[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-neurological-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-neurological-deficiency":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100605893","transfusion-exchanges-and-cognition-in-sickle-cell-disease-100605893",false,"NCT07168447","Transfusion Exchanges and Cognition in Sickle Cell Disease","Effect of Exchange Transfusions on Cognitive Efficiency in Patients With Sickle Cell Disease","DREPA-COG","Inclusion Criteria:\n\n* Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).\n* Enrolled in a regular monthly transfusion exchange program.\n* Not institutionalized.\n* No known dementia.\n* No severe aphasia.\n* Affiliated with or beneficiary of a social security system.\n\nExclusion criteria:\n\n* Insufficient mastery of spoken French.\n* Severe comorbidities preventing short-term follow-up.\n* Known psychiatric disorders.\n* Participation in another clinical study with ongoing exclusion periods.\n* Lack of adequate computer equipment (minimum 11-inch screen and internet connection).\n* Vulnerable patients under legal protection (guardianship or curatorship).","ALL","18 Years",{"count":20,"type":21},85,"ESTIMATED","6 Weeks","OBSERVATIONAL","DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed at three time points during the transfusion cycle using the Symbol Digit Modalities Test (SDMT) and additional validated neuropsychological measures. This minimal-risk, fully remote study aims to identify processing speed as a reproducible marker for clinical monitoring and future therapeutic trials.",[26,27],"Drepanocytosis","Chronic Neurological Deficiency",[29,30,31,32,33,34],"Sickle cell disease","cognitive function","neuropsychological assessment","transfusion exchange","non-interventional study","executive function, SDMT, T-MoCA, fatigue, anxiety, depression","NOT_YET_RECRUITING","2025-09-04",{"date":38,"type":39},"2025-09-11","ACTUAL",{"date":41,"type":21},"2025-12-03",{"date":43,"type":21},"2027-11-02",{"name":45,"class":46},"Centre Hospitalier St Anne","OTHER",6]