[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-post-surgical-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-post-surgical-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,43,73,108,132,164,188,209,237,265,287],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644382","effectiveness-of-perioperative-percutaneous-acupuncture-on-postoperative-sleep-disturbances-and-chronic-pain-in-patients-undergoing-video-assisted-thoracoscopic-lung-cancer-resection-a-prospective-randomized-single-blind-superiority-controlled-trial-100644382",false,"NCT07662733","Effectiveness of Perioperative Percutaneous Acupuncture on Postoperative Sleep Disturbances and Chronic Pain in Patients Undergoing Video-Assisted Thoracoscopic Lung Cancer Resection: A Prospective, Randomized, Single-Blind, Superiority Controlled Trial","Effectiveness of Perioperative Percutaneous Acupoint Acupuncture on Postoperative Sleep Disturbances in Patients Undergoing Video-Assisted Thoracoscopic Lung Cancer Resection: A Prospective, Randomized, Single-Blind, Superiority Controlled Trial","PASA-VATS","Inclusion Criteria：\n\n1. Patients aged 18-75 years scheduled for elective video-assisted thoracoscopic surgery (VATS) for lung cancer resection.\n2. American Society of Anesthesiologists (ASA) physical status classification I-II.\n3. Body Mass Index (BMI) between 18.5 and 28 kg\u002Fm².\n4. Clinical tumor stage according to the 8th edition of the AJCC\u002FUICC TNM Classification: cTis-3N0-1M0.\n5. Mentally competent, able to understand and correctly use the Numeric Rating Scale (NRS) for pain assessment.\n6. Willing and able to provide written informed consent prior to study participation.\n\nExclusion Criteria：\n\n1. Critical preoperative condition or inability to cooperate.\n2. History of sleep apnea or moderate to severe snoring.\n3. Pittsburgh Sleep Quality Index (PSQI) ≥7 or Athens Insomnia Scale (AIS) score ≥6.\n4. Implanted cardiac pacemaker, preoperative sinus bradycardia (heart rate ≤50 bpm), sinoatrial node disease, or second-\u002Fthird-degree atrioventricular block.\n5. Long-term use of anticonvulsants, antidepressants, or other psychotropic medications.\n6. Known hypersensitivity or allergy to the study materials (needles\u002Fdevices) or related medications.\n7. Severe cardiac, hepatic, or renal dysfunction.\n8. Participation in another clinical trial within the past 3 months.\n9. Hearing and\u002For language communication impairment.\n10. Pregnancy or breastfeeding.\n11. Fever (body temperature ≥38.5°C) or clinical evidence of infection (hematological, radiological, and\u002For microbiological) prior to surgery.\n12. Planned reoperation, or anticipated postoperative recurrence, severe complications, or critical illness requiring exclusion from follow-up.","ALL","18 Years","75 Years",{"count":21,"type":22},316,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates whether acupuncture at specific body points before and after surgery can improve sleep quality and reduce long-term postoperative pain in patients undergoing video-assisted thoracoscopic lung cancer resection. Eligible adult patients will be randomly assigned to receive either true acupuncture or sham (placebo) acupuncture in addition to standard care. Chronic pain will be assessed during hospital stay and up to 6 months after surgery.",[28,29],"Postoperative Sleep Disturbances","Chronic Post-surgical Pain","RECRUITING","2026-06-17",{"date":33,"type":34},"2026-06-23","ACTUAL",{"date":36,"type":34},"2025-06-13",{"date":38,"type":22},"2027-11-29",{"name":40,"class":41},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100639174","crops-study-chronification-of-post-surgical-pain-and-risk-assessment-100639174","NCT07629453","CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment","Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial","CROPS","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective cardiac surgery requiring median sternotomy, including:\n* coronary artery bypass grafting (CABG)\n* aortic valve replacement or repair\n* mitral valve replacement or repair\n* ascending aorta surgery\n* Ability to understand study information\n* Ability to provide written informed consent\n* Expected postoperative hospital stay longer than 3 days\n* Availability for follow-up at 1 week and 3 months after surgery\n\nExclusion Criteria:\n\n* Emergency surgery\n* Cognitive impairment preventing study participation\n* Serious psychiatric illness interfering with study participation\n* Language barrier preventing questionnaire completion\n* Participation in another interventional study affecting pain outcomes\n* Reoperation for postoperative bleeding\n* Severe chronic renal failure\n* Allergy or contraindication to study medication or regional anesthesia techniques\n* Pregnancy or breastfeeding\n* Chronic opioid therapy exceeding 60 mg morphine equivalents daily\n* Extensive emergency aortic surgery (e.g., Thoraflex implantation for acute aortic dissection)",{"count":52,"type":22},180,[25],"Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.\n\nThe CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.\n\nParticipants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.\n\nThe study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.\n\nThe study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.",[29,56,57],"Acute Postoperative Pain","Cardiac Surgery",[59,60,61,62],"chronic post-surgical pain","cardiac surgery","regional anesthesia","postoperative analgesia","NOT_YET_RECRUITING","2026-06-04",{"date":66,"type":34},"2026-06-05",{"date":68,"type":22},"2026-09-01",{"date":70,"type":22},"2029-06-01",{"name":72,"class":41},"Kočan Ladislav",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":82,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":91,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100617767","evaluation-of-chronic-postsurgical-pain-risk-in-patients-undergoing-cied-implantation-using-an-aid-support-system-100617767","NCT07322900","Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System","Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing Cardiac Implantable Electronic Device (CIED) Implantation Using an Artificial Intelligence-Based Clinical Decision (AID) Support System","PAIN-AID","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Patients who have undergone first-time implantation of a cardiac implantable electronic device (CIED), including pacemaker (PM), implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy device (CRT).\n* Device implantation performed within the past 12 months at Istanbul University-Cerrahpaşa Cardiology Institute.\n* Ability to attend scheduled follow-up visits at 3, 6, and 12 months post-implantation.\n* Ability to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* History of neuropathic or chronic pain syndromes prior to implantation (e.g., fibromyalgia, diabetic neuropathy).\n* Presence of neurodegenerative, autoimmune, or vascular disorders affecting peripheral or central pain pathways.\n* Known malignancy, active infection, or recent trauma in the chest or upper extremities.\n* Prior CIED replacement or battery exchange procedures.\n* Use of chronic analgesic or neuropathic pain medications (e.g., opioids, gabapentinoids, antidepressants) for conditions unrelated to the procedure.\n* Cognitive impairment or psychiatric disorders that may interfere with study participation or reliable pain assessment.\n* Inability to comply with follow-up or withdrawal of consent at any time.",{"count":52,"type":22},"15 Months","OBSERVATIONAL","Chronic postsurgical pain (CPSP) remains a significant clinical and public health challenge despite major advances in surgical and anesthetic techniques. Patients receiving cardiac implantable electronic devices (CIEDs)-including pacemakers, implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy devices (CRTs)-constitute a unique population with high rates of multimorbidity, psychological vulnerability, and limited analgesic options due to cardiovascular comorbidities. Insufficient postoperative pain management in this group may lead to persistent pain at the generator site, neuropathic pain features, reduced quality of life, and increased healthcare utilization.\n\nThe present study aims to evaluate the prevalence, risk factors, and clinical predictors of CPSP following CIED implantation using both subjective and objective pain assessments. Pain intensity will be measured using validated self-report scales (Visual Analog Scale and DN-4 questionnaire), and objective pain thresholds will be determined using a calibrated digital pressure algometer. Quality of life will be assessed with the validated Turkish version of the Short Form-12 (SF-12) instrument.\n\nThis prospective observational study will include 180 adult patients who underwent first-time CIED implantation at Istanbul University-Cerrahpaşa, Cardiology Institute. Participants will be evaluated at 3, 6, and 12 months post-implantation. Collected data will include preoperative, intraoperative, and postoperative variables such as demographics, comorbidities, anesthesia type, surgical duration, and acute postoperative pain control.\n\nUsing the obtained data, an artificial intelligence-based clinical decision support system will be developed to predict individual CPSP risk before implantation. The model will integrate subjective scales, objective algometric data, and clinical factors to generate personalized risk estimates. Ultimately, this system aims to improve early detection and prevention of CPSP, optimize postoperative pain management strategies, and enhance patient quality of life.",[86,87,88,89,90],"Pain Measurement","Chronic Pain","Cardiac Implantable Electrical Devices","Neuropathic Pain","Chronic Post Surgical Pain",[92,93,94,87,95,96,97,98],"Cardiac Resynchronization Therapy Devices","Pacemaker, Artificial","Defibrillators, Implantable","Quality of Life","Artificial Intelligence","Decision Support Systems, Clinical","postoperative pain","2026-05-04",{"date":101,"type":34},"2026-05-05",{"date":103,"type":22},"2026-09-30",{"date":105,"type":22},"2027-03-01",{"name":107,"class":41},"Istanbul University - Cerrahpasa",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":129,"locationsCount":131},"100605143","surgical-corncerns-and-psychological-evaluation-of-patients-undergoing-elective-surgery-100605143","NCT07158684","Surgical COrncerns and Psychological Evaluation of Patients Undergoing Elective Surgery","Psychological Evaluation of Patients Undergoing Elective Surgery With Anxiety and Surgical Concerns: a Qualitative Interview Study","SCOPE","Inclusion Criteria:\n\n* ≥ 18 years old\n* Dutch speaking\n* With a planned elective surgery, at the Antwerp University Hospital\n* Score of ≥ 11 on APAIS anxiety subscale\n* Must be able to complete questions on a tablet (digital literacy)\n* Signed informed consen (prescreening informed consent and study participation informed consent)\n\nExclusion Criteria:\n\n* Diagnostic procedures requiring anaesthesia",{"count":117,"type":22},30,[25],"This study wants to obtain more information regarding the patient's concerns since concerns of the patient about the procedure is found as a predictor for the development of chronic post-surgical pain. This step is crucial in translating early identification of a high-risk population into preventive policies. Using a semi-structured interview, the investigators aim to gather this additional information, which is essential in the development of an (individualized) biopsychosocial care pathway in the future.",[121,122,90],"Elective Surgery","Anxiety","2026-04-28",{"date":125,"type":34},"2026-04-29",{"date":127,"type":34},"2025-11-15",{"date":68,"type":22},{"name":130,"class":41},"University Hospital, Antwerp",1,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":138,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":145,"conditions":146,"keywords":151,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":131},"100615174","phase-1-effect-of-liposome-bupivacaine-serratus-plane-block-on-postoperative-hyperalgesia-and-chronic-post-surgical-pain-in-patients-undergoing-radical-mastectomy-100615174","NCT07289178","Effect of Liposome Bupivacaine Serratus Plane Block on Postoperative Hyperalgesia and Chronic Post-surgical Pain in Patients Undergoing Radical Mastectomy","Inclusion Criteria:\n\nSelect patients scheduled for elective radical mastectomy for breast cancer under general anesthesia, ASA grade I-IV, aged 18-80 years.\n\nExclusion Criteria:\n\nAllergy to the anesthetics used, infection at the puncture site, history of chronic pain and current use of opioid analgesics, history of chest surgery or trauma, drug or alcohol dependence, neurological or psychiatric disorders, severe hepatic or renal insufficiency, pregnancy, body mass index (BMI) greater than 30 kg\u002Fm².","FEMALE","80 Years",{"count":141,"type":22},120,[143,144],"PHASE1","PHASE2","Radical mastectomy is currently the mainstream surgical treatment for breast cancer. Patients often experience significant postoperative pain, and some may develop chronic pain. General anesthesia is commonly used, with remifentanil being the most frequently used intraoperative analgesic. However, prolonged high-dose use of remifentanil can induce opioid-induced hyperalgesia (OIH). Previous studies have shown that serratus anterior plane block can reduce acute postoperative pain after radical mastectomy, but it remains unclear whether it can reduce postoperative pain sensitization and the incidence of chronic pain. Liposomal bupivacaine is a new long-acting local anesthetic with an effect lasting up to 72 hours. This study aims to investigate the effect of liposomal bupivacaine serratus anterior plane block on postoperative pain sensitization and chronic pain in patients undergoing radical mastectomy, providing a reference for clinical treatment. The study includes 120 participants. A tactile measurement kit is used to measure the mechanical pain threshold around the surgical incision preoperatively and at 24 and 48 hours postoperatively, as well as postoperative persistent pain scores at 7 days, 1 month, 3 months, and 6 months. The data will then be analyzed to draw conclusions.",[147,148,29,149,150],"Serratus Plane Block","Postoperative Hyperalgesia","Liposomal Bupivacaine","Radical Mastectomy Surgery",[152,153,59,149,154],"serratus plane block","postoperative hyperalgesia","Radical mastectomy surgery","2025-12-04",{"date":157,"type":34},"2025-12-17",{"date":159,"type":22},"2026-01-01",{"date":161,"type":22},"2026-12-30",{"name":163,"class":41},"First Affiliated Hospital of Kunming Medical University",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":131},"100509972","radiofrequency-ablation-for-the-treatment-of-post-knee-arthroplasty-chronic-pain-100509972","NCT05920382","Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.","Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. A Randomized Double-blind Study. A Novel Approach.","CSAPG-37","Inclusion Criteria:\n\n* Individuals who have undergone knee arthroplasty.\n* Chronic knee pain post-knee arthroplasty for at least 6 months after the procedure and less than 5 years.\n* Pain intensity on the numerical visual scale ≥ 5 out of 10 points.\n* Stable pain for the last 30 days.\n* The knee is the location with the highest intensity of pain, in the case of patients with multiple joint pains.\n\nExclusion Criteria:\n\n* Acute knee pain.\n* Psychiatric illness or dementia that may interfere with or hinder study assessments.\n* Diagnosis of fibromyalgia, chronic fatigue syndrome, or central sensitization syndrome.\n* Knee infiltration with corticosteroids in the past 30 days.\n* Changes in oral analgesic medication in the past 30 days.",{"count":173,"type":22},86,[25],"Knee osteoarthritis pain is one of the conditions commonly seen in general and specialized medicine. Knee arthroplasty is one of the most successful orthopedic surgeries for the treatment of this disease, significantly improving pain, disability, and the overall quality of life for patients who undergo it. However, there is a subgroup of individuals in whom the pain persists or even worsens. Radiofrequency has been introduced over 10 years ago as a neuroablative technique targeting the genicular nerves, which innervate the sensory terminals of the knee joint, for the treatment of chronic pain in that region before or after arthroplasty. However, the results have not been entirely consistent. Recent anatomical studies have demonstrated the presence of other sensory terminal branches of the femoral nerve, such as the infrapatellar branch of the saphenous nerve, medial vastus nerve, intermediate vastus nerve, and lateral vastus nerve, which could be useful targets for the treatment of post-knee arthroplasty pain. To date, no studies have been conducted to address post-knee arthroplasty pain through the application of thermal radiofrequency on the sensory branches of the knee from the femoral nerve (infrapatellar branch of the saphenous nerve, medial vastus nerve, intermediate vastus nerve, lateral vastus nerve). Therefore, The investigators aim to conduct a randomized double-blind clinical trial where The investigators will apply thermal radiofrequency on the sensory terminal branches of the femoral nerve in the knee, based on recent anatomical studies. The objective of the study is to determine if radiofrequency ablation of sensory nerves in the knee improves pain and disability in patients with post-knee arthroplasty chronic pain at the L'Alt Penedés-Garraf Health Consortium. Method: This is a randomized double-blind clinical trial with two arms. Two groups will be used, where one group will receive thermal radiofrequency of sensory nerves in the knee, and the other group will receive a placebo treatment. The hypothesis The investigators propose is that radiofrequency ablation will alleviate at least 50% of baseline pain and disability in at least 50% of the patients.",[29,177,178],"Chronic Post Operative Pain","Chronic Knee Pain","2025-12-02",{"date":181,"type":34},"2025-12-09",{"date":183,"type":34},"2023-09-25",{"date":185,"type":22},"2027-12-01",{"name":187,"class":41},"Consorci Sanitari de l'Alt Penedès i Garraf",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":17,"minAge":194,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":131},"100462639","psychophysical-and-neural-mechanisms-contributing-to-chronic-post-surgical-pain-in-adolescents-and-adults-100462639","NCT05304286","Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults","Inclusion Criteria:\n\n--Females and males aged 12 and older who have previously undergone surgery at least 6 months ago and have chronic post surgical pain (3 months after surgery or longer)\n\nExclusion Criteria:\n\n* Inability to speak sufficient English or another language that can be interpreted orally and for questionnaires with the research team\n* Severe cognitive impairment by history (e.g., intellectual disability, severe head injury)\n* Patients with significant psychiatric disorders\n* Use of illegal hard drugs including MDMA, heroin, methamphetimes, amphetamines, cocaine, ketamine, benzodiazepines, and phencyclidine. Absence of such drugs will be confirmed in a urine drug screen during the visit. If prescription medication includes any of these compounds, that medication is not exclusionary.","12 Years",{"count":196,"type":22},110,[25],"The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobiological pain mechanism(s) active in CPSP, particularly those non-responsive to current therapies, may be used to validate novel strategies both pharmacological and non-pharmacological.",[29],"2025-10-31",{"date":202,"type":34},"2025-11-03",{"date":204,"type":34},"2022-04-07",{"date":206,"type":22},"2026-06-30",{"name":208,"class":41},"Massachusetts General Hospital",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":17,"minAge":217,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":221,"conditions":222,"keywords":224,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":42},"100498009","chronic-postsurgical-pain-100498009","NCT05764681","Chronic Postsurgical Pain","Chronic Postsurgical Pain in Cerebral Palsy","CPSP","Inclusion Criteria:\n\n* CP diagnosis\n* Have a scheduled lower extremity or spine orthopedic surgery\n\nExclusion Criteria:\n\n* Non-English speaking and reading parent\u002Fguardian","5 Years","17 Years",{"count":220,"type":22},500,"The study purpose is to document the typical trajectory of perioperative pain experience in Cerebral Palsy (CP) and to identify important predictive factors for the development of chronic postsurgical pain. The main aims of the investigators are to:\n\n1. Quantify the trajectory of pain and opioid use in the context of orthopedic surgery in children with CP.\n2. Identify predictors for CPSP in children with CP and develop an applicable risk index.\n3. Examine relationships between perioperative pain severity and functional\u002Fmobility outcomes achieved by orthopedic surgery in children with CP.\n\nParticipants will complete:\n\n1. Questionnaires\u002FSurveys via email and text message\n2. In-person Sensory Tests\n3. In-person Gait and Motion Analysis",[223,90],"Cerebral Palsy",[223,225,87,226,227],"Pain","Post Surgical Pain","Orthopedic Surgery","2025-09-15",{"date":230,"type":34},"2025-09-19",{"date":232,"type":34},"2023-03-17",{"date":234,"type":22},"2029-01",{"name":236,"class":41},"Chantel Burkitt",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":138,"minAge":244,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":131},"100542538","phase-2-dinalbuphine-ester-naldebain-for-pain-management-after-cesarean-section-100542538","NCT06344169","Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section","Efficacy of Parenteral Injection of an Extended Release Kappa-receptor Opioid Sebacoyl Dinalbuphine Ester for Pain Management After Cesarean Section: a Randomized, Open-label, Non-inferiority Trial","Inclusion Criteria:\n\n* term primipara or multipara who are scheduled for elective cesarean section\n\nExclusion Criteria:\n\n1. Severe pregnancy-induced complication (such as preeclampsia, eclampsia, poorly control pregnancy-induced hypertension and\u002For diabetes)\n2. High risk for postpartum hemorrhage\n3. Contraindicated for neuraxial block\n4. Preterm (gestational age\\\u003C 36 week) delivery\n5. Emergency cesarean section\n6. After-office hour schedule\n7. History of substance abuse\n8. Known allergy to nalbuphine, benzyl benzoate or sesame oil\n9. Eligible parturient who are not willing to follow the assignment of treatment after randomization","20 Years",{"count":141,"type":22},[144,247],"PHASE3","Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and thromboembolic events. Severe postoperative pain may also result in the development of chronic post-surgical pain (CPSP), which in turn can lead to prolonged use of opioids and increased health-care costs. A descriptive survey study in 60 postpartum women who received cesarean section suggested that the presence of postoperative pain significantly reduced the willingness of breastfeeding and infant care. The incidence of CPSP after cesarean delivery has been reported to vary from 1% to 18% up to 1 year after operation. Intrathecal morphine (ITM) injection is considered as the standard pain management strategy for post-cesarean pain. However, the overall analgesic effect of ITM is about 8-12h and it is associated with pruritus, nausea\u002Fvomiting, urinary retention, constipation, mental status change, and respiratory depression. Therefore, the development of a safe, conveniently operated, and long-lasting analgesic strategy, which serves as background pain control modality up to several days after cesarean section should provide clinically beneficial advantages in the management of acute postoperative pain and prevention of CPSP in postpartum women. Naldebain® is prodrug of nalbuphine, which was approved by the Taiwan FDA in 2017. Naldebain® is rapidly hydrolyzed by tissue of plasma esterase to release nalbuphine. The bioavailability of nalbuphine following intramuscular injection Naldebain® was 85.4%, and it took approximately 6 days for the complete release of Naldebain® into the blood circulation. Therefore, a single parenteral injection of Naldebain® could provide long lasting analgesic effect in several phase II trials. However, Naldebain® has not been tested in the pain control after cesarean section. Therefore, this PI-initiated prospective, randomized, open-label, non-inferiority trial aims to investigate the clinical efficacy of Naldebain® in management of acute postoperative pain in term parturient who receive elective cesarean section to provide analgesic effect that is not inferior to the standard ITM and prevent the development of CPSP.",[250,251,29],"Postsurgical Pain","Cesarean Section",[253,254,255],"kappa agonist","mu agonist","Intrathecal morphine","2025-05-06",{"date":258,"type":34},"2025-05-09",{"date":260,"type":34},"2024-05-06",{"date":262,"type":22},"2026-06-14",{"name":264,"class":41},"Dalin Tzu Chi General Hospital",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":139,"enrollmentInfo":272,"targetDuration":274,"studyType":83,"phases":4,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":131},"100583097","effect-of-perioperative-sleep-quality-on-chronic-post-surgical-pain-100583097","NCT06871891","Effect of Perioperative Sleep Quality on Chronic Post-Surgical Pain","Effect of Perioperative Sleep Quality on Chronic Post-Surgical Pain: a Prospective Cohort Study","Inclusion Criteria:\n\n1. Aged 18-80 years.\n2. Scheduled for elective video-assisted thoracic surgery (VATS).\n3. Scheduled for elective modified radical mastectomy (MRM).\n4. Scheduled for elective coronary artery bypass grafting (CABG).\n5. American Society of Anesthesiologists (ASA) physical status classification I-III.\n6. Willing to sign the informed consent form, participate in the study, and complete all follow-up assessments.\n\nExclusion Criteria:\n\n1. History of surgery within the past 3 months.\n2. Chronic use of opioids or sedatives (defined as use for 3 months or longer).\n3. Expected completion time of surgery after 16:00 on the day of operation.\n4. Planned transfer to the intensive care unit (ICU) postoperatively.\n5. Anticipated hospital stay \\\u003C24 hours.\n6. Contraindications to wearable device use (e.g., infection at the wrist site, allergy to the wristband material).",{"count":273,"type":22},1138,"6 Months","The goal of this prospective observational cohort study is to assess the impact of perioperative sleep quality on the development of chronic post-surgical pain (CPSP) in adult patients (aged 18-80 years, ASA I-III) undergoing elective video-assisted thoracic surgery (VATS), modified radical mastectomy (MRM), or coronary artery bypass grafting (CABG). The main questions it aims to answer are:\n\nDoes poor perioperative sleep quality increase the risk of CPSP at 3 months post-surgery? How do subjective and objective sleep parameters (e.g., total sleep duration, deep sleep time) correlate with CPSP and recovery outcomes? Researchers will compare patients with varying perioperative sleep quality levels (assessed via the Richards-Campbell Sleep Questionnaire \\[RCSQ\\] and wearable device data) to evaluate differences in CPSP incidence, pain and quality of life.\n\nParticipants will:\n\nWear a Huawei wearable device to collect objective sleep data (e.g., sleep duration, deep sleep time) during hospitalization.\n\nComplete questionnaires preoperatively and postoperatively, including RCSQ, Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Brief Pain Inventory (BPI).\n\nUndergo follow-up assessments at 1, 3, and 6 months post-surgery to evaluate pain scores , CPSP status, and quality of life (SF-36).",[277],"Chronic Post-Surgical Pain","2025-03-07",{"date":280,"type":34},"2025-03-12",{"date":282,"type":22},"2025-03-30",{"date":284,"type":22},"2025-06-30",{"name":286,"class":41},"Peking Union Medical College Hospital",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":17,"minAge":293,"maxAge":18,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":296,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":310},"100565150","prevention-of-postsurgical-chronic-pain-in-children-and-adolescents-prevendol-100565150","NCT06638437","Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)","Inclusion Criteria:\n\n1. Having to undergo surgery\n2. Being between 8 and 18 years old;\n3. Having signed the informed consent\n4. Having an ASA risk between I and III\n\nExclusion Criteria:\n\n1. Not being able to understand Spanish\n2. Having a physical and\u002For cognitive impairment that interferes with understanding the instructions and handling of the application (e.g., moderate to severe intellectual disability, blindness)\n3. Participating in another clinical trial\n4. Undergoing an urgent surgical intervention\n5. Being hospitalized in intensive care due to the need for ventilation or hemodynamic support or other complications\n6. Having an ASA risk of IV\n7. Not having signed the informed consent","8 Years",{"count":295,"type":22},125,[25],"Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain. Importantly, the risk and protective factors that are known (e.g., anxiety, catastrophizing, pain beliefs and pain coping) are modifiable, thus there is a huge potential for the development of both preventive and protective programs to avoid the transition from acute to chronic pain or reduce the impact in the lives of patients when it has already developed.",[213,29,299,300],"Chronic Postoperative Pain","Chronic Post-operative Pain","2024-10-11",{"date":303,"type":34},"2024-10-16",{"date":305,"type":22},"2025-02-01",{"date":307,"type":22},"2026-12-31",{"name":309,"class":41},"University Rovira i Virgili",3]