[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-critical-illness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-critical-illness":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100486596","pathological-myeloid-activation-after-sepsis-and-trauma-100486596",false,"NCT05616130","Pathological Myeloid Activation After Sepsis and Trauma","Pathological Myeloid Activation After Sepsis and Trauma Subtitle: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology","Trauma population\n\nInclusion Criteria:\n\n1. All adults age ≥ 18 years\n2. Blunt and\u002For penetrating trauma resulting in long bone or pelvic fractures requiring open reduction internal fixation or closed reduction percutaneous pinning\n3. Blunt and\u002For penetrating trauma patient with a. Injury Severity Score (ISS) greater than or equal to 25 b. ISS \\> 15 and one of the following: i. \\> 4 units of packed red blood cell or \\>3 units of whole blood or \\>1500 ml of autogenous blood product in the first 24 hours of admission ii. AIS (acute injury score) \\> 2 spine iii. Shock on arrival (SBP \\\u003C 90)\n\nOR\n\nc. ISS \\> 15 and two of the following: i. Age \\> 55 ii. AIS \\> 2 chest iii. +ethyl alcohol on arrival iv. Any red blood cell transfusion in first 24 hours\n\nExclusion Criteria:\n\n1. Patients not expected to survive greater than 48 hours.\n2. Prisoners.\n3. Pregnancy.\n4. Patients receiving chronic corticosteroids or immunosuppression therapies.\n5. Previous bone marrow transplantation.\n6. Patients with End Stage Renal Disease.\n7. Patients with any pre-existing hematological disease.\n8. Patients deemed to be futile care or have advanced directives limiting resuscitative efforts.\n9. Patients with severe congestive heart failure (NY Heart Association Class IV).\n10. Known HIV infection with CD4+ (clusters of differentiation) count \\\u003C200 cells\u002Fmm3\n11. Chronic liver disease with MELD (Model for End-Stage Liver Disease) score ≥15\n\nElective Hip population\n\nInclusion Criteria:\n\n1. All adults (age ≥18)\n2. Patient undergoing elective hip repair for non-infectious reasons.\n3. Ability to obtain Informed Consent prior to operation.\n\nExclusion Criteria:\n\n1. Pregnancy.\n2. Prisoners.\n3. Patients receiving chronic corticosteroids or immunosuppression therapies.\n4. Pre-existing conditions such as pathological fractures, cancer, history of HIV, or history of connective tissue disease.\n5. Previous bone marrow transplantation.\n6. Patients with End Stage Renal Disease.\n7. Patients with any pre-existing hematological disease.\n8. Patients with known active\u002Fsymptomatic COVID-19 (Coronavirus disease).","ALL","18 Years","100 Years",{"count":20,"type":21},255,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury. The main questions it aims to answer are: Is severe human trauma associated with specific patterns of development in the hematopoietic stem cells of these patients? and Does the initial severe trauma injury create immunosuppression and increase risk of in-hospital sepsis? Participants in study will give blood samples and a waste sample of bone marrow at time of operative repair of traumatic orthopedic injuries, supply medical information and participate in surveys and assessments during recovery from their injury(ies). Researchers will compare severe trauma injury patients to elective hip repair patients to see if immunosuppression and specific development patterns occur in the trauma patient versus the otherwise healthy hip surgery patient.",[25,26,27,28],"Trauma Injury","Sepsis","Immunosuppression","Chronic Critical Illness","RECRUITING","2025-12-23",{"date":32,"type":33},"2025-12-26","ACTUAL",{"date":35,"type":33},"2022-09-01",{"date":37,"type":21},"2028-09-30",{"name":39,"class":40},"University of Florida","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100550925","pulmonary-rehabilitation-in-the-chronically-critically-ill-patient-100550925","NCT06453421","Pulmonary Rehabilitation in the Chronically Critically Ill Patient","Pulmonary Rehabilitation in the Chronically Critically Ill Patient: Prospective Study About Clinical Characteristics and the Response to Rehabilitation in This Patient Population and Search for Potential Predictive Factors","Inclusion Criteria:\n\n* age \\>18 years;\n* episode of acute or acute-on-chronic respiratory failure with the need for prolonged invasive mechanical ventilation via tracheostomy\n\nExclusion Criteria:\n\ncondition of clinical instability such as to make it necessary to transfer the patient to acute hospital within the first 7 days of hospitalization.",{"count":50,"type":21},220,"12 Months","The goal of this observational study is to learn about the population of chronically critical ill patients who refer to respiratory rehabilitation units.\n\nThe main questions it aims to answer are:\n\n* what are the clinical and pathophysiological characteristics of the population of chronically critical ill patients who refer to respiratory rehabilitation units after hospital admission with the need for prolonged invasive mechanical ventilation via tracheostomy?\n* what is the response of this patient population to respiratory rehabilitation treatment in terms of functional recovery, weaning from invasive mechanical ventilation, weaning from tracheostomy tube, mortality and return to home?\n* are there any appreciable indices at admission and\u002For in the first period of hospitalization which may have a prognostic significance both on short-term objectives (weaning from invasive mechanical ventilation, weaning from the tracheostomy tube) and in the medium-long term (survival, state of health)?\n\nParticipants will be subjected to a rehabilitation and weaning program consisting of:\n\n* physical therapy,\n* speech therapy,\n* nutritional assessment and therapy,\n* in subjects on invasive mechanical ventilation at admission a program of weaning and, if needed, shift from invasive to Non-Invasive Ventilation will be performed.",[54,28],"Rehabilitation","2025-02-27",{"date":57,"type":33},"2025-03-03",{"date":59,"type":33},"2023-02-10",{"date":61,"type":21},"2029-08-10",{"name":63,"class":40},"Fondazione Don Carlo Gnocchi Onlus"]