[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-kidney-diease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-kidney-diease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100630965","chronic-kidney-disease-and-metabolic-disorders-in-the-elderly-100630965",false,"NCT07494526","Chronic Kidney Disease and Metabolic Disorders in the Elderly","Research on the Prevention, Control, and Intelligent Management Decision-Making for Comorbidities of Chronic Kidney Disease and Metabolic Disorders in the Elderly","For Sub-cohort 1, the inclusion and exclusion criteria are as follows:\n\nInclusion Criteria:\n\n1. Baseline age ≥ 65 years.\n2. Availability of baseline data on serum creatinine and at least one urinary protein measurement.\n3. Urinary protein measurements include: UACR, UPCR, 24-hour urine protein quantification, and urine protein dipstick test.\n4. Baseline date requirement: Between January 1, 2010, and December 31, 2025.\n5. Follow-up requirement meeting at least one of the following: At least one serum creatinine measurement with an interval of ≥ 6 months after baseline. Occurrence of a primary endpoint event (new-onset CKD).\n\nExclusion Criteria:\n\nPresence of CKD at baseline, defined as: Glomerular filtration rate (eGFR) \\\u003C 60 ml\u002F(min·1.73m²) or positive urine protein; or the presence of an ICD-10 diagnostic code for CKD in medical records.\n\nFor Sub-cohort 2 (CKD Patients), the inclusion and exclusion criteria are as follows:\n\nInclusion Criteria:\n\n1. Baseline age ≥ 65 years.\n2. Meeting the diagnostic criteria for CKD: Glomerular filtration rate (eGFR) \\\u003C 60 ml\u002F(min·1.73m²) or urine protein (UACR ≥ 30 mg\u002Fg); or based on ICD-10 codes.\n3. Baseline date requirement: Between January 1, 2010, and December 31, 2025.\n4. Follow-up requirement meeting at least one of the following:\n\nOccurrence of a primary endpoint event (mortality, ESRD); At least one serum creatinine measurement with an interval of ≥ 6 months after baseline.\n\nExclusion Criteria:\n\n1. End-stage renal disease (ESRD) at baseline (eGFR \\\u003C 15 ml\u002F(min·1.73m²), or prior receipt of kidney transplant or dialysis), based on ICD codes).\n2. Diagnosis of acute kidney injury (AKI) within the preceding 3 months.\n3. New York Heart Association (NYHA) Class III or IV heart failure or occurrence of acute myocardial infarction within the preceding 6 months.\n4. Child-Pugh Class B or C liver cirrhosis.\n5. Malignant neoplasm.",true,"ALL","65 Years",{"count":20,"type":21},100000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney disease (CKD) at baseline, and one comprising elderly patients with established CKD.\n\nThe main questions it aims to answer are:\n\nDo metabolic diseases (diabetes, hypertension, hyperlipidemia, hyperuricemia, calcium-phosphorus disorders) increase the risk of incident CKD, major adverse cardiovascular events (MACE), and all-cause mortality in elderly individuals without CKD at baseline? What are the optimal diagnostic thresholds and criteria for CKD in the elderly population? How do metabolic comorbidities affect long-term outcomes - including all-cause mortality, end-stage renal disease (ESRD), and cardiovascular events - in elderly patients with established CKD? What is the comorbidity profile and disease burden of elderly CKD patients in China?\n\nParticipants in both sub-cohorts will:\n\nUndergo baseline assessments including laboratory tests and clinical evaluations.\n\nProvide longitudinal follow-up data through scheduled clinic visits and medical record linkage.\n\nContribute to a large-scale cohort of 100,000 elderly participants across multiple centers in China.",[25,26,27,28,29],"Chronic Kidney Diease","Diabetes Mellitus","Hypertension","Hyperlipidemia","Hyperuricemia",[31,32,33],"chronic kidney disease","elderly","metabolic disorders","NOT_YET_RECRUITING","2026-03-20",{"date":37,"type":38},"2026-03-27","ACTUAL",{"date":40,"type":21},"2026-04",{"date":42,"type":21},"2028-12",{"name":44,"class":45},"Chinese PLA General Hospital","OTHER",2]