[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-pain-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-pain-postoperative":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100639547","quality-of-life-and-pain-after-appendectomy-in-children-100639547",false,"NCT07629362","Quality of Life and Pain After Appendectomy in Children","Chronic Postoperative Pain After Appendectomy: A Prospective Observational Study","CAPA-Peds","Inclusion Criteria:\n\nChildren between the ages of 8-18 years who underwent appendectomy, who had ASA physical status I-II\n\nExclusion Criteria:\n\nChildren who aged under 8 and over 18 years, who had American Society of Anesthesiologists (ASA) physical status III or higher, who had a history of previous surgery in the right lower abdominal quadrant, who had psychiatric disorders, who had preoperative chronic abdominal pain",true,"ALL","8 Years","18 Years",{"count":22,"type":23},231,"ESTIMATED","3 Months","OBSERVATIONAL","Acute appendicitis is one of the most common emergency general surgical conditions worldwide and represents the leading cause of emergency abdominal surgery in children. In some cases, appendectomy may result in persistent or recurrent pain in the right iliac fossa, which may negatively affect quality of life, particularly in children. The primary aim of this study is to determine the prevalence of chronic pain at the third postoperative month in pediatric patients who underwent appendectomy. The age, sex, body mass index, and comorbidities of patients aged 8-18 years who underwent appendectomy will be recorded. Pain in children who met the inclusion criteria was assessed using the Numeric Rating Scale (NRS). To evaluate the effects of pain on quality of life, the child and parent versions of the Pediatric Quality of Life Inventory (PedsQL) were administered at the third postoperative month. In addition, the Functional Disability Inventory (FDI) was used at the third postoperative month to assess the impact of pain on the patient's functional status.",[28,29,30,31,32],"Chronic Pain, Postoperative","Quality of Life","Functional Ability","Appendectomy","Numerical Rating Scale",[34,35,36,37],"chronic pain","appendectomy","FDI","PedsQL","NOT_YET_RECRUITING","2026-06-04",{"date":41,"type":42},"2026-06-05","ACTUAL",{"date":44,"type":23},"2026-07-01",{"date":46,"type":23},"2027-02-25",{"name":48,"class":49},"Kocaeli City Hospital","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":59,"targetDuration":61,"studyType":25,"phases":4,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":50},"100639847","early-screening-of-chronic-post-sternotomy-pain-using-the-dn4-i-questionnaire-100639847","NCT07603271","Early Screening of Chronic Post-sternotomy Pain Using the DN4-i Questionnaire","Association Between Early Neuropathic Pain and Chronic Post-Sternotomy Pain After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study","DEPDN4i","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled cardiac surgery with coronary artery bypass via median sternotomy with internal mammary artery harvesting\n* Patients receive an information sheet and a non-opposition form.\n\nExclusion Criteria:\n\n* History of sternotomy\n* Early reoperation \\\u003C 30 days\n* Chronic treatment with strong opioids or neuropahtic pain medications\n* Severe cognitive impairment\n* Patients under legal protection or guardianship",{"count":60,"type":23},120,"6 Months","Chronic post-sternotomy pain (CPSP) is a common complication after cardiac surgery, with a reported prevalence between 30% and 50%. Several studies show that a significant proportion of patients experience persistent pain long after cardiac surgery, often with a neuropathic component. Internal mammary artery harvesting is known to cause intercostal nerve injury. Recent data suggest that early neuropathic pain, assessed using the DN4 score, may predict the chronicization of postoperative pain.\n\nThis study is a prospective observationnal study to evaluate the association between early neuropathic pain (DN4-i ≥ 3\u002F7 on postoperative day 5) and the occurrence of chronic post-sternotomy pain at 3 months in patients who underwent median sternotomy for coronary artery bypass grafting with internal mammary artery harvesting",[28,64],"Sternotomy Pain",[66],"Early and chronic neuropathic pain","2026-05-19",{"date":69,"type":42},"2026-05-22",{"date":71,"type":23},"2026-05-03",{"date":73,"type":23},"2027-11-03",{"name":75,"class":76},"Institute Arnault Tzanck, France","OTHER",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100571571","effect-of-preventive-analgesia-with-oxycodone-and-parecoxib-sodium-on-the-chronification-of-acute-post-operative-pain-100571571","NCT06721988","Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain","Exploring the Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Pain in Adult Patients Underwent Laparoscopic-assisted Abdominal Major Surgery","AOPC","Inclusion Criteria:\n\n* ASA I\\~III；\n* BMI ranging from 18 to 28 kg\u002Fm²；\n* For elective laparoscopic-assisted major abdominal surgery under general anesthesia;\n* Estimated surgical duration (from incision to the last suture of the skin) was at least 2 hours.\n\nExclusion Criteria:\n\n* Pregnant or lactating patients;\n* Patients diagnosed with septic shock or multiple organ failure within 14 days;\n* Patients with preoperative severe electrolyte disorders;\n* Patients with stroke, transient ischemic attack, or other similar events within the past 3 months\n* Patients with unstable angina, myocardial infarction within the past 3 months; or presence of untreated arrhythmia or arrhythmia not well-controlled with treatment;\n* Patients with diabetes, uncontrolled blood glucose levels, or diabetes complications such as diabetic ketoacidosis, hyperosmolar coma, diabetes-related infections, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic peripheral neuropathy, diabetic foot, etc. before the surgery;\n* Patients with severe liver dysfunction (Child-Pugh score \\> 6), renal dysfunction (GFR \\\u003C 90 ml\u002F(min•1.73m²));\n* Exploratory surgeries, day surgeries, or surgeries that only involve opening and closing the abdomen;\n* Blood pressure ≥180\u002F110 mmHg at rest (≥Grade 3 hypertension according to the 2020 ISH Hypertension Guidelines); or systolic blood pressure \\\u003C90 mmHg or mean blood pressure \\\u003C65 mmHg;\n* Patients participated in other drug trials within the past 3 months;\n* Patients with communication difficulties, inability to understand pain scores or patient-controlled intravenous analgesia;\n* Patients with consciousness disorders or other psychiatric illnesses;\n* Patients with a confirmed or suspected history of substance abuse or long-term use of anesthetic sedatives and analgesics;\n* Cancer patients have received neoadjuvant treatment or chemotherapy preoperatively;\n* Allergic to the drugs used in this trial and their components.","65 Years",{"count":87,"type":23},1316,"INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery. The main question it aims to answer is:\n\n• Does administration of oxycodone before surgical incision reduce the occurrence of chronic pain or relieve the chronic pain symptoms 3 months after the operation? Researchers will compare oxycodone + parecoxib sodium to placebo + parecoxib sodium combinations to see if oxycodone works to reduce the chronification of acute postoperative pain.\n\nParticipants will:\n\n* Take oxycodone + parecoxib sodium or placebo + parecoxib sodium combinations before the surgical incision\n* Cooperate with the follow-up staffs and complete some checkups or tests within 3 months after the operation.",[93,28],"Oxycodone",[93,95,96],"Preventive analgesia","Chronification of acute postoperative pain","2024-12-03",{"date":99,"type":42},"2024-12-09",{"date":101,"type":23},"2025-01-01",{"date":103,"type":23},"2027-04-30",{"name":105,"class":76},"Ailin Luo"]