[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-low-back-and-leg-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-low-back-and-leg-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644531","the-lumbar-adjacent-segment-stenosis-trial-100644531",false,"NCT07670533","The Lumbar Adjacent Segment Stenosis Trial","The Lumbar Adjacent Segment Stenosis (LASS) Trial","LASS","Inclusion Criteria:\n\nParticipants must meet all the following criteria to be eligible for the study:\n\n1. Clinical symptoms of spinal stenosis, defined as neurogenic claudication or radiating pain into the lower limbs with duration \\>6 months\n2. MRI-confirmed adjacent segment stenosis, proximal to a previously fused lumbar segment (fusion of maximum two levels between L1 and S1, any type of previous lumbar fixation procedure).\n3. CT-verified solid fusion\n4. Minimum time since previous fusion: one year\n5. Eligible for both treatment alternatives: decompression with extended fusion and decompression alone.\n6. Age between 18 and 80 years.\n7. Insufficient improvement after at least 3 months of non-operative treatment.\n8. Understand Norwegian language, spoken and written.\n\nExclusion Criteria:\n\nParticipants will be excluded if any of the following criteria are met:\n\n1. Previous surgery at the actual adjacent stenotic level.\n2. More than two fused lumbar levels.\n3. Non-union (pseudoarthrosis) at the previously surgically fused level, radiologically verified.\n4. Foraminal stenosis grade 3 at the adjacent level.\n5. Spinal fracture.\n6. Presence of cauda equina syndrome.\n7. Complete motor deficit.\n8. ASA physical status classification IV or V.\n9. Alcohol or drug abuse.\n10. Active cancer\n11. Contradictions to MRI (e.g., Cardiac pacemaker electrodes, metal implants in the eye or brain, claustrophobia)\n12. Disabling chronic neurological disease (e.g., Parkinson's disease, ALS, MS)\n13. Ongoing serious psychiatric disease\\&\n14. Any condition that in the view of the investigator would suggest that the patient is unable to comply with the study protocol and procedures\n15. Declining specific treatment arm\n16. Are participating in another clinical trial that may interfere with this trial","ALL","18 Years","80 Years",{"count":21,"type":22},192,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if there are differences in the effectiveness of decompression surgery alone versus decompression combined with extended fusion in patients with a previous lumbar spinal fusion who now present with symptoms of lumbar adjacent segment stenosis (LASS). The main questions it aims to answer are:\n\n* Does decompression alone differ from decompression combined with extended fusion with regard to clinical outcomes two years after surgery?\n* Are there any clinical or radiological characteristics that can predict better or worse outcomes two years after surgery?\n* Are there any differences between the treatment groups in terms of health economics?\n\nResearchers will compare decompression surgery alone versus decompression combined with extended fusion to see if there are any differences in treatment effect.\n\nParticipants will:\n\n* Be randomized to one of the two surgical procedures\n* Visit the clinic four times postoperatively (at three months, 1, 2 and 5 years) for checkups and tests\n* Respond to questionnaires before surgery, and three months, 1, 2 and 5 years postoperatively",[28,29],"Lumbar Adjacent Spinal Stenosis","Chronic Low Back and Leg Pain",[31,32,33,34],"Randomized trial","Previous lumbar spinal fusion","Spinal stenosis","Surgery","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-26","ACTUAL",{"date":41,"type":22},"2026-08",{"date":43,"type":22},"2032-10",{"name":45,"class":46},"Oslo University Hospital","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100437952","early-phase-1-brain-mechanisms-supporting-cannabis-induced-pain-relief-100437952","NCT04982965","Brain Mechanisms Supporting Cannabis-induced Pain Relief","Inclusion Criteria:\n\n* Between 21-65 years old\n* Currently 30 days cannabis free\n* Lower back pain for three months or more\n* Are not taking opioids\n* If female and of a child bearing potential age, are not pregnant or nursing mothers\n* Do not have mental or neurological conditions inhibiting sensory\u002Fmotor functions\n* Do not have a lifetime history of dependence on cannabis\n* Do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, panic disorder, or psychosis\n* Prior THC-containing cannabis experience within the past two years\n* Agrees not to use cannabis outside of the study during participation in the study\n* Agrees not to use opioids or barbiturates during participation in the study\n* Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study\n\nExclusion Criteria:\n\n* Active pulmonary disease\n* Allergy or past adverse effects or negative past experiences from cannabis\n* Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone\n* Any significant illness, including cardiovascular disease, diabetes, renal and liver disease.\n* Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.)\n* Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury\u002Fhead injury\n* Any current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia\n* Any current or history of suicidal ideation or attempt\n* Overt sensitivity to thermal stimulation\n* Resting blood pressure \\> 140\u002F90\n* Resting heart rate \\> 100 beats\u002Fminute\n* Prisoner\n* Institutionalized\n* Claustrophobia\n* MRI contraindications\n* Participation in any new (within 2 weeks prior or any time after enrollment) pain management procedures during the study period\n* Known history of vasovagal fainting, syncope, or severe adverse reactions associated with blood draws or needle procedures",true,"21 Years","65 Years",{"count":58,"type":22},100,[60],"EARLY_PHASE1","Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.",[63,64,65,66,67,29,68],"Sciatica","Lumbar Radiculopathy","Lower Back Pain","Degenerative Disc Disease","Chronic Low-back Pain (cLBP)","Back Pain",[70,71,72,73],"Cannabis","Vaporized cannabis","THC","chronic low back pain","RECRUITING","2026-05-30",{"date":77,"type":39},"2026-06-03",{"date":79,"type":39},"2021-05-07",{"date":81,"type":22},"2027-03-15",{"name":83,"class":46},"University of California, San Diego",1]