[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-low-back-pain-non-specific-uncomplicated\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-low-back-pain-non-specific-uncomplicated":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,69,91,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644826","early-phase-1-evaluation-of-the-effectiveness-and-safety-of-mesotherapy-in-the-treatment-of-chronic-low-back-pain-syndrome-100644826",false,"NCT07675304","Evaluation of the Effectiveness and Safety of Mesotherapy in the Treatment of Chronic Low Back Pain Syndrome","Evaluation of the Effectiveness and Safety of Mesotherapy in the Treatment of Chronic Low Back Pain Syndrome: a Randomized Study","Inclusion Criteria:\n\nAge between 18 and 65 years Chronic localized pain in the lumbosacral spine without radicular symptoms or radiation to the lower limbs Recent spinal imaging (X-ray, computed tomography (CT), or magnetic resonance imaging (MRI)) performed within the last 6 months confirming the diagnosis\n\nExclusion Criteria:\n\nKnown allergy to collagen or lignocaine Active malignancy Autoimmune diseases Skin lesions in the lumbosacral region Active infection Lack of informed consent","ALL","18 Years","65 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The aim of this study is to evaluate the effectiveness of collagen mesotherapy in the treatment of chronic low back pain (CLBP) in the lumbosacral spine.\n\nMesotherapy is expected to reduce pain in the lumbosacral region, decrease soft tissue tension (including muscles, fascia, and ligaments), improve spinal mobility, and support subsequent physiotherapy.\n\nA total of five treatment sessions will be performed at weekly intervals.\n\nDuring each session, approximately 20 intradermal microinjections will be administered into the paraspinal soft tissues of the lumbosacral region. Participants will receive injections of either type I tropocollagen, 1% lignocaine (lidocaine), or a combination of both, with a volume of 0.1 mL per injection.",[27],"Chronic Low Back Pain (Non-specific, Uncomplicated)","RECRUITING","2026-06-29",{"date":31,"type":32},"2026-06-30","ACTUAL",{"date":34,"type":32},"2026-05-06",{"date":36,"type":21},"2027-03",{"name":38,"class":39},"National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland","NETWORK",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100563743","pain-education-and-patient-led-goal-setting-in-adults-with-chronic-low-back-pain-a-randomised-controlled-trial-100563743","NCT06620133","Pain Education and Patient-led Goal Setting in Adults With Chronic Low Back Pain: a Randomised Controlled Trial","The Effect of Pain Education and Patient-led Goal Setting Compared to Guideline-based Written Information on Pain and Disability in Adults With Chronic Low Back Pain: a Randomised Controlled Trial","CAPACITY","Inclusion Criteria:\n\n* Low back pain of at least 3 months duration\n* physically inactive (less than or equal to 150min\u002Fweek moderate intensity physical activity; 75 min\u002Fweek vigorous activity, or some combination of the two)\n* no known contraindication(s) to performing physical activity\n* English language proficiency\n* access to internet\n\nExclusion Criteria:\n\n* physically active (more than 150min\u002Fweek moderate intensity physical activity, 75 min\u002Fweek vigorous activity, or some combination of the two)\n* known contraindication(s) to performing physical activity\n* known or suspected serious spinal pathology (fracture, metastatic, inflammatory or infective diseases of the spine, cauda equina syndrome\u002Fwidespread neurological disorder)\n* scheduled for major surgery during the treatment or follow-up period",{"count":50,"type":21},392,[52],"NA","The goal of this clinical trial is to investigate the effectiveness of two treatments for adults with chronic low back pain. The main question this study seeks to answer is \"In adults with chronic low back pain, what is the effectiveness of pain education and patient-led goal setting compared to guideline-based written advice on reducing pain intensity and disability?\".\n\nA total of 392 participants will be randomised into two groups: 1) pain education and patient-led goal setting or 2) guideline-based written advice. Participants randomised to the pain education and patient-led goal setting group will receive 5 sessions of 45-60 min each over 8 weeks delivered online via telehealth. Participants randomised to written advice group will receive information developed for people with chronic low back pain. Outcomes will be assessed at baseline and week 8, 26 and 52.",[27],[56,57,58],"pain education","patient-led goal setting","chronic low back pain","2026-04-06",{"date":61,"type":32},"2026-04-09",{"date":63,"type":32},"2025-06-26",{"date":65,"type":21},"2029-12-31",{"name":67,"class":68},"Neuroscience Research Australia","OTHER",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100617425","comparison-of-abdominal-expansion-and-abdominal-drawing-in-training-with-manual-and-verbal-cueing-in-chronic-non-specific-low-back-pain-100617425","NCT07318454","Comparison of Abdominal Expansion and Abdominal Drawing-In Training With Manual and Verbal Cueing in Chronic Non-Specific Low Back Pain","A Randomized Controlled Trial Comparing Abdominal Expansion and Abdominal Drawing-In Training With Manual and Verbal Cueing in Individuals With Chronic Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Clinically diagnosed with chronic non-specific low back pain, with symptoms persisting for more than 12 weeks.\n* Able to understand the study procedures and comply with the full intervention and assessment protocol.\n\nExclusion Criteria:\n\n* History of surgery involving the lower back or lower extremities.\n* Presence of neurological symptoms, such as numbness or tingling sensations.\n* Signs or symptoms of nerve root compression.\n* History of any surgical procedure within the past 3 months.\n* Diagnosis of cancer.\n* Presence of major medical or psychiatric disorders.\n* Presence of systemic inflammatory disease.\n* Pregnancy.\n* Structural scoliosis of the spine.\n* Inability to ambulate or stand independently, or other conditions deemed unsuitable for participation.\n* Participation in any movement control-based exercise training within the past year.\n* Accumulated experience of more than 4 weeks of abdominal drawing-in manoeuvre (ADIM) training or Dynamic Neuromusculoskeletal Stabilization abdominal expansion (DNS-AE) training within the past year.",{"count":77,"type":21},96,[52],"This study aims to investigate the interactive effects of two core stability training strategies-abdominal drawing-in manoeuvre (ADIM) and Dynamic Neuromusculoskeletal Stabilization abdominal expansion (DNS-AE)-and two instructional approaches (verbal cueing and manual facilitation) on training outcomes in individuals with chronic non-specific low back pain.\n\nA 2×2 factorial randomized controlled trial design will be employed. Ninety-six participants with chronic non-specific low back pain will be randomly allocated, using block randomization, to one of four intervention groups in equal proportions. All groups will receive a 4-week intervention program, with training conducted twice per week.\n\nOutcome measures will be assessed at four time points: before the intervention (baseline), immediately after the first training session, at the completion of the 4-week intervention, and at a 3-month follow-up, to evaluate short-term and mid-term effects as well as the sustainability of training outcomes.",[27],"NOT_YET_RECRUITING","2026-01-22",{"date":84,"type":32},"2026-01-23",{"date":86,"type":21},"2026-04-01",{"date":88,"type":21},"2026-09-30",{"name":90,"class":68},"National Yang Ming Chiao Tung University",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100617893","immediate-effects-of-manual-and-verbal-cueing-during-movement-control-training-in-chronic-non-specific-low-back-pain-100617893","NCT07324538","Immediate Effects of Manual and Verbal Cueing During Movement Control Training in Chronic Non-Specific Low Back Pain","A Randomized Controlled Trial Comparing the Immediate Effects of Manual and Verbal Cueing During Movement Control Training in Individuals With Chronic Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinically diagnosed chronic non-specific low back pain with symptoms lasting longer than 12 weeks\n* Able to understand and comply with the assessment and intervention procedures\n\nExclusion Criteria:\n\n* History of surgery involving the lower back or lower extremities\n* Presence of neurological symptoms, such as paresthesia or numbness\n* Signs or symptoms of nerve root compression\n* History of surgery within the past 3 months\n* History of cancer\n* Presence of major medical or psychiatric disorders\n* Presence of systemic inflammatory conditions\n* Pregnancy\n* Structural scoliosis\n* Inability to walk or stand independently, or any condition deemed unsuitable for participation by the investigator\n* Participation in any movement control exercise training within the past year",{"count":99,"type":21},40,[52],"Chronic non-specific low back pain is commonly associated with impaired movement control. Movement control training is often used in rehabilitation, and different cueing methods may influence how patients perform and learn movements.\n\nThe purpose of this randomized controlled trial is to compare the immediate effects of manual cueing and verbal cueing during movement control training in individuals with chronic non-specific low back pain. Participants will be randomly assigned to receive either manual cueing or verbal cueing during a standardized movement training session.\n\nThe study will examine immediate changes in movement control performance, perceived difficulty, and related clinical outcomes following the intervention. The results of this study may help clinicians better understand how different cueing strategies influence movement performance in people with chronic non-specific low back pain.",[27],{"date":84,"type":32},{"date":105,"type":21},"2026-03-15",{"date":107,"type":21},"2027-01-31",{"name":90,"class":68},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":40},"100612071","telerehabilitation-program-to-improve-function-in-people-with-chronic-low-back-pain-compared-with-conventional-care-100612071","NCT07248813","Telerehabilitation Program to Improve Function in People With Chronic Low Back Pain Compared With Conventional Care","Effectiveness of an Additional Telerehabilitation Program Combined With Conventional Care on Functional Improvement in Patients With Chronic Low Back Pain at the Primary Care Level in the Mexican Institute of Social Security (IMSS): A Pragmatic Randomized Controlled Trial","TELEREHAB-LC","Inclusion Criteria:\n\n* Adults between 18 and 60 years of age.\n* Clinical diagnosis of chronic non-specific low back pain (duration ≥ 12 weeks).\n* Pain intensity ≥ 3 on the Visual Analogue Scale (VAS) at baseline.\n* Enrolled as beneficiaries of the Mexican Institute of Social Security (IMSS) and receiving care at a primary care clinic.\n* Access to a smartphone or computer with internet connection.\n* Ability to read and understand written instructions in Spanish.\n* Willingness to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Specific causes of low back pain (e.g., fractures, tumors, infections, inflammatory or rheumatic diseases).\n* Neurological deficits suggestive of radiculopathy or myelopathy.\n* Pregnancy.\n* Severe psychiatric or cognitive disorders that limit participation.\n* Recent spinal surgery (within the last 6 months).\n* Participation in another rehabilitation or exercise program for low back pain within the previous 3 months.\n* Any medical condition that contraindicates physical exercise, as determined by the treating physician.\n\nThe upper age limit of 60 years was established to minimize confounding factors related to advanced degenerative joint disease. Individuals older than 60 frequently present radiographic or clinical signs of grade III or higher lumbar osteoarthritis, which may produce chronic pain and functional limitation independent of the intervention. Including these participants could obscure the true effect of the telerehabilitation program on functional improvement and pain reduction in patients with non-specific chronic low back pain.","60 Years",{"count":119,"type":21},200,[52],"The goal of this clinical trial is to evaluate whether an additional telerehabilitation program, combined with conventional care, can improve functional recovery in adults with chronic low back pain treated in primary care clinics of the Mexican Institute of Social Security (IMSS).\n\nThe main questions it aims to answer are:\n\n* Does the telerehabilitation program lead to greater functional improvement, measured by the Oswestry Disability Index (ODI), compared with conventional care alone?\n* Does the program reduce pain intensity and improve adherence and satisfaction among participants?\n\nResearchers will compare patients receiving conventional care plus telerehabilitation with those receiving conventional care only to determine whether the digital intervention provides additional clinical benefits.\n\nParticipants will:\n\n* Continue their usual medical care for chronic low back pain at IMSS clinics.\n* Follow a 6-week telerehabilitation program delivered through an online platform, including educational videos, stretching and strengthening exercises, and weekly virtual check-ins.\n* Complete baseline and post-intervention assessments of pain, disability, and satisfaction.",[27],[124,125,126,127,128,129,130,131,132],"TELEMEDICINE","Physical Therapy","Primary Care","Oswestry Disability Index","Rehabilitation Program","Telerehabilitation","Pragmatic Clinical Trial","Pain Management","Adherence","2025-11-18",{"date":135,"type":32},"2025-11-25",{"date":137,"type":32},"2025-10-03",{"date":139,"type":21},"2026-12-20",{"name":141,"class":142},"Coordinación de Investigación en Salud, Mexico","OTHER_GOV"]