[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-apical-periodontitis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,40,64,92,114,148],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100622844","in-vivo-study-on-the-material-properties-of-iroot-sp-and-nroot-sp-root-canal-sealers-100622844",false,"NCT07388901","In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers","Randomized Controlled Trial of iRoot SP (Injectable Root Canal Sealer Paste) and nRoot SP (ENPUNUO Root Canal Sealer Paste) in Patients With Chronic Apical Periodontitis","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Diagnosis of apical periodontitis conforming to the diagnostic criteria in Endodontics.\n* The affected tooth is deemed restorable upon evaluation, with non-vital pulp requiring extirpation.\n* The affected tooth is a single tooth with a fully developed apical foramen.\n* No root resorption and no significant morphological variation of the root canal.\n* The affected tooth is undergoing primary root canal treatment.\n* Periapical radiolucency with a diameter of 1-5 mm and no peripheral sclerotic border observed on preoperative radiographs.\n* Patient is in normal mental state, conscious, and capable of normal communication.\n* Patient has provided informed consent.\n\nExclusion Criteria:\n\n* Patients with alveolar bone loss exceeding one-third of the root length.\n* Affected teeth with root fracture, root canal obstruction, calcification, or root surface caries.\n* Patients with severe systemic diseases (e.g., osteoporosis, mental disorders, hepatic or renal insufficiency).\n* Patients who have taken analgesics, immunosuppressants, or antibiotics within one week prior to enrollment.\n* Patients with concurrent periapical cysts, oral tumors, or other oral diseases.\n* Pregnant or lactating patients.\n* Patients with dental phobia, severe gag reflex, limited mouth opening, or poor compliance.\n* Patients with a known allergy to the root canal sealer materials.","ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","INTERVENTIONAL",[23],"NA","A randomized controlled trial was conducted to compare the treatment efficacy of iRoot SP and nRoot SP Root Canal Sealer Materials in patients with chronic apical periodontitis.",[26],"Chronic Apical Periodontitis","RECRUITING","2026-04-13",{"date":30,"type":31},"2026-04-15","ACTUAL",{"date":33,"type":31},"2025-05-27",{"date":35,"type":20},"2027-06-30",{"name":37,"class":38},"The Dental Hospital of Zhejiang University School of Medicine","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":4},"100633690","mmp-23-and-periapical-healing-outcomes-100633690","NCT07529964","MMP-2\u002F3 and Periapical Healing Outcomes","Association of MMP-2 and MMP-3 Polymorphisms With 12-Month Radiographic Healing After Nonsurgical Root Canal Treatment in Chronic Apical Periodontitis: A Prospective Clinical Study","Inclusion Criteria:\n\n* Single-rooted teeth\n* PAI score ≥ 3\n* Fully developed root apices\n* Periodontal probing depth less than 5 mm\n* Indication for primary nonsurgical root canal treatment\n\nExclusion Criteria:\n\n* Previous endodontic treatment in the selected tooth\n* Diagnosis of symptomatic apical abscess\n* Presence of root fracture or internal\u002Fexternal resorption\n* Use of systemic antibiotics within the previous 4 weeks\n* Analgesic intake within 48 hours before treatment\n* Ongoing immunosuppressive therapy\n* Pregnancy or breastfeeding","65 Years",{"count":49,"type":20},50,"OBSERVATIONAL","This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.",[26,53],"Periapical Healing","NOT_YET_RECRUITING","2026-04-08",{"date":57,"type":31},"2026-04-14",{"date":59,"type":20},"2026-05-15",{"date":61,"type":20},"2027-06-25",{"name":63,"class":38},"TC Erciyes University",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":21,"phases":73,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":39},"100607725","using-platelet-rich-fibrin-in-regenerative-endodontic-treatment-in-mature-permanent-teeth-100607725","NCT07192289","Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth","Inclusion Criteria:\n\nParticipants had a single-rooted tooth with necrotic pulp (negative response to electric pulp testing), with or without periapical pathology (acute apical periodontitis of pulpal origin, chronic periapical periodontitis, periapical abscess with sinus, periapical abscess without sinus), and gave their consent to participate in the study.\n\nExclusion Criteria: Study samples will be excluded if any of the following criteria are met:\n\n* The tooth has had previous endodontic treatment.\n* The root apex is not fully developed, or there is root resorption\u002Fcracking\u002Ffracture.\n* The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.\n* The root canal is calcified.\n* The root canal curvature is greater than 25º.\n* The tooth has a periapical cyst or is associated with a jawbone cyst.\n* The tooth has a periodontal pocket deeper than 4 mm.\n* The tooth has no occlusal contact.\n* The patient is pregnant.\n* The patient has diabetes or HIV or other immunocompromised conditions.",true,{"count":72,"type":20},57,[23],"This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.",[26,76,77,78],"Necrosis of Pulp","Acute Apical Periodontitis of Pulpal Origin","Periapical Abscess",[80,81,82],"PRF","regenerative endodontic treatment","mature permanent treatment","2025-09-21",{"date":85,"type":31},"2025-09-25",{"date":87,"type":20},"2025-09-15",{"date":89,"type":20},"2027-08-31",{"name":91,"class":38},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":39},"100598314","sonic-vs-passive-ultrasonic-irrigation-for-chronic-apical-periodontitis-100598314","NCT07069881","Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis","A Randomized Controlled Trial of Endodontic Treatment Using Sonic-activated Irrigation and Passive Ultrasonic Irrigation to Evaluate Healing in Chronic Apical Periodontitis","Inclusion Criteria:\n\n1. Agree to participate in this study and provide informed consent;\n2. Age 18-59 years at the time of enrolment;\n3. At least one permanent tooth diagnosed with chronic periapical periodontitis at root development stage of Nolla10th;\n4. Able to follow up on schedule.\n\nExclusion Criteria:\n\n1. Allergies to any medications or materials necessary to complete the procedures;\n2. Non-restorable teeth, teeth with severe defects, or teeth that need to be extracted due to orthodontic treatment;\n3. Teeth with root canal treatment or vital pulp therapy;\n4. Teeth with canal calcification or root canal instrument separation;\n5. Teeth with root fracture or vertical root fracture;\n6. Tooth with internal or external root resorption;\n7. Patients with periodontitis;\n8. Patients with orthodontic treatment;\n9. Presence of dental phobia;\n10. Women who are pregnant;\n11. Patients who have taken medications that affect central nervous system, such as tricyclic antidepressant;\n12. Patients who have taken medications that affect immune response, such as glucocorticoid or cyclosporin;\n13. Patients after radiotherapy of tumor head and neck;\n14. Patients who have taken medications that affect curative effect, such as bisphosphonates;\n15. Patients with serious systemic diseases that can affect curative effect;\n16. Participation in other clinical studies within the past several weeks;\n17. Patients who are deemed unsuitable to participate in the study by investigators.","59 Years",{"count":101,"type":20},300,[23],"This randomized, controlled, double-blinded clinical trial aims to directly compare the efficacy of Sonically Activated Irrigation (SAI) versus Passive Ultrasonic Irrigation (PUI) in the root canal treatment of teeth with chronic apical periodontitis, analyze potential influencing factors, and thereby identify a highly effective and safe root canal irrigation protocol. The ultimate goal is to provide an evidence-based rationale for optimizing irrigation technique selection and overall treatment strategies for chronic apical periodontitis.",[26],"2025-07-15",{"date":107,"type":31},"2025-07-17",{"date":109,"type":31},"2024-12-30",{"date":111,"type":20},"2026-12-31",{"name":113,"class":38},"Nanfang Hospital, Southern Medical University",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":70,"sex":16,"minAge":17,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":21,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":39},"100597514","effect-of-different-root-canal-sealers-on-oxidative-stress-markers-100597514","NCT07059481","Effect of Different Root Canal Sealers on Oxidative Stress Markers","Evaluation of Oxidative Stress in Patients With Chronic Apical Periodontitis Treated With Single Session Root Canal Treatment Using Different Root Canal Sealers: in Vivo Study","Inclusion Criteria:\n\n* Systemically healthy, ASA1 patients,\n* Phase 1 periodontal treatment was performed,\n* Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth,\n* The lesion measured \\\u003C2 cm on radiographic evaluation,\n* The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised,\n* Socioculturally able to participate in the treatment,\n* Individuals who did not smoke or drink alcohol\n\nExclusion Criteria:\n\n* Patients who have used antibiotics in the last three months and analgesics in the last two weeks\n* Patients who smoke and\u002For abuse alcohol\n* Patients younger than 18 years or older than 45 years,\n* Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6)\n* Pregnant or lactating women,\n* Patients with poor oral hygiene,\n* Patients who had head and neck radiotherapy,\n* With obesity,\n* Active periodontal disease,\n* Periodontal pocket depth over 3mm,\n* There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement,\n* Clinical examination of the relevant tooth showing symptoms in percussion-palpation,\n* Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus,\n* Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study.\n* Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.","45 Years",{"count":123,"type":20},40,[23],"The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are:\n\nIs there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment?\n\nResearchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment.\n\n* Participants will be informed about all procedures before starting the clinical process.\n* Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment.\n* Participants will be informed in writing about the treatment procedure before starting the clinical process.\n* Participants are expected to sign the informed consent form on a voluntary basis.",[127,26],"Oxidative Stress",[129,130,131,132,133,134,135,136,137,138],"oxidative stress","root canal sealers","chronic apical periodontitis","periapical index","total oxidant status","total antioxidant status","oxidative stress index","8-epi","malondialdehyde","myeloperoxidase","2025-07-09",{"date":141,"type":31},"2025-07-10",{"date":143,"type":31},"2024-03-18",{"date":145,"type":20},"2025-11-13",{"name":147,"class":38},"bengi gülgü",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":70,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":21,"phases":158,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100582198","phase-4-effect-of-different-sealers-and-activation-methods-on-pain-100582198","NCT06860191","Effect of Different Sealers and Activation Methods on Pain","Evaluation of the Effects of Different Root Canal Sealer and Irrigation Agitation Methods on Postoperative Pain in the Treatment of Teeth with Chronic Apical Periodontitis - Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged 18-60 years who are classified as medically healthy (ASA I or II),\n* Teeth that do not need periodontal and prosthetic treatment, with a periapical index score between 2 and 4,\n* Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,\n* Teeth that respond negatively to electric pulp test (Parkell) or cold test (Endo Ice; Coltene, Altstätten, İsviçre), without pain during percussion and palpation.\n\nExclusion Criteria:\n\n* Teeth with PAI scores lower than 2\n* Patients who had taken analgesics or anti-inflammatory drugs in the last 4 hours\n* Diabetic, immunocompromised, pregnant or history of antibiotic use in the last month or patients receiving antibiotic prophylaxis\n* Teeth with root resorption, immature, severe crown damage, calcified canals, and previous root canal fillings","60 Years",{"count":157,"type":20},80,[159],"PHASE4","In this study, the effects of different irrigation agitation methods and different root canal filling sealers on postoperative pain after root canal treatment will be evaluated.",[26],[163,164,165,166],"Caries","apical periodontitis","irrigation agitation","root canal sealer","2025-02-28",{"date":169,"type":31},"2025-03-05",{"date":171,"type":20},"2025-03-01",{"date":173,"type":20},"2025-05-01",{"name":63,"class":38}]