[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-musculoskeletal-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-musculoskeletal-pain":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,50,77,100,122,153,185,214,233,257,273,288,308,336,362,390,415,446,476,503],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100624417","non-invasive-vagus-nerve-stimulation-for-chronic-musculoskeletal-pain-100624417",false,"NCT07409363","Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal Pain","A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in Patients With Chronic Musculoskeletal Pain and Autonomic Dysfunction","RESTORE-MSK","Inclusion Criteria:\n\n1. Individuals diagnosed with musculoskeletal (MSK) conditions and currently experiencing MSK pain lasting for 12 weeks or longer, in line with the ICD-11 criteria for chronic pain.\n2. Identified as having autonomic dysfunction (AD) defined as a score of 17 or more on the Composite Autonomic Symptom Score-31 (COMPASS-31) questionnaire.\n3. Ability to understand and willingness to sign a written informed consent document.\n4. Stated willingness to comply with all study procedures and be available for the duration of the study (approximately 6 weeks).\n5. Ability to read and understand English sufficiently to complete study questionnaires.\n\nExclusion Criteria:\n\n1. Pregnancy (self-reported; safety of nVNS in pregnancy not established).\n2. Advanced heart disease, including: severe heart failure (NYHA Class III-IV), myocardial infarction within the preceding 6 months, or ongoing investigations for cardiac arrhythmias.\n3. Use of an active implantable medical device, including: cardiac pacemaker, implantable cardioverter-defibrillator (ICD), cochlear implant, hearing aid implant, or any other implanted electronic device.\n4. Concurrent use of another electrical stimulation device, including: transcutaneous electrical nerve stimulation (TENS) unit, muscle stimulator, or any other portable electronic stimulation device.\n5. Inability to provide informed consent.","ALL","18 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic musculoskeletal (MSK) pain affects an estimated 20-33% of the global population and is frequently associated with autonomic nervous system dysfunction, characterised by symptoms such as orthostatic intolerance, palpitations, gastrointestinal dysmotility, and fatigue. Conventional treatments often fail to address this autonomic component, limiting their effectiveness. This pilot study investigates whether non-invasive vagus nerve stimulation (nVNS) using the gammaCore Sapphire device can reduce autonomic symptom severity and improve pain in adults with chronic MSK pain and confirmed autonomic dysfunction.\n\nRESTORE-MSK is a randomised, single-blind, sham-controlled, crossover pilot study. Twelve participants with chronic MSK pain (lasting 12 weeks or longer) and autonomic dysfunction (COMPASS-31 score of 17 or more) will be recruited from musculoskeletal clinics at Chapel Allerton Hospital, Leeds. Participants will be randomly allocated to receive either active nVNS or sham stimulation first, followed by a 2-week washout period, then crossover to the alternative treatment. Each treatment period lasts 14 days, with participants self-administering the device twice daily (morning and evening).\n\nThe primary outcome is change in autonomic symptom severity measured by the Composite Autonomic Symptom Score-31 (COMPASS-31). Secondary outcomes include physiological response to the NASA Lean Test, pain severity and interference (Brief Pain Inventory), anxiety and depression (Hospital Anxiety and Depression Scale), quality of life (EQ-5D-5L), intervention acceptability, and recruitment feasibility.\n\nThis pilot study aims to establish feasibility and proof of concept for a larger randomised controlled trial investigating nVNS as a non-pharmacological treatment option for chronic MSK pain with autonomic dysfunction.",[27,28,29],"Chronic Musculoskeletal Pain","Autonomic Dysfunction","Dysautonomia",[31,32,33,34,35,36],"Vagus Nerve Stimulation","Non-invasive Neuromodulation","Chronic Pain","Autonomic Nervous System","GammaCore","COMPASS-31","NOT_YET_RECRUITING","2026-05-06",{"date":40,"type":41},"2026-05-11","ACTUAL",{"date":43,"type":21},"2026-05-14",{"date":45,"type":21},"2026-07-31",{"name":47,"class":48},"University of Leeds","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100593054","effectiveness-of-communication-focused-pain-neuroscience-education-in-chronic-musculoskeletal-pain-100593054","NCT07001449","Effectiveness of Communication-Focused Pain Neuroscience Education in Chronic Musculoskeletal Pain","Effectiveness of the 'Algo(S)Therapy' Pain Neuroscience Education Program Emphasizing Physiotherapists' Communication Skills in Patients With Chronic Musculoskeletal Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Diagnosis of chronic musculoskeletal pain in the lumbar spine, cervical spine, shoulder, or knee\n* Pain duration longer than 3 months\n* Pain intensity ≥3\u002F10 on the Numeric Pain Rating Scale (NPRS)\n* Pain present most days of the week\n* Able to understand and speak the Greek language\n\nExclusion Criteria:\n\n* Acute pain in any body region\n* Neurological disorders or myopathies\n* Chronic pain of non-musculoskeletal origin\n* Active cancer diagnosis\n* History of trauma, fractures, or surgery in the past year\n* Pregnancy\n* Diagnosis of fibromyalgia\n* Cognitive impairments affecting communication or completion of questionnaires\n* Current use of corticosteroid medication\n* Participation in other treatment programs or alternative therapies during the study period\n* Concurrent enrollment in another clinical trial","65 Years",{"count":59,"type":21},90,[24],"This randomized controlled trial aims to evaluate the effectiveness of the \"Algo(S)Therapy\" Pain Neuroscience Education (PNE) program in patients with chronic musculoskeletal pain. The study will assess whether the integration of communication skills training for physiotherapists enhances the outcomes of PNE. Participants will be randomly assigned to one of three groups: (1) PNE with communication-focused delivery, (2) PNE without communication emphasis, or (3) standard- usual physiotherapy care. The primary objective is to determine whether PNE combined with enhanced communication skills leads to greater improvements in pain, function, and psychosocial outcomes compared to the other interventions.",[27],[64,65,66],"Pain neuroscience education","Communication skills","Chronic musculoskeletal pain","RECRUITING","2026-04-30",{"date":70,"type":41},"2026-05-07",{"date":72,"type":41},"2025-06-17",{"date":74,"type":21},"2026-08-30",{"name":76,"class":48},"University of Thessaly",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100615236","correlation-between-diagnostic-nerve-block-response-and-cryoneurolysis-outcome-in-chronic-musculoskeletal-disorders-100615236","NCT07289984","Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders","CRYONIC","Inclusion Criteria:\n\n* Be over 18 year old\n* Adults (\\> 18y) with either chronic musculoskeletal pain (\\> 3 months; average NRS \\> 5\u002F10) or painful\u002Ffunctionally limiting spasticity\n* Have a clinical stable condition, \\> 3months\n* Any medications must be maintained on a stable schedule- Able to understand study instructions and provide informed consent (ICF) in French or Dutch.Provide written informed consent\n\nExclusion Criteria:\n\n* Contraindication to cryoneurolysis such as a diagnosis of cryoglobulinemia, paroxysmal cold haemoglobinuria, cold urticaria, Raynaud's disease, any form of peripheral neuropathy, open and or infected wounds of the affected limb\n* Patient's refusal to give consent to the procedure or to use of their data for research purposes.\n* Ongoing local or systemic infection before the procedure.\n* Predominantly neuropathic pain of the upper extremity as assessed with the Pain Detect questionnaire",{"count":85,"type":21},50,[24],"The clinical study is titled the CRYONIC PROTOCOL, which stands for Cryotherapy for Neurolysis In Chronic Pain. It is structured as a prospective, multi-cohort observational study.\n\nPurpose of the Study:\n\nThe overarching purpose of the CRYONIC PROTOCOL study is to assess the Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders. The study focuses on evaluating the effectiveness of ultrasound-guided peripheral nerve cryoneurolysis, a minimally invasive technique that uses extreme cold to induce temporary nerve blocks, for patients with treatment-resistant chronic musculoskeletal pain.\n\nThe study also seeks to determine if cryoneurolysis itself leads to meaningful improvements in both pain intensity and functional ability in the included patient cohorts.",[27,89,90],"Cryo Analgesia","Cryoablation","2026-04-21",{"date":93,"type":41},"2026-04-27",{"date":95,"type":21},"2026-07-01",{"date":97,"type":21},"2031-08-01",{"name":99,"class":48},"Universitair Ziekenhuis Brussel",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":49},"100582964","pain-disengagement-training-open-pilot-100582964","NCT06870162","Pain Disengagement Training (Open Pilot)","Pain Disengagement Training: A Self-directed Intervention for Pain Catastrophizing (Open Pilot)","Inclusion Criteria:\n\n1. Outpatient adults (i.e., greater than or equal to 18)\n2. Has self reported chronic musculoskeletal pain (i.e., pain persisting for at least 3 months)\n3. Pain score greater than or equal to 4 (moderate) on the Numerical Rating Scale\n4. Pain catastrophizing score greater than or equal to 20 on Pain Catastrophizing Scale\n5. Willingness to engage in a writing-based intervention and self-reported ability to write or type for at least 30 minutes in a sitting\n6. Received care at Massachusetts General Hospital\n7. English verbal and writing fluency\n\nExclusion Criteria:\n\n1. Clinically significant change in therapy or medication in the past 3 months\n2. Severe untreated mental health condition (e.g., psychosis)\n3. Active suicidality with history of plan or current intent\n4. Serious illness expected to worsen in the next 6 months (e.g., cancer)\n5. Untreated substance use problem that, per patient's self-report, would interfere with the ability to complete the intervention.",{"count":108,"type":21},10,[24],"The investigators aim to conduct an open pilot trial to determine the initial feasibility of a self-directed writing-based intervention in individuals with chronic musculoskeletal pain and elevated pain catastrophizing. The investigators will assess the feasibility of recruitment, acceptability of the treatment, credibility and participant satisfaction, treatment adherence, and feasibility of assessments following pre-specified benchmarks.",[27],[113],"pain catastrophizing","2026-04-17",{"date":91,"type":41},{"date":117,"type":41},"2025-10-14",{"date":119,"type":21},"2026-06-30",{"name":121,"class":48},"Massachusetts General Hospital",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":130,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":49},"100631232","paintrain-ai-pilot-feasibility-usability-sus-and-concept-shift-in-primary-care-and-a-specialized-setting-100631232","NCT07497997","PainTrain-AI Pilot: Feasibility, Usability (SUS) and Concept-Shift in Primary Care and a Specialized Setting","Feasibility and Usability of a Digital Clinical Simulation (PainTrain AI) for Chronic Pain Training in Health Professionals: A Multicenter Pilot in Primary Care (ICS) and a Specialized Comparative Setting","PT-AI Pilot","Inclusion Criteria:\n\n* Health professionals in Primary Care (medicine, physiotherapy, nursing, psychology, nutrition) and specialized setting; willingness to use the platform; institutional approval.\n\nExclusion Criteria:\n\n* lack of institutional access; unavailability during pilot window",true,{"count":132,"type":21},40,[24],"This pilot will assess feasibility and usability (SUS) and explore concept shift (reduction of neurophysiology misconceptions) after exposure to a behavioral educational intervention (PainTrain AI), a digital clinical simulation \"fenced\" by evidence (RAG) for safe, non diagnostic training. The study will be conducted in Primary Care and in a specialized comparative setting, without patient data collection. Primary endpoint: SUS score. Secondary endpoints: concept shift, adherence to micromodules, and interaction latency as friction metric. The platform does not generate clinical advice; it retrieves validated teaching content.",[27],[137,138,139,140,141,142,143],"chronic musculoskeletal pain","clinical simulation","digital training","educational intervention","usability (SUS)","concept shift","primary care professionals","2026-03-28",{"date":146,"type":41},"2026-04-02",{"date":148,"type":21},"2027-01",{"date":150,"type":21},"2028-09",{"name":152,"class":48},"Francesc Valenzuela Pascual",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":184},"100628412","multimodal-intervention-for-persistent-musculoskeletal-pain-in-primary-care-100628412","NCT07461298","Multimodal Intervention for Persistent Musculoskeletal Pain in Primary Care","Effectiveness of a Multimodal Intervention Based on Pain Neuroscience Education, Therapeutic Exercise and Healthy Lifestyle Promotion in Patients With Persistent Musculoskeletal Pain in Primary Care: A Multicenter Randomized Controlled Trial","DolorAP","Inclusion Criteria:\n\n* Adults aged between 18 and 70 years\n* Diagnosis of nonspecific persistent musculoskeletal pain lasting at least 6 months\n* Receiving care in participating primary care centers\n* Ability to understand study procedures and provide written informed consent\n* Ability to complete self-administered questionnaires\n\nExclusion Criteria:\n\n* Specific musculoskeletal pathology requiring specialized treatment (e.g., fracture, inflammatory rheumatic disease, malignancy)\n* Neurological disorders affecting movement or pain perception\n* Severe psychiatric disorders that may interfere with participation\n* Participation in another structured pain management program during the study period\n* Cognitive impairment preventing questionnaire completion\n* Pregnancy (if considered clinically relevant)","70 Years",{"count":163,"type":21},146,[24],"This multicenter randomized controlled trial aims to evaluate the effectiveness of a multimodal intervention for the active management of persistent musculoskeletal pain in primary care. The intervention combines pain neuroscience education, therapeutic exercise, and the promotion of self-care and healthy lifestyle habits to improve health-related quality of life in adults with persistent nonspecific musculoskeletal pain lasting at least six months.\n\nA total of 146 participants aged 18 to 70 years will be recruited from five primary care centers in the Comunitat Valenciana (Spain) and randomly assigned to either the experimental group or the control group. The primary outcome is health-related quality of life measured using the SF-36 Health Survey. Secondary outcomes include pain intensity, pain catastrophizing, kinesiophobia, central sensitization, emotional symptoms, perceived social support, medication use, and lifestyle-related variables. Assessments will be conducted at baseline, post-intervention, 6 months, and 12 months follow-up.",[27],[168,169,170,171,172,173,174],"Physical exercise","Patient Care Group","Primary Health Care","Multimodal Intervention","Health-Related Quality of Life","Self-Management","Pain Neuroscience Education","2026-03-06",{"date":177,"type":41},"2026-03-10",{"date":179,"type":21},"2026-06",{"date":181,"type":21},"2028-01",{"name":183,"class":48},"Universitat Jaume I",5,{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":49},"100493194","the-effect-of-a-technology-mediated-integrated-walking-and-tai-chi-intervention-on-physical-function-in-veterans-with-copd-and-chronic-musculoskeletal-pain-100493194","NCT05701982","The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain","WATCH for Pain","Inclusion Criteria:\n\n* Male and female participants, aged 40 and older\n* Clinical diagnosis of COPD defined as history of cigarette consumption of \\> 10 pack-years, and either a ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) \\\u003C 0.70 or chest computerized tomography (CT) evidence of emphysema\\*\n* Numeric Rating Scale pain score \\> 3 for \\> 3 months\n* Self-reported ability to walk a minimum of one block, bend at the hip, and transfer weight from one leg to another\n* Ability to complete 800 feet walk with Fitbit Inspire-2 recording \\> 90% accuracy to detect steps compared to manual counts\\*\n* Have access to a computer or smartphone with Internet connection or willing to come to study site to use study computers\n* Have access to videoconferencing audio and video capabilities\n* Competent to provide informed consent and willingness to make return study visits\n\n  * Different criteria are used if baseline study visit is a virtual one.\n\nExclusion Criteria:\n\n* COPD exacerbation in the previous 1 month\n* Clinical signs of unstable cardiovascular disease (active coronary artery disease, congestive heart failure, uncontrolled atrial fibrillation, or uncontrolled hypertension)\n* Oxygen saturation \\\u003C 85% recorded on baseline 4-meter walk\\*\n* High fall risk (unable to perform 5 chair stand tests)\n* Inability to ambulate\n* Inability to complete questionnaires\n* Inability to collect at least 7 of 10 days of baseline step counts\n* Active substance abuse\n* Participation in a regular exercise (i.e., MOVE! or Gerofit) or Tai Chi program in the previous 3 months\n* Concurrent participation in another interventional research study\n* Receipt of hospice or end-of-life palliative care\n* Active medical intervention that would cause a meaningful increase in pain such as surgery, chemotherapy, or radiation therapy\n\n  * Different criteria are used if baseline study visit is a virtual one.","40 Years","100 Years",{"count":195,"type":21},136,[24],"Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology-mediated walking and Tai Chi mindfulness intervention can improve physical function in Veterans with COPD and chronic musculoskeletal pain. The proposed research addresses VA Rehabilitation R\\&D Service's high priority area of improving health-related quality of life by reducing disease burden and maximizing function in Veterans with chronic disease.",[199,27],"COPD",[201,202,203],"physical activity","mindful movement","videoconference","2026-01-20",{"date":206,"type":41},"2026-01-22",{"date":208,"type":41},"2024-01-03",{"date":210,"type":21},"2028-03-31",{"name":212,"class":213},"VA Office of Research and Development","FED",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":224,"phases":4,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":230,"leadSponsor":231,"locationsCount":4},"100585169","functional-and-occupational-rehabilitation-of-troops-100585169","NCT06898866","Functional and Occupational Rehabilitation of Troops","An Effectiveness-Implementation Trial of Functional Restoration for Chronic Pain Management in Active Duty Military Personnel","FORT","Inclusion Criteria:\n\n\"patient referred to functional restoration program by provider\"\n\nExclusion Criteria:\n\n\"patient not referred to functional restoration program by provider\"",{"count":223,"type":21},480,"OBSERVATIONAL","The proposed implementation science project will evaluate the factors that support or hinder the successful implementation of the FORT Functional Restoration Program at six Military Treatment Facilities (MTF) across the Military Health System. It will also evaluate the associated effectiveness outcomes related to chronic musculoskeletal pain management in active-duty military personnel.",[27],"2026-01-15",{"date":204,"type":41},{"date":179,"type":21},{"date":181,"type":21},{"name":232,"class":48},"The University of Texas Health Science Center at San Antonio",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":240,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":22,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":49},"100619625","clinical-study-of-myofascial-trigger-pointsmtrps-injection-in-the-treatment-of-shoulder-osteoarthritisoa-100619625","NCT07347054","Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA)","Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Musculoskeletal Pain(CMP), Chronic Migraine and Cervicogenic Headache","Inclusion Criteria:\n\n* Diagnosis of shoulder osteoarthritis with radiographic evidence of osteoarthritis (Kellgren-Lawrence grade 1-4) confirmed by at least two orthopedic surgeons, pain specialists, or general practitioners, with physical examination confirming at least one myofascial trigger point;\n* Disease duration exceeding 3 months;\n* Age ≥ 45 years;\n* Numerical Rating Scale (NRS) score ≥ 3 points despite prior conservative pharmacological treatment;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* History of allergy to trial medications such as corticosteroids;\n* Alcohol abuse; long-term use of opioids (exceeding 2 weeks or more than 3 days per week for over 1 month); suspected use of sedative or analgesic medications; patients on long-term steroid therapy;\n* Severe neurological disorders, significant hepatic or renal dysfunction, heart failure, coagulation abnormalities, gastric ulcer, diabetes, inflammatory rheumatic diseases, etc.;\n* Intra-articular injection within the past 6 months or planned joint replacement surgery;\n* Inability to use pain assessment scales;\n* Presence of local or systemic infection;\n* Pregnant or lactating patients.","45 Years",{"count":242,"type":21},1036,[24],"Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Shoulder osteoarthritis is a common type of CMP. Currently, both domestic and international studies have confirmed that glucocorticoid injection at myofascial trigger points(MTrPs) can alleviate patients' pain symptoms. MTrPs injection is safe and easy to operate, and can improve the clinical management efficiency of patients with shoulder osteoarthritis. Therefore, we designed a prospective, randomized controlled, blinded outcome, non-inferiority study to compare the long-term clinical efficacy of glucocorticoid injection at myofascial trigger points and complex intra-articular injection in treating shoulder osteoarthritis. Patients will be randomly divided into two groups and receive either glucocorticoid injection at MTrPs or joint cavities. After treatment, patients will be followed up for 2 years. Their NRS scores, WOMAC scores, Patient Global Impression of Change(PGIC) scale, and adverse reactions will be recorded at 2 weeks, 4 weeks, 8 weeks, 12 weeks, and 24 weeks. If the results indicate that the clinical efficacy of myofascial trigger point injection for shoulder osteoarthritis is not inferior to that of injection at intra-articular injection, it will provide a safe and simple treatment option that is easy to promote for patients who do not respond to conservative treatment.",[246,27,247],"Myofascial Trigger Points","Shoulder Osteoarthritis","2026-01-11",{"date":250,"type":41},"2026-01-16",{"date":252,"type":41},"2025-12-01",{"date":254,"type":21},"2027-06-01",{"name":256,"class":48},"Beijing Tiantan Hospital",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":238,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":240,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":269,"startDateStruct":270,"completionDateStruct":271,"leadSponsor":272,"locationsCount":49},"100619623","clinical-study-of-myofascial-trigger-pointsmtrps-injection-in-the-treatment-of-knee-osteoarthritisoa-100619623","NCT07347028","Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA)","Inclusion Criteria:\n\n* Diagnosis of knee osteoarthritis with radiographic evidence of osteoarthritis (Kellgren-Lawrence grade 1-4) confirmed by at least two orthopedic surgeons, pain specialists, or general practitioners, with physical examination confirming at least one myofascial trigger point;\n* Disease duration exceeding 3 months;\n* Age ≥ 45 years;\n* Numerical Rating Scale (NRS) score ≥ 3 points despite prior conservative pharmacological treatment;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* History of allergy to trial medications such as corticosteroids;\n* Alcohol abuse; long-term use of opioids (exceeding 2 weeks or more than 3 days per week for over 1 month); suspected use of sedative or analgesic medications; patients on long-term steroid therapy;\n* Severe neurological disorders, significant hepatic or renal dysfunction, heart failure, coagulation abnormalities, gastric ulcer, diabetes, inflammatory rheumatic diseases, etc.;\n* Intra-articular injection within the past 6 months or planned joint replacement surgery;\n* Inability to use pain assessment scales;\n* Presence of local or systemic infection;\n* Pregnant or lactating patients.",{"count":242,"type":21},[24],"Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Knee osteoarthritis is a common type of CMP. Currently, both domestic and international studies have confirmed that glucocorticoid injection at myofascial trigger points(MTrPs) can alleviate patients' pain symptoms. MTrPs injection is safe and easy to operate, and can improve the clinical management efficiency of patients with knee osteoarthritis. Therefore, we designed a prospective, randomized controlled, blinded outcome, non-inferiority study to compare the long-term clinical efficacy of glucocorticoid injection at myofascial trigger points and complex intra-articular injection in treating knee osteoarthritis. Patients will be randomly divided into two groups and receive either glucocorticoid injection at MTrPs or joint cavities. After treatment, patients will be followed up for 2 years. Their NRS scores, WOMAC scores, Patient Global Impression of Change(PGIC) scale, and adverse reactions will be recorded at 2 weeks, 4 weeks, 8 weeks, 12 weeks, and 24 weeks. If the results indicate that the clinical efficacy of myofascial trigger point injection for knee osteoarthritis is not inferior to that of injection at intra-articular injection, it will provide a safe and simple treatment option that is easy to promote for patients who do not respond to conservative treatment.",[246,267,268,27],"Migraine","Cervicogenic Headache",{"date":250,"type":41},{"date":252,"type":41},{"date":254,"type":21},{"name":256,"class":48},{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":238,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":17,"minAge":240,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":22,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":286,"leadSponsor":287,"locationsCount":49},"100619624","clinical-study-of-myofascial-trigger-pointsmtrps-injection-in-the-treatment-of-hip-osteoarthritisoa-100619624","NCT07347041","Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Hip Osteoarthritis(OA)","Inclusion Criteria:\n\n* Diagnosis of hip osteoarthritis with radiographic evidence of osteoarthritis (Kellgren-Lawrence grade 1-4) confirmed by at least two orthopedic surgeons, pain specialists, or general practitioners, with physical examination confirming at least one myofascial trigger point;\n* Disease duration exceeding 3 months;\n* Age ≥ 45 years;\n* Numerical Rating Scale (NRS) score ≥ 3 points despite prior conservative pharmacological treatment;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* History of allergy to trial medications such as corticosteroids;\n* Alcohol abuse; long-term use of opioids (exceeding 2 weeks or more than 3 days per week for over 1 month); suspected use of sedative or analgesic medications; patients on long-term steroid therapy;\n* Severe neurological disorders, significant hepatic or renal dysfunction, heart failure, coagulation abnormalities, gastric ulcer, diabetes, inflammatory rheumatic diseases, etc.;\n* Intra-articular injection within the past 6 months or planned joint replacement surgery;\n* Inability to use pain assessment scales;\n* Presence of local or systemic infection;\n* Pregnant or lactating patients.",{"count":242,"type":21},[24],"Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Hip osteoarthritis is a common type of CMP. Currently, both domestic and international studies have confirmed that glucocorticoid injection at myofascial trigger points(MTrPs) can alleviate patients' pain symptoms. MTrPs injection is safe and easy to operate, and can improve the clinical management efficiency of patients with knee osteoarthritis. Therefore, we designed a prospective, randomized controlled, blinded outcome, non-inferiority study to compare the long-term clinical efficacy of glucocorticoid injection at myofascial trigger points and complex intra-articular injection in treating hip osteoarthritis. Patients will be randomly divided into two groups and receive either glucocorticoid injection at MTrPs or joint cavities. After treatment, patients will be followed up for 2 years. Their NRS scores, WOMAC scores, Patient Global Impression of Change(PGIC) scale, and adverse reactions will be recorded at 2 weeks, 4 weeks, 8 weeks, 12 weeks, and 24 weeks. If the results indicate that the clinical efficacy of myofascial trigger point injection for knee osteoarthritis is not inferior to that of injection at intra-articular injection, it will provide a safe and simple treatment option that is easy to promote for patients who do not respond to conservative treatment.",[246,27,283],"Hip Osteoarthritis",{"date":250,"type":41},{"date":252,"type":41},{"date":254,"type":21},{"name":256,"class":48},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":4},"100616001","multimodal-physiotherapy-and-pain-coping-in-primary-care-100616001","NCT07299929","Multimodal Physiotherapy and Pain Coping in Primary Care","Multimodal Physiotherapy Intervention for Active Coping With Persistent Musculoskeletal Pain in Primary Care","Inclusion Criteria:\n\n\\- Persistent nonspecific musculoskeletal pain lasting at least 6 months\n\nExclusion Criteria:\n\n* Oncologic pain.\n* Spinal fracture or surgical intervention within the 12 months prior to the intervention.\n* Cognitive impairment that prevents comprehension of the intervention content (in case of doubt, the Mini-Mental State Examination will be administered, requiring a minimum score of 25).\n* Physical performance deficit that prevents execution of the intervention (minimum requirement: completion of the Timed Up and Go test within the normal time of 10 seconds).\n* Pregnancy.\n* Cauda equina syndrome.\n* Presence of urinary and\u002For fecal incontinence.\n* Severe psychiatric disorders.\n* Autoimmune diseases.\n* Associated medical conditions that preclude participation in a physical exercise program (e.g., myopathies, neurological diseases with significant functional impairment).\n* Patients undergoing alternative therapies.\n* Patients with an implanted neurostimulator.",{"count":296,"type":21},68,[24],"This quasi-experimental, multicenter study aims to evaluate the effectiveness of a multimodal physiotherapy intervention-based on pain neuroscience education and therapeutic exercise-on health-related quality of life in patients with persistent musculoskeletal pain treated in Primary Care.\n\nThe study will be conducted in four Primary Care physiotherapy units in the Valencian Community (Spain). A total of at least 68 participants aged 18 to 70 years with nonspecific persistent musculoskeletal pain lasting at least six months will be recruited.\n\nThe intervention will consist of a structured multimodal physiotherapy program including educational sessions on pain neuroscience and guided therapeutic exercise. The main outcome will be health-related quality of life, assessed using the SF-36 Health Survey. Secondary outcomes will include pain catastrophizing (Pain Catastrophizing Scale), kinesiophobia (Tampa Scale for Kinesiophobia), and central sensitization (Central Sensitization Inventory), among others.\n\nData will be collected using the REDCap electronic platform at three time points: baseline (pre-intervention), immediately after the intervention, and six months post-intervention. Statistical analysis will include descriptive statistics, bivariate analyses, and paired comparisons to assess changes over time.\n\nThe study seeks to generate evidence on the feasibility and potential effectiveness of implementing a multimodal physiotherapy intervention for active coping with chronic musculoskeletal pain in the context of Primary Care.",[27],"2025-12-09",{"date":302,"type":41},"2025-12-23",{"date":304,"type":21},"2026-09",{"date":306,"type":21},"2027-09",{"name":183,"class":48},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":22,"phases":317,"briefSummary":318,"conditions":319,"keywords":322,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":334,"locationsCount":49},"100609687","stepped-care-intervention-of-music-and-imagery-to-assess-relief-scimitar-trial-100609687","NCT07217821","Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial","SCIMITAR","Inclusion Criteria:\n\n* musculoskeletal pain in the low back, cervical spine, or extremities (hips, knees, or shoulders) for ≥ 3 months\n* at least moderate pain severity, defined as a PEG score ≥ 4 on a 0 (no pain) to 10 (worst pain)\n* access to computer, tablet, or smartphone\n* ability to pass a technology assessment\n\nExclusion Criteria:\n\n* Past month hospitalization for medical or psychiatric illness\n* housing insecurity\n* suicidal ideation with current intent\u002Fplan\n* hearing or cognitive impairment that may interfere with music listening or abstract thinking needed for imagery work\n* currently receiving music therapy services",{"count":316,"type":21},180,[24],"Th Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial. SCIMITAR builds on our pilot study, the Feasibility and Acceptability of Music Imagery and Listening Interventions for Analgesia (FAMILIA), which demonstrated that telehealth delivery of music listening (ML) and music imagery (MI) interventions is feasible and acceptable to Veterans with chronic musculoskeletal pain. SCIMITAR leverages what we learned from FAMILIA into a fully powered trial, harnessing the benefits of sequential ML and MI into a stepped-care, music therapy intervention via telehealth for Veterans needing relief from pain.",[27,320,321],"Veterans","Music Therapy",[323,324,325,326,327],"chronic pain","veterans","musculoskeletal pain","music therapy","clinical trial","2025-10-15",{"date":330,"type":41},"2025-10-16",{"date":332,"type":41},"2023-08-30",{"date":68,"type":21},{"name":335,"class":48},"Henry M. Jackson Foundation for the Advancement of Military Medicine",{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":22,"phases":346,"briefSummary":347,"conditions":348,"keywords":349,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":49},"100607787","this-project-is-a-three-arm-rct-evaluating-two-single-session-behavioral-interventions-for-adults-with-chronic-musculoskeletal-pain-cmp----1-brief-mindfulness-oriented-recovery-enhancement-b-more-vs-empowered-relief-er----relative-to-the-traditional-8-week-version-of-more-100607787","NCT07193095","This Project is a Three-arm RCT Evaluating Two, Single-session Behavioral Interventions for Adults With Chronic Musculoskeletal Pain (CMP) -- 1) Brief Mindfulness-Oriented Recovery Enhancement (B-MORE) vs. Empowered Relief (ER) -- Relative to the Traditional 8-week Version of MORE.","Brief MORE: A Mindfulness Intervention For Chronic Musculoskeletal Pain","Brief Relief","Inclusion Criteria:\n\n* (1) having a chronic musculoskeletal pain condition, (2) average pain of ≥ 3 in the previous week, (3) willingness to engage with study assessments and interventions, (4) understanding English instructions fluently, and (5) being 18 and above.\n\nExclusion Criteria:\n\n* (1) unable to consent because of physical or mental incapacity, (2) have previous, formal mindfulness training (e.g., MBSR) or previously receiving Empowered Relief, (3) have pain from a current cancer diagnosis or cancer-related treatment, (4) unstable illness that may interfere with treatment, (5) had surgery within the previous three months, and (6) had pain relieving injections, such as cortisone or hyaluronate, within the previous three months.",{"count":345,"type":21},39,[24],"Researchers at Florida State University are investigating how the length of treatment influences outcomes for individuals with chronic musculoskeletal pain. The goal is to identify the most effective balance between treatment duration and pain relief. There are three treatment conditions in this study: two different brief pain management trainings and one standard-length training. Participants will be randomized to either of the brief trainings, attending a single, 2-hour, online training session, in which a trained facilitator will teach pain management techniques that are backed by research. If randomized to receive the standard-length training, participants will attend eight, 2-hour, online training session over eight weeks, in which a trained facilitator will also teach research-backed pain management techniques. Short surveys will be required at seven different time points: before starting treatment, immediately after the pain-management training, and then 2, 6, 12, 24, and 36 weeks after the training.",[27],[350,351,352],"Chronic pain","Brief intervention","Remote","2025-09-24",{"date":355,"type":41},"2025-09-25",{"date":357,"type":41},"2025-08-14",{"date":359,"type":21},"2026-09-01",{"name":361,"class":48},"Florida State University",{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":17,"minAge":370,"maxAge":371,"enrollmentInfo":372,"targetDuration":4,"studyType":22,"phases":374,"briefSummary":375,"conditions":376,"keywords":377,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":389},"100516460","group-based-psychological-treatments-over-video-conference-for-older-veterans-with-chronic-pain-100516460","NCT06004804","Group-Based Psychological Treatments Over Video Conference for Older Veterans With Chronic Pain","Evaluating Group-Based Psychological Treatments Over Home Video Teleconference for Older Veterans With Chronic Pain","GPTVTCOVCP","Inclusion Criteria:\n\nEligible individuals are\n\n* Veterans;\n* age 60-95 years;\n* have at least 3 months of musculoskeletal pain, including the following conditions: back, neck, leg, or pelvic pain; temporomandibular joint disorders; fibromyalgia; tension headaches; or any combination of these disorders; and\n* have an average daily pain intensity of at least 4 on a 0 to 10 scale.\n\nExclusion Criteria:\n\n* pain conditions likely to respond pharmacologic or surgical treatment only when they are the primary or sole complaint: hip or knee osteoarthritis, leg pain greater than back pain (to exclude radiculopathy), electromyography-confirmed \"tunnel\" syndromes (e.g., carpal tunnel syndrome), gout, neuralgias, migraine, and cluster headaches;\n* non-musculoskeletal pain conditions: autoimmune disease that typically generates pain (e.g., rheumatoid arthritis), cancer pain, sickle cell disease, burn pain, infection associated with pain, and cauda equina syndrome; and\n* these conditions or circumstances: severe psychiatric disorder such as schizophrenia or bipolar I disorder not controlled with medications, active suicide or violence risk, active severe alcohol or substance use disorder, substantial cognitive impairment or dementia (assessed using telephone Mini-Mental State Examination (tMMSE) score \\\u003C19), previously completed EAET, CBT-CP, or MM\u002FMBSR, currently enrolled in another psychological pain treatment, currently in pain-related litigation or applying for pain-related compensation or compensation increase, unable to fluently read or converse in English, no home internet access.","60 Years","95 Years",{"count":373,"type":21},216,[24],"This study is being performed to compare the effects of three types of group-based psychological treatments delivered over video telehealth for chronic musculoskeletal pain in older U.S. military Veterans. The three types of psychological treatments are: Cognitive-Behavioral Therapy (CBT), Emotional Awareness and Expression Therapy (EAET), and Mindfulness Meditation (MM). In addition, the investigators will evaluate which patients respond best to each treatment and how each treatment works.\n\nThe investigators are performing the study because chronic pain is a big problem among Veterans. Older Veterans are the focus because they have the highest rates of chronic pain, perhaps as high has 80%. The investigators are looking at psychological treatments because they are less risky than medications or procedures for older Veterans. Telehealth is an important aspect of the proposal, as delivery over telehealth could improve access to treatments. CBT is endorsed nationally by VA, but no standardized MM is available through VA, and only a few VA sites use EAET, which is a newer treatment focusing on how stress and emotions affect pain. The project aims to evaluate a standardized form of MM and the newer treatment, EAET, compared to the standard CBT used widely in VA.",[27],[350,378,379,380],"Psychological intervention","Musculoskeletal disease","Telehealth","2025-09-19",{"date":383,"type":41},"2025-09-22",{"date":385,"type":41},"2023-10-01",{"date":387,"type":21},"2027-09-30",{"name":212,"class":213},2,{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":22,"phases":399,"briefSummary":400,"conditions":401,"keywords":402,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":411,"leadSponsor":413,"locationsCount":389},"100593566","comparing-single-session-therapies-for-chronic-pain-100593566","NCT07008105","Comparing Single-Session Therapies for Chronic Pain","Comparing a Single-Session of Cognitive Behavioral Therapy, Pain Reprocessing Therapy, and Emotion Awareness and Expression Therapy for Chronic Pain","Inclusion Criteria:\n\n* Pain for at least 3 months and experienced 4 or more days\u002Fweek for the past 6 months\n* Pain intensity last week is \\>= 3 (0 to 10 rating scale)\n* Pain interference last week is \\>= 3 (0 to 10 rating scale)\n* At least age 18\n* Lives in United States\n* Fluent in English\n* Has personal computer\u002Ftablet and internet access\n* Able to attend one 90-minute session\n* Willing to be randomized\n* Seeking to improve their pain-related status via a psychological therapy\n\nExclusion Criteria:\n\n* Past 2 years (treated for or having experienced):\n* Complex regional pain syndrome\n* Epilepsy\u002Fseizure disorder\n* Autoimmune disease\n* Liver disease\n* Cancer\n* Heart disease\n* Substance dependence or use disorder\n* Schizophrenia or other psychotic disorder\n* Bipolar disorder\n* Obsessive-compulsive disorder\n* Borderline personality disorder\n* Suicide attempt or suicide intention or impulse\n* Major medical procedure scheduled within next 2 months\n* Applied for\u002F litigating for pain-related disability\u002Fworker's compensation (past year).\n* Major life event\u002Fstressor in past 6 months\n* Cognitive impairment (screener score \\\u003C=4)",{"count":398,"type":21},160,[24],"Many people in the US suffer from chronic pain. Often times, individuals who have chronic pain also feel depressed, anxious, or hopeless, which can worsen pain. Psychologists, therefore, have developed several treatments to help people with chronic pain. These psychological treatments differ. The most common treatment is Cognitive Behavioral Therapy (CBT) for chronic pain, which helps patients better manage pain through changing thoughts and behaviors. Two newer, less common psychological therapies are Pain Reprocessing Therapy (PRT) and Emotion Awareness and Expression Therapy (EAET). These therapies emphasize that chronic pain is mainly due to plastic processes of over-sensitization in the brain and nervous system, and that psychotherapies can significantly reduce or eliminate pain. Although similar, PRT and EAET stress different aspects of treatment. PRT emphasizes that one's fear of pain and bodily injury maintains the brain's sense of threat, thereby also maintaining the pain response; EAET emphasizes that one's conditioned psychological state of stress and tension maintains a sense of threat, thereby maintaining the pain response. These three treatments have yet to be compared; it is unclear which psychological processes are most important to treating chronic pain.\n\nThere is growing interest in single-session psychotherapy interventions. Studies have shown that just a single session of CBT or EAET can help individuals reduce their pain. PRT has yet to be condensed to a single-session intervention.\n\nThis study will compare a single session of CBT, PRT, and EAET with a no-treatment control group to test whether 1) one treatment outperforms the others, and 2) different mechanisms\u002F approaches matter to chronic pain treatment.",[27],[350,403,404,405,406],"behavioral treatment","CBT","EAET","PRT","2025-07-14",{"date":409,"type":41},"2025-07-15",{"date":409,"type":41},{"date":412,"type":21},"2026-08",{"name":414,"class":48},"Mark A. Lumley",{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":22,"phases":424,"briefSummary":425,"conditions":426,"keywords":429,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":389},"100598945","laterality-training-and-pain-drawings-100598945","NCT07078084","Laterality Training and Pain Drawings","Laterality Training and Pain Drawings: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of chronic shoulder or knee pain lasting more than 6 months\n* Able to read and understand English\n* Willing to provide written informed consent\n\nExclusion Criteria:\n\n* Visual impairments that would interfere with laterality training (e.g., blindness or significant difficulty with vision)\n* Previous participation in laterality (left\u002Fright discrimination) training\n* Unwilling or unable to participate in the study procedures",{"count":423,"type":21},60,[24],"The goal of this clinical trial is to learn if laterality training (a type of brain-based therapy) can help reduce pain and change how people with chronic musculoskeletal pain experience and describe their pain. The study will focus on adults with shoulder or knee pain lasting longer than 6 months.\n\nThe main questions it aims to answer are:\n\nDoes laterality training lead to a reduction in self-reported pain levels?\n\nDoes laterality training reduce the area of the body that participants indicate as painful in their pain drawings?\n\nDoes laterality training improve accuracy and speed in left\u002Fright judgment tasks?\n\nResearchers will compare participants who complete laterality training to those who complete a non-therapeutic cognitive task (a word puzzle) to see if laterality training changes pain drawings and improves pain outcomes.\n\nParticipants will:\n\nComplete a pre-intervention assessment including pain ratings, pain drawings, and a left\u002Fright judgment test\n\nBe randomly assigned to one of two groups:\n\nIntervention group: Complete 5 one-minute sessions of laterality training using a tablet-based app called Recognise™, identifying left or right hand\u002Ffoot images depending on the location of their pain\n\nControl group: Complete a 10-minute crossword puzzle activity (non-therapeutic)\n\nComplete the same assessments after the activity (pain ratings, pain drawings, left\u002Fright judgment test)\n\nThe study will take place at two outpatient physical therapy clinics. Participation involves a single session lasting approximately 30-45 minutes. There is no cost to participate, and no compensation is provided. Participation is voluntary, and all personal data will be kept confidential.\n\nThis research will help determine whether laterality training, a non-invasive brain-based technique, can reduce pain and improve quality of life in people with long-standing musculoskeletal pain.",[27,427,428],"Chronic Shoulder Pain","Chronic Knee Pain",[66,430,431,432,433,434,435,436],"Shoulder pain","Knee pain","Laterality training","Left\u002Fright discrimination","Graded motor imagery","Pain neuroscience","Pain drawings","2025-07-12",{"date":439,"type":41},"2025-07-22",{"date":441,"type":21},"2025-08",{"date":443,"type":21},"2026-02",{"name":445,"class":48},"Hawaii Pacific University",{"id":447,"slug":448,"hasResults":11,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":17,"minAge":370,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":22,"phases":456,"briefSummary":457,"conditions":458,"keywords":460,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":49},"100570647","the-effect-of-intermittent-theta-burst-stimulation-on-brain-characteristics-pain-intensity-and-cognitive-functions-in-older-people-with-chronic-musculoskeletal-pain-100570647","NCT06709963","The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain.","The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain: a Double-blinded, Randomized, Sham-controlled, Mixed-methods, Pilot Trial with a Six-month Post-treatment Follow-up.","Inclusion Criteria:\n\n* have normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)\n* be right-handed\n* be able to speak Cantonese\n* chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain that has lasted for at least 3 months\n* an average pain intensity of ≥ 5 out of 10 on an 11-point numerical rating scale in the last 7 days, where 0 means \"no pain\" and 10 means \"worst pain imaginable\"\n* having pain at least half of the days in the past 4 weeks.\n* have at least 6 years of formal education and know how to read and write Chinese\n* agree to sign an informed consent and complete the experiment tests\n* be able to communicate via email or text message, as several study measures will be collected electronically\n\nExclusion Criteria:\n\n* inability to ambulate without assistance from another person (canes or walkers will be allowed);\n* having specific causes of chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection);\n* having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck pain)\n* self-reported history of lumbar or lower extremity surgery\n* self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer history\n* self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis\n* unexplained, unintended weight loss of 20 lbs or more in the past year\n* cauda equina syndrome\n* uncorrected visual deficit\n* drug or alcohol addiction\n* taken alcohol, opioids or benzodiazepines medicines 24 hours before the experiment\n* claustrophobia\n* contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience (UBSN) at The Hong Kong Polytechnic University (PolyU)","85 Years",{"count":455,"type":21},30,[24],"The goal of this clinical trial is to explore the effects of accelerated intermittent Theta Burst Stimulation (iTBS) on pain relief and cognitive function in older adults with chronic musculoskeletal pain. It will also utilize magnetic resonance imaging to illustrate the neurophysiological mechanisms underlying the role of iTBS in improving various outcome indicators in this population.\n\nThe main questions it aims to answer are:\n\n1. Is left dorsolateral prefrontal cortex stimulation using accelerated iTBS effective for older adults with chronic musculoskeletal pain?\n2. What are the neurophysiological mechanisms underlying the role of iTBS in improving various outcome indicators in older adults with chronic musculoskeletal pain?\n\nParticipants will:\n\n1. Receive 1,200 stimuli during a single-session iTBS, totaling 14 days.\n2. Undergo MRI scanning before, immediately after treatment, cognitive and pain-related tests before, immediately after treatment, and during follow-up.",[459,428,27],"Chronic Non-Specific Low Back Pain",[461,462,463,464,465,137,466],"Chronic non-specific low back pain","rTMS","Sham","Chronic knee pain","DLPFC","iTBS","2025-01-14",{"date":469,"type":41},"2025-01-15",{"date":471,"type":41},"2024-09-20",{"date":473,"type":21},"2026-12-31",{"name":475,"class":48},"The Hong Kong Polytechnic University",{"id":477,"slug":478,"hasResults":11,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":482,"eligibilityCriteria":483,"healthyVolunteers":11,"sex":17,"minAge":484,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":22,"phases":487,"briefSummary":488,"conditions":489,"keywords":490,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":49},"100557247","community-based-exercise-for-older-adults-with-chronic-musculoskeletal-pain-100557247","NCT06535633","Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain","Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain: a Randomised Controlled Feasibility Trial","ComEx Pain","Inclusion Criteria:\n\n* Participants will be aged 50 or older,\n* report chronic MSK pain of ≥3 months duration,\n* not currently meeting the exercise guidelines of 150 minutes of moderate physical activity per week (determined using the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* Participants will be excluded if they have health conditions which could be worsened by exercise (e.g. neurological, or cardiovascular conditions, post-exertional malaise (screened using the DePaul Post-Exertional Malaise Questionnaire have recently undergone trauma or surgery, or have significant mobility issues which would limit exercise participation.\n* Participants who are unable to communicate in English sufficiently to complete consent or baseline assessment will be excluded","50 Years",{"count":486,"type":21},72,[24],"Chronic pain management services in Ireland are severely under-resourced. There is a key opportunity for community-based exercise to address some of the needs of people early in their chronic pain journey and potentially prevent or reduce their needs for secondary healthcare support, reducing the burden on healthcare waiting lists.\n\nMusculoskeletal pain is a significant barrier to participation in physical activity for these older adults, and at present, community-based exercise trainers do not have any education or resources to help support people with chronic pain to sustain their participation in physical activity programmes. Healthcare professionals who hold negative beliefs in relation to the role of physical activity for chronic pain are more likely to provide advice that reinforces unhelpful behaviours and increases disability. Pain education has been shown to positively change beliefs and shift views towards more evidence-based physical activity recommendations in a range of professionals including physiotherapists, nurses and sports therapists. In addition, specific psychological and behavioural approaches to support self-efficacy, develop pacing skills, and manage pain flareups are required to help people with chronic pain sustain their engagement in exercise. Appropriate education is required to equip those working with people in chronic pain to facilitate these skills. While exercise is a safe intervention, there are key differences in how people with chronic pain may respond to or recover from exercise that need to be planned for in exercise programmes. People with chronic pain vary greatly in their abilities and functional limitations, goals, and lifestyle, in comparison to those without troublesome pain. A review of qualitative data from people with fibromyalgia showed that they report self-selecting an exercise intensity lower than the guideline recommended level to avoid adverse effects and build pain management skills. Patient-public involvement (PPI) focus groups and a survey conducted in the development of this protocol showed that people with chronic pain were very reluctant to enrol in current community-based physical activity opportunities due to anxiety that the exercise leader would not understand or be able to meet their specific needs, and the consequent fear of symptom exacerbation. The most important priority identified for their participation was having an exercise leader who was trained in supporting people with pain. Exercise that is tailored to the specific needs of people with pain is likely to offer a more supportive, safe, and effective approach. There is a clear need for a project developing and delivering an educational intervention for exercise trainers, to support people with pain to exercise in their community.",[27],[491,492,493],"chronic musculoskeletal pain,","exercise","feasibility","2024-12-06",{"date":496,"type":41},"2024-12-12",{"date":498,"type":41},"2024-09-01",{"date":500,"type":21},"2025-11-01",{"name":502,"class":48},"University of Limerick",{"id":504,"slug":505,"hasResults":11,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":130,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":510,"targetDuration":4,"studyType":22,"phases":512,"briefSummary":513,"conditions":514,"keywords":515,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":49},"100529600","effectiveness-of-physiotherapists-communication-skills-on-clinical-outcomes-in-chronic-musculoskeletal-patients-100529600","NCT06175884","Effectiveness of Physiotherapist's Communication Skills on Clinical Outcomes in Chronic Musculoskeletal Patients","Effectiveness of Physiotherapist's Communication Skills on Clinical Outcomes in Patients With Chronic Musculoskeletal Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants should speak and understand the Greek language, as the questionnaires and the video will be in Greek\n* Participants should experience pain in one of the following four different areas: cervical or lumbar spine, knee, or shoulder\n* Pain of musculoskeletal origin\n* Pain lasting more than 3 months, evident on most days of the week to be classified as chronic pain, with a pain intensity of at least 3\u002F10 Numeric Pain Rating Scale.\n\nExclusion Criteria:\n\n* Medication for neurological\u002Fpsychiatric disorders\n* Pain medication on the day agreed upon with the researcher, in order to minimize the potential influence of medication\n* Undergoing surgery in the last six months\n* Pregnancy or childbirth before 1 year",{"count":511,"type":21},69,[24],"The purpose of this study is to investigate the impact of the physiotherapist's communication on the clinical presentation of patients with chronic musculoskeletal pain.",[27],[516,137],"communication skills","2024-10-22",{"date":519,"type":41},"2024-10-23",{"date":521,"type":41},"2024-01-15",{"date":523,"type":21},"2025-03-30",{"name":76,"class":48}]