[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-cancer-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-cancer-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100617430","cognitive-behavioral-theory-assisted-virtual-reality-for-chronic-cancer-pain-vr-can-100617430",false,"NCT07318519","Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)","Cognitive Behavioral Theory-assisted Virtual Reality for Chronic Cancer Pain (VR-CAN): Device Prototype Development and Feasibility Testing","VR-CAN","Inclusion Criteria:\n\n* age at least 18 years old\n* cancer diagnosis, undergoing treatment\n* chronic cancer pain (i.e., cancer pain at least 3 months duration) with baseline pain severity at least 4\u002F10 (where 0=no pain, 10=worst pain)\n\nExclusion Criteria:\n\n* intractable nausea\u002Fvomiting, motion sickness, seizures\u002Fepilepsy, and\u002For cranial structures\u002Fabnormalities preventing VR headset use\n* moderate-severe pain of non-cancer etiology\n* enrolled in another pain study\n* unable to complete survey measures or interviews in English or Spanish","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","While chronic cancer pain affecting as many as 75% of patients is typically addressed using pharmacologic interventions, experts and patients alike support maximizing any relevant non-pharmacologic interventions as well, such as cognitive behavioral therapy. Virtual reality, a novel technology that can temporarily immerse users in a calm, pleasant environment, has been increasingly shown to facilitate improvement in different acute and chronic pain syndromes by providing distraction from pain and lowering pain sensation. To address the significant needs of patients living with chronic cancer pain, we aim to develop and pilot test a prototype device that will leverage cognitive behavioral therapy principles to deliver a novel virtual reality pain therapy. The investigators will do this through the following steps:\n\nStep 1. Develop and refine a CBT-assisted VR prototype for patients with chronic cancer pain (VR-CAN).\n\nStep 2. Conduct a randomized controlled trial to examine the feasibility, acceptability, usability, safety, and initial clinical impact of the developed VR-CAN prototype compared to a tablet-based two-dimensional video control group.\n\nStep 3. Collect and evaluate qualitative post-intervention data on VR-CAN participants' preferences, thoughts, and feelings about the VR-CAN technology and protocol to optimize for a future, larger, fully powered randomized controlled trial.",[27,28,29],"Cancer","Cancer Pain","Chronic Cancer Pain",[31,32,33,34,35],"cancer","pain","chronic pain","cognitive behavioral therapy","virtual reality","RECRUITING","2026-01-02",{"date":39,"type":40},"2026-01-06","ACTUAL",{"date":42,"type":40},"2025-07-01",{"date":44,"type":21},"2027-05-31",{"name":46,"class":47},"Medstar Health Research Institute","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100616695","effect-of-patient-controlled-transcutaneous-electrical-acupoint-stimulation-on-quality-of-life-in-chronic-cancer-pain-100616695","NCT07308951","Effect of Patient-Controlled Transcutaneous Electrical Acupoint Stimulation on Quality of Life in Chronic Cancer Pain","Clinical Efficacy Evaluation of Patient-Controlled Transcutaneous Electrical Acupoint Stimulation in Improving the Quality of Life for Patients With Chronic Cancer Pain","Inclusion Criteria:\n\n* Age between 18 and 80 years, regardless of gender;\n* Diagnosis of primary or metastatic malignant tumor confirmed by histopathology and\u002For cytology, consistent with the American Cancer Society criteria for malignancy;\n* Presence of cancer-related pain, defined as an average Numeric Rating Scale (NRS) score ≥ 2 over the preceding week or current regular use of opioid analgesics;\n* Life expectancy ≥ 3 months;\n* Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score ≤ 2, stable vital signs, clear consciousness, intact pain perception, unimpaired communication, ability to cooperate with study procedures and complete assessments;\n* Provision of signed informed consent by the patient or their legal guardian after comprehensive explanation of the study;\n\nExclusion Criteria:\n\n* Pain not attributable to cancer;\n* Severe cardiopulmonary dysfunction or respiratory depression;\n* Implantation of cardiac pacemaker or metallic implants at stimulation sites;\n* Local skin lesions or conditions unsuitable for TEAS at the acupoint sites;\n* Severe psychiatric disorders or significant cognitive impairment;\n* Concurrent participation in other clinical trials that may interfere with the outcome evaluation of this study;\n* Previous history of transcutaneous electrical acupoint stimulation (TEAS) or transcutaneous electrical nerve stimulation (TENS);","80 Years",{"count":57,"type":21},290,[24],"This study aims to objectively evaluate the effect of Patient-Controlled Transcutaneous Electrical Acupoint Stimulation (PC-TEAS) on improving the quality of life in patients with chronic cancer pain, thereby providing evidence-based medical support for its efficacy and offering practical basis for patients to achieve home-based auxiliary treatment based on their own needs. Furthermore, by observing and comparing changes in indicators such as pain-related scores, analgesic consumption, emotional scores, spontaneous bowel movements, and adverse events, this research will comprehensively assess the advantages of PC-TEAS in the management of chronic cancer pain and explore other potential benefits of this intervention for patients.",[61,29],"Quality of Life","2025-12-15",{"date":64,"type":40},"2025-12-30",{"date":66,"type":40},"2025-09-10",{"date":68,"type":21},"2026-12-31",{"name":70,"class":47},"The Third Affiliated hospital of Zhejiang Chinese Medical University",1]