[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-non-specific-low-back-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-non-specific-low-back-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,49,80,110,137,163,184,219,246,276,303,329,351,378,407,426],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644080","effects-of-thoracolumbar-fascia-myofascial-release-in-chronic-low-back-pain-100644080",false,"NCT07667062","Effects of Thoracolumbar Fascia Myofascial Release in Chronic Low Back Pain","Effects of Myofascial Release Targeting the Thoracolumbar Fascia on Fascial Morphology, Functional Outcomes, and Pain Self-Efficacy in Adults With Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial","TLF-MFR-LBP","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Non-specific low back pain duration \\> 12 weeks\n* Average pain intensity NRS ≥ 3 over the past week\n* Able to provide written informed consent\n* Able to attend 18 supervised sessions over 6 weeks (3 sessions\u002Fweek)\n\nExclusion Criteria:\n\n* Specific spinal pathology (fracture, disc herniation with neurological deficit, spinal stenosis, inflammatory arthropathy, malignancy)\n* Previous lumbar surgery\n* Current pregnancy\n* Severe psychiatric disorder or active psychosis\n* Manual therapy or physiotherapy for LBP within the previous 3 months\n* Systemic connective tissue disorder (e.g., Ehlers-Danlos syndrome, Marfan syndrome)\n* Contraindication to ultrasound imaging or manual therapy.","ALL","18 Years","60 Years",{"count":21,"type":22},65,"ESTIMATED","INTERVENTIONAL",[25],"NA","The thoracolumbar fascia (TLF) is thickened and stiffer in individuals with chronic non-specific low back pain (CNSLBP) and may contribute to pain persistence. Myofascial release (MFR) has been shown to reduce TLF stiffness acutely; however, its longer-term effects on fascial morphology and pain self-efficacy remain unclear. This randomized controlled trial will investigate the effects of a standardized 6-week MFR program targeting the thoracolumbar fascia compared with sham MFR in adults with CNSLBP. A total of 65 participants aged 18-60 years with CNSLBP will be randomized in a 1:1 ratio to either standardized MFR or sham MFR. The intervention will consist of 18 treatment sessions delivered over 6 weeks. Primary outcomes include thoracolumbar fascia thickness measured by B-mode ultrasound, thoracolumbar fascia stiffness measured by shear-wave elastography, and pain self-efficacy measured using the Pain Self-Efficacy Questionnaire (PSEQ). Secondary outcomes include pain intensity, functional disability, lumbar flexion range of motion, and patient global impression of change. Outcomes will be assessed at baseline and after completion of the 6-week intervention period.",[28],"Chronic Non-specific Low Back Pain",[30,31,32,33,34,35],"Thoracolumbar fascia","Myofascial release","Chronic low back pain","Fascia thickness","Fascial stiffness","Pain self-efficacy","NOT_YET_RECRUITING","2026-06-23",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":22},"2026-06-20",{"date":44,"type":22},"2026-08",{"name":46,"class":47},"University of Health Sciences Lahore","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":48},"100642461","isokinetic-profile-of-ankle-joint-muscles-in-chronic-non-specific-low-back-pain-patients-100642461","NCT07636967","Isokinetic Profile of Ankle Joint Muscles in Chronic Non Specific Low Back Pain Patients","The Relationship Between Chronic Non-Specific Low Back Pain and Isokinetic Performance of Ankle Joint Muscles","Inclusion Criteria:\n\n1. 50 male patients diagnosed with Chronic non-specific low back pain through direct referral from their orthopedic surgeon.\n2. Each patient will be diagnosed by \"Waddle sign\"\n3. Age limit 20-40 years.\n4. BMI: less than 30.\n5. Pain duration: chronic more than 3 months or 12 weeks.\n6. Pain location: Between T12- and lower gluteal folds.\n7. Pain Intensity: At least have 3 out of 10 on VAS.\n8. Level of functional disability: 21%-40% on MODI.\n9. Each patient sign an informed consent.\n\nExclusion Criteria:\n\n1. Unexplained weight loss.\n2. History of malignancy.\n3. Recent trauma within last 12 months.\n4. Osteoporosis.\n5. Cauda Equina Symptoms.\n6. Herniated discs.\n7. Radicular signs.\n8. Spine fractures.\n9. Spinal Canal Stenosis.\n10. Myofascial Pain Syndrome.\n11. Spondylolisthesis.\n12. Rheumatological history.\n13. CVS manifestations.\n14. GIT manifestations.\n15. Psychiatric disorders.\n16. Weakness or parathesis in L.L.\n17. History of back surgery.\n18. Chronic Ankle Instability.\n19. Scoliosis or leg length discrepancies.\n20. Neurological and systemic manifestations such Epilepsy, muscular diseases, or seziures.\n21. Mechanical back pain","MALE","20 Years","40 Years",{"count":60,"type":22},50,"1 Day","OBSERVATIONAL","Chronic non-specific low back pain and its resulting infirmity have become a huge health and socioeconomic burden. Low back pain is reportedly associated with decreased activities of daily living and quality of life. Previous literature supports the presence of a link between CLBP and lower limb kinematics that can contribute to functional limitations and disability. For example, CLBP commonly coexist with postural and structural asymmetry. Ankle muscle performance of individuals with LBP during gait becomes more clinically important as it may provide insights into the mechanisms of ankle strategies. The isokinetic testing is an assessment method of high effectivity and trustworthiness that can be used to compare bilateral and agonist\u002F antagonist ankle muscles strength of normal subjects and athletes. It can be used to analyze muscular performance and differences in muscle performance between dominant and non-dominant limbs.",[28],[66,67,68,69,70],"Isokinetics","Muscle Performance","power parameter","Torque parameter","Time Parameter","RECRUITING","2026-06-13",{"date":74,"type":40},"2026-06-16",{"date":72,"type":40},{"date":77,"type":22},"2026-12-01",{"name":79,"class":47},"Cairo University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":48},"100642334","comparison-of-high-intensity-interval-training-with-moderate-intensity-continuous-training-in-chronic-non-specific-low-back-pain-patients-100642334","NCT07645859","Comparison of High-Intensity Interval Training With Moderate-Intensity Continuous Training in Chronic Non-Specific Low Back Pain Patients","Comparison of High-Intensity Interval Training With Moderate-Intensity Connuous Training In Chronic Non-Specific Low Back Pain Patients: Randomized Clinical Trial","Inclusion Criteria:\n\n* Referred patients of back pain persisting for \\> 12 weeks with no identifiable specific cause or underlying pathology from DUH OPD who meet the eligibility criteria.\n* Age group 20-48 with either gender.\n* NPRS score ranging between 3 and 5 (mild to moderate).\n* Modified ODI score is mild to moderate.\n\nExclusion Criteria:\n\n* Any client with a specific cause of LBP (neurological problems, fractures, malignancy, infections, or rheumatic diseases such as RA or ankylosing spondylitis).\n* Any client with cardiopulmonary problems (recent myocardial infarction, uncontrolled hypertension, asthma, COPD).\n* Any client with musculoskeletal disorders \\[injuries limiting exercises, spine injuries, recent trauma (fracture), scoliosis by Forward Adam's test\\].\n* Any client with metabolic conditions (thyroid problems, uncontrolled diabetes).\n* Pregnancy \u002F first 3-6 months postpartum.\n* Recent surgery.","48 Years",{"count":89,"type":22},80,[25],"The goal of this clinical trial is to compare the HIIT with MICT in chronic non-specific low back pain patients. The main questions it aims to answer are:\n\n* The broad aim of the study is to compare HIIT with MICT in pain reduction in chronic non-specific low back pain patients.\n* The purpose of this research is to compare HIIT with MICT on disability and quality of life among chronic non-specific low back pain patients.\n* It also attempts to investigate the relationship between the baseline attributes and outcome variables.\n\nResearcher will compare the HIIT to MICT to see the effects on CNSLBP\n\nParticipants will be:\n\n* Allocated to HIIT or MICT group for 6 weeks.\n* Assessed pre and post intervention.\n* Continuously monitored during treatment sessions.",[93],"Chronic Non-Specific Low Back Pain",[95,96,93,97,98,99,100],"High-Intensity Interval Training","Moderate-Intensity Continuous Training","Aerobic","Heart rate","Body composition","Anaerobic","2026-06-10",{"date":103,"type":40},"2026-06-12",{"date":105,"type":40},"2026-05-14",{"date":107,"type":22},"2026-12",{"name":109,"class":47},"Dow University of Health Sciences",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":48},"100640542","effect-of-vr-mbct-in-chronic-nonspecific-low-back-pain-100640542","NCT07589790","Effect of VR-MBCT in Chronic Nonspecific Low Back Pain","Effect of Virtual Reality-Based Mindfulness-Based Cognitive Therapy in Patients With Chronic Nonspecific Low Back Pain: Protocol for a Prospective, Multi-Center, Open-Label Randomized Controlled Trial","VR-MBCT-CNLBP","Inclusion Criteria:\n\nPatients who meet the following criteria will be included:\n\n1. Diagnosed with CNLBP according to standard criteria (3), with pain duration ≥3 months.\n2. Aged 20-70 years (inclusive), regardless of sex.\n3. Average self-reported back pain bothersomeness ≥4(scale, 0-10) in the past week.\n4. Provided informed consent and family members will be informed of the study as support persons.\n\nExclusion Criteria:\n\n1. Coexisting pain conditions that may interfere with the assessment of CNLBP\n2. Severe neurological or psychiatric disorders (e.g., unstable epilepsy, psychosis, dementia)\n3. Severe psychiatric comorbidities (e.g., active suicidal ideation, severe depression requiring antidepressant medication)\n4. History of substance abuse (including alcohol or drugs) in the past year\n5. History of accidents or injuries related to back pain in the past year\n6. Severe visual impairment, vertigo, or history of VR-induced motion sickness precluding safe VR use\n7. Inability to communicate effectively to express subjective feelings.","70 Years",{"count":120,"type":22},214,[25],"This is a multi-center, prospective, open-label randomized controlled trial evaluating the efficacy and safety of virtual reality-based mindfulness-based cognitive therapy (VR-MBCT) as an adjunct to usual care in adults with chronic nonspecific low back pain (CNLBP). A total of 214 participants aged 20-70 years with pain duration ≥3 months and average back pain bothersomeness ≥4 (0-10 scale) will be enrolled from three hospitals in China and randomized 1:1 to an 8-week VR-MBCT intervention group or a waitlist usual care control group. The co-primary outcomes are the proportions of patients achieving ≥30% improvement from baseline in Oswestry Disability Index (ODI) and self-rated back pain bothersomeness at week 8. Secondary outcomes include pain intensity (NRS), global improvement, anxiety (GAD-7), depression (PHQ-9), physical activity (IPAQ-SF), sleep quality (SQS), fear-avoidance beliefs (FABQ-PA), pain catastrophizing (PCS), work productivity (WPAI-GH), treatment use, system usability (SUS), and patient satisfaction. Safety will be monitored for VR-related adverse events. Assessments will be performed at baseline (T0), week 4 (T1), week 8 (T2), and week 26 (T3). Data will be analyzed following the intention-to-treat principle using mixed-effects models and per-protocol analyses.",[28],[32,125,126,127],"Virtual reality","Mindfulness-based cognitive therapy","Pain management","2026-05-10",{"date":130,"type":40},"2026-05-15",{"date":132,"type":40},"2026-04-01",{"date":134,"type":22},"2027-04-01",{"name":136,"class":47},"The First Affiliated Hospital of Soochow University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":48},"100585494","efficacy-of-text-messaging-on-activity-limitation-in-people-with-chronic-low-back-100585494","NCT06903091","Efficacy of Text-messaging on Activity Limitation in People With Chronic Low Back","Efficacy of Automated Text-messaging on Activity Limitation in Participants With Chronic Low Back Pain: a Randomized Controlled Trial","LOMBATEXT","Inclusion Criteria:\n\n* People with chronic low back pain (common low back pain, duration of low back pain \\> 3 months)\n* People who own a cell phone and have mastered the basics of using it (consulting and sending sms).\n* Person with a moderate to high self-efficacy for exercise score (SEE score ≥ 31\u002F90).\n* Patient having signed the study participation consent form. Patient affiliated to a social security scheme or entitled beneficiary\n\nExclusion Criteria:\n\n* Any other pathology affecting postural stability or voluntary active mobility\n* Contraindication to exercise\n* Lumbar spine surgery in the 12 months prior to inclusion in the study\n* Inability to write, speak or read French\n* Psychiatric and\u002For behavioral disorders\n* Current pregnancy (declarative) No inclusion of persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.).",{"count":146,"type":22},100,[25],"The main aim of this study was to evaluate the medium-term efficacy of an intervention involving personalized, automated text messaging (SMS), following face-to-face rehabilitation sessions, on activity limitation in people with chronic low back pain. We hypothesize that personalized SMS follow-up, following face-to-face rehabilitation sessions, could reduce activity limitation in people with chronic low back pain. Prospective multicenter randomized controlled trial.\n\nParticipants in both groups, experimental and comparator will have 4 face-to-face multidisciplinary rehabilitation sessions.\n\nParticipants in the 2 groups will have a face-to-face medical-kinesthetic clinical consultation at M3.\n\nParticipants in the experimental group will be monitored by personalized SMS messages over 6 months.",[28],[32,151,152,153],"SMS","adherence","therapeutic exercises","2026-04-30",{"date":156,"type":40},"2026-05-06",{"date":158,"type":22},"2026-06-01",{"date":160,"type":22},"2028-08-01",{"name":162,"class":47},"Assistance Publique - Hôpitaux de Paris",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":48},"100635333","comparison-of-the-effectiveness-of-myofascial-release-technique-and-pilates-exercises-in-chronic-non-specific-low-back-pain-100635333","NCT07551323","Comparison of the Effectiveness of Myofascial Release Technique and Pilates Exercises in Chronic Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Chronic non-specific low back pain lasting at least 3 months\n* No clinical signs of nerve root compression or neurological deficit\n* Aged 18-45 years\n* No physical therapy or manual therapy for low back pain in the last 1 month\n* Pain intensity of at least 3 on the Visual Analog Scale (VAS) in the last week\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Systemic, neurological, or orthopedic conditions limiting exercise participation\n* Lumbar radiculopathy or severe spinal pathology\n* History of lumbar spine surgery\n* Unhealed fracture or recent surgical intervention\n* Rheumatologic or inflammatory diseases\n* Neurological disorders affecting movement or balance\n* Participation in any physiotherapy or rehabilitation program in the last 6 months\n* Pregnancy or postpartum period within the last 6 months","45 Years",{"count":171,"type":22},30,[25],"Objective:\n\nTo evaluate the effectiveness of adding Myofascial Release Technique (MRT) to Clinical Pilates in adults with chronic non-specific low back pain (CNSLBP).\n\nHypothesis:\n\nMRT combined with Pilates will lead to greater improvements in pain, functional disability, and soft tissue mobility compared to Pilates alone.\n\nDesign \\& Intervention:\n\nRandomized controlled trial. Participants (18-45 years) will be randomly assigned to:\n\nMRT + Clinical Pilates Clinical Pilates only for 6 weeks (2 sessions\u002Fweek).\n\nOutcomes:\n\nPrimary: Pain (VAS), ultrasonographic thickness (multifidus \\& thoracolumbar fascia) Secondary: Disability (ODI), lumbar mobility, balance\n\nEligibility:\n\nAdults with CNSLBP ≥3 months; excluding spinal surgery, rheumatic disease, and pregnancy.",[28],"2026-04-24",{"date":177,"type":40},"2026-04-29",{"date":179,"type":22},"2026-04-10",{"date":181,"type":22},"2027-03-01",{"name":183,"class":47},"Bahçeşehir University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":203,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100611771","therapeutic-effects-of-instrument-assisted-versus-sound-assisted-soft-tissue-mobilization-in-chronic-non-specific-low-back-pain-100611771","NCT07244913","Therapeutic Effects of Instrument-assisted Versus Sound-assisted Soft Tissue Mobilization in Chronic Non-specific Low Back Pain","Therapeutic Effects of Instrument-assisted Versus Sound-assisted Soft Tissue Mobilization Among Patients With Chronic Non-specific Low Back Pain","IASTM VS SASTM","Inclusion Criteria:\n\n* Pain between the inferior gluteal folds and the costal margins.\n* Pain with a duration of a minimum of 24 weeks.\n* Moderate to severe pain (\\>3) was measured using the Numeric Pain Rating Scale.\n* Straight Leg raise Limited (hamstring tightness)\n\nExclusion Criteria:\n\n* Pain in lower back with radiating\u002Freferring but limited to proximal legs\n* Pain for the last 03 months and at least half of the days in the last six months.\n* Presence of neurological problem\u002Fdeficit\u002Fdisease (e.g., nerve root compression, motor deficit, paresthesia) and lower limb symptoms.\n* Presence of disease like Infection, tumors, spondylolisthesis grade II or higher, vertebral fractures, identifiable cause like endometriosis\n* Medicine like immunosuppression or steroid medication;\n* Spinal deformities\n* History of severe rheumatic, orthopedic, or cardiovascular disease in the last three months before study participation.\n* Previously diagnosed Osteoporosis\n* SIJ dysfunction is evaluated by a positive compression test.\n* BMI over 35.\n* Skin allergy or hypersensitivity that can lead to skin irritation due to IASTM\u002FSASTM tools.","55 Years",{"count":194,"type":22},60,[25],"Chronic low back pain (CLBP) is the most common medical problem observed among musculoskeletal pain and spinal pain problems. It can reduce the movements due to muscular imbalances, decreased activity of daily living, and effects on health-related quality of life. It is the major cause of activity limitation, work absence, and reported clinical issues. Most of the cases of low back pain remained undiagnosed and received only symptomatic management.",[93,198,199,200,201,202],"Pelvic Obliquity","Hamstring Flexibility","Physical Function","Disability","Lumbar Flexibility",[204,205,206,207,208,198,200,199],"IASTM","SASTM","CPGS","Disability Index","Flexibility","2025-12-30",{"date":211,"type":40},"2026-01-02",{"date":213,"type":40},"2025-12-23",{"date":215,"type":22},"2026-06-04",{"name":217,"class":47},"University of Lahore",2,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":17,"minAge":226,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":228,"briefSummary":230,"conditions":231,"keywords":232,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":48},"100615749","early-phase-1-prolotherapy-in-acupoints-in-chronic-non-specific-low-back-pain-clbp-100615749","NCT07296653","Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP)","Efficacy of Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP) - A Randomized Control Trial","Inclusion Criteria:\n\n* Body Mass Index (BMI) up to 45 kg\u002Fm2\n* Diagnoses corresponding to \\>1 of the following ICD-10 (International Classification of Diseases):\n\n  1. M51.3 Degeneration of intervertebral discs\n  2. M54.5 Low back pain\n  3. M54.8 Other forms of back pain\n  4. M54.9 Various forms of back pain\n  5. S33.5 Sprain of the lumbar spine\n  6. S33.6 Sprain of sacroiliac joint\n  7. S33.7 Sprain of other and various parts of lumbar spine and pelvis\n* Diagnosis of chronic nonspecific low back pain: Chronic nonspecific low back pain refers to pain in the lower back with or without radiation to the lower extremities, lasting for more than 3 months and not attributable to a specific anatomical structure or pathology on imaging, for example generalized degenerative changes, but no pathological findings (such as spinal stenosis or disorders of the sagittal\u002Fcoronal architecture or intervertebral foramen stenosis) with neurological deficits and no symptoms specific to the predominant pathology.\n* Numerical Rating Scale (NRS) \\> 3\u002F10 for at least 3 months prior to the study\n* Positive response to \\>1 muscle strength assessment tests in chronic low back pain A. prone plank bridge test (PBT) B. side bridge test (SBT) C. supine bridge test (SUBT) D. Range of Motion (ROM) E. Back Performance Scale (BPS) F. Straight leg raise test (SLR)\n* Pain, inability to walk, and stiffness in the lumbar spine, persisting for at least three months prior to the study.\n* Radiological imaging tests such as MRI or CT and, in cases of clinical suspicion (where appropriate), X-rays with dynamic flexion\u002Fextension or whole spine X-rays.\n* Signing of written consent prior to the injection of pharmaceutical agents.\n\nExclusion Criteria:\n\n* Any infection of the skin of the lumbar spine area, such as cellulitis, or periarticular or intra-articular infection or spondylodiscitis during the last 3 months\n* History of periarticular or intra-articular injection in the LMS with corticosteroids, local anesthetic, hyaluronic acid, radiofrequency application, electroacupuncture, or prolotherapy within the last three months.\n* Previous surgery (e.g., spinal fusion) in the LMS\n* Oral corticosteroids for low back pain or uncontrolled opioids\n* History of the following diseases:\n\n  1. connective tissue disease affecting the intervertebral spaces\n  2. insulin-dependent diabetes mellitus without adequate control\n  3. acute lumbosacral radiculopathy or peripheral neuropathy\n  4. neurological\u002Fpsychiatric disease\n  5. history of malignancy in the area or any other active malignancy in the body\n  6. Bleeding disorder\n  7. Trauma during the previous three months without imaging investigation\n  8. Systemic diseases such as rheumatic diseases\n  9. Known abdominal aortic aneurysm\n* Pregnancy (based on history)\n* History of allergy to local anesthetics\n* Needle phobia\n* Inability to communicate adequately, severe hearing loss, language problems, dementia\n* Inability to guarantee transportation to the hospital for treatments\u002Ffollow-up examinations","35 Years",{"count":194,"type":22},[229],"EARLY_PHASE1","Chronic non-specific low back pain (CNSLBP) is among the most prevalent causes of disability on the planet, which often proves to be refractory to conventional pharmacological, interventional, and rehabilitation approaches. Although acupuncture has also shown analgesic effectiveness, its variability and reliance on practitioner skill limit its universal introduction into Western medical practice. Prolotherapy, an emerging regenerative injection treatment with hypertonic dextrose solutions, has been of potential benefit in managing musculoskeletal pain by triggering tissue repair and controlling neurogenic inflammation. Interestingly, several acupuncture points correspond to neuroanatomically relevant sites.\n\nThis single-blind randomized controlled trial aims to ascertain whether combinational prolotherapy with dextrose 15% and lidocaine 1% is superior to lidocaine 1% in patients with CNSLBP. Sixty patients will be allocated randomly into two equal-sized groups and receive a maximum of 15 ultrasound-guided injections into standardized acupoints of the lumbar area (BL23, BL25, BL31, BL54, GV3, GV4, and Ashi points) during three treatment sessions. Outcomes will be evaluated using the Numeric Rating Scale (NRS), the Oswestry Disability Index (ODI), the TUG (Timed Up and Go) test, the BPI (Brief Pain Inventory) scale, the Rolland-Morris Low Back Pain Disability Questionnaire and the Global Impression of Pain Questionnaire at baseline, and at 15, 30, and 90 days post-treatment.\n\nOutcomes should clarify whether dextrose-enhanced prolotherapy provides improved analgesia and functional return in comparison with local anesthetic injection alone. This study can present an uncomplicated, low-cost, and integrative regimen for CNSLBP with significant clinical and socioeconomic implications.",[28],[233,234,235,236],"prolotherapy","acupoints","dextrose","low back pain","2025-12-08",{"date":239,"type":40},"2025-12-22",{"date":241,"type":40},"2025-12-01",{"date":243,"type":22},"2027-02",{"name":245,"class":47},"National and Kapodistrian University of Athens",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":252,"sex":17,"minAge":19,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":255,"conditions":256,"keywords":261,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":48},"100603298","the-impacts-of-chronic-non-specific-low-back-pain-on-cognitive-functions-of-older-adults-a-longitudinal-study-100603298","NCT07134699","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study","Inclusion Criteria:\n\n* Older adults with and without chronic non-specific low back pain (CNSLBP) aged between 60 and 85 years\n* Having normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)13\n* Right-handed\n* Cantonese speaking\n* Having at least 6 years of formal education and know how to read and write Chinese\n* Agreeing to sign an informed consent form\n* Being able to communicate via email or text message because several study measures will be collected electronically.\n\nExclusion Criteria:\n\n* Inability to ambulate without assistance from another person (canes or walkers will be allowed)\n* Having specific causes of LBP (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection)\n* Having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck or knee pain)\n* Self-reported history of lumbar or lower extremity surgery\n* Self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer history\n* Self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis\n* Unexplained, unintended weight loss of 20 lbs or more in the past year\n* Cauda equina syndrome\n* Uncorrected visual deficit\n* Drug or alcohol addiction\n* Taking alcohol, opioids or benzodiazepines medicines 24 hours before the experiment\n* Claustrophobia\n* Contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience at The Hong Kong Polytechnic University",true,"85 Years",{"count":194,"type":22},"Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment. Research shows that older adults experiencing chronic pain are more likely to show worse cognitive performance compared to healthy individuals. While there is a bidirectional relationship between pain and executive functions, cognitive performance especially for some executive functions (e.g. inhibition, switching, working memory) is crucial for managing pain in older adults. Furthermore, executive dysfunctions are associated with decline in functional status among the population, particularly in performing instrumental activities in daily living. Therefore, maintaining executive function emerges as a pivotal consideration for older adults with CNSLBP.\n\nStudies provide preliminary evidence that connects brain changes with chronic pain and cognitive functions. For instance, multisite chronic pain may increase the risk of cognitive decline through structural changes like hippocampal atrophy. Besides, functional brain changes in chronic pain may reduce deactivation several key default mode network regions, predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no direct evidence supports the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. It remains unclear that whether structural changes (e.g. reduced hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and\u002For functional changes (e.g. deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) cause by CNSLBP are associated with cognitive decline. With neuroimaging techniques, brain mechanisms connecting CNSLBP and executive function deficits can be explained.\n\nTo deepen understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. A longitudinal approach is established to quantify the relationship between CNSLBP-related brain changes and executive functions in older adults, providing insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.",[93,257,258,259,260],"Cognitive Decline","Longitudinal Study","Older Adults","Brain Imaging",[262,263,264,265,266],"Chronic Non-Specific low back pain","Cognitive decline","longitudinal study","older adults","brain imaging","2025-08-14",{"date":269,"type":40},"2025-08-21",{"date":271,"type":40},"2025-05-06",{"date":273,"type":22},"2026-08-31",{"name":275,"class":47},"The Hong Kong Polytechnic University",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":283,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":4},"100594003","correlation-between-motor-control-dysfunction-and-radiographic-parameter-in-non-specific-chronic-low-back-pain-100594003","NCT07013786","Correlation Between Motor Control Dysfunction and Radiographic Parameter in Non Specific Chronic Low Back Pain","MCD-RP-NSCLBP","Inclusion Criteria:\n\n* . Patients diagnosed with non-specific chronic low back pain (NSCLBP) for more than 3 months\n\n  * Age between 20 and 40 years\n  * Both males and females\n  * Body mass index (BMI) between 18.5 and 29.9\n  * No physical therapy or medical treatment during the last 3 months\n  * Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* • Patients with specific causes of low back pain (e.g., disc herniation, fractures, tumors, infections)\n\n  * History of spinal or lower limb surgery or injury\n  * Radiculopathy or neurological disorders affecting motor control\n  * Diagnosed spinal deformities (e.g., scoliosis, spondyloarthropathy, ankylosing spondylitis)\n  * Contraindications to X-ray (e.g., pregnancy)\n  * Patients currently undergoing physical therapy or medical intervention",{"count":284,"type":22},64,"This study aims to investigate the relationship between motor control dysfunction (MCD) and radiographic parameters in non-specific chronic low back pain (NSCLBP). Participants will undergo specific clinical motor control tests and lumbar spine X-rays to evaluate the alignment and coordination of spinal and pelvic structures. Understanding this relationship may help improve rehabilitation strategies and reduce pain in affected individuals.",[287],"Chronic Non Specific Low Back Pain",[289,290,291,292,293],"Lumbar motor control dysfunction","Lumbopelvic parameters","Radiographic alignment","Transverse abdominis","Multifidus","2025-06-06",{"date":296,"type":40},"2025-06-10",{"date":298,"type":22},"2025-06-01",{"date":300,"type":22},"2025-07-30",{"name":302,"class":47},"Mohammad Abdelazeem Darwish Saad",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":310,"targetDuration":4,"studyType":23,"phases":312,"briefSummary":313,"conditions":314,"keywords":315,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":48},"100503258","effects-of-core-stability-exercises-and-cognitive-tasks-on-chronic-non-specific-back-pain-100503258","NCT05832918","Effects of Core Stability Exercises and Cognitive Tasks on Chronic Non-specific Back Pain","Effects of Core Stability Exercises and Cognitive Tasks Compared to General Exercises and Cognitive Tasks on Chronic Non-specific Back Pain","Inclusion Criteria:\n\n* Orthopedist-confirmed diagnosis of chronic nonspecific low back pain that has lasted at least three months since its onset.\n* Pain score of 3 or more on a visual analog scale.\n* Pain during quiet standing.\n* Cognitive level above 24 based on mini-mental state examination (MMSE).\n\nExclusion Criteria:\n\n* Radicular pain and any neurological signs.\n* Uncorrected vision impairment.\n* Hearing problems.\n* Vestibular dysfunctions.\n* Cognitive deficit.\n* Previous spinal surgery.\n* Severe deformity or injury to the lower extremities.",{"count":311,"type":22},48,[25],"This randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. The main questions are:\n\n1. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the pain of chronic non-specific low back pain patients?\n2. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the disability of chronic non-specific low back pain patients?\n3. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving postural stability parameters of chronic non-specific low back pain patients?\n4. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving stabilogram diffusion analysis parameters of chronic non-specific low back pain patients? This study is designed to apply two exercise protocols on two groups of 17 people with non-specific back pain. Group A will receive core stability exercises along with cognitive tasks, and group B will receive general exercises along with cognitive tasks.",[28],[316,201,317,318,319],"Low back pain","Postural control","Core Stability Exercise","cognitive task","2025-05-03",{"date":322,"type":40},"2025-05-07",{"date":324,"type":40},"2023-05-02",{"date":326,"type":22},"2025-12-15",{"name":328,"class":47},"Iran University of Medical Sciences",{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":339,"conditions":340,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":48},"100586478","predictive-variables-of-outcome-in-subjects-with-chronic-rachialgia-referred-to-different-pathways-of-physiotherapy-100586478","NCT06915896","Predictive Variables of Outcome in Subjects With Chronic Rachialgia Referred to Different Pathways of Physiotherapy.","Predictive Variables of Outcome in Subjects With Chronic Rachialgia Referred to Different Pathways of Physiotherapy: Multicenter Prospective Study","PRE-CBP","Inclusion Criteria:\n\n* Age of majority;\n* Medical diagnosis of nonspecific low back pain or nonspecific neck pain;\n* Chronic symptoms, present for at least 6 months;\n* Waiting for rehabilitation in a public health pathways\n* Signature of informed consent to participate in the study and processing of personal data.\n\nExclusion Criteria:\n\n* Subjects with cognitive impairment",{"count":338,"type":22},200,"The aim of this study is to investigate the predictive value of various biopsychosocial variables on the outcomes of subjects with chronic spinal pain undergoing public health rehabilitation pathways. Secondly, the study aims to assess the reliability of certain questionnaires, classified as Patient-Reported Outcome Measures (PROMs), which are frequently used in the evaluation of spinal pain but whose metric properties have not yet been established. These objectives will be pursued through two comprehensive assessment sessions (before and after rehabilitation), a re-test session immediately before rehabilitation (to evaluate the reliability of the questionnaires in stable subjects), and two follow-up assessments at 3 and 6 months after discharge.",[93,341],"Chronic Non-specific Neck Pain","2025-03-31",{"date":344,"type":40},"2025-04-08",{"date":346,"type":40},"2023-10-30",{"date":348,"type":22},"2026-05-01",{"name":350,"class":47},"Fondazione Don Carlo Gnocchi Onlus",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":252,"sex":17,"minAge":18,"maxAge":358,"enrollmentInfo":359,"targetDuration":4,"studyType":23,"phases":360,"briefSummary":361,"conditions":362,"keywords":363,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":48},"100581925","comparison-of-abdominal-draw-in-maneuver-with-real-time-ultrasound-imaging-biofeedback-vs-conservative-physical-therapy-in-patients-with-chronic-low-back-pain-100581925","NCT06856642","Comparison of Abdominal Draw-in Maneuver With Real-time Ultrasound Imaging Biofeedback vs Conservative Physical Therapy in Patients With Chronic Low Back Pain","Comparison of Abdominal Draw-in Maneuver With Real-time Ultrasound Imaging Biofeedback vs Conservative Physical Therapy in Patients With Chronic Low Back Pain: A Prospective, Randomized Clinical Trial","Inclusion Criteria:\n\n* The duration of low back pain is at least 3 months.\n* Low back pain with or without radiation to the lower extremities.\n* Age between 18-65 years.\n* Chronic nonspecific low back pain patients.\n\nExclusion Criteria:\n\n* Neuropathic pain complaints.\n* Pregnancy status.\n* History of infection, cancer, or trauma.\n* Neurological abnormalities.\n* History of lumbar spine surgery.\n* History of conservative physical therapy and\u002For injections in the lumbar region within the last 6 months.\n* Neurological diseases such as Parkinson's or Multiple Sclerosis.\n* Systemic diseases that prevent exercise.\n* Patients with a Mini-Mental Test score below 24.","65 Years",{"count":171,"type":22},[25],"The aim of this study is to compare the effectiveness of abdominal drawing-in maneuver with real-time ultrasound biofeedback to conservative treatment in patients with chronic nonspecific low back pain.",[28],[364,236,365,366,367,368],"chronic non-specific low back pain","ultrasound imaging","real-time ultrasound biofeedback","biofeedback","abdominal draw-in manuever","2025-03-04",{"date":371,"type":40},"2025-03-06",{"date":373,"type":22},"2025-03-01",{"date":375,"type":22},"2026-02-28",{"name":377,"class":47},"Abant Izzet Baysal University",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":253,"enrollmentInfo":385,"targetDuration":4,"studyType":23,"phases":386,"briefSummary":387,"conditions":388,"keywords":391,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":48},"100570647","the-effect-of-intermittent-theta-burst-stimulation-on-brain-characteristics-pain-intensity-and-cognitive-functions-in-older-people-with-chronic-musculoskeletal-pain-100570647","NCT06709963","The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain.","The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain: a Double-blinded, Randomized, Sham-controlled, Mixed-methods, Pilot Trial with a Six-month Post-treatment Follow-up.","Inclusion Criteria:\n\n* have normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)\n* be right-handed\n* be able to speak Cantonese\n* chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain that has lasted for at least 3 months\n* an average pain intensity of ≥ 5 out of 10 on an 11-point numerical rating scale in the last 7 days, where 0 means \"no pain\" and 10 means \"worst pain imaginable\"\n* having pain at least half of the days in the past 4 weeks.\n* have at least 6 years of formal education and know how to read and write Chinese\n* agree to sign an informed consent and complete the experiment tests\n* be able to communicate via email or text message, as several study measures will be collected electronically\n\nExclusion Criteria:\n\n* inability to ambulate without assistance from another person (canes or walkers will be allowed);\n* having specific causes of chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection);\n* having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck pain)\n* self-reported history of lumbar or lower extremity surgery\n* self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer history\n* self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis\n* unexplained, unintended weight loss of 20 lbs or more in the past year\n* cauda equina syndrome\n* uncorrected visual deficit\n* drug or alcohol addiction\n* taken alcohol, opioids or benzodiazepines medicines 24 hours before the experiment\n* claustrophobia\n* contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience (UBSN) at The Hong Kong Polytechnic University (PolyU)",{"count":171,"type":22},[25],"The goal of this clinical trial is to explore the effects of accelerated intermittent Theta Burst Stimulation (iTBS) on pain relief and cognitive function in older adults with chronic musculoskeletal pain. It will also utilize magnetic resonance imaging to illustrate the neurophysiological mechanisms underlying the role of iTBS in improving various outcome indicators in this population.\n\nThe main questions it aims to answer are:\n\n1. Is left dorsolateral prefrontal cortex stimulation using accelerated iTBS effective for older adults with chronic musculoskeletal pain?\n2. What are the neurophysiological mechanisms underlying the role of iTBS in improving various outcome indicators in older adults with chronic musculoskeletal pain?\n\nParticipants will:\n\n1. Receive 1,200 stimuli during a single-session iTBS, totaling 14 days.\n2. Undergo MRI scanning before, immediately after treatment, cognitive and pain-related tests before, immediately after treatment, and during follow-up.",[93,389,390],"Chronic Knee Pain","Chronic Musculoskeletal Pain",[392,393,394,395,396,397,398],"Chronic non-specific low back pain","rTMS","Sham","Chronic knee pain","DLPFC","chronic musculoskeletal pain","iTBS","2025-01-14",{"date":401,"type":40},"2025-01-15",{"date":403,"type":40},"2024-09-20",{"date":405,"type":22},"2026-12-31",{"name":275,"class":47},{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":358,"enrollmentInfo":414,"targetDuration":4,"studyType":23,"phases":415,"briefSummary":416,"conditions":417,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":48},"100574720","pilates-mat-versus-segmental-control-exercises-in-patients-with-chronic-non-specific-low-back-pain-100574720","NCT06762951","Pilates Mat Versus Segmental Control Exercises In Patients With Chronic Non-Specific Low Back Pain","Pilates Mat Versus Segmental Control Exercises On Spinopelvic Angles In Patients With Chronic Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Age group: 18 to 65 years. (Yentür et al., 2021)\n* Both male and female gender will be included in the study. (Akhtar et al., 2017)\n* Nonspecific, non-radicular (axial) chronic LBP diagnosis with hyperlordosis (LBP for at least three months). (Kızıltaş et al., 2022)\n* Visual Analog Scale (VAS) score of 3 or higher. (Mannion et al., 2009)\n\nExclusion Criteria:\n\n* Patients with acute attacks of LBP. (Caglayan et al.,2014)\n* Pain referred from the lumbar to the lower extremities.\n* Serious spinal disorder including malignancy, osteoporosis, ankylosing spondylitis, cauda equina compression, and infection.\n* Fracture of vertebrae, and administered epidural injection. (Sarker et al., 2020)\n* Pregnancy and feeding\n* Structural abnormalities in the lumbar region\n* Surgical history in the lumbar spine area\n* Heart disease. (Kızıltaş et al., 2022)\n* History of Vestibular dysfunction\n* Regular Pilates\u002Fany other specific exercise program in the last 3 months. (Mehta et al.,2022)",{"count":194,"type":22},[25],"This study sought to determine the effect of Pilates exercises versus segmental control exercises on spinopelvic angles, pain intensity, and functional disability in patients with chronic non-specific low back pain.",[93],"2025-01-02",{"date":420,"type":40},"2025-01-08",{"date":422,"type":22},"2025-02-01",{"date":424,"type":22},"2026-03-01",{"name":79,"class":47},{"id":427,"slug":428,"hasResults":11,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":252,"sex":17,"minAge":19,"maxAge":253,"enrollmentInfo":432,"targetDuration":433,"studyType":62,"phases":4,"briefSummary":434,"conditions":435,"keywords":437,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":448},"100570221","the-impacts-of-chronic-non-specific-low-back-pain-on-cognitive-functions-of-older-adults-100570221","NCT06704425","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults","The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: a Cross-sectional Study",{"count":89,"type":22},"6 Months","Chronic non-specific low back pain (CNSLBP) is a prevalent condition among older adult and has been associated with an increased risk of executive function impairment. Studies have shown that older adults with chronic pain are more likely to show poor cognitive performance than healthy controls. Cognitive performance is particularly important when managing pain in older adults, especially for some executive functions (e.g., inhibition, switching, working memory) because pain and executive functions have their bidirectional relationship. Further, executive dysfunctions are associated with a decline in functional status among older adults, particularly the impairment of instrumental activities of daily living. Given the above, the preservation of executive functions emerges as a pivotal consideration among old adults with CNSLBP. Studies have provided preliminary evidence of the correlation between brain changes associated with chronic pain and cognitive functions. For example, multisite chronic pain may contribute to an increased risk of cognitive decline via structural change in hippocampal atrophy. For another example, functional brain changes in chronic pain reduced the deactivation of several key default mode network regions, thereby predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no research has provided direct evidence to support the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. Specifically, whether CNSLBP may lead to structural changes (e.g., smaller hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and\u002For functional changes (e.g., deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) associated with cognitive decline remains unclear. With the help of neuroimaging, the knowledge about the underlying brain mechanisms between CNSLBP (chronic non-specific low back pain) and executive functions can be explained.\n\nTo gain a better understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. The results of this study have the potential to quantify the association between CNSLBP-related brain changes and executive functions in older adults, and provide insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.",[93,257,436,259,260],"Cross-Sectional Study",[262,438,439,265,266],"cognitive decline","Cross-Sectional study","2024-11-23",{"date":442,"type":40},"2024-11-26",{"date":444,"type":40},"2024-04-20",{"date":446,"type":22},"2025-11-01",{"name":275,"class":47},3]