who have difficulty understanding or following instructions during assessment or training","45 Years",{"count":220,"type":22},25,[25],"This interventional study will investigate the effects of stroboscopic visual conditions on gait patterns and lower limb muscle activation in adults with chronic ankle instability (CAI). CAI often results in impaired sensorimotor control, leading to altered gait strategies such as slower walking speed, shorter step length, and increased visual reliance. Stroboscopic glasses intermittently restrict visual input, potentially reducing visual dependence and enhancing proprioceptive feedback.\n\nParticipants will complete walking trials under three randomized visual conditions: high-frequency stroboscopic, low-frequency stroboscopic, and no-glasses control. Gait parameters will be measured using the GAITRite system, and surface electromyography (sEMG) will record activation of the tibialis anterior, peroneus longus, and gastrocnemius muscles. Findings may provide insight into sensorimotor adaptation mechanisms and inform rehabilitation strategies to improve functional stability in individuals with CAI.",[28],[225,226,227,228],"Stroboscopic Glasses","Stroboscopic Vision","Gait Analysis","Surface Electromyography","2025-08-14",{"date":231,"type":39},"2025-08-21",{"date":233,"type":22},"2025-08-31",{"date":235,"type":22},"2025-10-12",{"name":237,"class":46},"Sahmyook University",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":244,"minAge":18,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":260,"locationsCount":47},"100597153","effect-of-kinesiotaping-on-lower-limb-kinematics-and-functional-related-outcomes-among-female-athletes-with-chronic-lateral-ankle-instability-100597153","NCT07054788","Effect of Kinesiotaping on Lower Limb Kinematics and Functional Related Outcomes Among Female Athletes With Chronic Lateral Ankle Instability","Inclusion Criteria:\n\n1. Aged 18-24 years.\n2. chronic ankle instability group has a history of unilateral ankle inversion injury since at least one year before the study onset\n3. A period of restricted weight-bearing and\u002For immobilization for at least one day\n4. The patient reported a tendency to give way during functional activities\n5. Positive anterior drawer test and\u002For talar tilt test\n6. At least 2 giving-way episodes within 6 months before the study enrollment and\u002For recurrent ankle sprain\n7. Score of 24 on the Cumberland ankle instability tool\n\nExclusion Criteria:\n\n1. Acute ankle injuries within the past 3 months.\n2. Any other lower extremity injuries or surgeries that could affect balance or ankle function.\n3. Participation in either formal or informal rehabilitation before enrollment in the study\n4. Skin allergy from kinesiotaping.","FEMALE","24 Years",{"count":247,"type":22},50,[25],"The current study aims to measure the effect of adding kinesiology tape to ankle mobilization with movement with calf muscles flexibility exercise on dorsiflexion range of motion, dynamic balance, lower limb kinematics, and self-reported physical function versus mobilization with movement, calf muscles flexibility exercise, and placebo kinesiotapping in female basketball players with unilateral chronic lateral ankle instability",[251,252,253,28],"Kinesiotapping","Kinematics","Athletes Foot","2025-06-28",{"date":256,"type":39},"2025-07-08",{"date":258,"type":22},"2025-06-30",{"date":207,"type":22},{"name":180,"class":46},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":273,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":47},"100558547","comparison-of-resistance-training-with-and-without-plyometric-exercises-on-athletes-with-chronic-ankle-instability-100558547","NCT06552533","Comparison of Resistance Training With and Without Plyometric Exercises on Athletes With Chronic Ankle Instability.","Comparison of Resistance Training With and Without Plyometric Exercises on Pain, Range of Motion, Dynamic Balance and Strength Among Athletes With Chronic Ankle Instability.","Inclusion Criteria:\n\n* A history of at least 1 substantial ankle sprain with associated inflammatory symptoms and at least 1 interrupted day of desired physical activity, multiple episodes of the ankle \"giving way,\" recurrent sprain, and \"feelings of instability\" in the 6 months before the study. Patients scoring the FAAM, there should be two scores, less than the ADL subscale and the Sports subscale, 20\u002F21 items and 7\u002F8 items must be completed, respectively\n* If both ankles qualified, the ankle with the highest score (i.e. the most severely affected ankle) was considered the involved limb.\n\nExclusion Criteria:\n\n* Volunteers were excluded if they had sustained an acute lower extremity injury in the 3 months before the study\n* Having participated in formal rehabilitation in the 3 months before the study\n* Having a history of lower extremity surgery or fracture that required alignment in the involved limb\n* Having any diagnosed neurologic dysfunction, such as multiple sclerosis, Parkinson disease, or head injury.",{"count":269,"type":22},24,[25],"Chronic ankle instability is characterized by a patient's being more than 12 months removed from the initial LAS and exhibiting a propensity for recurrent ankle sprains, frequent episodes or perceptions of the ankle giving way, and persistent symptoms such as pain, swelling, limited motion, weakness, and diminished self-reported function. This study will Compare Resistance Training with and without Plyometric exercises on Athletes with Chronic Ankle instability and changes will be recorded using different methods and tools. Patients will be randomly allocated into two different groups. Group A will be treated with resistance training and Group B will be treated with resistance training along with plyometric exercises . Participants will complete clinician-oriented tests. Participants of both groups will be evaluated before and after the application of respective interventions at the end of 8th week. Data will be analysed.",[28],[274],"goniometry, plyometric exercises, resistance training","2024-08-13",{"date":277,"type":39},"2024-08-14",{"date":279,"type":39},"2024-06-14",{"date":281,"type":22},"2024-09-14",{"name":283,"class":46},"Riphah International University",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":47},"100525218","role-of-sensory-deficits-on-sensorimotor-control-in-athletes-with-chronic-ankle-instability-100525218","NCT06118879","Role of Sensory Deficits on Sensorimotor Control in Athletes With Chronic Ankle Instability","Role of Sensory Deficits and the Effect of Sensory Stimulation on Sensorimotor Control and Neuromuscular Performance in Athletes With Chronic Ankle Instability","Inclusion Criteria:\n\n* between 18 and 40 years old\n* having at least one ankle sprain experience in the past year with sequelae; or having repeated ankle sprain experience in the past year,\n* having a \"soft foot\" sensation within three months\n* score ≤ 27 on the Cumberland Ankle Instability Tool (CAIT)\n\nExclusion Criteria:\n\n* having a history of lower extremity fracture or surgery, or a history of lower extremity trauma in the past three months\n* having experiences of sprained ankles within the previous six weeks\n* having pathological joint laxity (positive results on talar tilt test or drawer forward test","40 Years",{"count":293,"type":22},150,[25],"Purpose: Chronic ankle instability (CAI), characterized by instances of repetitive sprains and giving way, is a common chronic dysfunction among athletes. Despite well documented evidence showing impaired peripheral sensory and both central and peripheral motor control, little was known regarding how CAI affects somatosensory cortical activation. Traditionally, management of CAI mostly focused on restoration of motor deficits, with less emphasis on sensory pathway deficits. Only few sensory targeted intervention methods including joint mobilization and massage, have been described. However, methods such as joint mobilization provide not only sensory stimulation but also mechanical alignment correction. In addition, these studies showed functional improvement without exploring mechanisms. Therefore we would like to apply for a three year study grant to firstly investigate the effect of CAI on peripheral and central somatosensation and neuromuscular performance; and secondly to examine the immediate effect of sensory-level electrical stimulation on neurophysiological variables and neuromuscular performance; and lastly to determine the short-term effect of intervention (sensory stimulation with exercise, sham stimulation with exercise, and exercise alone) in athletes with CAI.\n\nResearch design and methods: This is a cross-sectional exploratory and randomized controlled study. For the first year, we plan to recruit 45 young athletes (20-40 years old) with CAI and 15 matched controls to compare the somatosensory evoked potentials (SEPs), corticomuscular coherence (CMC), α- band event-related desynchronization (ERD), proprioception, two point discrimination threshold of the plantar surfaces, muscle activation and reaching distances of the Y balance test. Activity in the sensorimotor cortex will be recorded using a 64-chanel EEG (SAGA 32\u002F64+ for EEG). Muscle activation is measured using an 8-channel electromyography (EMG) system (Noraxon myo METRICS Portable Lab, Noraxon U.S.A.). For the second year, the 45 young adults with CAI will be randomized into the sensory stimulation (TENS) group, the sham stimulation group, or the control group. The TENS group will receive 40 minutes of sensory electrical stimulation, and the sham group will receive 30 seconds of sensory stimulation at the beginning and end of the treatment. The control group will rest for 40 minutes. The assessment items are identical to those in the first year, and will be carried out before and immediately after the intervention. For the third year, the 45 young adults with CAI will be randomized into the exercise with sensory stimulation (EX-TENS) group, exercise with sham stimulation (EX-ss) group, or exercise alone (EX) group. Participants will receive five sessions of intervention (30 minutes neuromuscular training with or without 40 min stimulation) within two weeks and the assessment will be carried out before and after the intervention.\n\nData analysis: Comparisons of all continuous variables are performed using oneway analysis of variance (ANOVA), and repeated measures ANOVA. The significance level is set at 0.05. Significance.\n\nResults of this study provide a better understanding for central somatosensory control mechanisms for chronic ankle instability, and help clinicians and trainers to choose the most appropriate training strategy for people with unstable ankles. We plan to present our work in 3-4 international conferences, and publish 2-3 papers in SCI journals in 5 years.",[28],"2023-10-30",{"date":299,"type":39},"2023-11-07",{"date":301,"type":22},"2023-11-01",{"date":303,"type":22},"2026-07-01",{"name":305,"class":46},"National Yang Ming Chiao Tung University"]