[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-dizziness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-dizziness":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,72,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100625297","a-study-of-auricular-transcutaneous-vagus-nerve-stimulation-in-chronic-dizziness-100625297",false,"NCT07420803","A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness","Efficacy Of Auricular Transcutaneous Vagus Nerve Stimulation In Treating Chronic Dizziness","Inclusion Criteria:\n\n* Age 18-75, Persistent Postural-Perceptual Dizziness (PPPD) diagnosis per International Classification of Vestibular Disorders (ICVD).\n* Persistent dizziness ≥3 months and at least 1 dizziness exacerbation\u002Fday during 2-week run-in.\n* On stable medications\u002Ftherapy for ≥4 weeks prior to baseline (if any).\n\nExclusion Criteria:\n\n* Uncompensated peripheral\u002Fcentral vestibular deficit, sensory-afferent or cerebellar ataxia.\n* Cardiac disease (coronary disease, unstable arrhythmia), recurrent syncope (\\>1 in past 12 months).\n* Neck surgery, vagotomy, or any condition interfering with vagal stimulation.\n* Pregnancy.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to measure the change in dizziness, as measured by change in Dizziness Handicap Inventory (DHI) score, following a 4-week treatment period with auricular transcutaneous vagus nerve stimulation (aTVNS).",[26,27],"Chronic Dizziness","Persistent Postural Perceptual Dizziness",[29],"Vagus Nerve Stimulation","RECRUITING","2026-04-14",{"date":33,"type":34},"2026-04-17","ACTUAL",{"date":36,"type":34},"2026-03-23",{"date":38,"type":20},"2027-03",{"name":40,"class":41},"Mayo Clinic","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100621747","early-phase-1-virtual-reality-and-biofeedback-for-adolescents-with-chronic-dizziness-100621747","NCT07374640","Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness","Inclusion Criteria:\n\n\\- Patients who previously or are currently seen in our program who have not already undergone BFB, CBT, and SDERP for treatment of their chronic dizziness.\n\nExclusion Criteria:\n\n* Patients without chronic dizziness.\n* Patients for whom written consent is not available.\n* Patients who exhibit psychotic features, have untreated mental health conditions, or have an intellectual disability, developmental delay, or decisional impairment.\n* Non-English language preference patients.\n* Patients with a history of seizures, at risk of seizures, or who have a diagnosis of epilepsy.","13 Years","25 Years",{"count":52,"type":20},12,[54],"EARLY_PHASE1","Both persistent postural-perceptual dizziness (PPPD) and vestibular migraine (VM) are common diagnoses in patients presenting to physicians for evaluation of vestibular symptoms such as dizziness and vertigo. Although they are most often described in the adult population, they are also common in children and adolescents with dizziness. Chronic dizziness profoundly affects quality of life, often keeping children out of school and inhibiting their participation in the normal activities of childhood and adolescence. Overall, chronic dizziness is suspected to be due in large part to a \"rewiring\" of the brain that alters how cues related to balance and orientation are processed, with overreliance on visual inputs to maintain balance and equilibrium being a common development. Thus, chronic dizziness, especially that which is due to PPPD, is often caused by visual triggers.\n\nA multi-modal approach is often taken to treat chronic dizziness, attempting to recalibrate this maladaptive \"rewiring\" and return the sensory system to normal function. Given the role that visual inputs play in developing and perpetuating chronic dizziness, habituation to visual stimuli should be a significant component to treatment. Treatments often include cognitive behavioral therapy (CBT), systematic desensitization exposure response prevention (SDERP), and biofeedback therapy (BFB). However, these visually provoked symptoms are often resistant to treatment. One reason for this may be that visual stimuli are difficult to replicate in the clinic or office. One way to address this gap in treatment is through virtual reality (VR) technology, which immerses patients in realistic visual environments.\n\nVR has not been explicitly described in the treatment of PPPD or chronic dizziness, but it has been piloted, and shown to be effective, in the rehabilitation of peripheral vestibular dysfunction. This study aims to integrate VR into the current PPPD\u002Fchronic dizziness techniques of CBT, SDERP, and BFB. The investigators will use a commercially available VR headset, which enables the use of VR in the office setting in a relatively low-cost form of VR technology. This study will evaluate the feasibility and effectiveness of VR in conjunction with CBT, SDERP, and BFB to investigate if VR technology enhances previously established effective treatments to reduce chronic dizziness and PPPD.",[27,57,26],"Vestibular Migraine",[59,57,26,60,61],"Persistent Postural-Perceptual Dizziness","Virtual Reality","Biofeedback","NOT_YET_RECRUITING","2026-03-05",{"date":65,"type":34},"2026-03-06",{"date":67,"type":20},"2026-03",{"date":69,"type":20},"2027-05",{"name":71,"class":41},"Boston Children's Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100609152","comparison-between-traditional-vestibular-rehabilitation-therapy-and-virtual-reality-in-management-of-patients-with-chronic-dizziness-100609152","NCT07210840","Comparison Between Traditional Vestibular Rehabilitation Therapy And Virtual Reality In Management Of Patients With Chronic Dizziness","Inclusion Criteria:\n\n* • Adults aged 18-70 years.\n\n  * Patients diagnosed with chronic dizziness (duration \\>3 months) due to peripheral vestibular disorders (e.g., vestibular neuritis, BPPV, unilateral vestibular hypofunction).\n\nExclusion Criteria:\n\n* Presence of central vestibular disorders (e.g., multiple sclerosis, cerebellar ataxia,\n\n  * stroke).\n  * Patients in acute phase\n  * Presence of severe visual impairment\n  * Presence of motor disabilities that prevent safe participation in rehabilitation exercises.\n  * Cognitive impairment or psychiatric illness that decrease ability to follow instructions","70 Years",{"count":80,"type":20},40,[23],"Chronic dizziness is a common and often debilitating condition, especially among older adults. It typically presents as a persistent sensation of unsteadiness, spinning, or motion lasting weeks or months. Most cases stem from vestibular system disorders, such as vestibular neuritis, benign paroxysmal positional vertigo (BPPV), Menière's disease, and bilateral vestibulopathy \\[1,2\\]. Symptoms may persist beyond the acute phase due to the brain's incomplete adaptation or maladaptive behaviors, like avoiding movement. Psychological factors, such as anxiety and stress, can worsen or prolong symptoms \\[3\\].\n\nWhile many vestibular disorders resolve over time, some patients experience chronic symptoms due to poor central compensation or fear-based movement avoidance \\[2\\]. Chronic dizziness significantly impacts daily life-leading to imbalance, increased fall risk, reduced mobility, and emotional distress. Proper management is crucial to improving safety, independence, and quality of life \\[4\\].\n\nInitial treatments may include medications or maneuvers like the Epley technique for BPPV. If symptoms persist, Vestibular Rehabilitation Therapy (VRT) is often recommended. VRT is a personalized exercise program aimed at enhancing the brain's ability to adapt, habituate, or compensate through substitution \\[6-8\\].\n\nRecently, Virtual Reality (VR) has emerged as an innovative tool in vestibular rehab. It provides engaging, interactive environments for practicing balance and visual-vestibular tasks. Studies suggest that VR is feasible, well-tolerated, and effective, particularly for patients with persistent or visually-induced dizziness \\[9,10\\].",[26],"2025-09-30",{"date":86,"type":34},"2025-10-07",{"date":88,"type":20},"2025-11-01",{"date":90,"type":20},"2027-12-01",{"name":92,"class":41},"Assiut University",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100572583","repetitive-transcranial-magnetic-stimulation-paired-with-augmented-reality-to-alter-concussion-symptoms-100572583","NCT06735157","Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms","Inclusion Criteria:\n\n* Male or female aged 18-65 years\n* Diagnosis of mTBI according to the American Congress of Rehabilitation Medicine Diagnostic Criteria (Silverberg et al., 2023). All participants have diagnosis confirmed with Dr. Rathbone before enrollment.\n* Persistent dizziness beyond 3-months following the initial head injury.\n* Comprehension of spoken and written English language or have a language interpreter present for all study visits.\n\nExclusion Criteria:\n\n* History of chronic dizziness unrelated to concussive events.\n* Contraindications to TMS: presence of pacemaker, metal\u002Felectrical\u002Fmagnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, taking medications that increase the risk of seizure.\n* Inability to continue current medical therapies for the duration of the study.\n* If imaging was done at the time of injury, individuals with a positive CT head will be excluded from the study","65 Years",{"count":80,"type":20},[23],"This study aims to determine whether the delivery of brain stimulation paired with a balance training task can improve symptoms of dizziness for individuals experiencing these symptoms due to concussion. The main questions it aims to answer are:\n\n* Does repetitive transcranial magnetic stimulation (rTMS) paired with balance training improve the symptoms of dizziness in individuals with persistent dizziness due to concussion?\n* Is the proposed rTMS and balance training protocol feasible in this population?\n\nResearchers will compare results from a sham rTMS group with those from a real rTMS group to see if any observed changes are from the placebo effect rather than the expected effects of real rTMS.\n\nParticipants will receive pulses of rTMS to the area of the brain responsible for control of movement and then be asked to interact with digital objects using augmented reality glasses for 14 days over 3 weeks.",[104,26,105],"Mild Traumatic Brain Injury, Concussion","Vestibular Problem",[107,108,109,110,111,112,113,114,115,116],"Concussion","Dizziness","Transcranial magnetic stimulation","augmented reality","repetitive transcranial magnetic stimulation","mild traumatic brain injury","intermittent theta burst stimulation","accelerated iTBS","balance training","vestibular rehabilitation therapy","2025-01-09",{"date":119,"type":34},"2025-01-13",{"date":121,"type":20},"2025-01-01",{"date":123,"type":20},"2025-12-01",{"name":125,"class":41},"McMaster University",2]