[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-pain-widespread\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-pain-widespread":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,62,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":61},"100587531","shiatsu-for-chronic-non-inflammatory-pain-in-children-and-adolescents-100587531",false,"NCT06929598","Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents","The Efficacy of Adjunctive Shiatsu Therapy for Non-Inflammatory Chronic Pain in Pediatric Patients: A Single-Arm Prospective Trial","ShiQoL","Inclusion Criteria:\n\n* Children and adolescents aged 10-18 years\n* Diagnosed with non-inflammatory chronic pain syndromes\n* Actively followed by the Pediatric Rheumatology and\u002For Pediatric Pain Clinics at Tel Aviv Sourasky Medical Center (at least twice a year)\n* Informed consent signed by at least one legal guardian (or both guardians in cases of separated parents)\n* If participant is 16 years or older, they must also sign the informed consent\n\nExclusion Criteria:\n\n* Informed consent cannot be obtained from the participant or their legal guardians\n* Legal guardians unable to provide informed consent\n* Patients with severe conditions (e.g., bone metastasis)\n* Patients unable to participate in Shiatsu therapy sessions\n* Participation in Shiatsu therapy within 6 months prior to study enrollment\n* Participant or legal guardian refuses participation","ALL","10 Years","18 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if adding Shiatsu therapy to standard treatment can improve quality of life in children and adolescents with chronic pain that is not caused by inflammation. The main question it aims to answer is: Does Shiatsu therapy help improve the quality of life in children with long-lasting pain?\n\nAll participants will continue their regular treatment and will also:\n\n* Receive a 30-minute Shiatsu session once a week for six weeks\n* Complete questionnaires about their quality of life and family impact before, during, and after the treatment period\n\nThe study includes about 40 participants between the ages of 10 and 18, who are already being followed at the pediatric pain and rheumatology clinics at Tel Aviv Sourasky Medical Center.",[28,29,30,31,32,33,34,35],"Chronic Pain","Chronic Pain Syndrome","Chronic Pain and Comorbid Emotional Problems","Chronic Pain, Psychogenic","Chronic Pain, Widespread","Fibromyalgia","Fibromyalgia Syndrome","Functional Pain",[37,38,39,40,41,42,43,44,45,46,47,35,48],"Shiatsu","Complementary and Integrative Medicine","Pediatric Chronic Pain","Non-inflammatory Pain","Quality of Life","PedsQL","Adolescent Pain","Manual Therapy","Mind-Body Therapy","Pediatric Rheumatology","Integrative Medicine","Pain Management","RECRUITING","2025-08-27",{"date":52,"type":53},"2025-09-04","ACTUAL",{"date":55,"type":53},"2025-05-01",{"date":57,"type":22},"2027-04-30",{"name":59,"class":60},"Tel Aviv University","OTHER",2,{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":23,"phases":73,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100599226","person-centred-ai-support-in-interdisciplinary-rehabilitation-for-chronic-pain-100599226","NCT07081737","Person-Centred AI Support in Interdisciplinary Rehabilitation for Chronic Pain","The Future of Pain Management: Can Person-centred and Precision AI-Based Decision Support Enhance Interdisciplinary Rehabilitation for Chronic Pain?","pAIn","Inclusion Criteria:\n\n* Aged 18 to 67 years\n* Diagnosed with chronic non-malignant pain persisting longer than 3 months\n* Pain condition includes, but is not limited to: fibromyalgia, widespread pain, back pain, neck pain, or shoulder pain\n* Eligible for and referred to interdisciplinary rehabilitation (IDT) at a participating clinic\n* Willing and able to participate in digital assessment and follow-up procedures\n* Able to communicate and complete study materials in Swedish\n* Provides written informed consent\n\nExclusion Criteria\n\n* Pain caused by malignancy or cancer-related treatment\n* Pain caused by systemic diseases such as rheumatoid arthritis, lupus, or other autoimmune or inflammatory conditions\n* Severe psychiatric conditions interfering with study participation (e.g., untreated psychosis or severe depression requiring immediate psychiatric care)\n* Documented cognitive impairment limiting ability to understand study participation or complete self-reported measures\n* Currently enrolled in another interventional clinical trial that may confound the outcomes of this study\n* Not expected to remain in the clinic's follow-up system for the duration of the study","67 Years",{"count":72,"type":22},400,[25],"This cluster randomized controlled trial evaluates whether a person-centred, AI-supported Clinical Decision Support System (CDSS) can improve outcomes and cost-effectiveness in interdisciplinary rehabilitation for people with complex chronic pain. The CDSS is designed to assist clinicians in making personalized treatment decisions within standard interdisciplinary treatment (IDT). It has been developed using machine learning models trained on real-world data from over 100,000 patients in the Swedish Quality Registry for Pain Rehabilitation (SQRP), linked to several national registers, including the National Patient Register, the Prescribed Drug Register, the Social Insurance Agency database (MiDAS), and the Cause of Death Register. This enables individualized predictions of treatment outcomes, work ability, and healthcare utilization.\n\nThe trial includes 400 adult patients with chronic pain, enrolled at 20 IDT clinics randomized to either CDSS-supported or standard IDT. The study has three phases: feasibility, effectiveness, and implementation. The primary outcome is a patient-prioritized composite single-index of health-related well-being, based on domains such as pain, sleep, physical and mental health, emotional distress, and work ability. Patients prioritize these domains together with their clinical team, enabling a person-centred assessment. Secondary outcomes include HRQoL (EQ-5D, SF-36), emotional distress (HADS), and work ability (WAI), measured at baseline, post-treatment, 6- and 12-month follow-up.\n\nA parallel mixed-methods process evaluation will examine implementation outcomes such as usability, clinician adherence, and workflow integration, using logs, surveys (e.g., S-NoMAD), and interviews. Normalization Process Theory guides the analysis. Cost-utility will be assessed using QALYs and ICERs from a societal perspective, with long-term projections using simulation models. Results will be reported in peer-reviewed publications.",[76,32,48],"Pain, Chronic",[78,79,80,81,82,83],"chronic pain","prediction","Artificial Intelligence","Interdisciplinary pain rehabilitation","Machine learning","Clinical Decision Support System (CDSS)","NOT_YET_RECRUITING","2025-07-16",{"date":87,"type":53},"2025-07-23",{"date":89,"type":22},"2026-05-01",{"date":91,"type":22},"2029-03-31",{"name":93,"class":60},"Bjorn Ang",1,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":5},"100577214","chronic-widespread-pain-after-rapid-weight-loss-in-non-hispanic-black-and-hispaniclatinoax-adults-100577214","NCT06795386","Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic\u002FLatino\u002Fa\u002Fx Adults","Determining Mechanisms of Pain Reduction in Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic\u002FLatino\u002Fa\u002Fx Adults","Inclusion Criteria:\n\n* Self-identify as Black\u002FAfrican American or Hispanic\u002FLatino ethnicity based on the U.S Census racial categories\n* Eligible candidates for bariatric surgery (BMI greater than or equal to 40 or BMI greater than or equal to 35 with comorbidity\n* Meets criteria for chronic widespread pain (CWP) based on the following:\n\n  1. self-reported pain at 3 or more anatomical sites\n  2. painful regions on both sides of the body\n  3. self-reported pain intensity at rest of 3 out of 10 or higher using the Numeric Pain Rating Scale (NPRS) or equivalent\n* Conversational language fluency in English or Spanish\n* Able to give voluntary, written informed consent to participate\n* Able to walk independently or with a cane prior to study enrollment\n\nExclusion Criteria:\n\n* Prospective participants with a previous history of bariatric surgery\n* Have acute pain (pain for less than 6 weeks) at 1 month prior to study enrollment\n* Have a systemic autoimmune disorder or immunodeficiency\n* Have an unstable psychological condition\n* Are non-ambulatory or ambulate with an assistive device other than a cane\n* Pain localized to surgical sites at 3 months post-surgery","75 Years",{"count":104,"type":22},60,"OBSERVATIONAL","The goal of this observational study is to learn if surgical weight loss can improve chronic widespread pain in people living with higher BMI who self-identify as Hispanic\u002FLatino ethnicity or non-Hispanic Black based on the United States census racial categories. The main questions the study aims to answer are:\n\n1. Do pain at rest (primary outcome) and movement-evoked pain (secondary outcome) improve after bariatric surgery?\n2. Do pain processing and joint function change after bariatric surgery?\n3. Are pain processing and joint function associated with clinically significant pain change after surgical weight loss?\n\nResearchers will compare pain and function before and 6 months after bariatric surgery in a single cohort.",[32,108,109],"Obesity","Bariatric Surgery Candidate",[111],"chronic pain, adult obesity, pain equity, rehabilitation","2025-01-22",{"date":114,"type":53},"2025-01-28",{"date":116,"type":53},"2023-10-09",{"date":118,"type":22},"2028-03",{"name":120,"class":60},"New York University"]