[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-postsurgical-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-postsurgical-pain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,50,81,109,138,159,182,209,234],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641814","perioperative-quantitative-sensory-testing-and-incision-pain-mapping-in-thoracic-surgery-100641814",false,"NCT07653932","Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery","Perioperative Pain Phenotyping and Incision Pain Mapping Using Quantitative Sensory Testing in Patients Undergoing Thoracoscopic or Robotic-assisted Lung Resection: A Prospective Observational Pilot Cohort Study","Inclusion Criteria:\n\n1. Male\n2. Scheduled to undergo elective thoracoscopic or robotic-assisted lung resection.\n3. American Society of Anesthesiologists physical status I to III.\n4. Able to understand and communicate adequately and to complete study questionnaires independently or with assistance from study staff.\n5. Willing to undergo QST assessment, perioperative venous blood sampling, and postoperative follow-up.\n6. Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Definite chronic chest wall, shoulder, back, or upper limb pain with an average 2. Numeric Rating Scale score of 3 or higher during the preceding week.\n\n3\\. Definite painful neuropathic disease or long-term use of opioids or other analgesics for more than 2 weeks.\n\n4\\. Peripheral neuropathy, spinal cord disease, or other neurological disease that may substantially interfere with interpretation of QST results.\n\n5\\. Severe cognitive impairment, psychiatric disorder, communication disorder, or inability to complete questionnaires and QST assessments.\n\n6\\. Active infection, active autoimmune disease, or other disease condition that may substantially affect inflammatory protein measurements.\n\n7\\. Emergency surgery, conversion to open thoracotomy, extensive chest wall resection, or severe intraoperative complications.\n\n8\\. Any condition that, in the opinion of the investigator, makes the participant unsuitable for continued participation in the study.","MALE","18 Years",{"count":19,"type":20},46,"ESTIMATED","3 Months","OBSERVATIONAL","Postoperative pain remains a common and clinically important burden after thoracic surgery and may progress to chronic postsurgical pain. Conventional pain assessment mainly relies on patient-reported pain intensity and analgesic consumption, which may not fully capture peri-incisional sensory abnormalities, mechanical hyperalgesia, or central sensitization.\n\nThis prospective observational pilot cohort study aims to evaluate the feasibility and acceptability of perioperative quantitative sensory testing (QST) and incision pain mapping in adult patients undergoing elective thoracoscopic or robotic-assisted lung resection. Participants will undergo baseline assessment before surgery, serial postoperative pain assessments during the first 72 hours, QST and mechanical hyperalgesia pain mapping at 48-72 hours after surgery, and follow-up assessments at discharge, 1 month, and 3 months after surgery.\n\nThe primary feasibility outcomes include recruitment rate, QST completion rates, follow-up completion rates, QST-related discontinuation rate, study-related adverse events, and data completeness. The main clinical mechanistic outcome is the area of peri-incisional mechanical hyperalgesia at 48-72 hours after surgery. Secondary outcomes include acute postoperative pain intensity, pain burden over 72 hours, opioid consumption, quality of recovery, QST changes, pain-map characteristics, and chronic postsurgical pain at 3 months.\n\nThis study will not assign or modify therapeutic interventions. All anesthetic, surgical, and analgesic management will be determined by the routine clinical care team. The study is expected to provide feasibility data, preliminary effect estimates, and mechanistic information for future larger perioperative pain studies.",[25,26,27,28,29,30],"Postoperative Pain","Chronic Postsurgical Pain","Thoracic Surgery","Lung Resection","Mechanical Hyperalgesia","Central Sensitization",[32,33,34,35,36],"Quantitative sensory testing","QST","Incision pain mapping","Thoracoscopic surgery","Perioperative pain phenotype","NOT_YET_RECRUITING","2026-06-13",{"date":40,"type":41},"2026-06-17","ACTUAL",{"date":43,"type":20},"2026-06-08",{"date":45,"type":20},"2027-02-28",{"name":47,"class":48},"Tongji Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":49},"100454358","phase-3-efficacy-of-an-intraoperative-periradicular-application-of-platelet-rich-fibrin-prf-on-the-intensity-of-residual-post-surgical-neuropathic-pain-after-a-surgery-for-disc-herniation-100454358","NCT05196503","Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation","Efficacy of Platelet Rich Fibrin in the Prevention of Residual Neuropathic Pain Following Disc Herniation Surgery","NeuroPRF","Inclusion criteria:\n\n* Patient, male or female, \\>18 years old at the time of signing informed consent;\n* Patient for whom a diagnosis of radiculopathy on lumbar disc herniation has been made, and for whom surgery has been scheduled in the Neurosurgery department;\n* Patient affiliated to a social security health insurance scheme;\n* Patient able to understand the objectives and risks of research and to give informed, dated and signed consent;\n* Patient having been informed of the results of the prior medical examination;\n* Women of childbearing age provided that a negative blood pregnancy test is recorded at the inclusion visit and effective contraception used throughout the study.\n\nExclusion criteria:\n\n* Patient with a history of lumbar spinal surgery (multiple herniated discs, herniated disc other than lumbar);\n* Patient with HIV, active cancer, HBV, HCV (verified by interview);\n* Patient on long-term systemic corticosteroid therapy;\n* Patient with an ASA score \\> 3 during the consultation with the anesthesiologist;\n* Inability to give the patient informed information (patient in an emergency or life-threatening situation, difficulties in understanding);\n* Patient in exclusion period (determined by a previous or ongoing study);\n* Subject under safeguard of justice;\n* Subject under curatorship;\n* Pregnancy;\n* Breastfeeding.","ALL",{"count":60,"type":20},60,"INTERVENTIONAL",[63],"PHASE3","The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and\u002For gabapentinoids, requires the development of new techniques to prevent this chronic pain. Certain well-tolerated techniques, such as the administration of plasma enriched with platelets and fibrin (PRF), are increasingly used in regenerative medicine for their anti-inflammatory and analgesic properties. Thus, a periradicular intraoperative application of PRF may have an analgesic effect on the intensity of residual postsurgical neuropathic pain after disc herniation surgery.",[66,26],"Neuropathic Pain",[68,69,70,71],"Neuropathic pain","Chronic postsurgical pain prevention","Intraoperative platelet rich fibrin","Disc herniation surgery","RECRUITING","2026-06-05",{"date":43,"type":41},{"date":76,"type":41},"2022-02-23",{"date":78,"type":20},"2028-01",{"name":80,"class":48},"University Hospital, Strasbourg, France",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":61,"phases":90,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":49},"100588814","intertransverse-process-block-to-improve-quality-of-recovery-and-pain-management-in-adult-cardiac-surgical-patients-100588814","NCT06946290","Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients","Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients: a Prospective Double-Blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* adult patients aged 18 or older\n* undergoing elective CABG, valve repair\u002Freplacement, or combined CABG\u002Fvalve procedure via sternotomy\n\nExclusion Criteria:\n\n* Emergency surgery\n* redo surgery\n* history of chronic pain or being on chronic opioids\u002Fsedatives\n* renal failure with an estimated glomerular filtration rate ≤30 ml\u002Fmin (calculated by Cockcroft-Gault formula)\n* re-operation within 24 hours after surgery\n* intraoperative use of remifentanil\n* inability to provide informed consent.",{"count":89,"type":20},96,[91],"NA","The goal of this clinical trial is to evaluate the efficacy of intertransverse process block (ITPB) in improving quality of recovery and potentially preventing chronic postsurgical pain (CPSP) in adult patients undergoing elective cardiac surgery (e.g., coronary artery bypass graft \\[CABG\\], valve repair\u002Freplacement, or combined CABG\u002Fvalve procedures).\n\nThe main questions it aims to answer are:\n\n1. To investigate the quality of recovery after cardiac surgery, and its analgesic efficacy in the immediate postoperative period\n2. To investigate the efficacy of intertransverse process block (ITPB) on CPSP after cardiac surgery by determining the incidence of CPSP at 3 month, defined as persistent pain that was not present before surgery or that had different characteristics, and other possible causes of pain are excluded.\n3. To investigate the efficacy of ITPB on the incidence of CPSP at 6 month, 12 month, and the pain interference (sensory and affective components, physical activities) at 3 month, 6 month and 12 month after surgery",[26],[95,96,97,98,99],"ITPB","Intertransverse process block","Chronic postsurgical pain","Cardiac surgery","quality of recovery","2026-03-16",{"date":102,"type":41},"2026-03-18",{"date":104,"type":41},"2026-01-02",{"date":106,"type":20},"2028-01-02",{"name":108,"class":48},"Chinese University of Hong Kong",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":61,"phases":118,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":49},"100558744","acute-preoperative-pain-and-chronic-post-surgical-pain-in-emergency-surgery-100558744","NCT06555107","Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery","POCSE","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Emergency orthopaedic and\u002For abdominal surgery.\n* Informed consent.\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* Intraoperative complications that are life-threatening or require the surgical procedure to be discontinued.\n* Post-operative intensive care unit admission.\n* Ambulatory surgery.\n* Endoscopic surgery.\n* Repeat surgery at the same site in less that 3months.\n* Pregnant or breast-feeding patients.\n* Patients under guardianship or deprived of liberty.\n* Patients suffering from psychiatric pathologies.\n* Patients suffering from neurodegenerative pathologies.\n* Patients for whom self-assessment of pain using a numerical scale (0-10) cannot be carried out (non-communicative patients, non-French-speaking patients, and so on).",{"count":117,"type":20},693,[91],"Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery. As a result, the preoperative pain studied as a risk factor for chronicity is essentially a state of pain that has persisted for several weeks or even several months.\n\nIn emergency surgeries, patients are subject to acute preoperative pain of varying intensity and the duration of which may vary by a few days. A few studies have highlighted the intensity of acute preoperative pain as a factor favouring moderate to severe postoperative pain. At this point, no study has addressed the long-term consequences of this intense preoperative pain the emergency context.\n\nAn evaluation in the field of emergency surgery, where the preoperative pain is often intense and limited in time, would enable us to identify more precisely the impact of acute pain on the incidence of CPSP.\n\nThe investigators are hypothesising that the occurrence of CPSP at 3 months in patients undergoing emergency orthopaedic or abdominal surgery is associated with acute preoperative pain.",[26,121,122,123,25,124],"Acute Pain","Emergency Surgery","Opioid","Risk Factors",[126,26,121,127,128,25],"risk factors","emergency surgery","opioid","2026-01-15",{"date":131,"type":41},"2026-01-16",{"date":133,"type":41},"2024-08-29",{"date":135,"type":20},"2027-04",{"name":137,"class":48},"Centre Hospitalier Universitaire, Amiens",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":61,"phases":147,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100594356","phase-4-the-effect-of-oliceridine-patient-controlled-intravenous-analgesia-on-postoperative-chronic-pain-after-video-assisted-thoracoscopic-lobectomy-100594356","NCT07018375","The Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lobectomy","Inclusion Criteria:\n\n* ① Age 18-75 years, ASA physical status I-III, BMI 18-30 kg\u002Fm²;\n\n  * Scheduled for unilateral video-assisted thoracoscopic surgery (VATS) lung resection, including wedge resection, segmentectomy, lobectomy, or radical resection for lung cancer;\n\n    * Preoperative pain score \\\u003C1 on the Numeric Rating Scale (NRS);\n\n      * Ability to understand the study objectives and procedures, with voluntary informed consent obtained;\n\n        * Expected postoperative recovery in the general ward setting.\n\nExclusion Criteria:\n\n* ① History of chronic pain or long-term analgesic use prior to surgery;\n\n  * Previous ipsilateral thoracic surgery;\n\n    * Prior neoadjuvant radiotherapy or chemotherapy;\n\n      * Severe cardiovascular or cerebrovascular disease, or hepatic\u002Frenal dysfunction (ALT\u002FAST \\>3× upper limit of normal; eGFR \\\u003C60 mL\u002Fmin\u002F1.73m²);\n\n        * Concurrent malignancy or active infection;\n\n          * Pre-existing psychiatric disorders or communication barriers precluding study participation;\n\n            * Known hypersensitivity to study medications (opioids, adjuvant analgesics, anesthetics, or antiemetics);\n\n              * Any condition deemed unsuitable for study participation by the investigator","75 Years",{"count":146,"type":20},320,[148],"PHASE4","The primary objective is to evaluate the impact of oliceridine versus sufentanil for perioperative analgesia on the incidence of chronic postsurgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgery.",[26],"2026-01-05",{"date":153,"type":41},"2026-01-06",{"date":153,"type":20},{"date":156,"type":20},"2027-04-30",{"name":158,"class":48},"Tianjin Medical University General Hospital",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":58,"minAge":165,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":61,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":49},"100522504","phase-4-reducing-perioperative-oxidative-stress-to-prevent-postoperative-chronic-pain-following-total-knee-arthroplasty-100522504","NCT06083480","Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty","Inclusion Criteria:\n\n* Age 50 or older\n* Intact cognitive status and ability to provide informed consent (based on cognitive screening with the Mini Mental State Examination)\n* Ability to read and write in English sufficiently to understand and complete study questionnaires\n* Undergoing unilateral primary TKA\n* Medical diagnosis of osteoarthritis\n* Past 24 hour worst numeric rating scale (NRS) pain of at least 4\u002F10.\n\nExclusion Criteria:\n\n* Diagnosis of pre-existing neuropathy\n* Untreated hypo\u002Fhyperthyroidism\n* Untreated heart disease\n* Alanine transaminase\u002Faspartate transaminase \\>2x upper-limit of normal range\n* serum creatinine \\>1.5 mg\u002Fdl\n* Pregnancy\n* Complex Regional Pain Syndrome (CRPS) diagnosis prior to undergoing TKA\n* Presence of lower extremity vascular disease, inflammatory or autoimmune disorders, or malignancy\n* Presence of current clinically significant chronic pain conditions outside of the lower extremity ( daily pain for \\>3 months and greater ≥3\u002F10 in intensity or the focus of medical care)\n* Presence of other medical conditions that in the opinion of the orthopedic surgeon co-investigators would make a patient's study participation unsafe","50 Years",{"count":167,"type":20},148,[148],"This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).",[171,172,26],"Osteoarthritis, Knee","Total Knee Arthroplasty","2025-12-05",{"date":175,"type":41},"2025-12-11",{"date":177,"type":41},"2024-12-06",{"date":179,"type":20},"2029-03",{"name":181,"class":48},"Vanderbilt University Medical Center",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":61,"phases":191,"briefSummary":192,"conditions":193,"keywords":198,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":49},"100522814","phase-4-different-dose-esketamine-and-dexmedetomidine-for-supplemental-analgesia-and-longterm-outcomes-100522814","NCT06087510","Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes","Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial","Inclusion Criteria:\n\n* Patients aged ≥18 years and body weight≥40 kg;\n* Scheduled to undergo scoliosis correction with pedicle screw fixation;\n* Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n* Preoperative sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 beats per minute), atrioventricular block grade II or above without pacemaker, congenital heart disease, arrhythmia, or other serious cardiovascular diseases with a New York Heart Association class ≥III;\n* Patients with moderate or severe obstructive sleep apnea diagnosed preoperatively or according to the STOP-Bang score;\n* History of hyperthyroidism or pheochromocytoma;\n* History of schizophrenia, epilepsy, myasthenia gravis;\n* Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (preoperative dialysis), or American Society of Anaesthesiologists grade ≥IV;\n* Barrier in communication;\n* Other conditions that were considered unsuitable for study participation.",{"count":190,"type":20},312,[148],"Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe acute postoperative pain is one of the major risk factors of CPSP. Spinal correction surgery is associated with severe pain due to large trauma and long duration. Ketamine and esketamine are N-methyl-D-aspartate receptor antagonists; they have antihyperalgesic effects and may reduce CPSP. Dexmedetomidine is an alpha 2-adrenoceptor agonist with sedative, anxiolytic, and analgesic effect; it is frequently used as an adjuvant to postoperative analgesia. In a previous trial of 200 patients after scoliosis correction surgery, mini-dose esketamine-dexmedetomidine in combination with opioids significantly improved analgesia and sleep quality but did not reduce CPSP. The authors speculate that increasing esketamine dose in the combination may further improve analgesia and, therefore, reduce the occurrence of CPSP.",[194,195,196,197,26],"Scoliosis Correction","Postoperative Analgesia","Esketamine","Dexmedetomidine",[194,199,196,197,26],"Postoperative analgesia","2025-07-29",{"date":202,"type":41},"2025-07-30",{"date":204,"type":41},"2024-01-24",{"date":206,"type":20},"2026-09",{"name":208,"class":48},"Peking University First Hospital",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":58,"minAge":215,"maxAge":17,"enrollmentInfo":216,"targetDuration":4,"studyType":61,"phases":218,"briefSummary":219,"conditions":220,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":233},"100565150","prevention-of-postsurgical-chronic-pain-in-children-and-adolescents-prevendol-100565150","NCT06638437","Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL)","Inclusion Criteria:\n\n1. Having to undergo surgery\n2. Being between 8 and 18 years old;\n3. Having signed the informed consent\n4. Having an ASA risk between I and III\n\nExclusion Criteria:\n\n1. Not being able to understand Spanish\n2. Having a physical and\u002For cognitive impairment that interferes with understanding the instructions and handling of the application (e.g., moderate to severe intellectual disability, blindness)\n3. Participating in another clinical trial\n4. Undergoing an urgent surgical intervention\n5. Being hospitalized in intensive care due to the need for ventilation or hemodynamic support or other complications\n6. Having an ASA risk of IV\n7. Not having signed the informed consent","8 Years",{"count":217,"type":20},125,[91],"Chronic postsurgical pain is a health problem with a great societal impact: approximately 20% of all children and adolescents undergoing surgery will develop chronic pain. Importantly, the risk and protective factors that are known (e.g., anxiety, catastrophizing, pain beliefs and pain coping) are modifiable, thus there is a huge potential for the development of both preventive and protective programs to avoid the transition from acute to chronic pain or reduce the impact in the lives of patients when it has already developed.",[26,221,222,223],"Chronic Post-surgical Pain","Chronic Postoperative Pain","Chronic Post-operative Pain","2024-10-11",{"date":226,"type":41},"2024-10-16",{"date":228,"type":20},"2025-02-01",{"date":230,"type":20},"2026-12-31",{"name":232,"class":48},"University Rovira i Virgili",3,{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":58,"minAge":240,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":61,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":49},"100564517","effectiveness-of-myofascial-release-in-patients-with-chronic-post-sternotomy-pain-syndrome-100564517","NCT06630208","Effectiveness of Myofascial Release in Patients With Chronic Post Sternotomy Pain Syndrome","Inclusion Criteria:\n\n* Chronic Post-sternotomy pain (CPSP), defined as discomfort at the thorax after cardiac surgery, persisting for at least 2 months, and without apparent cause (I.e., such as infection or the underlying disease that motivated the surgery).\n* Age between 55 to 65 years old.\n* All patients will be under full medical supervision.\n* Adherence to informed consent.\n* Cardiac sternotomy intervention\n\nExclusion Criteria:\n\n* Neuromuscular disorders.\n* Any Active hemorrhage.\n* The presence of an unstable cardiac, pulmonary or cerebral pathology.\n* Poor cognition and mentality.\n* Patients with active contagious skin conditions\n* Any Cardiopulmonary problems (eg. Uncontrolled hypertension, Heart Failure, Arrhythmia)\n* Patients with malignancy.\n* Any acute viral infection.\n* Patients with ascites or end-stage liver or kidney failure.\n* Patients will participate in other physiotherapy programs rather than the prescribed protocol.\n* Chest infection in last 3 months.\n* Patients with musculoskeletal problems like any bone fracture\n* Osteoporotic patients.\n* Any recent open wound in the chest are.\n* Hemodynamic instability.","55 Years","65 Years",{"count":60,"type":20},[91],"The main aim of this study is to investigate the effectiveness of Myofascial release in patients with chronic sternotomy pain.",[26],"2024-10-04",{"date":248,"type":41},"2024-10-08",{"date":250,"type":20},"2024-12-15",{"date":252,"type":20},"2025-03-01",{"name":254,"class":48},"Cairo University"]