[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-dacryocystitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-dacryocystitis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100631370","phase-2-absorbable-drug-eluting-lacrimal-sac-stent-for-recurrent-chronic-dacryocystitis-100631370",false,"NCT07499791","Absorbable Drug-Eluting Lacrimal Sac Stent for Recurrent Chronic Dacryocystitis","A Prospective, Multicenter, Randomized Controlled Trial of an Absorbable Drug-Eluting Lacrimal Sac Stent in Recurrent Chronic Dacryocystitis Undergoing Endoscopic Endonasal Dacryocystorhinostomy","Inclusion Criteria:\n\n* Diagnosed chronic dacryocystitis\n\nHistory of failed E-DCR or lacrimal intubation\n\nPreoperative dacryocystography showing lacrimal sac diameter ≥4 mm\n\nAge ≥18 years\n\nAble to consent and comply with procedures\n\nExclusion Criteria:\n\n* Nasal cavity structural disease: severe septal deviation, tumor, severe sinusitis\n\nLacrimal sac non-visualization on imaging\n\nLacrimal sac rupture, traumatic duct\u002Fbone injuries\n\nAllergy to mometasone furoate or PLA\u002FPGA polymers\n\nPoor general health, unable to tolerate surgery\n\nPsychiatric disorders or antipsychotic drug use\n\nUncontrolled hypertension, diabetes, or severe systemic diseases\n\nKeloid tendency\n\nCoagulation disorders\n\nPregnancy","ALL","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This study aims to evaluate the safety and effectiveness of an absorbable lacrimal sac drug-eluting stent placed at the osteotomy site during endoscopic endonasal dacryocystorhinostomy (E-DCR) in patients with recurrent chronic dacryocystitis. The stent is composed of absorbable polymer mesh coated with mometasone furoate to reduce postoperative inflammation and adhesion, maintain ostium patency, and improve surgical outcomes. A total of 40 patients will be randomized 1:1 to receive either the absorbable stent or conventional packing with routine postoperative intranasal budesonide therapy.",[27],"Chronic Dacryocystitis",[27],"NOT_YET_RECRUITING","2026-03-25",{"date":32,"type":33},"2026-03-30","ACTUAL",{"date":35,"type":21},"2026-05-01",{"date":37,"type":21},"2027-12-01",{"name":39,"class":40},"Beijing Tongren Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100558488","the-application-of-photosensitive-hydrogel-in-intranasal-endoscopic-dacryocystorhinostomy-100558488","NCT06551766","The Application of Photosensitive Hydrogel in Intranasal Endoscopic Dacryocystorhinostomy","The Application of Photosensitive Hydrogel in Intranasal Endoscopic Dacryocystorhinostomy for the Anastomosis of Lacrimal Cyst Flap and Nasal Mucoperiosteal Flap","Inclusion Criteria:\n\n1. Voluntarily participate in this clinical study and sign the informed consent;\n2. Gender is not limited, age 18-75 years old;\n3. The patient had symptoms and signs of chronic dacryocystitis, and the results of lacrimal passage irrigation suggested that the lower rush and return or upper rush and lower return, accompanied by mucous or purulent discharge reflux;\n4. Lacrimal duct angiography suggests nasolacrimal duct obstruction without lacrimal canaliculi and\u002For duct obstruction.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 or \\> 75 years old;\n2. Previous history of dacryocystonasal anastomosis;\n3. Abnormal coagulation function;\n4. Tumors of lacrimal passage, especially in patients with papilloma or malignant tumors;\n5. in the acute dacryocystitis attack stage;\n6. obvious scar constitution;\n7. Complicated with serious nasal diseases, such as severe allergic rhinitis, chronic rhinosinusitis and nasal polyps, acute suppurative rhinosinusitis, severe atrophic rhinitis, and severe deviation of nasal septum;\n8. Have serious heart, liver, kidney, lung and other basic diseases, can not tolerate general anesthesia;\n9. Distance from the hospital, postoperative review is not convenient;\n10. Participated in other clinical trials within the last 3 months;\n11. Any medical history that the investigator determines may interfere with the test results or increase the patient's risk.","75 Years",{"count":51,"type":21},20,[53],"NA","To study the effect of Photosensitive hydrogel used for suture free anastomosis of lacrimal cyst and nasal mucoperiosteal flap in endoscopic nasal dacryocystostomy, and evaluate its adhesion to lacrimal cyst and nasal mucoperiosteal flap, promoting wound healing, forming a good anastomosis, preventing postoperative anastomosis and shortening operation time. Twenty patients with chronic dacryocystitis were randomly divided into photosensitive hydrogel group and suture group.Symptoms and nasal endoscopy were followed up 2, 6, and 12 weeks after surgery for both groups. And also adverse events were recorded at each follow-up.",[27],"RECRUITING","2024-08-09",{"date":59,"type":33},"2024-08-13",{"date":61,"type":33},"2023-03-01",{"date":63,"type":21},"2024-12-31",{"name":65,"class":40},"Eye & ENT Hospital of Fudan University"]