[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-stroke-survivors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-stroke-survivors":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,60,89,115,141,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100574927","the-effect-of-non-invasive-brain-stimulation-rtms-on-hand-muscles-in-chronic-stroke-patients-100574927",false,"NCT06765642","The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.","Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients","REALISE","Inclusion criteria:\n\n1. Age \\>=21 years old of any race or gender\n2. First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 3 months from stroke onset\n3. Unilateral arm weakness measured by FM-UM scale \\\u003C= 62 out of 66\n4. Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject\n\nExclusion criteria\n\n1. Bilateral strokes (infarcts and\u002For hematoma)\n2. Other co-existent neuromuscular disorders affecting upper extremity motor impairment.\n3. History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study.\n4. Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later).\n5. Presence of any MRI\u002FrTMS risk factors including but not limited to:\n\n   1. an electrically, magnetically, or mechanically activated metallic or nonmetallic implant including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system.\n   2. a non-fixed metallic part in any part of the body, including a previous metallic injury to the eye.\n   3. history of seizure disorder before stroke or seizure after stroke.\n   4. preexisting scalp lesion or bone defect or hemicraniectomy.\n6. Concurrent enrollment in another interventional stroke recovery study.\n7. Concerns that the subject cannot comply with study procedures and visits.\n8. Pregnant individuals","ALL","21 Years",{"count":20,"type":21},26,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.",[27,28,29,30,31,32,33,34,35],"Stroke","Stroke Patients","Arm Weakness as a Consequence of Stroke","Brain Stimulation","Transcranial Magnetic Stimulation Repetitive","Transcranial Magnetic Stimulation","Motor Learning","Chronic Stroke Patients","Chronic Stroke Survivors",[37,38,39,40,41,42,43,44,45,46],"stroke","arm weakness","arm weakness as a consequence of stroke","stroke patients","transcranial magnetic stimulation","transcranial magnetic stimulation repetitive","motor learning","chronic stroke","chronic stroke patients","chronic stroke survivors","RECRUITING","2026-05-19",{"date":50,"type":51},"2026-05-22","ACTUAL",{"date":53,"type":51},"2025-06-09",{"date":55,"type":21},"2027-04-30",{"name":57,"class":58},"Duke University","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":59},"100632443","focal-vibration-therapy-in-post-stroke-shoulder-pain-100632443","NCT07513753","Focal Vibration Therapy in Post-stroke Shoulder Pain","Efficacy of Focal Vibrational Therapy in Reducing Post-stroke Shoulder Pain: a Double-blind, Randomized Controlled Trial","VIBRA-HSP","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Ischemic or hemorrhagic stroke confirmed by CT or MRI\n* Chronic post-stroke phase (≥ 6 months from event)\n* Presence of hemiplegic shoulder pain (NRS ≥ 4)\n* Preserved cognitive function sufficient to provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment or language deficits (e.g., severe aphasia) that prevent understanding of study procedures or reliable reporting of pain (e.g., inability to complete NRS or questionnaires).\n* Severe neglect, apraxia, or disorders of consciousness that interfere with participation in rehabilitation or outcome assessments.\n* Pre-existing shoulder pathology of the affected side unrelated to stroke (e.g., full-thickness rotator cuff tear, advanced glenohumeral osteoarthritis, inflammatory arthritis, prior shoulder surgery).\n* Fixed shoulder contractures or severe joint deformities limiting passive range of motion and preventing standardized assessment.\n* Botulinum toxin injections to shoulder upper limb muscles within the last 3-4 months prior to enrollment .\n* Current treatment with other experimental or non-conventional physical therapies for shoulder pain during the study period.","18 Years","80 Years",{"count":71,"type":21},60,[24],"Hemiplegic Shoulder Pain (HSP) is a common and disabling complication after stroke, negatively affecting upper limb function, participation in rehabilitation, and quality of life. Despite the widespread use of conservative and physical therapies, evidence supporting the efficacy of specific non-invasive neuromodulation techniques remains limited.\n\nFocal Vibration Therapy (FVT) is a non-invasive physical modality that delivers localized mechanical vibration to targeted muscles or tendons and may modulate pain, muscle tone, and proprioception through frequency-dependent mechanisms.\n\nThis randomized controlled trial aims to evaluate the efficacy of a multimodal FVT protocol, in addition to standard rehabilitation, compared with a sham intervention plus standard rehabilitation, in reducing pain in patients with chronic post-stroke Hemiplegic Shoulder Pain.",[27,75,35],"Hemiplegic Shoulder Pain",[77,37,78,75],"Focal vibration Therapy","pain","NOT_YET_RECRUITING","2026-03-30",{"date":82,"type":51},"2026-04-07",{"date":84,"type":21},"2026-04-01",{"date":86,"type":21},"2026-12-01",{"name":88,"class":58},"University of Foggia",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":59},"100626310","changes-in-hemodynamic-response-following-transcranial-electrical-stimulation-in-sroke-individuals-100626310","NCT07433972","Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals","Inclusion Criteria:\n\n1. Unilateral stroke individuals aged 18-80 years.\n2. A first-ever stroke.\n3. Stroke onset from at least 2 weeks-5 years.\n4. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)\n5. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.\n6. Ability to read, communicate, follow and understand instructions.\n\nExclusion Criteria:\n\n1. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury\n2. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)\n3. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture\n4. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.\n5. Presence of an opened wound, infectious wound around scalp or craniectomy with unreplaced bone flap\n6. Moderate pain (numeric pain rating score \\> 4\u002F10) in any joint of the upper or lower limb, whether paretic or non-paretic\n7. Presence of color blindness\n8. Presence of any substance use including cannabis and kratom",{"count":71,"type":21},[24],"The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dualt ask gait training in sub-acute (at least 2 weeks after stroke onset) to chronic stroke (within 5 years post-stroke) to investigate changes in brain hemodynamics (oxy-hemoglobin and deoxy-hemoglobin concentration) as measured by functional near infrared spectroscopy (fNIRS). The findings may provides insights changes in combining tES with rehabilitation on improvements in brain hemodynamics in sub-acute to chronic stroke.",[99,100,101,35],"Hemorrhagic Stroke","Ischemic Stroke","Subacute Stroke",[27,103,104,105],"functional near-infrared spectroscopy","rehbailitation","transcranial electrical stimulation","2026-02-19",{"date":108,"type":51},"2026-02-25",{"date":110,"type":21},"2026-03-01",{"date":112,"type":21},"2026-12-30",{"name":114,"class":58},"Mahidol University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":59},"100610356","walking-and-tscs-in-non-ambulatory-stroke-survivors-100610356","NCT07226518","Walking and tSCS in Non-ambulatory Stroke Survivors","Robot-assisted Gait Training and Transcutaneous Spinal Cord Stimulation in Chronic Non-ambulatory Stroke Survivors: Pilot RCT Trial","Inclusion Criteria:\n\n1. Age 18-80 years at time of consent\n2. All genders included.\n3. Chronic ischemic or hemorrhagic stroke \\>=6 months, with limited within-home comfortable walking speed \\\u003C= 0.49 m\u002Fs and unable to walk independently in community (FAC \\\u003C= 3)\n4. Able to communicate with investigators, follow 2-step command, and correctly answer consent comprehension questions in English.\n5. Currently not participating in treadmill walking exercises or exercises involving weight-bearing activities.\n6. Have physicians' approval for exercise and be in a stable medical condition\n\nExclusion Criteria:\n\n1. Hospitalization for cardiac or pulmonary disease within the past 3 months\n2. Have musculoskeletal disorders that prevent the participant from participating in the exercise\n3. Blood pressure higher than 200\u002F110 mm Hg\n4. Significant ataxia or unilateral spatial neglect (score of 2 on NIH stroke scale item 7 or 11)\n5. Reported pain that limits or interferes with activities of daily living and physical activity\u002Fexercise\n6. Diagnosis of other neurological diseases (multiple sclerosis, Alzheimer's disease, Parkinson's disease)\n7. Diagnosis of severe depression (HADS score 15-21)\n8. Unable to speak or understand English, and travel to the research laboratory.\n9. Contraindications to tSCS and TMS",{"count":123,"type":21},20,[24],"Rehabilitation interventions commonly used for stroke survivors include task-specific training, balance and strength exercises, and the use of assistive devices to enhance mobility and independence. Advanced technologies, such as body-weight-supported treadmill systems and robotic devices, may be employed when appropriate. Current rehabilitation therapies for stroke survivors are moderately effective with a limited effect size, especially in stroke survivors with severe impairment. Novel therapies, such as transcutaneous spinal cord stimulation (tSCS), may further improve outcomes in the target population. This pilot study will allow us to examine the feasibility and gather pilot data on a combined intervention of assistive gait training and tSCS in non-ambulatory stroke survivors.",[35,34,27],[128,129,130,131],"stroke gait rehabilitation","Transcutaneous spinal cord stimulation","Non invasive spinal cord stimulation","Robot assisted gait training","2025-11-07",{"date":134,"type":51},"2025-11-10",{"date":136,"type":21},"2026-01-01",{"date":138,"type":21},"2026-12-31",{"name":140,"class":58},"University of Kansas Medical Center",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":148,"minAge":149,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":59},"100593857","innovative-physiotherapy-in-stroke-rehabilitation-100593857","NCT07011888","Innovative Physiotherapy in Stroke Rehabilitation","Current and Innovative Physiotherapy Practices in Stroke Rehabilitation: A Clinical Case Report","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* Diagnosis of chronic ischemic stroke (more than 6 months post-stroke).\n* Presence of motor dysfunction, balance impairment, or gait difficulties related to stroke.\n* Willingness and ability to participate in a comprehensive rehabilitation program involving physical therapy and device-assisted interventions (e.g., SaeboStim GO, Saebo Glove).\n\nExclusion Criteria:\n\n* Presence of uncontrolled systemic diseases or active infections that would interfere with rehabilitation.\n* Severe psychiatric disorders that would impede participation.\n* Contraindications to the use of physical therapy devices or interventions used in the study.\n* Severe orthopedic conditions that preclude participation in the rehabilitation program.","MALE","50 Years",{"count":59,"type":21},[24],"This study reports a single-case rehabilitation program for a chronic stroke patient focusing on innovative physiotherapy techniques. Over six weeks, the patient will undergo combined treatments including vestibular rehabilitation therapy, ultrasound therapy, and functional hand therapy using Saebo devices. The goal is to improve motor functions and daily living independence. This report aims to share clinical insights and outcomes to support stroke rehabilitation practices.",[154,35],"Stroke, Ischemic",[44,156,157,158,159,160,161,162],"Saebo","ultrasound therapy","vestibular training","stroke rehabilitation","balance","case report","functional independence","2025-09-26",{"date":165,"type":51},"2025-10-01",{"date":167,"type":21},"2025-11-15",{"date":169,"type":21},"2026-01-30",{"name":171,"class":58},"Sevval Yesilkır",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":184,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":59},"100569117","the-effect-of-motor-relearning-program-on-functional-mobility-in-stroke-rehabilitation-100569117","NCT06690073","The Effect of Motor Relearning Program on Functional Mobility in Stroke Rehabilitation.","The Effect of Motor Relearning Program on Functional Mobility in Stroke Rehabilitation","MRP","Inclusion criteria: The following subjects were included:\n\n* Right or left-sided chronic hemiplegic subjects.\n* More than six months after the onset of stroke.\n* Age group between 45-65 years of both genders.\n* Scored minimally 24\u002F30 on the Mini-Mental State Exam (MMSE).\n* Motor assessment scale of sitting to standing section.\n* Having normal visual perception.\n* Able to follow verbal commands.\n\nExclusion criteria: The following subjects were excluded:\n\n* Less than six months after the onset of stroke.\n* Unable to follow visual and oral commands.\n* The age group is below 45 years and more than 65 years.\n* Unilateral neglect.\n* Cognitive impairments (MMSE scores less than 24\u002F30), or language deficits.\n* Any other neurological disorders and recent surgeries.\n* Previous exposure to MRP.","45 Years","65 Years",{"count":183,"type":21},32,[24],"1. To find out the effectiveness of conventional physiotherapy on improving functional mobility of lower extremity among chronic hemiplegic subjects.\n2. To find out the effcctiveness of motor relearning program along with conventional physical therapy treatment on improving functional mobility of lower extremity among chronic hemiplegic subjects.\n3. To find out the effectiveness of motor relearning program along with conventional physical therapy treatment over conventional physical therapy on improving functional mobility of lower extremity among chronic hemiplegic subjects.",[27,34,35,187],"Hemiplegia",[27,187,189,190],"Functional mobility","motor relearning program","2024-11-12",{"date":193,"type":51},"2024-11-15",{"date":195,"type":51},"2024-11-04",{"date":197,"type":21},"2025-06-30",{"name":199,"class":200},"University of Jazan","OTHER_GOV"]