[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-post-operative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-post-operative-pain":153},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,45,67,93,117,138,163,190,212,238],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100551965","understanding-the-acute-pain-phenotype-in-patients-undergoing-surgery-100551965",false,"NCT06466941","Understanding the Acute Pain Phenotype in Patients Undergoing Surgery","Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain","Inclusion Criteria:\n\n* Age ≥ 18\n* English speaking\n* Surgical or procedural patient who will be admitted postoperatively\n* Willingness to answer psychosocial survey and\u002For audio recorded semi-structured interview\n\nExclusion Criteria:\n\n-Cognitive dysfunction that precludes communication","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.\n\nThe main questions are:\n\n1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia?\n2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery?\n3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?",[24,25,26],"Acute Pain","Chronic Post Operative Pain","Opioid Use",[28,29,30,31],"regional anesthesia","peripheral nerve blocks","psychosocial phenotype","pain catastrophizing","RECRUITING","2026-05-20",{"date":35,"type":36},"2026-05-22","ACTUAL",{"date":38,"type":36},"2024-07-03",{"date":40,"type":20},"2028-12-31",{"name":42,"class":43},"Brigham and Women's Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":17,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100501970","longitudinal-study-of-chronic-postsurgical-pain-in-children-and-adolescents-100501970","NCT05816174","Longitudinal Study of Chronic Postsurgical Pain in Children and Adolescents","Child and Parent Emotion-related Risk and Resilience Factors Associated With the Transition From Acute to Chronic Pain After Surgery: A Prospective Longitudinal Study","Inclusion Criteria:\n\n* Children and adolescents aged between 8 and 18 years\n* Planned orthopedic surgery requiring in-patient care in one of the participating children's hospitals\n* Able to read and understand German\n\nExclusion Criteria:\n\n* Serious comorbid health condition (e.g., cancer, severe neurological impairment, chronic illness requiring daily medication)\n* Prior major orthopedic surgery (e.g., prior spine surgery)\n* Parent\u002Fcaregiver and child not able to read and understand German","8 Years",{"count":54,"type":20},281,"Chronic postsurgical pain is defined as pain that develops or intensifies following a surgical procedure. After major surgery, around 20% of children and adolescents develop chronic postsurgical pain, and, as part of it, negative consequences on their quality of life. Emotion-related factors such as the variability of emotions, how emotions are regulated, and how well someone is able to differentiate between different emotions have in part been studied in other types of chronic pain. To date, no study examined emotion-related factors in the development and maintenance of chronic postsurgical pain. This observational study includes five assessment time points, one before and four after major surgery, with the goal to identify emotion-related factors that increase or decrease the risk for the development of chronic postsurgical pain.",[25],"2026-04-28",{"date":59,"type":36},"2026-04-29",{"date":61,"type":36},"2023-11-01",{"date":63,"type":20},"2027-01",{"name":65,"class":43},"Helen Koechlin",3,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":44},"100509972","radiofrequency-ablation-for-the-treatment-of-post-knee-arthroplasty-chronic-pain-100509972","NCT05920382","Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.","Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. A Randomized Double-blind Study. A Novel Approach.","CSAPG-37","Inclusion Criteria:\n\n* Individuals who have undergone knee arthroplasty.\n* Chronic knee pain post-knee arthroplasty for at least 6 months after the procedure and less than 5 years.\n* Pain intensity on the numerical visual scale ≥ 5 out of 10 points.\n* Stable pain for the last 30 days.\n* The knee is the location with the highest intensity of pain, in the case of patients with multiple joint pains.\n\nExclusion Criteria:\n\n* Acute knee pain.\n* Psychiatric illness or dementia that may interfere with or hinder study assessments.\n* Diagnosis of fibromyalgia, chronic fatigue syndrome, or central sensitization syndrome.\n* Knee infiltration with corticosteroids in the past 30 days.\n* Changes in oral analgesic medication in the past 30 days.",{"count":76,"type":20},86,"INTERVENTIONAL",[79],"NA","Knee osteoarthritis pain is one of the conditions commonly seen in general and specialized medicine. Knee arthroplasty is one of the most successful orthopedic surgeries for the treatment of this disease, significantly improving pain, disability, and the overall quality of life for patients who undergo it. However, there is a subgroup of individuals in whom the pain persists or even worsens. Radiofrequency has been introduced over 10 years ago as a neuroablative technique targeting the genicular nerves, which innervate the sensory terminals of the knee joint, for the treatment of chronic pain in that region before or after arthroplasty. However, the results have not been entirely consistent. Recent anatomical studies have demonstrated the presence of other sensory terminal branches of the femoral nerve, such as the infrapatellar branch of the saphenous nerve, medial vastus nerve, intermediate vastus nerve, and lateral vastus nerve, which could be useful targets for the treatment of post-knee arthroplasty pain. To date, no studies have been conducted to address post-knee arthroplasty pain through the application of thermal radiofrequency on the sensory branches of the knee from the femoral nerve (infrapatellar branch of the saphenous nerve, medial vastus nerve, intermediate vastus nerve, lateral vastus nerve). Therefore, The investigators aim to conduct a randomized double-blind clinical trial where The investigators will apply thermal radiofrequency on the sensory terminal branches of the femoral nerve in the knee, based on recent anatomical studies. The objective of the study is to determine if radiofrequency ablation of sensory nerves in the knee improves pain and disability in patients with post-knee arthroplasty chronic pain at the L'Alt Penedés-Garraf Health Consortium. Method: This is a randomized double-blind clinical trial with two arms. Two groups will be used, where one group will receive thermal radiofrequency of sensory nerves in the knee, and the other group will receive a placebo treatment. The hypothesis The investigators propose is that radiofrequency ablation will alleviate at least 50% of baseline pain and disability in at least 50% of the patients.",[82,25,83],"Chronic Post-surgical Pain","Chronic Knee Pain","2025-12-02",{"date":86,"type":36},"2025-12-09",{"date":88,"type":36},"2023-09-25",{"date":90,"type":20},"2027-12-01",{"name":92,"class":43},"Consorci Sanitari de l'Alt Penedès i Garraf",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":77,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":44},"100604016","butyrate-and-taurine-for-chronic-postsurgical-pain-in-adult-cardiac-surgical-patients-100604016","NCT07144033","Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients","Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients: Bayesian Optimized Double-blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18 or older\n* elective surgery\n* coronary artery bypass graft (CABG), valve repair\u002Freplacement, combined CABG\u002Fvalve procedure, or major aortic procedure via sternotomy\n\nExclusion Criteria:\n\n* emergency surgery\n* redo surgery\n* history of chronic pain or on chronic opioids\u002Fsedatives\n* already taking taurine or butyrate prior to enrolment\n* renal failure with estimated glomerular filtration rate \\\u003C30mL\u002Fmin (calculated by Cockcroft-Gault formula)\n* re-operation within 24 hours after surgery\n* intraoperative use of remifentanil\n* inability to provide informed consent.",{"count":101,"type":20},216,[79],"This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial\n\nGoal and Questions:\n\nThe primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic postsurgical pain (CPSP) in adult cardiac surgical patients. The study also aims to determine if these compounds are safe, effective in perioperative pain control, and feasible for improving postoperative outcomes.\n\nParticipants:\n\nThe study will include adult patients (aged 18 or older) undergoing elective coronary artery bypass graft (CABG), valve repair\u002Freplacement, combined CABG\u002Fvalve, or major aortic procedure via sternotomy. Exclusion criteria include emergency surgery, redo surgery, a history of chronic pain or chronic opioid\u002Fsedative use, and an estimated glomerular filtration rate (eGFR) less than 30 mL\u002Fmin. The target sample size is 216 patients.\n\nIntervention group: Patients will receive 4g of taurine and 4.8g of sodium butyrate orally once daily, starting the day before surgery and continuing for three months post-surgery.\n\nPlacebo group: Patients will receive indistinguishable placebo capsules orally once daily, following the same schedule as the intervention group.\n\nPrimary Outcome: The incidence of chronic postsurgical pain at 3 months,\n\nSecondary Outcomes:\n\nQuality of Recovery Questionnaire (QoR-15) at 72 hours after extubation.\n\nPain scores (NRS) at rest and with movement at 12, 24, 48, and 72 hours post-extubation.\n\nPostoperative morphine requirements and time to first morphine rescue.\n\nIncidence of opioid-related side effects, such as postoperative nausea and vomiting (PONV).\n\nDuration of mechanical ventilation, and length of stay in the ICU and hospital.\n\nLong-term pain assessment using the Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2), Brief Pain Inventory (BPI) Interference Scale, and Neuropathic Pain Questionnaire (NPQ) at 1, 3, 6, and 12 months post-surgery\n\nProteomic analysis:\n\nBlood samples within 72 hours after surgery will be collected for proteomic analysis to investigate predictors for chronic postsurgical pain.",[105,106,25],"Pain, Acute","Pain, Chronic","NOT_YET_RECRUITING","2025-08-28",{"date":110,"type":36},"2025-09-05",{"date":112,"type":20},"2026-01-01",{"date":114,"type":20},"2028-01-31",{"name":116,"class":43},"Chinese University of Hong Kong",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":126,"conditions":127,"keywords":128,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":135,"leadSponsor":136,"locationsCount":4},"100548230","cytokine-alterations-and-chronic-post-surgical-pain-100548230","NCT06418295","Cytokine Alterations and Chronic Post-Surgical Pain","Cytokine Alterations Associated With Persistent Post-surgical Pain and Their Regulation Through Epigenetic Changes - A Pilot Study","Inclusion Criteria:\n\n1. 18 years of age or older\n2. Undergoing unilateral thoracotomy for the first time on that side\n3. Willing to provide informed consent for study participation.\n4. Patient with malignancy that needs thoracotomy for surgical resection.\n\nExclusion Criteria:\n\n1. Chronic pain prior to surgery\n2. Pre-existing fibromyalgia\n3. Long-term opioid use\n4. Diabetes mellitus\n5. Inflammatory bowel disease\n6. Pre-existing neurological disease\n7. Pre-existing nerve injury\n8. Evidence of dementia, delirium or cognitive disorder that may interfere with study participation\n9. Malignancy other than lung cancer\n10. Autoimmune disorder (e.g. rheumatoid arthritis and psoriatic arthritis)\n11. Pregnancy\n12. Inability to communicate in the English language (required for completion of questionnaires and provision of pain scores).\n13. Patents on antiepileptic medications",{"count":125,"type":20},60,"Chronic Post-Surgical Pain (CPSP) is a condition that involves experiencing pain and\u002For discomfort that lasts for more than 3 months following surgery without any explainable cause of this pain such chronic infection or pain caused from a condition preceding surgery. This condition negatively impacts health related quality of life and is associated with significant financial burden both for the patient and health care system. Patients undergoing common surgeries such as amputation, breast surgery, hernia repair, coronary artery bypass, and caesarean section can be prone to developing CPSP. CPSP may be caused by the release and expression of different cellular molecules called cytokines and chemokines that can cause a pain response when they are present in the body at certain levels. After surgical incision, tissue cells have been shown to release cytokines and chemokines, thus increasing the concentration of these molecules in the patient's blood. It is not entirely known what mechanisms cause the increased expression of chemokines and cytokines. One method that may play a role in in this expression is epigenetics which is the alteration of gene expression without permanently altering the structure of DNA. Unlike mutations, epigenetic changes are dynamic, possibly reversible, and are influenced by environmental and behavioral changes such as diet, exercise, disease, stress, toxin exposure etc. Epigenetic changes occur all throughout our life and have been associated with several disease processes such as cancer, diabetic complications, and chronic pain. At the molecular level, certain events take place that can regulate (increase or decrease) the expression of cytokines and chemokines, most notably DNA methylation of their promotor (which involves adding molecules to DNA that does not change its structure but changes it's activity). The investigators are conducting this study to determine if the alteration of specific cytokines are associated with the occurrence of CPSP and whether these cytokines are regulated by DNA methylation at their promoter. This study will take place at London Health Sciences Centre and will recruit up to 60 patients who will be undergoing a thoracotomy procedure (surgery of the chest area).",[25],[129,130],"chronic pain","epigentics","2025-08-27",{"date":133,"type":36},"2025-09-04",{"date":112,"type":20},{"date":40,"type":20},{"name":137,"class":43},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":77,"phases":149,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100601291","phase-3-reducing-chronic-pain-after-lung-surgery-a-trial-of-limiting-nsaids-during-recovery-100601291","NCT07108582","Reducing Chronic Pain After Lung Surgery: A Trial of Limiting NSAIDs During Recovery","Evaluation of the Impact of a Strategy of Perioperative NSAID Suppression in Patients Undergoing Video-assisted Thoracic Surgery (VATS) on the Presence of Chronic Postoperative Pain (CPOP): a Randomised Clinical Trial","EVADRAINS","Inclusion Criteria:\n\n* Adult patients aged 18 to 75\n* Patients scheduled for video-assisted thoracic surgery\n* Able to give informed consent to participate in the study\n* Affiliated to a social health insurance scheme\n\nExclusion Criteria:\n\n* History of renal insufficiency or chronic pain\n* Surgical contraindications to NSAIDs (talc surgery)\n* Contraindications to NSAIDs described in the VIDAL RCP (renal insufficiency, allergy, etc.)\n* History of chronic use of opioids or anti-inflammatories (continuous use for more than 3 months in the year preceding surgery)\n* Urgent surgery;\n* Participation in another interventional drug clinical trial.\n* Impossibility of giving the subject informed information in the event of difficulties in understanding the subject\n* Incapacitated subject (subject to a legal protection measure: safeguard of justice, curatorship, guardianship, future protection mandate, family habilitation)\n* Pregnant or breast-feeding","75 Years",{"count":148,"type":20},270,[150],"PHASE3","Chronic postoperative pain (CPOP) after video-assisted thoracic surgery (VATS) is severe because it results from lesions at multiple levels: incisions, pulmonary or nerve contusions. PCOD is defined by the IASP (International Association for the Study of Pain) as persistent pain 3 months after surgery. It affects around 30% of patients and significantly impairs recovery and quality of life.\n\nOne of the many factors contributing to the appearance of PCOD is acute perioperative pain. To combat this acute pain and limit postoperative chronic pain, a multimodal analgesia strategy is necessary, particularly during thoracic surgery with a high nociceptive potential. This type of protocol will enable acute pain to be controlled by various means: tier 1 analgesics (paracetamol, NSAIDs), tier 2 (nefopam, tramadol) and tier 3 (opioid drugs), locoregional anaesthesia, co-analgesics and non-medicinal techniques. Thus, avoiding NSAIDs will have no effect on the increase in acute pain. A study of the impact of eliminating NSAIDs on chronic pain can therefore be carried out without increasing patients' acute pain.\n\nA team from McGill University, Montreal, Canada, recently discovered a paradoxical effect of anti-inflammatory drugs on the chronicisation of pain. They demonstrated that although anti-inflammatory drugs initially had an acute analgesic effect, they induced neutrophil depletion and a drastic change in the transcriptome postoperatively, leading to more chronic pain. These studies highlight the fact that although NSAIDs have an acute analgesic effect, their use could ultimately prove counterproductive by encouraging the development of CD. However, to date there are no studies demonstrating that a minimum dose or duration of NSAID treatment leads to the development of DCPO. On the basis of these results, it is justified to assess the impact of NSAIDs widely used in routine care in thoracic surgery on the development of DCPO.\n\nIn order to improve pain management in the intraoperative phase, nociception monitoring is necessary. The PMD200® (Medasense Biometrics Ltd.) is the most recent monitor designed for this purpose, having demonstrated sensitivity and specificity in detecting nociceptive stimuli under general anaesthesia (4). It will make it possible to guide the administration of analgesic agents by displaying a nociception index (NOL index).\n\nOur hypothesis, based on this work, is that anti-inflammatory drugs, despite having an acute analgesic effect, could promote the development of DCPO after VATS.",[153],"Chronic Post-operative Pain","2025-07-30",{"date":156,"type":36},"2025-08-07",{"date":158,"type":20},"2026-04-01",{"date":160,"type":20},"2028-07-01",{"name":162,"class":43},"University Hospital, Strasbourg, France",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":172,"conditions":173,"keywords":175,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":189},"100566935","clinical-prediction-of-post-surgical-pain-100566935","NCT06661642","Clinical Prediction of Post-surgical Pain","Clinical Prediction of Post-surgical Pain: External Validation","Inclusion Criteria:\n\nAll patients ≥ 18 years undergoing elective or sub-acute surgery\n\nExclusion Criteria:\n\nCognitive impairment not allowing for informed consent",{"count":171,"type":20},748,"This study aims to externally validate two clinical prediction models for moderate-to-severe acute post-surgical pain and chronic post-surgical pain. This multi-centre, prospective cohort study will be conducted in Denmark and will include adult patients undergoing various types of elective or sub-acute surgical procedures.",[174,25],"Acute Postoperative Pain",[176,177,178,179],"Acute postoperative pain","Chronic postoperative pain","Prediction","Risk tool","2024-10-25",{"date":182,"type":36},"2024-10-28",{"date":184,"type":36},"2024-08-26",{"date":186,"type":20},"2025-08-31",{"name":188,"class":43},"Aarhus University Hospital",2,{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":17,"enrollmentInfo":196,"targetDuration":4,"studyType":77,"phases":198,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":66},"100565150","prevention-of-postsurgical-chronic-pain-in-children-and-adolescents-prevendol-100565150","NCT06638437","Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)","Inclusion Criteria:\n\n1. Having to undergo surgery\n2. Being between 8 and 18 years old;\n3. Having signed the informed consent\n4. Having an ASA risk between I and III\n\nExclusion Criteria:\n\n1. Not being able to understand Spanish\n2. Having a physical and\u002For cognitive impairment that interferes with understanding the instructions and handling of the application (e.g., moderate to severe intellectual disability, blindness)\n3. Participating in another clinical trial\n4. Undergoing an urgent surgical intervention\n5. Being hospitalized in intensive care due to the need for ventilation or hemodynamic support or other complications\n6. Having an ASA risk of IV\n7. Not having signed the informed consent",{"count":197,"type":20},125,[79],"Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain. Importantly, the risk and protective factors that are known (e.g., anxiety, catastrophizing, pain beliefs and pain coping) are modifiable, thus there is a huge potential for the development of both preventive and protective programs to avoid the transition from acute to chronic pain or reduce the impact in the lives of patients when it has already developed.",[201,82,202,153],"Chronic Postsurgical Pain","Chronic Postoperative Pain","2024-10-11",{"date":205,"type":36},"2024-10-16",{"date":207,"type":20},"2025-02-01",{"date":209,"type":20},"2026-12-31",{"name":211,"class":43},"University Rovira i Virgili",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":77,"phases":220,"briefSummary":221,"conditions":222,"keywords":226,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":44},"100562946","the-effect-of-individualised-pain-education-on-chronic-postoperative-pain-development-and-quality-of-life-in-living-liver-donors-100562946","NCT06609772","The Effect of Individualised Pain Education on Chronic Postoperative Pain Development and Quality of Life in Living Liver Donors","Inclusion Criteria:\n\n* No condition that prevents communication\n* Having the ability to read and write\n* No major complications in the early postoperative period\n* No previous abdominal surgery\n* No additional disease that may cause chronic pain\n\nExclusion Criteria:\n\n* Having any condition that prevents communication\n* Lack of reading and writing skills\n* Having a major complication in the early postoperative period\n* Having had abdominal surgery before\n* Having an additional disease that may cause chronic pain",{"count":219,"type":20},120,[79],"Chronic postoperative pain is defined as pain that is a continuation of acute pain or develops after a pain-free period, is localised to the surgical site, affects quality of life, and persists for at least 3 months after surgery when other pain factors are excluded. Chronic postoperative pain, as a major complication of surgery, increases the use of analgesics, restricts activities of daily living, reduces quality of life and creates a serious economic burden. Prolonged pain in the preoperative period and poorly treated postoperative acute pain may trigger the development of chronic pain. Chronic postoperative pain is an important and current problem in living liver transplant donors as in many patient groups.\n\nChronic pain due to severe postoperative acute pain is reported as an expected outcome after open surgical resection in living liver transplant donors. The reason for this is thought to be inadequate perioperative pain management. Inadequate perioperative pain management may lead to sub-optimal pain management, delayed recovery, unexpected readmissions, decreased patient satisfaction, prolonged duration of opioid analgesia with potential for narcotic abuse, and clinical, psychological and socioeconomic consequences that may possibly lead to chronic postoperative pain. Chronic postoperative pain is a common but overlooked complication of surgery that can cause functional limitation, psychological distress and poor quality of life in patients and its management is very important for nurses. An important aim of nursing care is to help liver living donors regain their health and quality of life. Providing management of acute postoperative pain, preventing the development of chronic postoperative pain and improving quality of life in patients undergoing surgical procedures are important issues for nurses. At the same time, chronic postoperative pain management, as a very current issue, requires nurses to plan and implement more effective interventions. With appropriate pain interventions in the preoperative and early postoperative period, the patient should be educated and counselled about self-management strategies, return to normal functionality and the possibility of developing chronic pain after surgery. Adequate perioperative education about the surgery and expected outcomes may alleviate stress, reduce the severity of acute pain and help prevent chronic postoperative pain.\n\nIt is thought that individualised pain education will be effective on chronic postoperative pain development and quality of life of patients. When the literature was reviewed, no study on individualised pain education for liver living donors was found. At the same time, no study was found in the literature in which chronic postoperative pain and quality of life were examined together in liver living donors. The fact that the subject will be investigated for the first time adds originality to the study.\n\nWith this study, the effect of individualised pain education on prevention or reduction of chronic postoperative pain and improvement of quality of life will be determined. Thus, the data obtained can be evaluated holistically and can form the basis for new and large-scale studies in the related field. At the same time, in this prospective study, the rates and characteristics of chronic postoperative pain development in liver living donors at the 3rd month after transplantation will be evaluated. Thus, this study will contribute to the limited literature on this subject.\n\nResearch Hypotheses:\n\nH0a: Individualized pain education applied to living liver donors is not effective on the development of chronic postoperative pain.\n\nH1a: Individualized pain education applied to living liver donors is effective on the development of chronic postoperative pain.\n\nH0b: Individualized pain education applied to living liver donors is not effective on the quality of life of patients.\n\nH1b: Individualized pain education applied to living liver donors is effective on the quality of life of patients.",[223,224,25,225],"Quality of Life","Living-donor Liver Transplantation","Pain Management",[227,202,228,223],"Living Liver Donors","Individualised Pain Education","2024-09-21",{"date":231,"type":36},"2024-09-24",{"date":233,"type":36},"2024-07-19",{"date":235,"type":20},"2025-06",{"name":237,"class":43},"Nazlican Bagci",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":77,"phases":247,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":44},"100500378","effects-of-oxycodone-combined-with-pregabalin-on-chronic-postsurgical-pain-in-spinal-surgery-100500378","NCT05795478","Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery","Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery: a Randomized Control, Double-blinded, Factorial Design Trial","Inclusion Criteria:\n\n* Patient undergoing elective spinal surgery\n* Ages equal to or more than 18 years old\n* ASA I-III\n* Signed informed consent\n\nExclusion Criteria:\n\n* Previous allergic history to gabapentinoids or oxycodone;\n* Patients with aphasia or inability to cooperate with scales assessments;\n* Patients with a diagnosed history of psychiatric disorder;\n* Known severe insufficiency of vitals(such as heart failure\u002Frenal dysfunction\u002Fhepatic failure);\n* Patients treated with gabapentin\u002Fpregabalin in the last three months;\n* History of drug abuse;\n* Body Mass Index more than 35 kg\u002F㎡;\n* Pregnant or breastfeeding woman.",{"count":246,"type":20},264,[79],"Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in preventing and treating chronic postoperative pain in patients undergoing spinal surgery. At present, oxycodone has been widely recognized in different surgical populations for the control of acute postoperative pain, but its contribution to chronic postoperative pain remains unknown. Meanwhile, whether pregabalin can reduce the occurrence of chronic postoperative pain remains controversial, and whether the combination of the two drugs can control the occurrence of chronic postoperative pain in a more comprehensive way remains unknown. Therefore, we intend to conduct this randomized-controlled, factorial design study to determine the efficacy and safety of oxycodone combined with pregabalin in the treatment of chronic postoperative pain in patients undergoing spinal surgery.",[25,250,251,252],"Oxycodone","Pregabalin","Postoperative Complications","2024-07-31",{"date":255,"type":36},"2024-08-01",{"date":257,"type":36},"2023-10-24",{"date":259,"type":20},"2024-12-31",{"name":261,"class":43},"Beijing Tiantan Hospital"]