[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-stroke-patient\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-stroke-patient":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,76,108,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642195","relationship-between-balance-arm-function-and-body-awareness-in-people-with-stroke-100642195",false,"NCT07652710","Relationship Between Balance, Arm Function and Body Awareness in People With Stroke","Investigation of Balance, Upper Extremity and Body Awareness in Individuals With Stroke","Inclusion Criteria:\n\n* Individuals who experienced a cerebrovascular event at least 6 months previously\n* Individuals between 18 and 75 years of age\n* Individuals who have experienced stroke for the first time\n* Individuals with shoulder, elbow, wrist, and finger muscle tone graded as 2 or 3 according to the Modified Ashworth Scale (MAS)\n* Individuals scoring 24 points or higher on the Standardized Mini Mental State Examination\n* Individuals with at least 120° of shoulder range of motion\n* Individuals who are able to walk independently or with a walking aid\n\nExclusion Criteria:\n\n* Presence of communication problems such as difficulties in reading, writing, or speaking\n* Botulinum toxin injection within the last 3 months\n* Presence of hemispatial neglect syndrome\n* Presence of ataxia due to posterior circulation ischemia\n* Bilateral involvement (bilateral hemiparesis)\n* Having received physiotherapy within the last 6 months\n* Presence of orthopedic problems such as shoulder subluxation, shoulder pain, contracture of the hand and wrist\n* History of upper extremity or thoracic surgery\n* Presence of stroke-related visual impairments (hemianopia)\n* Presence of color blindness\n* Use of antiepileptic medication\n* History of convulsions","ALL","18 Years","75 Years",{"count":20,"type":21},53,"ESTIMATED","OBSERVATIONAL","Stroke is one of the leading causes of long-term disability worldwide and is frequently associated with impairments in balance, upper extremity function, and body awareness. These impairments may negatively affect independence in activities of daily living and overall quality of life. Although previous studies have investigated the relationships between balance and upper extremity function after stroke, body awareness has received relatively limited attention.\n\nThe aim of this observational cross-sectional study is to investigate the relationship between balance, upper extremity skills, and body awareness in individuals with chronic stroke. Fifty-three individuals with chronic stroke will be recruited from the Department of Physical Medicine and Rehabilitation at Baskent University Hospital.\n\nBalance will be assessed using the Berg Balance Scale and the Tetrax computerized posturography system. Upper extremity motor impairment and functional performance will be evaluated using the Fugl-Meyer Upper Extremity Assessment and the Wolf Motor Function Test. Body awareness will be assessed using the Body Awareness Questionnaire. Additional assessments will include lower extremity motor function, muscle tone, cognitive status, shoulder range of motion, and upper extremity reaction time.\n\nThe study is expected to provide a better understanding of the relationships among balance, upper extremity function, and body awareness in individuals with chronic stroke. The findings may contribute to the development of individualized rehabilitation strategies and improve clinical assessment approaches in stroke rehabilitation.",[25],"Chronic Stroke Patient",[27,28,29,30],"stroke","postural balance","upper extremity","body image","NOT_YET_RECRUITING","2026-06-11",{"date":34,"type":35},"2026-06-17","ACTUAL",{"date":37,"type":21},"2026-06-20",{"date":39,"type":21},"2026-10-20",{"name":41,"class":42},"Baskent University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100639563","efficacy-of-swiss-ball-exercises-versus-kinesthetic-training-for-improving-balance-and-functional-mobility-in-chronic-stroke-patients-100639563","NCT07587463","Efficacy of Swiss Ball Exercises Versus Kinesthetic Training for Improving Balance and Functional Mobility in Chronic Stroke Patients.","Efficacy of Swiss Ball Exercises Versus Kinesthetic Training for Improving Balance and Functional Mobility in Chronic Stroke Patients","Not any","Inclusion Criteria:\n\nPatients diagnosed with stroke for past 6 or more then 6 months both sides (R, L).\n\nAge: 45-65 years . Absence of cognitive impairment ( Mini Mental State Examination Score \\>23). Able to follow 3 step command. Medically stable. Both genders. Who can manage to come to the medical centre. Who score 21-50 on berg balance scale (BBS). Able to participate in the exercise program. Who don't have any cardiovascular or musculoskeletal problem.\n\nExclusion Criteria:\n\nCognitive impairment hindering performance. Other neurological problems. Acute or subacute stroke. Impair vision without correction. Other health problem ( cardiovascular, DM etc). Pain during standing or walking. Lake the ability to participate.","45 Years","65 Years",{"count":55,"type":21},36,"INTERVENTIONAL",[58],"NA","Stroke is one of the leading causes of long-term disability and commonly results in impaired balance, reduced trunk control, and difficulty in functional mobility. Chronic stroke patients often experience limitations in daily activities due to poor postural stability and decreased motor coordination. Various rehabilitation approaches are used to improve balance and mobility, among which Swiss ball exercises and kinesthetic training are considered beneficial interventions.\n\nThe purpose of this randomized controlled trial is to compare the effectiveness of Swiss ball exercises versus kinesthetic training in improving balance and functional mobility in patients with chronic stroke. A total of 36 participants diagnosed with chronic stroke for more than six months will be recruited and randomly allocated into two groups. Group A will receive Swiss ball exercises focusing on trunk stability, coordination, and balance control, while Group B will receive kinesthetic training aimed at improving proprioception, sensory feedback, and motor control.\n\nThe intervention program will continue for 8 weeks under the supervision of qualified physiotherapists in the Physiotherapy Department of Shalimar Health Centre. Balance and functional mobility will be assessed before and after the intervention using the Berg Balance Scale (BBS) and Timed Up and Go (TUG) test.\n\nThis study aims to determine which intervention is more effective in enhancing balance and mobility in chronic stroke patients and may help improve rehabilitation strategies for stroke recovery.",[25],[62,63,64,65],"Chronic Stroke","Swiss Ball Exercises","Kinesthetic Training","Balance Training","RECRUITING","2026-05-16",{"date":69,"type":35},"2026-05-20",{"date":71,"type":21},"2026-05-07",{"date":73,"type":21},"2026-06-30",{"name":75,"class":42},"Nisha Fazal",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":56,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":43},"100626725","multifocal-theta-burst-stimulation-to-enhance-upper-limb-motor-recovery-after-stroke-inspire-100626725","NCT07439367","Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)","Advancing Stroke Rehabilitation Through Multifocal Network-based Theta-burst Stimulation and Assistive Technology: Enhancing Upper Limb Motor Learning: A Single-center, Randomized, Sham-controlled Study With Parallel Groups.","INSPIRE","Inclusion Criteria:\n\nFor Stroke Participants:\n\n* Age ≥ 18 years\n* First-ever ischemic or hemorrhagic stroke\n* Time since stroke ≥ 6 months\n* Unilateral upper limb hemiparesis\n* Fugl-Meyer Assessment Upper Extremity (FMA-UE) score between 29 and 57\n* Modified Ashworth Scale score \\\u003C 2 at elbow, wrist, or finger flexors\n* Manual muscle testing ≥ 3\u002F5 in proximal upper limb muscles (deltoid, biceps, triceps, wrist pronators\u002Fsupinators)\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nFor Healthy Participants:\n\n* Age ≥ 18 years\n* No history of neurological disease\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nExclusion Criteria:\n\nFor Stroke Participants:\n\n* Second stroke occurring during the study period\n* Botulinum toxin injection within 3 months prior to study start\n* History of one or more epileptic seizures\n* Metallic object near the stimulation site\n* Implanted electronic or metallic devices (e.g., pacemaker, neurostimulator) incompatible with TMS\n* Severe comorbid conditions affecting the upper limb (traumatic, rheumatologic, osteoarticular, or neurodegenerative disorders)\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures (e.g., language barrier, psychological disorder, dementia)\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment\n\nFor Healthy Participants:\n\n* Severe musculoskeletal or neurological condition affecting the non-dominant upper limb\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment",true,{"count":86,"type":21},46,[58],"Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event. These motor impairments significantly affect independence, daily activities, and quality of life. Despite rehabilitation efforts, recovery of upper limb function remains incomplete for many patients.\n\nMotor recovery after stroke depends on the brain's ability to reorganize itself, a process known as neuroplasticity. Recent research suggests that motor learning and brain recovery are influenced not only by activity in the primary motor cortex (M1), but also by its functional connectivity with other brain regions, particularly the parietal cortex (PC). Strengthening communication between these regions may enhance motor recovery.\n\nThis study aims to investigate a novel, non-invasive brain stimulation approach called intermittent theta-burst stimulation (iTBS). Unlike traditional stimulation methods that target a single brain region, this study uses a multifocal stimulation protocol targeting both the primary motor cortex and the parietal cortex. The stimulation is combined with structured motor training using an interactive tablet-based rehabilitation device (REAtouch®Lite 2), designed to improve arm movement through goal-directed reaching tasks.\n\nThe study is a single-center, randomized, sham-controlled, triple-blind clinical trial with parallel groups. Thirty-six individuals with chronic stroke-related upper limb impairment will be randomly assigned to receive either active multifocal iTBS or sham (placebo) stimulation. Both groups will complete identical motor training sessions. In addition, ten healthy participants will complete the same motor training protocol (without brain stimulation) to provide reference data.\n\nParticipants will attend six visits over approximately 10 days. Assessments will include motor performance tests using the interactive tablet, a standardized clinical motor scale (Fugl-Meyer Assessment for Upper Extremity), and resting-state electroencephalography (EEG) to measure brain connectivity changes.\n\nThe primary outcome is improvement in motor performance between baseline and one week after the intervention. Secondary outcomes include short-term motor improvements, retention of learning, changes in movement quality, and changes in brain functional connectivity.\n\nThis study seeks to determine whether combining multifocal brain stimulation with targeted motor training can enhance motor learning and promote better recovery of arm function after stroke. If effective, this approach could contribute to the development of more precise, network-based neurorehabilitation strategies.",[25,90,91,92],"Motor Impairment","Neurorehabilitation","Theta Burst Stimulation",[62,94,95,96,97,98],"Upper Limb Rehabilitation","Intermittent Theta Burst Stimulation","Tablet-Based Rehabilitation","Neuroplasticity","Motor Learning","2026-02-23",{"date":101,"type":35},"2026-02-27",{"date":103,"type":35},"2025-09-05",{"date":105,"type":21},"2026-08-31",{"name":107,"class":42},"School of Health Sciences Geneva",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":56,"phases":118,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":43},"100611102","effects-of-tes-combined-with-cmdt-gait-training-on-cognition-cortical-activity-spinal-motoneuron-excitability-and-motor-performance-in-stroke-individuals-100611102","NCT07236216","Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals","Effects of Transcranial Electrical Stimulation (tES) Combined With Cognitive-motor Dual-task Gait Training on Cortical Activity, Spinal Motoneuron Excitability, Cognition and Motor Performance in Stroke Individuals","Inclusion Criteria:\n\n1. Unilateral stroke individuals aged 18-80 years.\n2. A first-ever stroke.\n3. Stroke onset from at least 2 weeks-5 years.\n4. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)\n5. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.\n6. Ability to read, communicate, follow and understand instructions.\n\nExclusion Criteria:\n\n1. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury\n2. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)\n3. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture\n4. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.\n5. Presence of an opened wound, infectious wound around scalp or craniectomy with unreplaced bone flap\n6. Moderate pain (numeric pain rating score \\> 4\u002F10) in any joint of the upper or lower limb, whether paretic or non-paretic\n7. Presence of color blindness\n8. Presence of any substance use including cannabis and kratom","80 Years",{"count":117,"type":21},60,[58],"The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dual task gait training in sub-acute (at least 2 weeks after stroke onset) to chronic (within 5 years post-stroke) to investigate the effect on cortical activity, spinal motoneuron excitability, cognition and motor performance. The findings may enhance the evidence to support usages of tES for improvimg cognition, motor performance as well as cortical activity and spinal motoneuron excitability in a clinical setting.",[121,122,123,25],"Hemorrhagic Stroke","Ischemic Stroke","Subacute Stroke",[27,125,126,127,128,129],"electroencephalography","event related potentials","rehabilitation","gait training","High-definition transcranial electrical stimulation","2026-02-19",{"date":99,"type":35},{"date":133,"type":35},"2025-12-20",{"date":135,"type":21},"2027-12-30",{"name":137,"class":42},"Mahidol University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":115,"enrollmentInfo":146,"targetDuration":4,"studyType":56,"phases":148,"briefSummary":149,"conditions":150,"keywords":155,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":43},"100591364","q-therapeutic-system-for-chronic-stroke-recovery-100591364","NCT06979466","Q Therapeutic System for Chronic Stroke Recovery","Facilitation Recovery For Patients With Chronic Stroke: The Q Therapeutic System, Frequency-Tuned Electromagnetic Field Treatment","EMAGINE-C","Inclusion Criteria:\n\n* FMA-UE score between 22-50 (inclusive) of impaired limb.\n* Difference between Screening and Baseline visit FMA-UE is 3 points or fewer.\n* Age 18 to 80 years of age (inclusive).\n* Stroke due to ischemia or to intracerebral hemorrhage.\n* \\>6 months to 5 years from index stroke onset.\n* Box \\& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit.\n* Able to sit with the investigational System for 40 consecutive minutes.\n* Can follow a 3-step command, such as \"take the paper, fold it in half, and return it to me\", or a non-verbal equivalent.\n* Willingness to participate in physical exercises during study intervention sessions.\n* Availability of a relative or other caregiver able to assist during study treatment sessions and visits.\n* If female, not pregnant or breastfeeding or planning pregnancy during the study period.\n* Informed consent signed by subject.\n\nExclusion Criteria:\n\n* Severe neglect impairment interfering with assessments or treatments.\n* Severe depression, defined as GDS Score \\>10\u002F15\n* The presence of MR-incompatible implanted devices or MR-incompatible retained objects; or the presence of life-sustaining MR-compatible devices (e.g. pacemaker or internal cardiac defibrillator).\n* Active epilepsy or currently taking anti-epileptic medication (indicated for the treatment of a seizure disorder), or any epileptic seizure in the last 5 years\n* Botulinum toxin to the paretic arm: received in the prior 3 months OR expected before the 6-Month Visit\n* Severe UE spasticity, defined as presence of upper extremity contracture or modified Ashworth Scale score≥3 in either biceps or pectoralis\n* Pre-existing neurological condition (eg, Alzheimer's disease, Parkinson's disease, multiple sclerosis, traumatic brain injury, spinal cord injury) or physical limitation that would interfere significantly with the subject's participation in the study and\u002For confound neurological or functional evaluation.\n* Significant visual disturbances, pre-existing or resulting from the index stroke, that cannot be corrected and that would interfere significantly with the subject's participation in the study and\u002For confound neurological or functional evaluation.\n* Unstable serious illness\u002Fcondition (eg, active cancer, severe heart failure, active major psychiatric condition) or life expectancy of less than 12 months.\n* Alcohol abuse and\u002For illicit drug abuse in the past 6 months, which is likely to influence ability to fully participate in the trial.\n* Participation in another interventional trial that would conflict with the current study or clinical endpoint interference may occur.\n* Participation in an upper extremity rehabilitation program provided by a licensed provider in the 4 weeks prior to the Screening visit, or a or planned participation in such program at any time between the Screening Visit and the primary endpoint visit.\n* Employee of the Sponsor.\n* Prisoner.",{"count":147,"type":21},25,[58],"Evaluate the effectiveness of the Q Therapeutic (BQ 3.0) System for individuals with chronic stroke in improving upper extremity function as determined by change in functional outcome measures after 3-month treatment, including in-clinic and at-home sessions.",[151,152,153,154,25],"Stroke","Hemorrhage","Brain Injury","Cerebrovascular Accident (CVA)",[156,151,157,158],"BrainQ","Cerebrovascular Disorders","Electromagnetic Stimulation","2025-08-07",{"date":161,"type":35},"2025-08-12",{"date":163,"type":35},"2025-05-26",{"date":73,"type":21},{"name":166,"class":42},"Burke Rehabilitation Hospital"]