[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-pain-back--neck\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-pain-back--neck":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,80,120,151,175,204,234,276],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100626374","exploring-the-feasibility-of-using-virtual-reality-as-an-educational-tool-in-chronic-pain-rehabilitation-100626374",false,"NCT07434804","Exploring the Feasibility of Using Virtual Reality as an Educational Tool in Chronic Pain Rehabilitation","Inclusion Criteria:\n\n* ≥18 years old\n* Diagnosed with chronic pain by a consultant in pain medicine or a general practitioner with any type of chronic pain for at least 3 months\n* Report a pain intensity of \\>3 on a Numerical Rating Scale\n* Be proficient in written and spoken English\n\nExclusion Criteria:\n\n* Not able to provide informed consent\n* Scheduled for surgical treatment related to their pain condition within the next 6 months\n* Have a medical\u002Fpsychiatric condition that would prevent engagement in the pain education programme","ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","Introduction: Chronic pain significantly impacts quality of life and requires comprehensive management strategies. Traditional pain education programs are beneficial but often require significant and prolonged patient engagement. Virtual reality (VR) offers a novel approach by creating immersive environments that may enhance the effectiveness of pain education. This protocol outlines a feasibility study to investigate the use of a Virtual Reality (VR) pain education program for people living with chronic pain (PwCP).\n\nAim of the investigation: To evaluate the feasibility and acceptability of delivering a VR pain education program for PwCP. The secondary aim will explore the pre-to-post-test changes in clinical outcomes as proof of concept for a future larger scale investigation.\n\nMethods: We will use Reality Health™ as the VR tool to deliver pain science education. The study will be conducted as a single-arm feasibility study using a pretest:posttest design. Fifty PwCP will engage in the six-week Reality Health™ programme. This education programme focuses on the neurophysiology of pain, pain modulation techniques, cognitive-behavioural strategies and guided virtual exercises.\n\nResults: Primary outcome measures will include the feasibility, acceptability and safety of Reality Health™ including recruitment, retention, intervention adherence and attrition rates. Secondary outcomes will explore the pre-to-post-test changes in outcome measures relating to pain intensity, pain interference, pain self-efficacy, pain self catastrophizing, quality of life and depression as proof of concept for a future larger scale investigation.\n\nConclusions: Results will establish the feasibility, acceptability and safety of using Reality Health™ in the treatment of chronic pain, informing a future randomised control trial.\n\nEthical approval: Ethics has been granted from University College Dublin's Human Research Ethics Board (HREC-LS-25-868587).\n\nAcknowledgements: This work is funded through the Interreg north-west Europe project 'Scale-Up Rehab,'approved and funded by the European Commission \\[NWE0100082\\].\n\nDisclosures: None.\n\nKeywords: Virtual Reality, Chronic Pain, Pain Education, Feasibility Study, Protocol",[25,26,27,28,29,30],"Pain","Chronic Pain","Chronic Pain (Back \u002F Neck)","Adults","Virtual Reality","Neuroscience Pain Education",[32,33,34],"Physiotherapy","rehabilitation","Ireland","NOT_YET_RECRUITING","2026-02-19",{"date":38,"type":39},"2026-02-27","ACTUAL",{"date":41,"type":19},"2026-02-20",{"date":43,"type":19},"2026-12-31",{"name":45,"class":46},"University College Dublin","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":20,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100590595","managing-chronic-spinal-pain-with-exercise-and-neuromodulation-100590595","NCT06969456","Managing Chronic Spinal Pain With Exercise and Neuromodulation","Patient-centered Management of Chronic Spinal Pain by Addressing the Peripheral and Central Component With Exercise and Non-invasive Neuromodulation: A Randomized Control Trial (RCT)","UCV\u002FPSPS","Inclusion Criteria:\n\n* Have a diagnostic of PSPS-T2\n* Neuropathic pain (DNA4 ≥ 4)\n* Patients older than 18 years\n* ≥ 6 months with pain\n* VAS score ≥ 7\n\nExclusion Criteria:\n\n* Previous or programmed surgeries in abdominal area\n* Pregnant or lactating\n* Severe fractures or pathologies\n* Spine structural deformity\n* Neurologic or psychiatric issues","70 Years",{"count":58,"type":19},42,[22],"Chronic spinal pain is a multifaceted condition frequently characterized by an absence of discernible structural causes, manifesting in symptoms such as significant disability and diminished quality of life. Persistent Spinal Pain Syndrome Type 2 (PSPS-T2) represents a common variant, implicating both peripheral and central nervous system mechanisms. This study investigates the synergistic effects of transcranial direct current stimulation (tDCS) in conjunction with motor control exercises on PSPS-T2 patients who have not responded to conventional treatments. A randomized controlled trial (RCT) will be conducted to compare an experimental group (tDCS + exercise) with a control group (exercise only), with the objective of enhancing functionality, alleviating pain levels, and improving psychological well-being. The findings may contribute to the development of more effective, patient-centered treatment strategies.",[62,27],"Spinal Pain Syndrome",[64,65,66,67,68,69],"Chronic spinal pain","neuromodulation","motor control exercises","biopsychosocial approach","disability","quality of life","RECRUITING","2025-12-01",{"date":73,"type":39},"2025-12-08",{"date":75,"type":39},"2025-10-27",{"date":77,"type":19},"2027-01-01",{"name":79,"class":46},"Fundación Universidad Católica de Valencia San Vicente Mártir",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":20,"phases":90,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":47},"100602554","a-multicomponent-intervention-for-patients-with-lumbosacral-radiculopathy-move-more-100602554","NCT07125027","A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE","Move-MORE","Inclusion Criteria:\n\n* ● Adults age 18-65 years at the time of enrollment\n\n  * Ability to stand for 10 minutes\n  * Presence of lumbosacral radicular pain within the past week that extends below the knee (i.e., pain radiating from the low back into the leg in a nerve root distribution) with or without accompanying low back pain, of at least 12 weeks' duration, AND\n  * Tampa Scale of Kinesiophobia score ≥ 23\n  * At least one positive physical examination finding consistent with lumbosacral radiculopathy, including at least one of the following:\n\n    * Positive straight leg raise test (eliciting radicular pain below the knee at ≤70 degrees of elevation);\n    * Positive Valsalva maneuver (eliciting radiculcar pain below the knee);\n    * Positive slump test;\n    * Neurological deficit in a lumbar nerve root distribution, including at least one of the following:\n\n      * Dermatomal sensory loss,\n      * Myotomal weakness, or\n      * Reduced or absent deep tendon reflexes (e.g., patellar or Achilles reflex) corresponding to the affected nerve root.\n  * Daily access to the internet via cell phone, tablet, or computer\n  * Willing to engage with Move-MORE 4-5 times per week on your own\n  * Willing to attend a two-hour-long virtual Zoom meeting once per week for eight weeks\n  * Willing to attend two in-person study visits and a follow-up visit\n  * Willing to complete 18 questionnaires pertaining to your pain symptoms, quality of life, psychosocial experiences, and your experiences in the trial\n  * Willing to wear an actigraphy device all day, every day, and while sleeping, for the duration of study participation and willing to keep it charged\n  * Willing to respond to a daily online survey for the duration of study participation\n  * Able to speak, read, and understand the English language\n  * Able to provide written informed consent\n  * Moderately motivated to participate as reported on a numeric rating scale (≥ 4\u002F10)\n\nExclusion Criteria:\n\n* ● Participants will be excluded if they have clinical signs or symptoms of lumbosacral radiculopathy with progressive neurologic deficits (loss of motor or sensory function) or intolerable pain.\n\n  * Participants with lumbosacral radiculopathy with progressive neurologic deficits will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n    ● Participants will be excluded if they have clinical signs or symptoms suggestive of cauda equina syndrome, including any of the following:\n  * New-onset urinary retention or overflow incontinence not attributable to other known causes;\n  * Fecal incontinence;\n  * New onset of saddle anesthesia (loss of sensation in the buttocks, perineum, and inner thighs);\n  * Severe or progressive bilateral lower extremity weakness;\n\n    * Participants with suspected cauda equina syndrome will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n      * Presence of moderate to severe foot drop, defined as noticeable weakness in ankle dorsiflexion that interferes with walking or requires the use of an assistive device (e.g., ankle-foot orthosis). Participants with suspected or worsening foot drop will be referred for further evaluation and are not eligible for study participation.\n      * Current use of a spinal cord stimulator\n      * Have received epidural steroid injection in the prior 3 months\n      * Have received a surgical intervention for low back pain or lumbosacral radiculopathy in the previous 6 months\n      * Current active mindfulness meditation practice 1 time\u002Fweek or more, and\u002For history of formal training in mindfulness\u002Fmeditation practice\n      * Concurrent diagnosis of cancer\n      * Current unmanaged or uncontrolled mental illness known to cause psychosis: schizophrenia, schizotypal disorders, bipolar I disorder with psychosis, major depressive disorder with psychosis\n      * Diagnosis of Borderline Personality Disorder or score \\>6 on the McLean Screening Instrument for Borderline Personality Disorder\n      * Initiation of or changes to an exercise regimen within 2 weeks prior to screening and\u002For enrollment\n      * Major medical or surgical event requiring hospitalization (for any reason other than a minor scheduled medical procedure) within 3 months prior to screening; or, scheduled or will be scheduled to occur within the 20 weeks (i.e., five months) after enrollment\n      * Currently participating in another interventional research study or participated in another interventional study within 2 weeks prior to screening\n      * Any reason the Clinical Investigator or Principal Investigator believes confers increased risk to the potential participant, if they were to enroll in the study","66 Years",{"count":89,"type":19},32,[22],"The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy. The program brings together mindfulness training to help participants develop awareness of their body and manage pain-related stress, gentle movement practice to improve comfort with physical activity and support function, and motivational interviewing to strengthen motivation, confidence, and the ability to make healthy changes.\n\nThe main objectives are to determine whether it is feasible for participants to use each component of the program when delivered online, to assess how acceptable and engaging each component is, and to evaluate the impact on pain, physical function, and daily activity levels. The study intervention will be conducted entirely remotely. Participants will complete online surveys, brief daily check-ins on their phone, and wear a small activity monitor on the hip to measure movement. They will also undergo quantitative sensory testing to evaluate pain sensitivity. At the end of the program, participants will share feedback about their experiences via qualitative interviews.\n\nThe findings will help identify which parts of the program provide the greatest benefit, with the ultimate goal of developing a more targeted and effective digital program for people with this condition.",[93,94,95,96,27],"Lumbosacral Radiculopathy","Sciatica","Chronic Low Back Pain With a Neuropathic Component","Radiculopathy Lumbar",[98,99,100,101,102,103,104,105,106,93,107,108,109,110],"Mindfulness","Physical Activity","Motivational Interviewing","Meditation","Tai Chi\u002FQi Gong","Movement","Mindfulness-Oriented Recovery Enhancement","Mindfulness-Based Interventions","Radiculopathy","Lumbar Radiculopathy","Chronic low back pain","Low back pain","Back Pain","2025-11-10",{"date":113,"type":39},"2025-11-12",{"date":115,"type":39},"2025-08-15",{"date":117,"type":19},"2026-11",{"name":119,"class":46},"National University of Natural Medicine",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":20,"phases":130,"briefSummary":131,"conditions":132,"keywords":136,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":150},"100606704","evaluating-the-auricular-point-acupressure-self-management-program-for-chronic-musculoskeletal-pain-among-rural-populations-100606704","NCT07179016","Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations","A Pragmatic, Randomized Controlled Trial of a Auricular Point Acupressure - Self-Management (APA-SM) Program for Chronic Musculoskeletal Pain Among Rural Populations.","Inclusion Criteria:\n\n* Receive any pain management for CMP (neck, back, shoulder, hands, hips, knees, feet)\n* Have CMP ≥ 4 on a scale of 0-10 that has persisted for at least 3 months or has resulted in pain on at least half the days in the past 6 months\n\nExclusion Criteria:\n\n* Severe ear skin disorder (Diagnosed with conditions e.g., eczema, lupus with skin involvement) which often require medical intervention and severe allergy to tape\n* Inability or unwillingness to provide informed consent\n* Use of some type of hearing aid where size may obstruct seed placement\n* Not living in rural area","85 Years",{"count":129,"type":19},693,[22],"The investigators will test an Auricular Point Acupressure Self-Management (APA-SM) program integrated into rural primary and specialty care and rural communities for chronic musculoskeletal pain (CMP). To maximize self-management of pain, the investigators developed a smartphone app which will allow the participants to learn to self-administer APA. The investigators will have 3 arms (APA-SM self-guided with remote training, APA-SM with in-person training, and Education Control) with 231 participants per arm (total=693 for 3 arms). The investigators will evaluate the clinical effectiveness of our 4-week APA-SM intervention compared to control in primary outcomes (pain intensity, pain interference, activity), secondary outcomes (HEAL Clinical Pain Core common data elements), and analgesic use up to 6 months follow-up.",[27,133,134,135],"Chronic Pain Management","Chronic Knee Pain","Joint Pain",[26,137,138,139,140],"Rural population","Self-management","Chronic musculoskeletal pain","Auricular point acupressure","2025-09-24",{"date":143,"type":39},"2025-10-01",{"date":145,"type":39},"2025-09-11",{"date":147,"type":19},"2029-08-31",{"name":149,"class":46},"The University of Texas Health Science Center, Houston",3,{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":20,"phases":160,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":47},"100608221","effect-of-virtual-reality-and-trans-auricular-x-vagus-nerve-stimulation-for-anxiety-and-depression-in-chronic-shoulder-pain-patients-100608221","NCT07198737","Effect of Virtual Reality and Trans Auricular X-Vagus Nerve Stimulation for Anxiety and Depression in Chronic Shoulder Pain Patients","VIRTAX-ADSP","Inclusion Criteria:\n\n* Aged over 18.\n* Ability to understand English\n* Ability to provide informed consent and attend in-person sessions\n* Chronic shoulder pain (pain lasting for at least 6 months) waiting on surgical pathway.\n* Comorbid mild-to-moderate anxiety or depression\n* Referred by a consultant orthopaedic surgeon.\n* Unresponsive to conventional treatment for 6 months including antidepressants, physiotherapy, and\u002F or oral analgesics\n* Mean NRS pain score ≥ 5 on most or all days either continuously or in motion\n\nExclusion Criteria:● Inability to understand English and consent process\n\n* History of significant neurological or psychiatric conditions unrelated to chronic pain (e.g., epilepsy, psychosis, schizophrenia).\n* Skin lesions or piercing or extensive tattooing of the concha or Skin disease: infection, eczema or cancer of the ears or skin in region where VR headset or taVNS would sit\n* Presence of active implants (e.g. cochlear implant, implanted vagus nerve stimulator, cardiac pacemaker, implantable cardioverter defibrillator (ICD) deep brain stimulations or spinal cord stimulators, ventriculoperitoneal (VP) shunt).\n* Inability to tolerate VR (e.g., severe motion sickness, vertigo or balance issues, claustrophobia).\n* Fear of heights\n* Active infections, significant trauma, or other acute conditions affecting the shoulder.\n* Pregnancy and women trying actively to conceive\n* Pre-existing Persistent post-surgical pain-(\\>6 months) from surgeries other than shoulder replacements\n* On- going alcohol and\u002F or drug problem\n* Widespread chronic pain conditions (fibromyalgia, complex regional pain syndrome)\n* Involvement in any clinical studies within the last 28 days prior to assessment\n* Other therapies such as other psychological interventions for A\u002FD and pain in the shoulder are not allowed for the period of the study and follow up unless there is a psychiatric emergency. Participants may also not be involved in any trial on pain management or related to shoulders while participating in this VR\u002FVNS trial.",{"count":159,"type":19},10,[22],"Chronic shoulder pain is a debilitating condition that significantly impacts quality of life, daily functioning, and mental well-being. For individuals awaiting surgical intervention for a long period, prolonged pain often leads to heightened psychological distress, poor sleep quality, and reduced overall health outcomes. Innovative approaches are urgently needed to address these challenges and improve preoperative management.\n\nThis study will combine 2 technologies which have both been shown to help relax and calm users.\n\nTranscutaneous Auricular Vagus Nerve Stimulation (taVNS) is\n\n* a gentle non-invasive therapy that uses a small device to send tiny electrical pulses to a spot on your outer ear. The principle of using electrical pulses are similar to pacemaker or TENS machines.\n* These pulses help stimulate a special nerve called the vagus nerve, which is like a superhighway between your brain and your body\n\nYour vagus nerve helps control:\n\n* Your mood and anxiety levels\n* Healing of nerves and other organs in the body\n* How your body handles pain\n* Digestion, heart rate, and more By stimulating the vagus nerve, taVNS can help your body relax, reset, and feel better.\n\nWhile virtual reality (VR) has demonstrated effectiveness in distracting from pain and improving psychological resilience.\n\nThese two will be combined so that the participant experiences a relaxing VR environment that helps them control their breathing while receiving taVNS. With the aim of managing chronic pain by targeting both physical and psychological dimensions.\n\nThis study aims to evaluate the feasibility and safety, of a trial of taVNS paired with VR looking at trial recruitment, retention and compliance. Secondary to this the study will look to see if there is evidence of taVNS +VR in reducing pain, enhancing psychological well-being, and improving quality of life for individuals with chronic shoulder pain awaiting surgery. It will provide critical insights into the potential of this combined intervention as a preoperative and potentially post operative pain management strategy.",[27],[164],"VR VNS","2025-09-22",{"date":167,"type":39},"2025-09-30",{"date":169,"type":19},"2025-11-01",{"date":171,"type":19},"2026-08-01",{"name":173,"class":174},"East Kent Hospitals University NHS Foundation Trust","OTHER_GOV",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":56,"enrollmentInfo":183,"targetDuration":4,"studyType":20,"phases":185,"briefSummary":186,"conditions":187,"keywords":188,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":202,"locationsCount":4},"100603214","effectiveness-of-a-pain-neuroscience-education-and-therapeutic-exercise-program-delivered-by-primary-care-physiotherapists-to-patients-with-chronic-nociplastic-spinal-pain-100603214","NCT07133607","Effectiveness of a Pain Neuroscience Education and Therapeutic Exercise Program Delivered by Primary Care Physiotherapists to Patients With Chronic Nociplastic Spinal Pain","Effectiveness of a Pain Neuroscience Education and Therapeutic Exercise Program Delivered by Primary Care Physiotherapists to Patients With Chronic Nociplastic Spinal Pain: a Multicenter Randomized Controlled Trial.","AP-AADC","Inclusion Criteria:\n\n* Users of the Public Health System of Andalusia, registered in the User Database (BDU) of the Sevilla Health District.\n* Ages between 18 and 70.\n* Chronic lumbar pain lasting more than 3 months, likely due to central sensitization (likely nociplastic pain).\n* The diagnosis of Central Sensitization will be made according to the most recent algorithm published by Nijs et al. in Lancet.\n\nExclusion Criteria:\n\n* Oncological pain (pain related to cancer)\n* Spinal fracture or spinal surgery in the previous year.\n* Neurological cognitive impairment that prevents understanding of pain neuroeducation (if in doubt, the Minimental Test will be performed, requiring a minimum score of 25)\n* Physical conditioning deficit that prevents the execution of the Physical --Education program (minimum requirement: normal execution time of \\\u003C10 seconds for the timed \"Up and Go\" test).\n* Pregnancy\n* Cauda equina syndrome\n* Chronic fatigue syndrome\n* Fibromyalgia\n* Complex Regional Pain Syndrome\n* Clinical conditions that may aggravate chronic spinal pain.\n* Associated pathologies that prevent the performance of a physical exercise program (myopathies and neurological disorders).\n* Currently undergoing alternative therapies.\n* The presence of pain in other anatomical regions, apart from spinal pain, is not a reason for exclusion.",{"count":184,"type":19},135,[22],"The main objective of the project is to evaluate the effectiveness, in terms of quality of life, of a therapy based on an Active Coping Protocol for Non-Cancer Chronic Pain in the Primary Care setting. This approach involves no medications or invasive procedures and is based on pain neuroscience education and physical exercise, either alone or combined with treatment targeting body schema and somatosensory disturbances. The comparison will be made against a treatment involving thermotherapy and traditional physical exercise.\n\nOne of the most well-documented national primary care experiences combining pain neuroeducation and physical exercise, with a detailed methodology, was carried out by the Health System of Castilla y León (Sacyl) in Valladolid. It yielded significant results using a protocol consisting of 6 sessions of pain neuroscience education and 18 sessions of group exercise.\n\nBased on this reference study, two hypotheses are proposed: the first is that reducing the number of sessions in the Active Coping Protocol for Chronic Pain would maintain treatment effectiveness. The second hypothesis suggests the potential for improved outcomes by combining the Active Coping Protocol with body schema and somatosensory disturbance treatment.\n\nTo test these hypotheses, a randomized experimental study with three parallel groups will be conducted on patients aged 18 to 70, referred to Physiotherapy from health centers in the Sevilla Health District. These patients experience daily spinal chronic pain for more than 3 months or on at least half of the days over more than 6 months, with central sensitization as the underlying cause.\n\nEffectiveness will be measured in terms of quality of life (SF-36), pain intensity (Visual Analog Scale), satisfaction level, kinesiophobia, catastrophizing, pressure pain threshold, disability index (NDI\u002FOswestry), medication reduction, and number of monthly medical appointments.\n\nSecondary objectives include evaluating, in both experimental groups compared to the control, the outcome variables: pain intensity, treatment adherence, kinesiophobia, catastrophizing, pressure pain threshold, descending modulation system, lumbar disability index, severity level, anxiety, sleep quality, analgesic consumption, healthcare visits, and satisfaction with care received.\n\nA sample size of 135 patients has been calculated and will be randomized into the three study groups. The control group will receive thermotherapy-electrotherapy and conventional therapeutic exercise. Experimental group 1 will follow the Active Coping Program for Chronic Pain (4 education sessions and 12 physical exercise sessions). Experimental group 2 will receive somatosensory and body schema treatment along with the Active Coping Program.\n\nThe study is evaluator-blinded. Statistical analysis will be performed using SPSS version 28 and R Core Team (2023). Statistical significance will be set at p-values \\\u003C0.05. Authorization will be requested from the relevant Research Ethics Committee.\n\nThe results of this study may lead to updates of existing protocols, development of guidelines and manuals for managing chronic musculoskeletal pain, ongoing training for primary care professionals, and publication in high-impact scientific journals to disseminate knowledge.",[27],[189,190,191,192,193,194,195,196],"pain chronic","central sensibilitation","public health system","pain education","physiotherapy","somatosensory","body outline","therapeutic physical exercise","2025-09-05",{"date":145,"type":39},{"date":200,"type":19},"2025-09-01",{"date":43,"type":19},{"name":203,"class":46},"Distrito de Atención Primaria Sevilla",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":20,"phases":214,"briefSummary":215,"conditions":216,"keywords":222,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":47},"100591740","digitally-delivered-treatments-to-reduce-chronic-low-back-pain-100591740","NCT06984354","Digitally Delivered Treatments to Reduce Chronic Low Back Pain","NOTUS Trial: A Randomised Controlled Trial of Two Digitally Delivered Treatment Options for Chronic Back Pain","NOTUS","Inclusion Criteria:\n\n* Experiencing non-specific chronic low back pain (LBP), defined as pain between the 12th rib and the buttock crease.\n* LBP with or without leg pain (in case of leg pain, LBP is worse than leg pain).\n* Currently consulting with a general practitioner for their non-specific chronic LBP across Australia.\n* Mean pain intensity score on the Numeric Rating Scale ≥ 3\u002F10 in the past week.\n* A score of at least moderate on question 8 of the physical functioning component of the SF-36 questionnaire.\n* Access to a mobile device with minimal requirements to download the study app (300MB).\n* An internet connection to access the mobile app functionalities.\n* Able to understand English via reading and audio materials.\n\nExclusion Criteria:\n\n* Known or suspected specific spinal (e.g., radiculopathy, fracture) or specific non-spinal non- (e.g., tumour, infection) pathology.\n* Less than six months post-spinal surgery.\n* Scheduled for major surgery during the program or the follow-up period.\n* Known or suspected serious psychiatric condition not being treated by a health professional that would impact adherence to the trial activities.\n* Known or suspected sight or hearing problems that would limit access to the intervention components (reading and listening using headphones).",{"count":213,"type":19},720,[22],"This study aims to evaluate the effectiveness of pain education and clinical hypnosis delivered via a mobile app compared to a guideline-informed factsheet for reducing pain and disability in people experiencing chronic low back pain attending general practice.",[217,27,218,219,220,221],"Low Back Pain","General Practice (GP), Primary Care Settings","Digital Health","Hypnosis, Chronic Pain Management","Patient Education",[110,219,223,224,26],"Hypnosis","Pain Education","2025-07-16",{"date":227,"type":39},"2025-07-20",{"date":229,"type":39},"2025-06-02",{"date":231,"type":19},"2028-05-26",{"name":233,"class":46},"Neuroscience Research Australia",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":15,"minAge":242,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":20,"phases":245,"briefSummary":246,"conditions":247,"keywords":250,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":47},"100593162","nature-based-intervention-for-chronic-pain-in-older-people-100593162","NCT07002853","Nature-based Intervention for Chronic Pain in Older People","Nature-based Intervention Program for Sustainable Health in Older People Living With Chronic Non-specific Lower Back Pain (PARC Project 2) - A Feasibility Trial","PARC-2","Inclusion Criteria:\n\n* Aged 65 years +\n* Having low back pain for 3 months or more\n* Being able to walk independently\n* Mental state \\>25\u002F30 in the MMSE questionnaire\n* Frailty score \\\u003C3\u002F5 (Fried criterias)\n\nExclusion Criteria:\n\n* Presenting other severe musculoskeletal, cardiovascular, or neurological conditions, or systemic diseases (e.g., cancer).","65 Years",{"count":244,"type":19},15,[22],"The goal of this clinical trial is to learn if a nature-based intervention program has positive effects on the physical and psychosocial health in a group of older participants with chronic non-specific lower back pain. The main questions it aims to answer are:\n\nWill the program improve:\n\n* The physical outcomes such as mobility, strength and balance?\n* The psychosocial health outcomes?\n\nParticipants will:\n\n* Be assessed before and after the program;\n* Participate in one session per week of the intervention.",[248,27,249],"Chronic Disease","Older Adults (65 Years and Older)",[251,252,253,254,255,256,257,258,259,260,261,98,101,262,263,264,265,266],"Aging","Chronic pain","Non-specific low back pain","Nature-based interventions","Falls","Forest bathing","Shinrin-yoku","Social","Nature connectedness","Functionning","Physical activity","Rehabilitation","Postural control","Strength","Quality of life","Balance","2025-05-24",{"date":269,"type":39},"2025-06-04",{"date":271,"type":39},"2025-05-22",{"date":273,"type":19},"2026-12-01",{"name":275,"class":46},"Université du Québec à Chicoutimi",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":15,"minAge":283,"maxAge":284,"enrollmentInfo":285,"targetDuration":4,"studyType":20,"phases":287,"briefSummary":288,"conditions":289,"keywords":291,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":47},"100585733","low-intensity-focused-ultrasound-for-chronic-pain-high-resolution-targeting-of-the-human-insula-100585733","NCT06906211","Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula","LIFU_Pain","Inclusion Criteria:\n\n* Veterans aged 21 to 75 with Chronic Back Pain (CBP).\n* CBP duration daily for last 3 months or half of days for last 6 months\n* Endorse pain rating of 4\u002F10 BPI-SF\n* Evidence of widespread pain symptoms as determined by report of CBP and pain in a contralateral limb (pain in the upper, lower, left or right side of the body) in fewer than 11 sites. Upper body sites include hand, wrist, elbow or shoulder. Lower sites include hip, knee, ankle or foot.\n\nExclusion Criteria:\n\n* Surgery recommended as primary treatment intervention for CBP\n* Current diagnosis of fibromyalgia\n* Current substance use disorder other than nicotine.\n* Psychiatric disorder and not on a stable pharmacologic regimen for ≥ 4 weeks prior to screening\n* Opiate use daily\n* Currently pregnant or breast feeding.\n* Unable to understand the consent form.\n* History of head injury with loss of consciousness for more than 5 minutes, seizures, history of stroke, brain surgery, brain tumor, multiple sclerosis.\n* History of metastatic cancer, rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus, or polymyositis\n* Unintended weight loss of 20 pounds or more in the last year\n* Cauda equina syndrome\n* Ferromagnetic implants or other contraindications for MRI\n* Uncompensated congestive heart failure, unstable angina, poorly controlled arrhythmia, active systemic infection end stage renal disease.","21 Years","75 Years",{"count":286,"type":19},66,[22],"In this study, the research team will use low-intensity focused ultrasound (LIFU) to temporarily change brain activity in a brain region that is known to be involved in chronic pain. Through this, the research team hopes to learn about how the brain area works in response to pain. There are main questions this study aims to answer:\n\n* The effect of LIFU to inhibit the posterior region of the insula (PI) compared to sham stimulation in individuals with chronic back pain (CBP) and widespread pain symptoms.\n* The effect of LIFU to PI compared to sham stimulation to reduce pain intensity and magnitude of the Neurologic Pain Signature (NPS) in response to evoked thermal pain.\n* The effect of LIFU to PI compared to sham stimulation to reduce pain intensity and magnitude of Tonic Pain Signature in response to tonic pain.",[290,27],"Chronic Back Pain",[292,293,294,295],"low intensity focused ultrasound","chronic back pain","chronic pain","functional magnetic resonance imaging","2025-03-25",{"date":298,"type":39},"2025-04-02",{"date":300,"type":39},"2025-01-15",{"date":302,"type":19},"2028-01-26",{"name":304,"class":305},"Washington D.C. Veterans Affairs Medical Center","FED"]