[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-fatigue-syndrome-cfs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-fatigue-syndrome-cfs":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,83,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100634965","photobiomodulation-in-chronic-fatigue-syndrome-100634965",false,"NCT07546539","Photobiomodulation in Chronic Fatigue Syndrome","The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrome","Inclusion Criteria\n\n* Age 18-60 years\n* Diagnosis of a CFS according to the 2015 Institute of Medicine criteria\n* Fatigue Severity Scale (FSS) score ≥ 4\n* Ability to understand study procedures and provide informed consent\n\nExclusion Criteria\n\n* Comorbid psychiatric conditions (e.g., major depression, schizophrenia)\n* Current use of corticosteroids or immunomodulators\n* Known photosensitivity or dermatologic contraindications to LLLT\n* Participation in structured exercise programs more than twice weekly\n* Diagnosed malignancy or active infection -Not willing to be the part of study -","ALL","18 Years","60 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether photobiomodulation therapy (low-level laser therapy) can reduce fatigue and improve quality of life in patients with chronic fatigue syndrome (CFS). The study will include adults aged 18-60 years diagnosed with chronic fatigue syndrome.\n\nThe main questions it aims to answer are:\n\nDoes photobiomodulation therapy significantly reduce fatigue levels as measured by the Fatigue Severity Scale (FSS) and Multidimensional Fatigue Inventory (MFI-20)? Does photobiomodulation therapy improve pain, functional capacity, sleep quality, and psychological well-being in patients with chronic fatigue syndrome?\n\nResearchers will compare the low-level laser therapy group with a placebo (sham laser) group to determine whether photobiomodulation therapy leads to greater improvements in fatigue, pain, and overall quality of life.\n\nParticipants will:\n\nReceive either active low-level laser therapy or placebo treatment three times per week for eight weeks Undergo assessments of fatigue, pain, functional capacity, quality of life, sleep quality, and psychological well-being at baseline and follow-up intervals (3, 6, and 12 months)",[27,28],"Chronic Fatigue Syndrome (CFS)","Quality of Life",[30,31,32,33,34,35],"PHOTOBIOMODULATION","LOW-LEVEL LASER THERAPY","Chronic Fatigue Syndrome","Rehabilitation","Physiotherapy","Fatigue","RECRUITING","2026-06-21",{"date":39,"type":40},"2026-06-24","ACTUAL",{"date":42,"type":40},"2026-06-15",{"date":44,"type":21},"2026-09",{"name":46,"class":47},"University of Lahore","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":68,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100633163","mecfs-brain-fog-cognitive-rehabilitation-trial-100633163","NCT07523113","ME\u002FCFS Brain Fog: Cognitive Rehabilitation Trial","Brain Training for Chronic, Post-viral, Brain Fog: Study A","Inclusion Criteria:\n\n* diagnosis of ME\u002FCFS that preceded cognitive complaints\n* mild or greater cognitive impairment\n* moderate or greater brain fog\n* some impairment in the performance of daily activities\n* ≥ 18 years, no upper limit if medically stable\n* reside in the community (as opposed to a hospital or skilled nursing facility)\n* able to travel to the laboratory on multiple occasions\n* has Internet service\n* has a personal computer, laptop, or tablet that can access the Internet\n* sufficiently fit, from both a physical and mental health perspective, to take part in the study\n* adequate sight and hearing to complete the UFOV test\n* adequate thinking skills, e.g., ability to follow directions and retain information to complete UFOV and CTAL, as marked by the judgement of the screener that the candidate is able to adequately complete the UFOV and CTAL\n* sufficient English proficiency (i.e., ability to speak, understand, read, and write to take part in study activities)\n\nExclusion Criteria:\n\n* cognitive impairment due to a developmental disability, psychiatric disorder, or substance abuse, or due to another type of brain injury, such as traumatic brain injury, stroke, or a progressive brain disease, such as Alzheimer's Dementia\n* current substance abuse disorder\n* diagnosis of postural orthostatic tachycardia syndrome (POTS) by a healthcare provider\n* prior cognitive processing speed training on DoubleDecision or a similar program\n* cannot tolerate taVNS\n* prior history of heart attack or other serious cardiac events\n* implanted medical device of any type\n* vasovagal syncope or history of fainting\n* history of seizures or epilepsy\n* temporomandibular Joint (TMJ) syndrome or other conditions that cause substantial jaw pain\n* history of peripheral nerve injury to the head, neck, or face\n* pregnant or breastfeeding\n* not able or willing to get an MRI scan\n* not able or willing to get a blood draw",{"count":57,"type":21},30,[24],"The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog. All participants will be screened for eligibility prior to participation. Most of the procedures will take place over a phone call or secure telehealth platform (i.e., Zoom). However, participants will be asked to visit UAB on three occasions for blood sample collection and brain imaging (about 2 hours each). Online testing will happen one month before treatment, one day before treatment, one day afterwards, and 6 months afterwards. The study will utilize two different forms of rehabilitation training to improve participants' cognitive ability. Participants will be randomized to one of the two treatment groups. The first treatment approach, known as Constraint-Induced Cognitive Therapy (CICT), will feature (A) web-based computer \"games\" that trains how quickly individuals process information that they receive through their senses; (B) online training on everyday activities with important cognitive components, (C) procedures designed to transfer improvements in cognition from the treatment setting to everyday life, and (D) a non-invasive form of vagus nerve stimulation, also known as trans-auricular VNS (taVNS). The second approach, known as Brain Fitness Training (BFT), will include (A) web-based computer \"games\" that train reaction time and eye-hand coordination; (B) in-lab training on relaxation, breathing, healthy nutrition, and healthy sleep, (C) education about how relaxation, breathing, nutrition, and sleep are connected to thinking effectiveness, and (D) taVNS. Approximately 30 hours of training will be conducted over a secure telehealth platform (i.e., Zoom) in the span of two- to four- weeks. A typical CICT session will consist of one hour of gaming, with the bulk of the session being spent on cognitive training of the target behaviors and procedures designed to promote transfer of therapeutic gains to daily life. ta-VNS will be administered for 10 minutes before gaming and in-lab target behavior training. A typical BFT session will consist of one hour of gaming, training on healthy lifestyle behaviors (i.e., healthy sleep, nutrition, and relaxation habits), as well as procedures designed to promote transfer of behavior changes to daily life. Ta-VNS will be administered for 10 minutes before gaming and in-lab target behavior training. Training sessions in both conditions will be scheduled based on participants' availability, with the options for sessions scheduled to be as close as every weekday over 2 weeks or as loosely as every other weekday (i.e., over a 4-week span). If a caregiver is available, they will receive training on how to best support participants in their therapeutic program. After the training ends, both groups will receive 4 follow-up phone calls approximately one week apart to promote integration of the gained skills into everyday life. Outcomes measured will include cognitive processing speed, cognitive function on laboratory tests, and spontaneous performance of everyday activities with important cognitive components in daily life.",[61,62,63,64,27,65,66,67],"ME\u002FCFS","ME\u002FCFS Following EBV-associated Infectious Mononucleosis","ME\u002FCFS Following COVID-19","Chronic Fatigue","Brain Fog","Cognitive Impairment","Cognitive Dysfunction",[61,64,69,66,67,70,71,72],"Brain fog","post-viral syndrome","Cognitive Rehabilitation","CICT","NOT_YET_RECRUITING","2026-06-04",{"date":76,"type":40},"2026-06-08",{"date":78,"type":21},"2026-06",{"date":80,"type":21},"2028-06",{"name":82,"class":47},"University of Alabama at Birmingham",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":48},"100611591","effect-of-physical-exercise-and-neuromodulation-on-pain-sleep-and-fatigue-in-patients-with-fibromyalgia-100611591","NCT07242573","Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia","Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 20 and 80 years\n* Confirmed diagnosis of fibromyalgia\n* Presence of chronic fatigue symptoms\n* Stable health condition\n* Presence of sleep disturbances\n* Ability to provide written informed consent and cooperate during the study\n\nExclusion Criteria:\n\n* Lack of informed consent or cooperation\n* Refusal to undergo procedures beyond standard NFZ physiotherapy\n* Cancer\n* Neurological disorders (e.g., neuralgia, multiple sclerosis, diabetic polyneuropathy, stroke)\n* Diagnosed dementia or cognitive impairment\n* Implanted electronic devices (e.g., pacemaker)\n* Internal bleeding or acute febrile illness\n* Acute thrombophlebitis\n* Hysteria or electric phobia\n* Neurotic addiction to stimulation\n* Infectious skin diseases (e.g., mycosis, purulent dermatitis)\n* Inability to communicate in Polish sufficiently to complete questionnaires or follow instructions","20 Years","80 Years",{"count":93,"type":21},75,[24],"Fibromyalgia (FMS) is a chronic, multifactorial syndrome characterized by widespread pain, fatigue, and cognitive disturbances. This interventional study evaluates the impact of structured physical training using diagnostic-training devices (Zebris treadmill and Alfa balance platform) and transcutaneous neuromodulation (NESA X-Signal) on pain, sleep quality, and overall health status in patients with fibromyalgia and chronic fatigue symptom.\n\nParticipants are allocated into three groups:\n\n1. Physical training + conventional physiotherapy,\n2. Transcutaneous neuromodulation + conventional physiotherapy,\n3. Control (conventional physiotherapy only). The results will support the development of evidence-based rehabilitation protocols for fibromyalgia patients.",[97,27],"Fibromyalgia",[97,33,99,100,101,102,103,104,34,105,32],"Sleep Quality","Pain Management","Exercise Therapy","NESA X-Signal","Transcutaneous Electrical Stimulation","Neuromodulation","Physical Training","2026-02-20",{"date":108,"type":40},"2026-02-24",{"date":110,"type":40},"2025-11-01",{"date":112,"type":21},"2027-12-15",{"name":114,"class":115},"National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland","NETWORK",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":123,"maxAge":18,"enrollmentInfo":124,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":48},"100572934","phase-2-rct-of-efficacy-and-safety-of-cp003-on-cfsme-or-post-covid-fatigue-100572934","NCT06739720","RCT of Efficacy and Safety of CP003 on CFS\u002FME or Post-COVID Fatigue","A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue","Inclusion Criteria:\n\n* Meet the Fukuda diagnostic definition of CFS\u002FME or have persisting fatigue after the infection of SARS-CoV-2\n* Are able to complete a 6-week course of intervention;\n* Able to complete the online validated fatigue surveys.\n\nExclusion Criteria:\n\n* Have participated in any type of complements or herbal medicine within the past six months;\n* Have serious medical conditions that might limit their participation in this intervention;\n* Diagnosed with acute inflammation;\n* Are pregnant or are planning a pregnancy in the next 3 months.","40 Years",{"count":125,"type":21},130,[127,128],"PHASE2","PHASE3","The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use. The main questions it aims to answer are:\n\nDoes the Lingzhi supplement reduce fatigue symptoms? Is it safe to take? How does it affect the body's immune system and inflammation?\n\nResearchers will compare people taking the Lingzhi supplement to those who don't take anything (waitlist group) to see if it works.\n\nParticipants will:\n\n* Take 5 capsules once daily for 6 weeks (or wait to start treatment if in waitlist group)\n* Visit the clinic 2 times for blood tests (before and after taking the supplement)\n* Complete questionnaires 3 times about their fatigue and quality of life (4 times questionnaires for waitlist group)",[27,131],"Post-COVID ME\u002FCFS","2024-12-16",{"date":134,"type":40},"2024-12-18",{"date":136,"type":21},"2025-01-02",{"date":138,"type":21},"2026-12-31",{"name":140,"class":47},"The University of Hong Kong"]