[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-diseases-in-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-diseases-in-children":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,77,103,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100605425","food-as-medicine-study-100605425",false,"NCT07162350","Food as Medicine Study","Food as Medicine (FAME): An Innovative Approach to Improve Health and Nutrition Security Among High-Risk Children and Families in South Dallas","FAME","Eligibility Criteria:\n\nInclusion criteria for the participant include:\n\n1. Between the ages of 8-15 years,\n2. Have risk factors of chronic disease based on elevated BMI (\\>25; 85th percentile),\n3. Be seen at one of the selected Parkland COPC clinics,\n4. Have not completed a dietitian visit within the last 12 months,\n5. Both the participant and caregiver must be fluent in English or Spanish (read, write, and speak) and be willing to participate in the study over a 12-month duration.\n\nExclusion criteria for the participant include presence of any of the following:\n\n1. Autism with feeding difficulties\n2. Intellectual disability\n3. Cushing Disease\n4. Severe feeding difficulties for over 2 years\n5. Dietary restrictions (medically prescribed)\n6. Severe food allergy\n7. Severe psychiatric disorders\n8. Non-alcoholic fatty liver disease\n9. Non-alcoholic steatohepatitis\n10. Metabolic-associated fatty liver disease\n11. Metabolic-associated steatohepatitis\n12. Type 1 Diabetes\n13. Antipsychotics\n14. GLP1 Medication Prescribed\n15. Bariatric Surgery\n16. Pregnancy","ALL","8 Years","15 Years",{"count":21,"type":22},250,"ESTIMATED","INTERVENTIONAL",[25],"NA","The Food as Medicine (FAME) intervention aims to improve dietary quality in lower income, primarily ethnic minority youth through food navigation that bridges clinical care and community food resources. This study will evaluate the FAME intervention on dietary quality, food behaviors, health outcomes, and cost-effectiveness, using a pragmatic randomized clinical trial design in 250 at risk youth (8-15 years of age) and their caregiver(s) as compared to Usual Care through the following aims:\n\nAim 1: To evaluate the impact of the FAME intervention on child and caregiver(s) dietary quality at 6 and 12 months as compared to Usual Care. Hypothesis: FAME participants will have increased dietary quality as measured by ASA-24\u002FDQI.\n\nAim 2: To assess the intervention's impact on food behaviors, food insecurity, healthy food sourcing, knowledge, self-efficacy, health outcomes and cost-effectiveness at 6 and 12 months as compared to Usual Care.\n\nAim 3: Evaluate implementation outcomes including dose, satisfaction, and individual interviews and focus groups with youth, parents, physicians, clinic staff, community partners, and CHWs.",[28],"Chronic Diseases in Children","NOT_YET_RECRUITING","2026-04-02",{"date":32,"type":33},"2026-04-06","ACTUAL",{"date":35,"type":22},"2026-05",{"date":37,"type":22},"2028-06-30",{"name":39,"class":40},"Parkland Health and Hospital System","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100448470","effects-of-the-mediterranean-diet-during-pregnancy-on-the-onset-of-allergies-in-the-offspring-100448470","NCT05119868","Effects of the Mediterranean Diet During Pregnancy on the Onset of Allergies in the Offspring","Effects of the Mediterranean Diet During Pregnancy on the Onset of Allergies in the Offspring: a Multi-center Randomised-controlled Trial (the PREMEDI Project)","PREMEDI","Inclusion Criteria:\n\n\\- healthy women (aged 20-35 years), at first trimester of pregnancy, of at risk for atopy baby\n\nExclusion Criteria:\n\n* concomitant presence of infections;\n* concomitant presence of malignancies;\n* concomitant presence of major gastrointestinal malformations;\n* concomitant presence of immunodeficiencies;\n* concomitant presence of autoimmune diseases;\n* concomitant presence of chronic inflammatory bowel diseases;\n* concomitant presence of functional gastrointestinal disorders;\n* concomitant presence of celiac disease;\n* history of abdominal surgery with gastrointestinal resection;\n* concomitant presence of neuropsychiatric disorders;\n* concomitant presence of central nervous system disorders;\n* vegan diet;\n* twin pregnancy;\n* concomitant presence of genetic disorders;\n* concomitant presence of metabolic disorders.",true,"FEMALE","20 Years","35 Years",{"count":55,"type":22},276,[25],"Allergy prevalence is increasing steadily with some describing as the \"epidemic of the twenty-first century\". Maternal diet during pregnancy has been linked to offspring allergy risk, so it represents a potential target for allergy prevention. The Mediterranean Diet (MD) is considered one of the healthiest dietary models which exerts regulatory effects on immune system, due to the synergistic and interactive combinations of nutrients. We aim to study the effects of MD in pregnancy on the onset of allergic diseases at 2 years of age in the offspring.",[59,60,61,62,63,64,28,65],"Allergies","Obesity","Gestational Complications","Gestational Weight Gain","Perinatal Condition","Birth Weight","Breast Feeding","RECRUITING","2026-02-11",{"date":69,"type":33},"2026-02-12",{"date":71,"type":33},"2021-11-02",{"date":73,"type":22},"2026-03-10",{"name":75,"class":40},"Federico II University",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":50,"sex":17,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":41},"100579153","technology-enhanced-asthma-care-in-children-at-clinic-and-home-study-100579153","NCT06820593","Technology-Enhanced Asthma Care in Children at Clinic and Home Study","Technology-Enhanced Asthma Care in Children at Clinic and Home (TEACCCH) Study (Aim 2): A Feasibility Randomized Controlled Trial","TEACCCH","Inclusion into the study will not depend on sex, ethnicity, or race. We will monitor enrollment to ensure a diversity of sex and race\u002Fethnicity are represented.\n\nPARENT-CHILD PAIR INCLUSION CRITERIA\n\n1. Caregivers must be at least 18 years old (defined as parent or legal guardian)\n2. The child (patient) has a diagnosis of asthma associated with a clinic visit in the electronic health record\n3. The child is between the ages of 4-17 years old at the time of recruitment\n\n   1. The study is interested in the self-management of asthma by caregivers, whom are still primarily responsible for their child's chronic disease management.\n   2. Children younger than 4 years old will not be included in this study as the diagnosis of asthma is typically difficult to confirm in younger ages.\n4. The child is prescribed inhaled corticosteroid or corticosteroid\u002Flong-acting beta agonist combination for daily use. The patient can have an inhaled corticosteroid\u002Flong-acting beta agonist for both daily preventive and rescue use, as in Single Maintenance and Reliever Therapy (SMART).\n5. Persistent or un controlled asthma based on NHLBI guidelines40; Any 1 of the following:\n\n   1. In past month, \\>2 days per week with asthma symptoms\n   2. \\>2 days per week with rescue medication use\n   3. \\>2 days per month with nighttime awakenings (for children who are not taking a controller asthma medication) OR \\>2 days per month with nighttime awakenings (for children who are currently taking a controller asthma medication)\n   4. \\>2 asthma episodes during the past year that required systemic corticosteroids\n6. The child is a patient in Primary Care Uptown, Primary Care Deming, Allergy, or Pulmonary Clinics at LCH\n\nPARENT-CHILD PAIR EXCLUSION CRITERIA\n\n1. The caregiver has a smartphone that is not compatible with the Hailie® app.\n2. The patient is prescribed a controller (preventive) or rescue inhaler medication to which the Hailie electronic sensor cannot affix.\n3. The caregiver is unable to speak and understand English.\n\n   a. With this trial, the intent is to first establish feasibility and broaden to different languages in future.\n4. The child has clinically significant, comorbid diagnoses, such as cystic fibrosis, cyanotic heart disease, or bronchopulmonary dysplasia, that could interact with their assessment of asthma-related measures.\n5. The family has active Department of Child and Family Services (DCFS) involvement\n6. The participant is enrolled in another asthma intervention study at the time of enrollment to this study.\n7. Child or sibling living in the same home was previously enrolled in this study.\n8. Consent is not obtained from the parent\u002Fguardian.\n9. Parent\u002Fguardian does not pass the test of understanding at study enrollment.\n\nHEALTH CARE PROVIDER INCLUSION CRITERIA (IMPLEMENTATION OUTCOMES)\n\n1. Participant is an employee of LCH system\n2. Works at or supports the operations of Primary Care Uptown, Primary Care Deming, Allergy, or Pulmonary Clinics at LCH\n3. Able to provide informed consent\n\nHEALTH CARE PROVIDER EXCLUSION CRITERIA (IMPLEMENTATION OUTCOMES)\n\n1\\. Participant departs LCH and is no longer an active employee at the time of assessment","4 Years",{"count":87,"type":22},80,[25],"A randomized controlled trial with parent-child pairs of children with persistent or uncontrolled asthma. An intervention group (n=40 parent-child pairs) will receive the mobile health (mHealth) app and digital sensors with enhanced support from a population health manager role, hereinafter referred to as an asthma coordinator, to provide remote patient monitoring (RPM). A comparison group (n=40 parent-child pairs) will receive the mHealth app and sensors without RPM support to silently collect inhaler use information without mHealth app features. The focus of this project is to evaluate the feasibility and acceptability of delivering a digital intervention for pediatric asthma with RPM in the outpatient setting.",[91,28],"Asthma in Children",[93],"Digital Health","2025-09-09",{"date":96,"type":33},"2025-09-10",{"date":98,"type":33},"2025-03-14",{"date":100,"type":22},"2027-01",{"name":102,"class":40},"Ann & Robert H Lurie Children's Hospital of Chicago",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":41},"100558569","user-experience-of-a-gait-training-treadmill-for-home-rehabilitation-of-children-with-chronic-conditions-100558569","NCT06552819","User Experience of a Gait Training Treadmill for Home Rehabilitation of Children With Chronic Conditions","EMMVIES-UX","\"Inclusion Criteria for the children:\n\n* aged between 8 and 18 years old\n* capable of walking during 5 minutes on a treadmill with or without walking aid, and with or without body weight support\n* diagnosis of one the following pathology: bilateral cerebral palsy, obesity, spinal muscular amiotrophy type 3, Duchenne, congenital myopathy, Charcot Marie Tooth\n* Gross Motor Function Classification System (GMFCS) I to III for the children with cerebral palsy\n* IMC superior to the centile IOTF-30 for the children with obesity\n* Functionnal level of 2 to 6 on the Walton scale, or 3 to 7 on the Vignos scale for the children with neuromuscular disease\n\nInclusion Criteria for the parents:\n\n\\- parent of an eligible child\n\nInclusion Criteria for the therapists:\n\n\\- Therapist of at least one eligible child\n\nInclusion Criteria for all:\n\n* Able to express oneself and respond to a questionnaire in French\n* Formulate their non-opposition to participate in the research\n\nExclusion Criteria:\n\n* Deprived of liberty by judicial or administrative decision\n* Subject to a legal protection measure\"","18 Years",{"count":112,"type":22},75,"OBSERVATIONAL","\"In the context of limited accessibility to prolonged and efficient rehabilitation programs based on physical activity, this study aims to develop a home program for children with chronic diseases affecting physical health (including cerebral palsy, obesity, and neuromuscular diseases). The French company EzyGain has designed a compact treadmill equipped with sensors and a safety system, which communicates with a tablet application and a virtual reality headset to support at-home rehabilitation. This study seeks to advance the development of this solution into a prolonged and progressive training program, tailored to positively impact children's health. Future users, including children, their parents, and therapists, will be at the heart of the development process. A qualitative methodology will be employed, incorporating focus groups and a series of user experience (UX) questionnaires. The research hypothesis is that user feedbacks will enable the development of an appropriate solution that meets their specific needs and ensures high adoption rates of the device.\n\nThis study is the first step before assessing the impact of the solution in these 3 groups of children (with cerebral palsy, obesity and neuromuscular disease).\"",[28],[117],"User experience, home program, treadmill, virtual reality","2024-08-09",{"date":120,"type":33},"2024-08-14",{"date":122,"type":22},"2024-09",{"date":124,"type":22},"2025-05",{"name":126,"class":127},"University Hospital, Angers","OTHER_GOV",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":110,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":41},"100470613","an-enhanced-home-based-telemedicine-program-using-remote-examination-devices-for-children-with-medical-complexity-100470613","NCT05408143","An Enhanced Home-Based Telemedicine Program Using Remote Examination Devices for Children With Medical Complexity","An Enhanced Home-Based Telemedicine Program Using Remote Examination Devices for Children With Medical Complexity Receiving Comprehensive Care: a Single-Center Randomized Controlled Trial","Inclusion Criteria:\n\n* Greater than or equal to 2 hospitalizations or greater than or equal to 1 ICU admission in the year before joining the comprehensive care program\n* Greater than 50 percent estimated risk of hospitalization without our care as judged by the medical director\n\nExclusion Criteria:\n\n* Major heart disease\n* Mitochondrial disorders\n* Active cancer\n* Do-Not-Resuscitate (DNR) order\n* Patients receiving compassionate care",{"count":136,"type":22},300,[25],"The purpose of this study is to assess if the benefits for children with medical complexity (CMC) receiving comprehensive care (CC) in an enhanced medical home can be further improved by enhanced telemedicine program (ETM) provided during clinic hours using mobile devices to measure temperature\\& oxygen saturation, auscultate the heart \\& lungs, and view the skin, throat, \\& tympanic membranes in the home.",[28],[141,142,143,144],"Comprehensive Care","Telemedicine enhanced with TytoCare devices.","Telemedicine","children with medical complexity","2023-05-10",{"date":147,"type":33},"2023-05-12",{"date":149,"type":33},"2022-07-12",{"date":151,"type":22},"2025-11-01",{"name":153,"class":40},"The University of Texas Health Science Center, Houston"]