[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-obstructive-pulmonary-disease-moderate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-obstructive-pulmonary-disease-moderate":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100521676","respiratory-and-cardiovascular-alterations-in-patients-with-chronic-obstructive-pulmonary-disease-100521676",false,"NCT06072690","Respiratory and Cardiovascular Alterations in Patients With Chronic Obstructive Pulmonary Disease","The Impact of Dual Bronchodilation on Respiratory and Cardiovascular Systems in Patients With Newly Diagnosed Moderate-to-severe Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Aged 40 years and older\n* Smoking index of 10 pack-years and more\n* Newly diagnosed chronic obstructive pulmonary disease (COPD) with forced expiratory volume in 1 second (FEV1) 30-79 percent of predicted and forced expiratory volume in 1 second to forced vital capacity ratio (FEV1\u002FFVC) less than 70 percent of predicted.\n\nExclusion Criteria:\n\n* Active lung infection\n* Present or previously treated lung cancer\n* Alpha-1 antitrypsin deficiency\n* Diagnosed interstitial lung disease\n* Previously diagnosed asthma\n* Diagnosed chronic hypercapnic respiratory failure\n* Treatment with systemic glucocorticoids\n* Unstable ischaemic heart disease\n* Pregnancy\n* Present cardiac arrhythmias\n* Uncontrolled arterial hypertension\n* Dementia and other mental states that determine patient's inability to consent\n* Other medical conditions that in the opinion of the investigator disqualify the subject for inclusion","ALL","40 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","Chronic obstructive pulmonary disease (COPD) is a lung condition characterized by chronic respiratory symptoms (dyspnoea, cough, sputum production and\u002For exacerbations) due to abnormalities of the airways (e.g. bronchitis, bronchiolitis) and\u002For alveoli (emphysema) that lead to persistent, often progressive, airflow obstruction.\n\nIt is a major cause of disability and death worldwide. Moreover, people with COPD often have cardiovascular diseases (CVDs) that are associated with increased risk for hospitalization and prolonged stay as well as all-cause and CVD-related mortality. Nevertheless, CVDs in patients with COPD are tend to be underestimated in clinical practice. Mechanisms that define the relation between COPD and cardiovascular morbidity include lung hyperinflation, hypoxia, pulmonary hypertension, systemic inflammation and oxidative stress, exacerbation, shared risk factors and COPD phenotypes. In the past years, some authors have announced that COPD treatment with dual bronchodilation may not only improve pulmonary function and quality of life, but also have a positive effect on cardiac function. However, there is a lack of studies with treatment-naïve patients that would describe the initial effect of dual bronchodilation on respiratory and cardiovascular systems. In this study we aimed to evaluate the effect of initial dual bronchodilation on the quality of life, respiratory and cardiovascular systems in patients with newly-diagnosed chronic obstructive pulmonary disease.",[24,25,26,27],"Chronic Obstructive Pulmonary Disease Moderate","Chronic Obstructive Pulmonary Disease Severe","Cardiovascular Diseases","Quality of Life",[29,30,31,32,33,34],"COPD","cardiac autonomic integrity","cardiac function","dual bronchodilation","biomarkers","quality of life","RECRUITING","2026-03-28",{"date":38,"type":39},"2026-04-02","ACTUAL",{"date":41,"type":39},"2021-04-15",{"date":43,"type":20},"2026-08-31",{"name":45,"class":46},"Lithuanian University of Health Sciences","OTHER"]