[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-stress":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,73,101,130,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100638306","dual-language-b-more-for-hypertension-100638306",false,"NCT07623031","Dual-Language B-MORE for Hypertension","B-MORE for Hypertension","Inclusion Criteria:\n\n* Age ≥18\n* Having self-reported hypertension (BP ≥ 140\u002F90)\n* Understanding English or Spanish instructions fluently\n\nExclusion Criteria:\n\n* Known or planned pregnancy in the next 3 months assessed via self-report\n* Cognitive impairment preventing completion of study procedures.\n* Have previous, formal mindfulness training (e.g., MBSR)\n* Other unstable illness judged by medical staff to interfere with study involvement.","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","This pilot study is a single-arm clinical feasibility trial evaluating the feasibility, acceptability, and preliminary efficacy of a brief adaptation of Mindfulness-Oriented Recovery Enhancement (B-MORE) for reducing stress and high blood pressure in hypertensive English- and Spanish-speaking patients (n=20). The intervention, a 2-hour online training in stress management and hypertension, will be delivered virtually in a small-group format over two 60-minute sessions.",[26,27],"Hypertension (HTN)","Chronic Stress","NOT_YET_RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-03","ACTUAL",{"date":34,"type":20},"2026-06",{"date":36,"type":20},"2026-12",{"name":38,"class":39},"Florida State University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":40},"100614924","the-role-of-stress-in-cardiac-arrest-cortizol-cpr-100614924","NCT07285915","The Role of Stress in Cardiac Arrest (Cortizol CPR)","Stress as a Key Factor Influencing the Onset and Course of Cardiac Arrest","Cortizol","Inclusion Criteria:\n\n* Cardiac arrest\n* Heart attack\n* 18 - 100 years\n\nExclusion Criteria:\n\n* Disapproval patient´s relatives with the study\n* Chronical treatment with corticoids and antidepresives","100 Years",{"count":51,"type":20},136,[23],"The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples. Cortisol is produced in larger amounts during periods of ongoing stress and builds up in the hair as it grows. Because hair grows about 1 cm per month, a 3 cm hair sample can show your average stress level over the past three months. The results will be compared with anonymized information from your medical records and the care you received before and during your hospital stay.",[27,55,56,57],"Cardiac Arrest (CA)","Post-Resuscitation Syndrome","Heart Attack",[59,60,61,62],"cardiac arrest","chronic stress","kortizol","hair","RECRUITING","2026-04-27",{"date":66,"type":32},"2026-05-01",{"date":68,"type":32},"2026-01-08",{"date":70,"type":20},"2027-10-31",{"name":72,"class":39},"University Hospital Pilsen",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":40},"100611062","game-intervention-for-resilience-100611062","NCT07235696","Game Intervention for Resilience","A Randomized Controlled Trial to Examine the Impact of a Game-based Intervention in Promoting Positive Affectivity and Enhancing Psychological Resilience","Inclusion Criteria:\n\n* fluency in oral and written Cantonese or Mandarin;\n* having experienced at least one major life stress in the recent 5 years (assessed by the Life Stress Index);\n* normal or corrected-to-normal vision and hearing.\n\nExclusion Criteria:\n\n* formal diagnosis of any major psychiatric illnesses or history of suicidal behaviour;\n* major physical illness, neurological condition or traumatic brain injury;\n* Intake of medication within the previous 6 months that may affect emotion or cognitive functions;\n* pregnancy (for women);\n* prior experience with any commercial computer repair simulation game.","23 Years","35 Years",{"count":83,"type":20},60,[23],"The goal of this clinical trial is to learn if a game-based intervention can enhance psychological resilience and promote positive affectivity in adults who have experienced major life stress.\n\nThe main questions it aims to answer are:\n\n* Does the game-based intervention improve positive affectivity and mental health compared to a waitlist control group immediately after the intervention and at 3-month follow-up?\n* Are the mental health benefits of the game-based intervention mediated by improvements in positive affectivity over time?\n\nResearchers will compare the game-based intervention to an active control group and a waitlist control group to see if the game leads to better emotional and mental health outcomes.\n\nParticipants will:\n\n* Be randomly assigned to the game-based intervention group, the psychoeducation intervention group (as active control group), or the waitlist control group\n* Engage with the assigned program for 10 days within two weeks\n* Complete psychological assessments before and after the intervention, and again at 3-month follow-up",[27,87,88,89],"Trauma Exposure","Resilience, Psychological","Major Life Stress",[91,92,89,93],"Game-Based Intervention","Psychological Resilience","Positive Affectivity",{"date":66,"type":32},{"date":96,"type":20},"2026-07-15",{"date":98,"type":20},"2026-12-20",{"name":100,"class":39},"The University of Hong Kong",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":109,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":40},"100608359","does-psychotherapy-change-the-gut-microbiome-in-women-of-child-bearing-age-100608359","NCT07200531","Does Psychotherapy Change the Gut Microbiome in Women of Child-bearing Age?","Impact of Biopsychosocial Psychotherapy Intervention on Maternal Life-Course Trauma and the Gut Microbiome","Inclusion Criteria:\n\n* Women over the age of 19 and less than 54. Able to understand\u002Fread English\n\nExclusion Criteria:\n\n* Pregnant women and breast-feeding women Women who are actively participating in psychotherapy on a regular basis",true,"FEMALE","19 Years","54 Years",{"count":113,"type":20},30,[23],"The goal of this clinical trial is to learn if group therapy for six weeks changes the gut microbiome in women. The main questions it aims to answer are:\n\nIs chronic stress associated with the gut microbiome? Will six weeks of therapy change the gut microbiota?\n\nParticipants will:\n\nAnswer questionnaires about chronic stress Mail a stool sample before and after the intervention. Participate in a 1-hour group therapy session over the course of six weeks.",[27],[118,119,120],"Gut Microbiome","Life-course trauma","Psychotherapy","2026-03-24",{"date":123,"type":32},"2026-03-25",{"date":125,"type":32},"2025-12-01",{"date":127,"type":20},"2026-07",{"name":129,"class":39},"University of Nebraska",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":108,"sex":16,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":138,"phases":4,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":40},"100609697","assessing-the-feasibility-of-multi-modal-biosensing-for-monitoring-mobility-and-cognition-in-older-adults-100609697","NCT07217951","Assessing the Feasibility of Multi-modal Biosensing for Monitoring Mobility and Cognition in Older Adults","Inclusion Criteria:\n\n1. Aged 65 or older\n2. Expressed willingness to participate.\n3. Able to give written informed consent\n4. Able to operate a smartphone and complete surveys\n\nExclusion Criteria:\n\n1. Reliance on assistive walking devices\n2. Inability to operate a smartphone\n3. Unable to complete surveys\n4. Unable to give written informed consent\n5. Younger than 65 years old\n6. Known skin allergies to kinesiology tape (KT tape)","65 Years",{"count":19,"type":20},"OBSERVATIONAL","Current health devices often overlook older users, who may face both health challenges and technology barriers. We are investigating the feasibility of wearable sensors to track posture, heart rate, and breathing, alongside a microneedle patch that collect body fluids to measure stress and inflammation markers. By combining this data, we aim to create an easy to use system that supports personalized, at home health monitoring for older adults.",[27,141,142],"Systemic Inflammation","Mobility and Independence",[144,145,146,147,148],"wearable sensors","older adults","aging","mobility","inflammation","2025-10-16",{"date":151,"type":32},"2025-10-20",{"date":153,"type":20},"2025-12",{"date":155,"type":20},"2028-09",{"name":157,"class":39},"Tufts University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":108,"sex":16,"minAge":165,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":21,"phases":168,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":187},"100499914","confirmatory-efficacy-of-the-building-a-strong-identity-and-coping-skills-program-100499914","NCT05789446","Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program","Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program for Low-income and Minoritized Young Adolescents","Inclusion Criteria:\n\n* Children ages 11-14 at intake\n* Family income at or below 200% federal poverty level\n* Child speaks English\n* Parent speaks English or Spanish\n\nExclusion Criteria:\n\n* Intellectual disability\n* Autism spectrum disorder\n* High suicidal risk (score of 17 or more on the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-Kid))\n* Severe depression (score of 19 or more on Patient health questionnaire (PHQ).","11 Years",{"count":167,"type":20},360,[23],"The goal of this clinical trial is to the efficacy of the Building a Strong Identity and Coping Skills intervention within a sample of low-income and minoritized youth aged 11-14 who are seeking mental health treatment and have been placed on a waitlist to receive services.\n\nThe aims of this study are to: (1) confirm the efficacy of BaSICS by replicating previous findings, (2) Examine the changes of coping mechanisms and symptom change over the course of the BaSICS intervention, and (3) test models of physiologic stress reactivity and regulation to capture biological \"risk\" and recalibration.\n\nCohorts of 20 participants will randomly be enrolled in either the intervention (10) or control (10) groups. Participants enrolled in the intervention group will complete the BaSICS program and participants enrolled in the no intervention group will not be enrolled in the intervention program. The BaSICS program is designed to help treat anxiety, depression, and post-traumatic stress symptoms and disorders and have direct effects on physiologic stress response systems (hypothalamic-pituitary-adrenal (HPA) axis). Researchers will compare the intervention and no intervention groups to see if there is a difference in the reduction of markers for anxiety, depression, and suicide scores, changes in coping mechanism, and HPA reactivity profiles",[27,171,172],"Anxiety","Depression",[174,175,176,177],"Poverty","Discrimination","Stress","Coping","2025-04-11",{"date":180,"type":32},"2025-04-16",{"date":182,"type":32},"2025-02-01",{"date":184,"type":20},"2029-05-31",{"name":186,"class":39},"Penn State University",5]