[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-myelogenous-leukemia-cml\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-myelogenous-leukemia-cml":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100159702","a-multicenter-access-and-distribution-protocol-for-unlicensed-cryopreserved-cord-blood-units-cbus-100159702",false,"NCT01351545","A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)","A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications","Inclusion Criteria:\n\n* Disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment\n* Signed informed consent (and signed assent, if applicable) obtained prior to study enrollment\n* Pediatric and adult patients of any age\n\nExclusion Criteria:\n\n* Patients who are receiving only licensed CBUs\n* Cord blood transplant recipients at international transplant centers\n* Patients who are enrolled on another IND protocol to access the unlicensed CBU(s)\n* Patients whose selected unlicensed CBU(s) will be more than minimally manipulated","ALL",{"count":18,"type":19},99999,"ESTIMATED","OBSERVATIONAL","This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.",[23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Hematologic Malignancies","Inherited Disorders of Metabolism","Inherited Abnormalities of Platelets","Histiocytic Disorders","Acute Myelogenous Leukemia (AML or ANLL)","Acute Lymphoblastic Leukemia (ALL)","Other Acute Leukemia","Chronic Myelogenous Leukemia (CML)","Myelodysplastic (MDS) \u002F Myeloproliferative (MPN) Diseases","Other Leukemia","Hodgkin Lymphoma","Non-hodgkin Lymphoma","Multiple Myeloma\u002F Plasma Cell Disorder (PCD)","Inherited Abnormalities of Erythrocyte Differentiation or Function","Disorders of the Immune System","Autoimmune Diseases","Severe Aplastic Anemia","RECRUITING","2026-06-02",{"date":43,"type":44},"2026-06-04","ACTUAL",{"date":46,"type":4},"2011-10",{"date":48,"type":19},"2041-10",{"name":50,"class":51},"Center for International Blood and Marrow Transplant Research","NETWORK",142,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":91},"100507203","phase-2-cord-blood-transplant-in-adults-with-blood-cancers-100507203","NCT05884333","Cord Blood Transplant in Adults With Blood Cancers","Optimized Cord Blood Transplantation for the Treatment of High-Risk Hematologic Malignancies in Adults","Inclusion Criteria:\n\n* I. Acute myelogenous leukemia (AML):\n* Complete first remission (CR1) at high risk for relapse such as any of the following:\n\n  * Known prior diagnosis of myelodysplasia (MDS) or myeloproliferative disorder (MPD).\n  * Therapy-related AML.\n  * Presence of extramedullary leukemia at diagnosis.\n  * Requirement for 2 or more inductions to achieve CR1.\n  * Intermediate or high ELN2017 genetic risk AML.\n  * Any patient unable to tolerate consolidation chemotherapy as would have been deemed appropriate by the treating physician.\n  * Other high-risk features not defined above.\n* Complete second remission (CR2) or greater (CR2+).\n* Patients in morphologic remission with persistent cytogenetic, flow cytometric, or molecular aberrations are eligible\n\nII. Acute lymphoblastic leukemia (ALL):\n\n* Complete first remission (CR1) at high risk for relapse such as any of the following:\n\n  * Presence of any high-risk cytogenetic abnormalities such as t(9;22), t(1;19), t(4;11) or other MLL rearrangements (11q23) or other high-risk molecular abnormality.\n  * Failure to achieve MRD- complete remission after induction therapy.\n  * Persistence or recurrence of minimal residual disease on therapy.\n  * Any patient unable to tolerate consolidation and\u002For maintenance chemotherapy as would have been deemed appropriate by the treating physician.\n  * Other high-risk features not defined above.\n* Complete second remission (CR2) or greater (CR2+). Note: ALL with less than 5% blasts at time of transplant but persistent cytogenetic, flow cytometric or molecular aberrations are eligible.\n\nIII. Other acute leukemias: Acute leukemias of ambiguous lineage or mixed phenotype with less than 5% blasts. Leukemias in morphologic remission with persistent cytogenetic, flow cytometric or molecular aberrations are eligible.\n\nIV. Myelodysplastic Syndromes (MDS) and Myeloproliferative Disorders (MPD) other than myelofibrosis:\n\n* International prognostic scoring system (IPSS) risk score of INT-2 or high risk at the time of diagnosis.\n* Any IPSS risk category if life-threatening cytopenia(s) exists.\n* Any IPSS risk category with karyotype or genomic changes that indicate high risk for progression to acute myelogenous leukemia.\n* MDS\u002FMPD overlap syndromes without myelofibrosis.\n* MDS\u002F MPD patients must have less than 10% bone marrow myeloblasts and ANC \\> 0.2 (growth factor supported if necessary) at transplant work-up.\n\nV. Non-Hodgkin lymphoma (NHL) at high-risk of relapse or progression if not in remission:\n\nEligible patients with aggressive histologies (such as, but not limited to, diffuse large B-cell NHL, mantle cell NHL, and T-cell histologies) in CR by PET\u002FCT imaging.\n\no Eligible patients with indolent B-cell NHL (such as, but not limited to, follicular, small cell or marginal zone NHL) will have 2 nd or subsequent progression with PR or CR by PET\u002FCT imaging.\n\nVI. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) in morphologic remission.\n\nOrgan Function and Performance Status Criteria:\n\n* Karnofsky score equal or greater than 80% (See Appendix B; inpatient Leukemia service transfers without discharge are acceptable provided patient has equivalent KPS as if were outpatient).\n* Calculated creatinine clearance \\> 70 ml\u002Fmin.\n* Bilirubin \\\u003C 1.5 mg\u002FdL (unless benign congenital hyperbilirubinemia or hemolysis).\n* ALT \\\u003C 3 x upper limit of normal (ULN).\n* Pulmonary function: Spirometry (FVC and FEV1) and corrected DLCO) \\> 60% predicted.\n* Left ventricular ejection fraction (MOD-bp)\\> 50%.\n* Albumin \\> 3.0.\n* Hematopoietic Cell Transplantation Comorbidity index (HCT-CI) ≤5.\n\nGraft criteria:\n\nTwo CB units will be selected according to current MSKCC CB unit selection algorithm. High resolution 8-allele HLA typing and recipient HLA antibody profile will be performed. Unit selection will occur based on HLA-match, total nucleated cell (TNC) and CD34+ cell dose adjusted per patient body weight. The bank of origin will also be considered. Donor specific HLA antibodies, if present, will also be taken into consideration and may influence the selection of the graft.\n\n* Each CB unit must be at least 3\u002F8 HLA-matched to the patient considering high-resolution 8-allele HLA typing. \\[Taken from the Cord Blood Summary\\]\n* Each CB unit will be required to have a cryopreserved TNC dose of at least 1.5 x 10\\^7 TNC\u002F recipient body weight (TNC\u002F kg). \\[Taken from the Cord Blood Summary\\]\n* Each CB unit will be required to have a cryopreserved CD34+ cell dose of at least 1.5 x 10\\^5 CD34+ cells\u002F recipient body weight (CD34+ cells\u002Fkg). \\[Taken from the Cord Blood Summary\\]\n* A minimum of one unit will be reserved as a backup graft. \\[Taken from the Cord Blood Summary\\]\n* Each CB unit will be required to be cryopreserved in standard cryovolume (24-27 ml\u002Fs per unit or per bag if unit in two bags) and be red blood cell depleted. \\[Taken from the Cord Blood Summary\\]\n\nExclusion Criteria:\n\n* Diagnosis of myelofibrosis or other malignancy with moderate-severe bone marrow fibrosis.\n* Patients with persistent with CNS involvement in CSF or CNS disease at time of screening\n* Prior checkpoint inhibitors\u002F blockade in the last 12 months.\n* Two prior stem cell transplants of any kind.\n* One prior autologous stem cell transplant within the preceding 12 months.\n* Prior allogeneic transplantation.\n* Prior involved field radiation therapy that would preclude safe delivery of 400cGy TBI in the opinion of Radiation Oncology.\n* Active and uncontrolled infection at time of transplantation.\n* HIV infection.\n* Seropositivity for HTLV-1.\n* Inadequate performance status\u002F organ function.\n* Pregnancy or breast feeding.\n* Patient or guardian unable to give informed consent or unable to comply with the treatment protocol including appropriate supportive care, long-term follow-up, and research tests.","21 Years","65 Years",{"count":63,"type":19},54,"INTERVENTIONAL",[66],"PHASE2","Cord blood transplants (CBT) are a standard treatment for adults with blood cancers. MSK has developed a standard (\"optimized\") practice for cord blood transplant (CBT). This optimized practice includes how patients are evaluated for transplant, the conditioning treatment (standard chemotherapy and total body irradiation therapy) given to prepare the body for transplant, the amount of stem cells transplanted, and how patients are followed during and after transplant.The purpose of this study is to collect information about participant outcomes after CBT following MSK's optimized practice. The researchers will look at outcomes of the CBT treatment such as side effects, disease relapse, GVHD, and immune system recovery after CBT treatment.",[69,28,30,70,71,72],"Acute Myelogenous Leukemia (AML)","Myelodysplastic Syndromes (MDS)","Myeloproliferative Disorder","Non-Hodgkin's Lymphoma",[74,75,76,77,78,79,80],"Cord Blood Transplant","CYCLOPHOSPHAMIDE (CYTOXAN)","CYCLOSPORINE A","FLUDARABINE","MYCOPHENOLATE MOFETIL (MMF)","THIOTEPA","23-143","2025-09-05",{"date":83,"type":44},"2025-09-08",{"date":85,"type":44},"2023-05-22",{"date":87,"type":19},"2028-05-22",{"name":89,"class":90},"Memorial Sloan Kettering Cancer Center","OTHER",1]