[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-lung-disease-of-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-lung-disease-of-newborn":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100611173","pulmonary-volume-changes-during-synchonized-noninvasive-positive-pressure-ventilation-100611173",false,"NCT07237139","Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation","Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants","INSPIRE","Inclusion Criteria:\n\n* Written informed consent by one or both parents or legal guardians\n* Gestational age at birth \\\u003C 30 0\u002F7 weeks\n* Infants on sNIPPV respiratory support\n* Below 4 weeks chronological age\n\nExclusion Criteria:\n\n* Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)\n* Too ill\u002Funstable in the opinion of the treating physician.","ALL","4 Weeks",{"count":20,"type":21},27,"ESTIMATED","OBSERVATIONAL","Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.",[25,26,27,28,29,30],"Infant, Preterm","Respiratory Distress Syndrome (Neonatal)","Chronic Lung Disease of Newborn","Respiratory Support","Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)","Lung Volume",[32,33,34,35],"Synchronized noninvasive positive pressure ventilation (SNIPPV)","Lung volume","Electrical Impedance Tomography (EIT)","infant, preterm","RECRUITING","2025-12-08",{"date":39,"type":40},"2025-12-09","ACTUAL",{"date":42,"type":40},"2025-11-17",{"date":44,"type":21},"2027-01-30",{"name":46,"class":47},"University of Zurich","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100603274","long-term-burden-of-bpd-and-health-related-quality-of-life-bronq-family-100603274","NCT07134387","Long-Term Burden of BPD and Health-Related Quality of Life (BronQ Family)","BronQ Family: Assessing the Long-term Impact of Bronchopulmonary Dysplasia (BPD) on Affected Families' Health-related Quality of Life","BronQ Family","Inclusion Criteria:\n\nBPD-group:\n\n* Being a parent or primary caregiver of a child until the age of 18 years (0 to under 18 years),\n\n  * who was born preterm (before 37 weeks of gestation),\n  * who has been discharged from their initial hospital stay after birth,\n  * who suffered from BPD in the newborn period and\n  * who was born or is currently living in the following countries: France, Germany, Italy, the Netherlands, Spain, the United Kingdom (including Northern Ireland) and the United States\n* providing sufficient proficiency in one of the languages of the questionnaire\n\nControl group:\n\n* Being a parent or primary caregiver of a child until the age of 18 years (0 to under 18 years),\n\n  * who was born preterm (before 37 weeks of gestation),\n  * who has been discharged from their initial hospital stay after birth,\n  * who did not suffer from BPD in the newborn period and\n  * who was born or is currently living in the following countries: France, Germany, Italy, the Netherlands, Spain, the United Kingdom (including Northern Ireland) and the United States\n* providing sufficient proficiency in one of the languages of the questionnaire\n\nExclusion Criteria:\n\nBPD-group:\n\n* Other family members than parents\u002Fprimary caregivers\n* Parents or primary caregivers\n\n  * of a child older\u002Fequal than 18 years of age\n  * of a child with BPD who has not been discharged yet\n  * of a child without a BPD in the newborn period\n  * with insufficient proficiency in one of the languages available in the questionnaire\n\nControl group:\n\n* Other family members than parents\u002Fprimary caregivers\n* Parents or primary caregivers\n\n  * of children older\u002Fequal than 18 years of age\n  * of a child born term\n  * of a child without BPD who has not been discharged yet\n  * with insufficient proficiency in one of the languages available in the questionnaire",true,"0 Years","18 Years",{"count":61,"type":21},480,"The objective of this study is to examine the long-term impact of having a child with Bronchopulmonary Dysplasia (BPD) on the parents and caregivers from the time of diagnosis through adulthood. The primary focus will be on parents and caregivers of children until the age of 18 (\\\u003C 18) years who were diagnosed with BPD as newborns. Data will be collected through an online questionnaire in France, Germany, Italy, the Netherlands, Spain, the United Kingdom (including Northern Ireland), and the United States. It will ask about inclusion and exclusion criteria, background information (caregiver, child, and family situation), the child's medical situation, parental health-related quality of life (HRQoL), health literacy, feelings, support structures, and economic burden of the family.",[64,27,65],"Bronchopulmonary Dysplasia (BPD)","HRQOL (Health Related Quality Of Life)",[67,68,69,70,71,72,73,64,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96],"Parental Quality of life","QoL","Health-related quality of life","HRQoL","Caregiver burden","Parental well-being","Family","Chronic Lung Disease (CLD)","Chronic Lung Diseaseof Newborn","Respiratory Morbidity","Long-term outcomes","Parents","Caregivers","Infants","Newborn","Children","Preterm","Prematurity","NICU","Intensive Care","Neonatal","Survey","Questionnaire","Multinational study","retrospective data collection","participatory research","Patient-reported outcomes","PROs","Patient-reported outcome measures","PROMs","2025-11-18",{"date":99,"type":40},"2025-11-21",{"date":101,"type":40},"2025-09-16",{"date":103,"type":21},"2027-01",{"name":105,"class":47},"Global Foundation for the Care of Newborn Infants",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":113,"maxAge":59,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":48},"100524572","reversibility-of-bronchial-obstruction-in-children-born-preterm-100524572","NCT06110481","Reversibility of Bronchial Obstruction in Children Born Preterm","Bronchodilator Response To Inhaled Beta-2 Agonist and Anticholinergic Drugs in Children Born Preterm","Inclusion Criteria:\n\n* children born preterm \u002Fbefore the 35th week of gestational age (35+0)\u002F\n* all subjects must have chronic lung disease of prematurity with bronchial obstruction, confirmed by spirometry\n* subjects must be able to cooperate well in spirometry\n\nExclusion Criteria:\n\n* The presence of another chronic respiratory disease (e.g., cystic fibrosis, primary ciliary dyskinesia, etc.). Asthma bronchiale is not an exclusion criterion, but subjects with CLDI combined with asthma bronchiale represent a specific subgroup of subjects and we perform a standardized therapeutic test with inhaled corticosteroids (ICS) administered for at least 12 weeks via a pressurized aerosol dispenser (pMDI) via an inhaler attachment before enrollement.\n* Insufficient cooperation during spirometry.","5 Years",{"count":115,"type":21},80,"This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry. All children were diagnosed with Chronic Lung Disease of Immaturity (CLDI).\n\nThe main questions are:\n\n* Is any inhaled bronchodilator or their combination generally superior in children with CLDI when assessing the reversibility of bronchial obstruction?\n* Is there an individual difference in the effect of betamimetic, anticholinergic or their combination between children with CLDI?\n\nParticipants will:\n\n* Come to our clinic in a stable state without acute infection and they will be randomly assigned to the first inhaled bronchodilator.\n* They will then perform a spirometry test before and after the inhalation of the drug.\n* This visit will repeat 3 times, each with a different bronchodilator (beta2agonist, anticholinergic and their combination).",[118,119,27,120,121,122,123],"Bronchopulmonary Dysplasia","Chronic Lung Disease of Prematurity","Preterm Birth Complication","Bronchial Hyperreactivity","Bronchial Obstruction","Reversible Dilatation","2025-05-19",{"date":126,"type":40},"2025-05-22",{"date":128,"type":40},"2021-04-01",{"date":130,"type":21},"2026-01-01",{"name":132,"class":47},"Charles University, Czech Republic"]