[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-medical-conditions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-medical-conditions":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,63,90],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100630104","comparative-effectiveness-of-sparcs-and-unified-protocol-for-youth-with-chronic-medical-conditions-and-trauma-related-distress-100630104",false,"NCT07483333","Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress","Supporting Purposeful Interventions & Resilience In Trauma (SPIRIT) Program: Implementing Trauma-Specific Screening and Stratified Interventions for Youth With a Chronic Medical Condition","Inclusion Criteria:\n\n* Youth (aged 8-18 years) who received a SPIRIT program psychological trauma screening and were deemed clinically appropriate for SPIRIT group therapy. Clinically appropriate means the youth can historically engage in a group setting (e.g., school, camp, therapy group) without significant disruption to the group process or other participants.\n* Youth and parent\u002Flegal guardian are willing and able to provide informed consent\u002Fassent for randomization.\n* Youth and parent\u002Flegal guardian are fluent in English or Spanish.\n* Youth is not currently engaged in individual therapy at the time of enrollment (per patient\u002Fparent report).\n\nExclusion Criteria:\n\n* Wards of the state or DCFS youth in care.\n* Youth with reported or observed symptoms that would significantly impair group therapy engagement, including but not limited to: intellectual disability, moderate-to-severe autism spectrum disorder, active suicidal ideation, uncontrolled psychosis, or other acute psychiatric symptoms that could disrupt the group process.\n* Regular use of alcohol or other substances that interfere with participation or disrupt the group process.\n* Youth requiring immediate higher-level psychiatric care (e.g., intensive outpatient programming, partial hospitalization, inpatient psychiatric admission, or residential treatment) at the time of first randomization.","ALL","8 Years","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological trauma and trauma-related distress. The study evaluates two evidence-based cognitive-behavioral therapies - Structured Psychotherapy for Adolescents Responding to Chronic Stress (SPARCS) and the Unified Protocol (UP) - delivered in group and individual formats to determine which approach, or combination of approaches, best reduces trauma symptoms and supports coping and adjustment. The study will also help researchers understand how to best support youth who continue to experience distress after an initial round of therapy.\n\nThe main questions it aims to answer are:\n\n* Does SPARCS group therapy or UP group therapy lead to greater improvements in trauma symptoms and functional impairment?\n* For youth who do not show enough improvement after group therapy, does adding SPARCS or UP individual therapy lead to better outcomes?\n* Which sequence of group and individual therapies leads to the greatest improvements in trauma symptoms and functioning?\n\nResearchers will compare two evidence-based therapies currently offered at Ann \\& Robert H. Lurie Children's Hospital of Chicago. Youth will first be randomly assigned to receive either SPARCS or UP in a group format. After completing group therapy, youth who still need additional support will be randomly assigned again to receive individual or family therapy using SPARCS or UP. This stepwise approach will help identify which sequence of therapies leads to the best overall outcomes for youth.\n\nParticipants will:\n\n* Take part in group therapy sessions using either SPARCS or UP\n* For those needing additional support after group therapy, participate in individual SPARCS or UP therapy\n* Complete brief assessments of mental health and daily functioning at enrollment, and every 12 weeks thereafter for 48 weeks, as part of their regular care through Ann \\& Robert H. Lurie Children's Supporting Purposeful Interventions \\& Resilience in Trauma (SPIRIT) program",[27,28,29,30,31,32,33,34,35,36,37],"Trauma Exposure","Trauma","Trauma and Stressor Related Disorder","Mental Health Functioning","Chronic Medical Conditions","Chronic Medical Condition","Chronic Medical Illness","Posttraumatic Stress Disorder PTSD","Posttraumatic Stress Disorders","Posttraumatic Stress Symptoms","Posttraumatic Stress",[39,40,41,42,43,44,45,46,47,48,49],"pediatric trauma","posttraumatic stress disorder","chronic medical conditions","pediatrics","trauma symptoms","trauma and stressor related disorder","trauma informed care","Sequential, Multiple Assignment Randomized Trial","Supporting Purposeful Interventions and Resilience in Trauma","Unified Protocol","Structured Psychotherapy for Adolescents Responding to Chronic Stress","NOT_YET_RECRUITING","2026-03-16",{"date":53,"type":54},"2026-03-19","ACTUAL",{"date":56,"type":21},"2026-07",{"date":58,"type":21},"2029-09-29",{"name":60,"class":61},"Anthony Vesco","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":62},"100577183","calls-and-coordination-for-transitions-of-care-at-re-entry-100577183","NCT06794983","Calls and Coordination for Transitions of Care at Re-entry","Health Systems Innovations for Supporting Transitions of Care for Incarcerated People Living With Substance Use Disorders","Call2Care","Inclusion Criteria:\n\n* age 18 or older\n* eligibility for WI Medicaid and intention to enroll before release\n* substance use history (i.e., \"have you ever considered your alcohol or drug use to be a problem?\"), and\n* living with, or history of, a chronic medical or psychiatric condition other than substance use disorder. This is defined as ever having been diagnosed with a medical or psychiatric chronic condition, or currently taking prescription medications for a chronic condition.\n* able to read, understand, and speak English.\n\nExclusion Criteria:\n\n* ineligible for WI Medicaid\n* no substance use history\n* not living with, or no history of, chronic medical or psychiatric condition",{"count":72,"type":21},488,[24],"The goal of this clinical trial is to learn if a short program for people being released from prison can help connect them to medical care. The main question it aims to answer is:\n\n* Will there be more non-emergency, outpatient clinic visits?\n\nResearchers will compare the number of clinic visits between people who use a Nurse Case Manager (NCM) to people in enhanced usual care.\n\nParticipants will:\n\n* Complete surveys\n* Talk to a study team member 2-3 times, or talk to a study team member 2-3 times and talk to an NCM 6-11 times",[76,77,31,78,79],"Prisoners","Substance Use History","Psychiatric Condition","Substance Use Disorder (SUD)","RECRUITING","2026-03-11",{"date":83,"type":54},"2026-03-13",{"date":85,"type":54},"2025-09-19",{"date":87,"type":21},"2029-04-30",{"name":89,"class":61},"University of Wisconsin, Madison",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":62},"100516209","web-based-program-to-improve-self-management-among-veterans-caregiver-dyads-100516209","NCT06001541","Web-based Program to Improve Self-management Among Veterans-caregiver Dyads","A Web-based Program to Improve Chronic Illness Self-management by Engaging Patients and Informal Caregivers","Web-SUCCEED","Inclusion Criteria:\n\n* Participants will be medically eligible if they have been diagnosed with at least one common chronic condition considered responsive to outpatient management as defined by being on the AHRQ list of Patient Quality Indicators, which are conditions that are considered responsive to high quality outpatient care.\n* The investigators will also include conditions that are disproportionately high among Veterans (pain, mental health conditions).\n* Based on the pilot study, the investigators anticipate this to include:\n\n  * musculoskeletal pain\n  * cardiovascular disease\n  * diabetes\n  * kidney disease\n  * depression\n* Eligible participants will have at least one outpatient visit in the prior 12 months related to their diagnosis and have a primary caregiver who lives with the Veteran. Dyads will be excluded if either the Veterans or their caregiver:\n\n  * 1\\) have an implantable cardioverter defibrillator\n  * 2\\) are on hemodialysis\n  * 3\\) have received an organ transplant or are waitlisted for one\n  * 4\\) are undergoing chemotherapy or radiation for cancer\n  * 5\\) have limited life expectancy as determined by the provider or hospice care\n  * 6\\) have dementia or other major cognitive deficits\n  * 7\\) have a substance use disorder (SUD), since supporting interpersonal relationships in SUDs require specialized training that is outside the scope of web-SUCCEED\n  * 8\\) have a paid caregiver who provides 50% or more support to the Veteran\n  * 9\\) are actively psychotic or suicidal. Due to content overlap, the investigators will exclude Veterans who have participated in the Stanford CDSMP program, and caregivers who have participated in the Building Better Caregiver program\n\nExclusion Criteria:\n\nDyads deemed eligible with these criteria will be further screened by the study staff for internet use, self-management distress, and interpersonal violence.\n\n* a. Internet Use: The investigators will use the question that used in the pilot study, \"How often do you use a computer?\" The investigators will exclude dyads where either Veterans or caregivers answer \"less than once a week.\"\n* b. Self-management Distress: The investigators will screen Veterans and caregivers for self-management distress using the same two-item measure that have been used for the pilot study of web-SUCCEED:\n\n  * 1\\) How overwhelmed do you feel by the demands of living with your \\[OR Veteran's\\] health condition(s)?\n  * 2\\) How often do you feel that you are failing in your routine to manage your \\[OR Veteran's\\] health conditions?\" Respondents rate items from 1 (Not a problem) to 6 (A very serious problem), and scores are added. Dyads will be eligible if both individuals score a minimum of 2 and at least one scores \\>3.\n* c. Interpersonal Violence: Veterans and caregivers will be separately screened with the question, \"How do you and \\[Veteran, caregiver\\] handle stressful conversations or conflict?\" If needed, this will be followed up with: \"In the last year, has it gotten physical or have there been threats of physical force?\". If the answer to the last question is \"yes\", dyads will not be eligible. Dr. Trivedi will assess for immediate safety, provide local resources, and involve authorities if appropriate. In the investigators' experience, this is a low likelihood event.",true,{"count":100,"type":21},560,[24],"The majority of Veterans will suffer from at least one chronic illness, often at great emotional and personal cost. Self-management is critical to improving physical and emotional outcomes, and many chronically ill Veterans receive self-management assistance from an informal caregiver, and both Veterans and informal caregivers experience individual and interpersonal stress as they navigate this journey. Yet, current clinical practices are not designed to effectively support the needs of both Veterans and their informal caregiver. Furthermore, self-management practices often require in-person visits, limiting access for Veterans and informal caregivers who live in rural areas, those with a physical disability, or those with financial challenges. This project tests a web-based, self-guided, behavioral intervention that targets the stress coping needs of Veterans with chronic illness and their informal caregivers. Results from this study could provide an important solution to the problem of poor self-management, which complicates the lives and prognosis of many Veterans.",[31],[105],"Chronic Disease","2025-06-12",{"date":108,"type":54},"2025-06-13",{"date":110,"type":54},"2024-05-01",{"date":112,"type":21},"2027-03-31",{"name":114,"class":115},"VA Office of Research and Development","FED"]