[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-stroke":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,41,60,92,119,147,177,199,227,256,282,320,348,375,400,423,444,467,493,512,534,559,577,604,631],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642779","the-effect-of-action-observation-therapy-including-unimanual-and-bimanual-activities-in-chronic-stroke-100642779",false,"NCT07631169","The Effect of Action Observation Therapy Including Unimanual and Bimanual Activities in Chronic Stroke","Investigation of the Effects of Action Observation Therapy Including Unimanual and Bimanual Activities on Upper Extremity Functions, Activities of Daily Living, and Quality of Life in Chronic Stroke","Inclusion Criteria:\n\n* Being over 18 years of age,\n* Diagnosis of left hemiparetic stroke,\n* Having passed between 6 months since the onset of stroke,\n* Being in stage 4 or 5 of the hand and stage 4, 5 or 6 of the upper extremity --according to Brunnstrom staging,\n* Being able to sit on a chair for 30 minutes without support (patients who scored 20 or more points in total from the Trunk Impairment Scale),\n* Scoring 24 or more points from the Mini Mental Test\n\nExclusion Criteria:\n\n* Unwillingness to participate in the study,\n* Having spasticity that prevents grasping and releasing an object (levels 3 and 4 on the Modified Ashworth Scale),\n* Having a contracture in any of the affected upper extremity joints,\n* Having severe neglect disorder (scoring 21 or higher on the Catherine Bergego Scale),\n* Having impaired cooperation, compliance, and behavior during the administration of tests used to obtain data,\n* Having a mental impairment that prevents communication and following basic commands (scoring less than 24 on the Mini-Mental Test),\n* Having additional neurological and\u002For orthopedic problems that may affect motor performance and sitting balance,\n* Having severe visual and hearing problems (if any, these problems not corrected with assistive devices such as glasses, contact lenses, hearing aids, etc.)","ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"NA","Functional impairments in the upper extremities following a stroke significantly restrict individuals' activities of daily living and overall quality of life; in this context, Action Observation Training (AOT) has emerged in recent years as an effective rehabilitation method that promotes motor learning processes and cortical activity by activating the mirror neuron system. Although the literature acknowledges the positive effects on neural mechanisms of both unimanuel approaches, which focus on the paretic hand alone, and bimanual approaches, which involve the simultaneous use of both hands, there remains a gap regarding which method yields superior outcomes. This study aims to compare the effectiveness of AOT interventions consisting of exclusively unimanual versus exclusively bimanual activities on upper extremity functions, activities of daily living, and quality of life in chronic stroke patients, while investigating the potential differences between the outcomes of these two distinct approaches.",[27],"Chronic Stroke","RECRUITING","2026-06-05",{"date":31,"type":32},"2026-06-09","ACTUAL",{"date":34,"type":21},"2026-05-18",{"date":36,"type":21},"2027-05-18",{"name":38,"class":39},"Karabuk University","OTHER",1,{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":53,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":59},"100643482","action-observation-therapy-in-chronic-stroke-via-telerehabilitation-100643482","NCT07631182","Action Observation Therapy in Chronic Stroke Via Telerehabilitation","Investigation of the Effect of Action Observation Therapy Via Telerehabilitation Method on Upper Extremity Functions, Daily Living Activities and Quality of Life in Chronic Stroke Patients","Inclusion Criteria:\n\n* Being over 18 years of age,\n* Diagnosis of left hemiparetic stroke,\n* Having passed between 6 months since the onset of stroke,\n* Being in stage 4 or 5 of the hand and stage 4, 5 or 6 of the upper extremity according to Brunnstrom staging,\n* Being able to sit on a chair for 30 minutes without support (patients who scored 20 or more points in total from the Trunk Impairment Scale),\n* Scoring 24 or more points from the Mini Mental Test\n\nExclusion Criteria:\n\n* Unwillingness to participate in the study,\n* Having spasticity that prevents grasping and releasing an object (levels 3 and 4 on the Modified Ashworth Scale),\n* Having a contracture in any of the affected upper extremity joints,\n* Having severe neglect disorder (scoring 21 or higher on the Catherine Bergego Scale),\n* Having impaired cooperation, compliance, and behavior during the administration of tests used to obtain data,\n* Having a mental impairment that prevents communication and following basic commands (scoring less than 24 on the Mini-Mental Test),\n* Having additional neurological and\u002For orthopedic problems that may affect motor performance and sitting balance,\n* Having severe visual and hearing problems (if any, these problems not corrected with assistive devices such as glasses, contact lenses, hearing aids, etc.)",{"count":49,"type":21},30,[24],"Stroke, a leading cause of disability worldwide, particularly affects upper extremity function, rendering individuals dependent on others for daily living activities and reducing their quality of life. To mitigate these effects, Action Observation Therapy (AOT), which has gained prominence in recent years, activates the mirror neuron system, triggering learning processes in the motor cortex and supporting functional recovery through the imitation of observed movements. Furthermore, telerehabilitation offers a significant advantage in facilitating access to rehabilitation services for these patients requiring long-term treatment, eliminating barriers such as transportation and cost. The absence of studies in the literature comparing the effectiveness of combining these two methods on hand skills and quality of life in individuals with chronic stroke with conventional physiotherapy makes investigating the clinical value of this approach academically unique and necessary.",[27],{"date":31,"type":32},{"date":55,"type":21},"2026-06-15",{"date":57,"type":21},"2026-10-01",{"name":38,"class":39},2,{"id":61,"slug":62,"hasResults":12,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":22,"phases":71,"briefSummary":72,"conditions":73,"keywords":74,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":40},"100435986","effect-of-nmes-on-balance-and-fall-risk-in-chronic-stroke-100435986","NCT04957355","Effect of NMES on Balance and Fall Risk in Chronic Stroke","Effect of Neuromuscular Electrical Stimulation (NMES) on Reactive Balance, Gait and Fall-risk in Individuals With Stroke","NMES","Inclusion Criteria:\n\nAge group: 18-90 years.\n\n1. Presence of hemiparesis.\n2. Onset of stroke (\\> 6 months).\n3. Ability to walk independently with or without an assistive device for at least 300 ft.\n4. Can understand and communicate in English.\n5. Cognitively and behaviorally capable of complying with the regimen (Montreal Cognitive Assessment \\> 25\u002F30).\n\nExclusion Criteria:\n\nSubjects will not proceed with the test if any of the following occurs at baseline measurement: 1) HR \\> 85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \\> 165 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg during rest, or 3) oxygen saturation (measured by pulse oximeter) \\\u003C 95% during rest.\n\n1. Body weight more than 250 lbs.\n2. Any neurological condition other than stroke.\n3. Any cardiopulmonary, musculoskeletal, or systemic diagnosis.\n4. Recent major surgery (\\\u003C 6 months) or hospitalization (\\\u003C 3 months).\n5. Deep venous thrombosis.\n6. Antecedent of cancer.\n7. Peripheral nerve injury or neuropathy in the affected limb with motor disability.\n8. Spasticity (Ashworth scale \\> 2).\n9. Uncontrolled high blood pressure\u002Fangina.\n10. Skin condition not tolerant with FES therapy.\n11. Uncontrolled seizure disorder.\n12. Botox treatment within the last 5 months.\n13. History of epilepsy.\n14. Pacemaker users.\n\nExcluded or Vulnerable Populations Non-English speaking populations will be excluded as the consent procedures and instructions will be in English.","90 Years",{"count":70,"type":21},20,[24],"The aim of this study is to describe the effect of neuromuscular electrical stimulation (NMES) in the form of functional electrical stimulation (FES) applied to different lower limb muscles on reactive balance and gait performance in stroke participants.\n\nMethods: Twenty individuals with chronic stroke will be asked to perform an experimental protocol that includes a postural disturbance in the form of a slip- or trip-like perturbation and a standardized walking test in both laboratory and outdoor environments with and without FES applied to different lower limb muscles of the paretic leg. FES will be applied using an advanced software that is able to synchronize muscle activation with the time of perturbation onset and according to the phases of gait.\n\nThis project design aims to examine whether a specific pattern of lower limb muscle stimulation could improve the kinematic and behavioral responses during reactive balance following slip- and trip-like perturbations. Additionally, the project aims to see if the kinematic and spatio-temporal gait parameters can be modified during a standardized walking test under different sensory and environmental conditions.",[27],[75,76,77,78,79,80,81,82],"functional electrical stimulation","neuromuscular electrical stimulation","walk-training","treadmill training","reactive balance","perturbation","falls","fall prevention","2026-05-20",{"date":85,"type":32},"2026-05-22",{"date":87,"type":32},"2021-05-15",{"date":89,"type":21},"2027-11-30",{"name":91,"class":39},"University of Illinois at Chicago",{"id":93,"slug":94,"hasResults":12,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100638932","effects-of-a-combined-repetitive-transcranial-magnetic-stimulation-and-physical-therapy-protocol-on-motor-function-balance-and-quality-of-life-in-chronic-post-stroke-hemiplegia-a-case-series-100638932","NCT07597746","\"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series\"","Inclusion Criteria:\n\n* Diagnosis of first-ever unilateral ischemic or hemorrhagic stroke confirmed by neuroimaging (CT or MRI)\n* Chronic post-stroke hemiplegia (≥ 6 months since stroke onset)\n* Moderate to severe motor impairment of the affected lower limb (FMA-LE score between 10 and 28 points)\n* Age between 18 and 75 years\n* Medically stable and able to participate in a rehabilitation program\n* Ability to understand study procedures and provide written informed consent\n* No contraindications to repetitive transcranial magnetic stimulation (rTMS), according to current safety guidelines.\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* Presence of pacemakers, cochlear implants, intracranial metallic implants, or other contraindications to rTMS\n* Severe cognitive impairment or communication deficits preventing participation\n* Progressive neurological disorders or unstable medical conditions\n* Participation in other experimental neurorehabilitation interventions during the study period\n* Any condition judged by investigators to compromise safety or data valid","75 Years",{"count":70,"type":21},[24],"Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often plateaus during the chronic phase. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown potential to enhance motor recovery by modulating cortical excitability and promoting neuroplasticity.\n\nThis case series aims to investigate the effects of a combined protocol of repetitive transcranial magnetic stimulation and conventional physical therapy on motor function, balance, and quality of life in individuals with chronic post-stroke hemiplegia. Participants will undergo rTMS applied to the motor cortex in conjunction with a structured physical therapy program. Clinical outcomes will be assessed before and after the intervention to explore feasibility, safety, and potential functional benefits of the combined approach.",[27,103],"Balance",[105,106,107,108,109],"repetitive transcraneal magnetic stimulation","chronic stroke","motor recovery","balance","physical therapy","NOT_YET_RECRUITING","2026-05-13",{"date":113,"type":32},"2026-05-19",{"date":29,"type":21},{"date":116,"type":21},"2026-08-30",{"name":118,"class":39},"Sierra Varona SL",{"id":120,"slug":121,"hasResults":12,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":40},"100462034","exoskeleton-research-myoelectric-orthosis-for-rehab-of-severe-chronic-arm-motor-deficits-100462034","NCT05296408","Exoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits","Inclusion Criteria:\n\n* 18-89 years of age\n* Unilateral arm weakness due to stroke (6 months or more since onset)\n* Adequate range of motion at the elbow, forearm, wrist, and hand to don the device\n* Active shoulder flexion of at least 30 degrees and active shoulder abduction of at least 20 degrees\n* Ability to generate volitional, consistent, and detectable EMG signals from the upper arm and forearm sensor sites with wrist in neutral or flexed positions as detected by the MyoPro software\n* MAS score less or equal to 3 for the biceps, triceps, supinators and pronators of the impaired arm\n* Able to read and comprehend the English language\n* Able to follow directions\n* Able to provide informed consent\n* Medically and psychologically stable.\n* Ability to don\u002Fdoff MyoPro independently or have support as needed.\n* Ability to undergo MRI\n* Ability to undergo TMS procedures\n\nExclusion Criteria:\n\n* Previous stroke(s) affecting motor function on the opposite side.\n* Persistent and severe shoulder subluxation, pain or dislocation\n* Shoulder passive range of motion \\\u003C 45 degrees in flexion and abduction\n* Fixed upper limb contractures on the impaired arm and hand\n* Unable to safely support the weight of their arm plus 4 lbs (1.82 kg; the weight of the device) without pain even with arm supported.\n* Skin rash or open non-healing wound on impaired arm\n* Involuntary movements of the impaired arm\n* Pacemaker or other implanted devices that are not compatible with testing procedures or would interfere with donning\u002Fdoffing and functioning of device.\n* Metal in the skull or deformity of the skull\n* Claustrophobia, or inability to operate the MRI patient call button\n* Contraindications for MRI (standardized screening form for MRI).\n* Past history of seizures\n* Family history of medication refractory epilepsy\n* Pregnancy or pregnancy planning during the study period\n* Currently taking medications or substances that lower the threshold for onset of seizure.","89 Years",{"count":127,"type":21},60,[24],"This study will evaluate the effects of combining motor learning-based therapy with use of the MyoPro , a wearable exoskeletal myoelectrically controlled orthotic device. MyoPro uses electromyographic (EMG) signals from the weak muscles to assist movement of the user's affected arm. The primary objective of this randomized controlled trial is to study the efficacy of using MyoPro in motor learning-based therapy for individuals with chronic stroke (\\>6 months post) with severe upper limb motor deficits (Fugl-Meyer for Upper Limb score less than 30) compared with a similar dose of motor learning-based therapy alone. The secondary objectives are to evaluate neuroplasticity mechanisms, identify biomarkers of greater response to the intervention, and explore cost-effectiveness.",[27],[132,133,134,135,136],"stroke","rehabilitation","upper limb","motor learning","cerebrovascular accident","2026-04-16",{"date":139,"type":32},"2026-04-21",{"date":141,"type":32},"2022-04-01",{"date":143,"type":21},"2027-04-01",{"name":145,"class":146},"VA Office of Research and Development","FED",{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":40},"100628935","evaluation-of-the-relationship-between-the-conut-score-and-balance-and-functional-status-in-patients-with-chronic-stroke-100628935","NCT07468110","Evaluation Of The Relationship Between The Conut Score And Balance And Functional Status In Patients With Chronic Stroke","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Having a diagnosis of ischemic or hemorrhagic stroke\n* At least 6 months having elapsed since the stroke event (chronic phase)\n* Being clinically stable\n* Being able to participate in standing and balance assessments (walking with an assistive device is acceptable)\n* Having sufficient cognitive capacity to understand and respond to the assessment scales used in the study\n* Voluntarily agreeing to participate in the study and providing written informed consent\n\nExclusion Criteria:\n\n* Acute or subacute stroke phase (\\\u003C 6 months)\n* Inability to administer assessment scales due to severe cognitive impairment or aphasia\n* Presence of other neurological disorders that may significantly affect balance and functional status (e.g., Parkinson's disease, multiple sclerosis, peripheral neuropathy)\n* Significant orthopedic conditions unrelated to stroke (e.g., advanced hip or knee osteoarthritis, lower extremity amputation)\n* Presence of active infection, malignancy, or systemic inflammatory disease (as these conditions may affect the CONUT score)\n* Cerebellar localization of the cerebrovascular event\n* History of major surgery or intensive care unit admission within the past 3 months\n* Inability to safely perform balance tests due to severe visual or hearing impairment\n* Patients with incomplete laboratory data or insufficient information to calculate the CONUT score","85 Years",{"count":155,"type":21},47,"OBSERVATIONAL","The primary aim of this study is to evaluate the relationship between the CONUT score, which reflects nutritional status, and balance performance in patients with chronic stroke. The secondary aims are to investigate the association between the CONUT score and functional status and stroke-specific quality of life, as well as to assess the relationships of mid-upper arm circumference, an anthropometric indicator of nutritional status, and ultrasonographic rectus femoris muscle thickness, which reflects muscle mass, with balance performance, functional status, and stroke-specific quality of life. In addition, the study aims to examine the relationships between bone mineral density and balance, functional status, and ambulation level in patients with chronic stroke.",[27,159,160,161],"CONUT Score","Balance Assessment","Functional Status",[159,163,164,165,166,167],"Tinetti Performance-Oriented Mobility Assessment (POMA)","Stroke-Specific Quality of Life Scale (SS-QOL)","Rectus femoris muscle thickness","Mid-upper arm circumference measurement","Bone Mineral Density (BMD)","2026-03-19",{"date":170,"type":32},"2026-03-24",{"date":172,"type":32},"2026-03-10",{"date":174,"type":21},"2027-03-10",{"name":176,"class":39},"Marmara University",{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":17,"minAge":184,"maxAge":153,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":187,"conditions":188,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":4},"100628291","comparison-of-eeg-timed-vs-repetitive-robot-therapy-for-chronic-stroke-100628291","NCT07459725","Comparison of EEG-Timed vs. Repetitive Robot Therapy for Chronic Stroke","Exploratory Comparison of Movement Observation\u002FImagery-Timed Robot Activation and Repetitive Robot Activation on Training Effects and Neurophysiological Responses in Chronic Stroke Patients","Inclusion Criteria:\n\n* Patients diagnosed with stroke.\n* Adults aged 19 to 85 years old at the time of screening.\n\nExclusion Criteria:\n\n* Patients with severe, uncontrolled medical conditions.\n* Patients with uncontrolled hypertension, diabetes mellitus, or renal disease.\n* Patients with severe cognitive impairment that prevents them from following instructions for motor tasks (Mini-Mental State Examination \\[MMSE\\] score of 15 or below).\n\nNote: Patients with an MMSE score of 15 or below may still be included if the Principal Investigator (or a delegated physician) determines that they have the capacity to perform the tasks and provide informed consent.","19 Years",{"count":70,"type":21},[24],"This clinical trial compares two types of robotic hand rehabilitation-brain wave (EEG)-timed therapy versus simple repetitive therapy-to see which is more effective for recovering hand function in patients with chronic stroke. Participants will be randomly assigned to either group and will attend sessions using a wearable robotic hand device while wearing an EEG cap. In the EEG-timed group, the robot assists hand movements when participants successfully imagine moving and create specific brain signals, whereas in the repetitive group, the robot moves the hand automatically at set intervals. Both groups will receive a matched dose of robotic training to ensure a fair comparison of how the brain and hand function respond to the therapy.",[189,27,190],"Stroke","Hemiparesis","2026-03-05",{"date":172,"type":32},{"date":194,"type":21},"2026-03-16",{"date":196,"type":21},"2028-12-31",{"name":198,"class":39},"Seoul National University Bundang Hospital",{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":206,"sex":17,"minAge":207,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":213,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":40},"100520516","effect-of-somatosensory-motor-intergration-training-on-post-stroke-upper-limb-function-100520516","NCT06057584","Effect of Somatosensory Motor Intergration Training on Post-stroke Upper Limb Function.","The Neural Mechanism and Efficacy of Somatosensory Motor Intergration Training on the Upper Extremity Somatosensory Motor Function in Patients With Chronic Stroke.","Inclusion Criteria:\n\n1. Age ≥ 20.\n2. Diagnosed with stroke.\n3. Stroke duration ≥ 6 months.\n4. Upper limb Brunnstrom stage III-V.\n5. No severe muscle spasticity (Modified Ashworth Scale ≤ 2) in all segments of the affected upper limb.\n6. Self-perceived or therapist-assessed somatosensory impairment.\n\nExclusion Criteria:\n\n1. Significant cognitive impairment (Montreal Cognitive Assessment \\\u003C 20).\n2. Severe mental disorders (e.g., schizophrenia, major depression).\n3. Substance abuse or alcoholism.\n4. Claustrophobia.\n5. Severe aphasia affecting comprehension and clear expression of somatosensory information.\n6. Hemineglect.\n7. Other muscle or joint problems affecting upper limb function (e.g., contractures, rheumatoid arthritis, myositis ossificans).\n8. Concurrent participation in other somatosensory or motor therapy studies.",true,"20 Years",{"count":209,"type":21},153,[24],"Background: Most patients suffer from post-stroke somatosensory and motor impairments, and 50% to 70% of patients in the chronic stage still have upper extremity impairments that severely limit their functional independence and quality of life. Somatosensory and motor functions are closely related to each other. Previous evidence showed that somatosensory training or stimulation can modulate motor performance and enhance the efficacy of motor training, and motor training has the potential to promote the reorganization of the somatosensory cortex and enhance somatosensory-motor integration. Therefore, combining somatosensory and motor training may optimize the recovery of upper limb function. However, due to the small number of relevant empirical studies and the low quality of evidence, the effects and neural mechanisms of combined somatosensory and motor training compared with pure somatosensory training or pure motor training are still unknown or uncertain.\n\nPurposes: This project will compare the immediate and long-term effects of somatosensory-motor integration training, pure motor training, and pure somatosensory training on the somatosensory and motor functions of patients with chronic stroke, and will investigate the neural mechanisms of somatosensory-motor recovery using neuroimaging and neurophysiological techniques.\n\nResearch methods: A single-blind (assessor-blinded) randomized controlled trial design will be used in this three-year project. A sample of 153 patients with chronic stroke will be recruited, and subjects who meet the selection criteria will undergo a baseline assessment and then be randomly assigned in stratified blocks to either the somatosensory-motor integration training group, pure somatosensory training group or pure motor training group. Subjects will receive three to five 60-minute sessions per week for a total of 15 sessions, followed by post-intervention (immediate effect) and three-month follow-up (long-term effect) assessments. Outcome measures will include neuroimaging (functional near-infrared spectroscopy.), and clinical scales (somatosensory function, motor function, upper extremity function, real life functional upper extremity performance., daily activities, and quality of life). The data will be analyzed using intention-to-treat analysis. The treatment effects within each group will be determined by paired t tests. The difference in effects among the three groups will be analyzed by analyses of covariate. Multiple linear regressions will also be used to explore the factors affecting the recovery of somatosensory and motor functions.\n\nExpected results and contributions: The researchers expect that somatosensory-motor integration training, pure somatosensory training and pure motor training can all effectively improve the somatosensory and motor functions of patients with stroke. Among the three groups, somatosensory-motor integration training will show the greatest improvement in upper extremity function. The results of this project will provide empirical evidence on the effects and neural mechanisms of somatosensory-motor integration training, which will help clinicians select appropriate treatment strategies, facilitate clinical reasoning, and predict the recovery potential of somatosensory-motor function based on patient characteristics.",[27],[132,214,215,216,217],"somatosensory-motor integration","somatosensory","motor","randomized controlled trial","2026-03-01",{"date":220,"type":32},"2026-03-03",{"date":222,"type":32},"2023-10-11",{"date":224,"type":21},"2026-07-31",{"name":226,"class":39},"National Taiwan University Hospital",{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":22,"phases":236,"briefSummary":237,"conditions":238,"keywords":241,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":40},"100538128","personalized-transcranial-direct-current-stimulation-in-stroke-recovery-100538128","NCT06286800","Personalized Transcranial Direct Current Stimulation in Stroke Recovery","Inclusion Criteria:\n\n* Symptomatic ischemic or hemorrhagic stroke verified by computerized axial tomography or magnetic resonance imaging resulting in hemiparesis (MRC 1-4).\n* Age more than 18, Male or Female, All racial and ethnic groups\n* Entry into the study \\>3 months post onset\n* Modified Ashworth Scale Score \\\u003C3 in the involved upper extremity\n* Passive range of motion within functional ranges at the shoulder, elbow, wrist and hand\n* Able to follow 2 step commands\n\nExclusion Criteria:\n\n* Patients with history of severe alcohol or drug abuse, psychiatric illnesses like severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as unable to follow study instructions).\n* Patients with bilateral paresis, or weakness or sensory damage due to peripheral causes (e.g. peripheral nerve injury, muscle or orthopedic injury etc.)\n* Patients with severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age,epilepsy or others).\n* Patients with unstable cardiac arrhythmia.\n* Pregnancy\n* Patients with metallic implants in the head, patients with pacemakers, patients with craniotomies, including burr holes who cannot be safely stimulated\n* Patients with seizures\n* Non-English speaking individuals will only be eligible if they can provide the appropriate translator for all the sessions of the study as no funding is available to pay for such services.","80 Years",{"count":235,"type":21},80,[24],"The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement through increased connectivity as measured by a biomarker of plasticity.",[189,27,239,240],"Hemorrhage Brain","Ischemic Stroke",[242,243,244,245,246],"tdcs","noninvasive cortical stimulation","functional connectivity","hemiparesis","arm weakness","2026-02-27",{"date":249,"type":32},"2026-03-02",{"date":251,"type":32},"2024-12-18",{"date":253,"type":21},"2027-09-14",{"name":255,"class":39},"The Methodist Hospital Research Institute",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":265,"briefSummary":266,"conditions":267,"keywords":268,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":4},"100625473","exergame-based-upper-limb-rehabilitation-in-adults-with-chronic-stroke-100625473","NCT07423091","Exergame-Based Upper-Limb Rehabilitation in Adults With Chronic Stroke","A Randomized Controlled Trial Assessing the Efficacy, Feasibility, and Usability of an Exergame-Based Semi-Autonomous Upper-Limb Rehabilitation Program in Individuals With Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Confirmed diagnosis of chronic stroke with more than 6 months of evolution.\n* Ability to maintain independent sitting and standing (with or without assistive devices).\n* Upper-limb functional capacity ranging from limited to moderate, defined as an ARAT score between 11 and 54 points.\n* Ability to understand and follow simple instructions (Mini-Mental State Examination ≥ 23).\n* Ability to provide informed consent personally or through a legal representative.\n\nExclusion Criteria:\n\n* Acute illness, musculoskeletal pathology, or pain that interferes with the performance of rehabilitation exercises.\n* Uncompensated sensory deficits, including significant visual or hearing impairments.\n* Disruptive behavior or neuropsychiatric conditions that may limit participation.\n* Active epilepsy or any medical contraindication to physical exercise.\n* Botulinum toxin treatment affecting the upper limb within the previous 6 months.",{"count":264,"type":21},32,[24],"This study is a randomized controlled trial designed to evaluate the effectiveness of a semi-autonomous upper-limb rehabilitation program based on exergames in adults with chronic stroke. Participants will be randomly assigned (1:1) to either an exergame-based intervention or an individually delivered conventional home-based therapy program. The primary outcome is upper-limb functionality as measured by the Action Research Arm Test (ARAT). Secondary outcomes include upper-limb motor function and quality of life. The study also examines adherence, usability, and the feasibility of remote monitoring for long-term implementation.",[27],[27,269,270,271,272],"Upper Limb Rehabilitation","Exergames","Serious Games","Telerehabilitation","2026-02-18",{"date":275,"type":32},"2026-02-20",{"date":277,"type":21},"2026-04",{"date":279,"type":21},"2026-12",{"name":281,"class":39},"Marina Castel Sánchez",{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":22,"phases":290,"briefSummary":292,"conditions":293,"keywords":303,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":40},"100597086","phase-1-psychedelic-healing-adjunct-therapy-harnessing-opened-malleability-100597086","NCT07053917","Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability","PHATHOM","Inclusion Criteria:\n\n* Over age 18 years, inclusive.\n* Ischemic or hemorrhagic stroke confirmed by CT or MRI, at least 12 months prior to admission date\n* Ability to give informed consent and understand the tasks involved.\n* Agree that, for the study duration, will refrain from: (1) No new prescription medications during the time of the study without approval of the study team, (2) taking any herbal supplement (except with prior approval of the research team), (3) taking any nonprescription medications with the exception of: 1. non-steroidal anti-inflammatory drugs. 2. acetaminophen. 3. vitamins. 4. or other over-the-counter medications approved by the research team\n* Are willing to follow restrictions and guidelines concerning medications, consumption of food, beverages, and nicotine the night before and just prior to psilocybin administration.\n* Agree to have transportation other than driving themselves home or to where the participants are staying after the administration of psilocybin.\n* Are willing to be contacted via telephone for all necessary telephone contacts.\n* Must have a negative pregnancy test if able to bear children.\n* Must provide a contact (relative, spouse, close friend or other caregiver) who is willing and able to be reached by the investigators in the event of a participant becoming suicidal.\n* Must agree to inform the investigators within 48 hours of any new medical conditions and procedures.\n* Are proficient in speaking and reading English.\n* Agree to have all clinical visit sessions recorded to audio and video.\n* Agree to not participate in any other interventional clinical trials during the duration of this study.\n\nExclusion Criteria:\n\n* Taking one of the following medications in the 30 days prior to psilocybin administration:\n\n  1. selective serotonin reuptake inhibitor (SSRI)\n  2. Serotonin-norepinephrine reuptake inhibitors (SNRI)\n  3. Buproprion\n  4. Valproic acid\n  5. Zolpidem\n  6. Trazodone\n  7. Carbamazepine.\n  8. tricyclic antidepressants\n  9. Monoamine Oxidase Inhibitors\n  10. Mirtazapine\n\n  l. Lithium m. Buspirone n. Atypical antipsychotics o. Zolpidem p.Carbamazepine q. Clonazepam r. Gabapentin s. Lamotrigine t. Levetiracetam u. Phenobarbital v. Phenytoin w. Topiramate x. Valproic Acid y. Zonisamide\n* History of medically significant suicide attempt.\n* Evidence of acute cardiac dysfunction as evidenced by either elevated troponin or EKG changes within 48 hours of administration.\n* Systolic blood pressure that is greater than 150 mmHg systolic on \\> 2 readings during the 7-day monitoring period AND blood pressure medication management has been assured.\n* Diastolic blood pressure that is greater than 100 mmHg systolic on \\> 2 readings during the 7-day monitoring period AND blood pressure medication management has been assured.\n* Systolic blood pressure is less than 90 mmHg systolic on \\> 2 readings during the 7-day monitoring period after blood pressure medication management has been assured.\n* Diastolic blood pressure is less than 30 mmHg systolic on \\> 2 readings during the 7-day monitoring period after blood pressure medication management has been assured.\n* Systolic blood pressure exceeds 160 mmHg or is less than 90 mmHg immediately prior to administration of psilocybin; patients are allowed to be on anti-hypertensives.\n* Diastolic blood pressure exceeds 100 mmHg or is less than 30 mmHg immediately prior to administration of psilocybin; patients are allowed to be on anti-hypertensives.\n* Cognitive impairment that, in the estimation of the study team, would preclude the use of the MindPod Dolphin.\n* History of physical or neurological condition that interferes with study procedures or assessment of motor function (e.g. severe arthritis, severe neuropathy, Parkinson's disease).\n* Social and\u002For personal circumstances that interfere with ability to perform follow up assessments.\n* Are pregnant or nursing.\n* Weigh less than 48 kg.\n* Are not able to give adequate informed consent.\n* Are actively abusing opioids, cocaine, Phencyclidine (PCP), amphetamines, or alcohol.\n* Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID-5) criteria for moderate or severe substance use disorder\n* Diagnosis of schizophrenia, history of prior psychosis, anxiety requiring hospitalization, or Type 1 bipolar.\n* Hypernatremia\n* Hypokalemia (but can have received repletion during the prior 24 hours)\n* Hyperkalemia\n* Glomerular filtration rate of \\\u003C 30 ml\u002Fmin\n* Elevated of white blood cell count\n* Hemoglobin \\\u003C 7 g\u002Fdl\n* Platelet count \\\u003C 100,000 g\u002Fdl\n* Acute cardiac dysfunction demonstrated by either troponin elevation (chronic elevation is acceptable), or EKG changes suggestive of acute coronary syndrome.\n* Active suicidal ideation as assess by the C-SSRS.",{"count":70,"type":21},[291],"PHASE1","The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.",[189,27,294,295,296,240,297,298,299,300,301,302],"Intracerebral Haemorrhage","Intracerebral Haemorrhage (ICH)","Intracerebral Hemorrhage Basal Ganglia","Ischemic Stroke and Hemorrhagic Stroke","Hemiparesis After Stroke","Hemiplegia Following Ischemic Stroke","Hemiplegia and Hemiparesis","Hemiplegia and\u002For Hemiparesis Following Stroke","Middle Cerebral Artery Stroke",[304,132,106,305,306,107,307,308,309,310],"psychedelic","intracerebral hemorrhage","stroke recovery","poststroke recovery","poststroke motor recovery","hemiparesis recovery","psychedelic safety","2026-02-11",{"date":313,"type":32},"2026-02-13",{"date":315,"type":32},"2026-02-09",{"date":317,"type":21},"2027-03",{"name":319,"class":39},"Johns Hopkins University",{"id":321,"slug":322,"hasResults":12,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":22,"phases":331,"briefSummary":332,"conditions":333,"keywords":334,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":40},"100622065","constraint-induced-movement-therapy-and-bilateral-training-in-chronic-stroke-100622065","NCT07378774","Constraint Induced Movement Therapy and Bilateral Training in Chronic Stroke","Constraint-Induced Movement Therapy and Bilateral Training in Chronic Stroke","CIMT-BT","Inclusion Criteria:\n\n* Patients diagnosed with stroke in chronic phase. Patients with normal cognition (MMS 21 and above) Both male and female patients will be included. Adult patients will be included. (age 18-65) Participants with spasticity score of 2 or less on MAS.\n\nExclusion Criteria:\n\n* Acute and other neurological and musculoskeletal conditions e.g. Parkinson's, multiple sclerosis. Patients who do not agree to treatment.","65 Years",{"count":330,"type":21},112,[24],"Stroke is a leading cause of long-term disability, with upper limb spasticity and impaired hand function being common problems in the chronic phase. These impairments significantly affect independence in activities of daily living and overall quality of life. Constraint-Induced Movement Therapy (CIMT) and Bilateral Training (BT) are two widely used neurorehabilitation approaches aimed at improving upper limb motor recovery after stroke; however, evidence comparing their effectiveness on wrist spasticity and hand function in chronic stroke patients remains limited.\n\nThis single-blinded randomized controlled trial aims to compare the effects of Constraint-Induced Movement Therapy combined with Functional Electrical Stimulation (FES) versus Bilateral Training combined with Functional Electrical Stimulation on wrist spasticity and hand function in patients with chronic stroke. A total of 94 participants diagnosed with chronic stroke will be randomly allocated into two groups. Group A will receive CIMT with FES, while Group B will receive Bilateral Training with FES. Both interventions will be administered three times per week for eight weeks.\n\nOutcome measures will include wrist spasticity assessed using the Modified Ashworth Scale (MAS) and upper limb motor function assessed using the Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and the Chedoke Arm and Hand Activity Inventory (CAHAI). Assessments will be conducted at baseline and after completion of the intervention period.\n\nThe findings of this study are expected to provide evidence on the comparative effectiveness of CIMT and Bilateral Training in improving wrist spasticity and hand function, thereby assisting clinicians in selecting optimal rehabilitation strategies for chronic stroke patients.",[27],[335,336,337,338],"Chronic stroke","Constraint-induced movement therapy","Bilateral training","Upper limb rehabilitation","2026-01-22",{"date":341,"type":32},"2026-01-30",{"date":343,"type":21},"2026-02-05",{"date":345,"type":21},"2026-04-06",{"name":347,"class":39},"Zikra Azhar",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":358,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":40},"100547092","transcutaneous-vagus-nerve-stimulation-in-aphasia-after-stroke-100547092","NCT06403475","Transcutaneous Vagus Nerve Stimulation in Aphasia After Stroke","Transcutaneous Vagus Nerve Stimulation for Language Recovery After Stroke: a Pilot Study","TRANSLATE","Inclusion Criteria:\n\n* Supratentorial stroke at least 6 months prior to recruitment\n* Aphasia (with word finding difficulties)\n* Ability to engage in the programme (support can be provided for cognitive or receptive difficulties)\n* Sufficient vision to engage in the computer-based SLT programme\n\nExclusion Criteria:\n\n* Implanted devices (e.g. pacemaker) or implanted stimulation devices\n* Currently receiving a programme of Speech and Language Therapy (SLT)\n* Damage to the vagus nerve\n* Symptomatic bradycardia\u002F 2nd or 3rd heart block\n* Pregnancy\n* Unable to speak English\n* Severe deafness (despite using hear aids)",{"count":357,"type":21},36,[24],"Aphasia is an acquired language disorder. Stroke is the most common cause of aphasia, which affects 30% of stroke survivors. Speech and Language Therapy (SLT) can help people with aphasia but it may not be provided at the required intensity. Access to therapy is often limited after the first few months following stroke. People with aphasia can improve with therapy many years after stroke but these benefits have not been found to translate to day to day conversation.\n\nTranscutaneous Vagus Nerve Stimulation (tVNS) is a non-invasive technique which involves stimulating a branch of the vagus nerve through the skin of the ear, using a small earpiece. This technique is safe and has been approved for use in headache. There is promising evidence that tVNS can improve motor rehabilitation in chronic stroke. This technique may be helpful in aiding language recovery in individuals with chronic aphasia.\n\nThe current pilot study will primarily assess the feasibility, safety and tolerability of self-directed tVNS paired with computer-based SLT, in individuals with chronic stroke-related aphasia. Secondly, the study aims to explore the effect of the intervention on word-finding ability and to explore potential mechanisms of action. Participants will be randomly allocated to an active or sham tVNS group. Participants will be asked to use the stimulation device at home for 6 weeks, whilst completing computer-based SLT. To date, there are no published studies exploring the use of tVNS in aphasia. An indication of study feasibility may support the development of a larger RCT to explore treatment efficacy.",[361,27],"Aphasia",[363,364,132,365],"aphasia","vagus nerve stimulation","transcutaneous vagus nerve stimulation","2025-12-01",{"date":368,"type":32},"2025-12-08",{"date":370,"type":32},"2024-04-25",{"date":372,"type":21},"2027-01-01",{"name":374,"class":39},"Sheffield Teaching Hospitals NHS Foundation Trust",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":17,"minAge":382,"maxAge":98,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":384,"briefSummary":385,"conditions":386,"keywords":387,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":40},"100573448","the-effect-of-robot-assisted-gait-training-in-individuals-with-chronic-stroke-100573448","NCT06746415","The Effect of Robot-assisted Gait Training in Individuals With Chronic Stroke","The Effect of Robot-assisted Gait Training on Quadriceps Muscle Thickness, Balance and Gait Parameters in Chronic Stroke Patients","Inclusion Criteria:\n\n* a history of cerebrovascular accident at least 6 months ago;\n* a score of at least 20 on the mini mental test;\n* no botulinum toxin treatment for the last 3 months;\n* a score of 2 or above on the Functional Ambulation Scale;\n* a score of 3 or above on the Brunnstrom motor staging scale in terms of lower extremity recovery level\n\nExclusion Criteria:\n\n* presence of concomitant neurologic, orthopedic, cardiovascular disease and acute comorbidities\n* severe spasticity of lower extremity muscles, more than 2 on the Modified Ashworth Scale","40 Years",{"count":49,"type":21},[24],"The aim of our study was to investigate the effect of robot-assisted gait training on quadriceps muscle thickness, balance and gait parameters in individuals with chronic stroke.\n\nFor these purposes:-Improving gait and balance functions of patients with chronic stroke,-Increasing functional independence in daily life with walking trainings-Increase lower extremity muscle thickness with walking training, To investigate the effects of robot-assisted gait training on quadriceps muscle thickness, balance and gait parameters in individuals with chronic stroke.-It is aimed to contribute to the literature in this field by transforming the results to be obtained as a result of the study into a scientific publication",[27],[388,389,108,390],"exercise","robotic gait training","gait","2025-09-16",{"date":393,"type":32},"2025-09-17",{"date":395,"type":32},"2024-12-01",{"date":397,"type":21},"2025-12-15",{"name":399,"class":39},"Biruni University",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":68,"enrollmentInfo":408,"targetDuration":4,"studyType":22,"phases":409,"briefSummary":410,"conditions":411,"keywords":412,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":40},"100504530","home-based-fes-training-in-people-with-chronic-stroke-100504530","NCT05849532","Home-based FES Training in People With Chronic Stroke","Feasibility and Efficacy of Home-Based Functional Electrical Stimulation and Task-Specific Training in Adults With Chronic Stroke","HomeFES","Inclusion Criteria:\n\n1. Age group: 18-90 years.\n2. Presence of unilateral hemiparesis.\n3. Onset of stroke (\\> 6 months).\n4. Ability to walk independently with or without an assistive device for at least 300 ft.\n5. Can understand and communicate in English and can verbalize discomfort or pain in English\n6. Use of smartphone on a daily basis\n7. Availability of internet\u002FWi-Fi at home\n\nExclusion Criteria:\n\n1. Body weight more than 250 lbs.\n2. Heel bone density measurement using an ultrasound device. Individuals classified as osteoporotic (i.e., with a T-score \\\u003C -2) will be excluded.\n3. Cognitive impairment (Montreal Cognitive assessment score \\\u003C26\u002F30)\n4. Verbal Aphasia (i.e \\\u003C71% score on Mississippi Aphasia Screening)\n5. Severe depression (\\> 15 points on geriatric depression scale)\n6. Any neurological condition other than stroke.\n7. Uncontrolled and\u002For untreated hypertension\u002Fhypotension, uncontrolled and\u002For untreated diabetes and any musculoskeletal, neuromuscular or systemic diagnosis .\n8. Recent major surgery (\\\u003C 6 months) or hospitalization (\\\u003C 3 months).\n9. Deep venous thrombosis.\n10. Past or current history of any type of active cancer\n11. Peripheral nerve injury or neuropathy in the affected limb with motor disability.\n12. Uncontrolled high blood pressure\u002Fangina.\n13. Skin condition not tolerant with FES therapy.\n14. Past or current history of uncontrolled\u002Fcontrolled epilepsy or any other types of seizure disorders\n15. Botox treatment within the last 5 months.\n16. Pacemaker users.\n\n    \\-",{"count":49,"type":21},[24],"This project will examine the feasibility, safety and effect of home-based functional electrical stimulation (FES) applied to different lower limb muscles in combination with task-specific training on gait, balance and mobility in adults with chronic stroke. 30 individuals with chronic stroke will first undergo initial screening and baseline walking, mobility, balance and strength assessments in the laboratory. After determining their eligibility for the study, they will undergo 12-weeks of home-based FES and task-specific training. Following the initial screening (week 1) and pre-intervention assessment (week 2), participants will be trained in the lab for 6 sessions (week 3-4) for a FES home program and then given a FES home kit (FES device and an android tablet). Participants will then undergo home-training for 2 weeks (week 5-6) followed by mid-training assessment (week 7). Again, participants will undergo 4-weeks of home training (week 8-11) and final assessment at the end of training (week 12).\n\nThis project has the following specific aims:\n\nAim 1: To investigate the feasibility, safety and efficacy of 12-weeks of home-based FES and task-specific training in adults with chronic stroke.\n\nAim 2: To examine the effect of 12-weeks of home-based FES and task-specific training on mobility, gait and balance (anticipatory and reactive balance) in adults with chronic stroke.",[27],[335,413,414],"Functional electrical stimulation","Home-training","2025-09-15",{"date":417,"type":32},"2025-09-19",{"date":419,"type":32},"2022-12-10",{"date":421,"type":21},"2026-03-30",{"name":91,"class":39},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":17,"minAge":430,"maxAge":233,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":433,"briefSummary":434,"conditions":435,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":442,"locationsCount":40},"100486556","effects-of-transcutaneous-electrical-nerve-stimulation-on-cognitive-function-and-upper-limb-motor-function-in-people-with-chronic-stroke-100486556","NCT05615610","Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke","A Randomized Controlled Clinical Trial of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke","Inclusion Criteria:\n\n1. aged between 50 and 80;\n2. have suffered from a single stroke at least 6 months;\n3. had volitional control of the non-paretic arm and at least minimal antigravity movement in the paretic shoulder;\n\nExclusion Criteria:\n\n1. have cardiac pacemaker or cochlear implant;\n2. have other neurological diseases;\n3. are taking medication that may affect measured outcomes;\n4. have skin lesions, infection, or inflammation near selected position;\n5. are participating in other drug\u002Ftreatment programs.","50 Years",{"count":432,"type":21},90,[24],"Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke. Previous study also revealed that 53.4% of people after stroke experienced cognitive impairment. Different cognitive domains might be affected following stroke, such as attention, memory, language, and orientation, and the problems with memory are often prominent. Yet, there is no effective treatment for the post-stroke cognitive impairment.\n\nTranscutaneous spinal cord stimulation (tSCS) and transcutaneous vagus nerve stimulation (tVNS) are simple and non-invasive treatment to improve upper limb motor function and cognitive function. However, no existing studies have explored on the effects of tSCS and tVNS on cognitive function in people with stroke. Therefore, the purpose of this study is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on improving upper limb function and cognitive function in people with chronic stroke.",[27],"2025-08-14",{"date":438,"type":32},"2025-08-20",{"date":440,"type":32},"2023-11-01",{"date":397,"type":21},{"name":443,"class":39},"The Hong Kong Polytechnic University",{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":206,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":22,"phases":451,"briefSummary":452,"conditions":453,"keywords":455,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":40},"100598630","investigating-the-impact-of-afferent-stimulation-on-proprioceptive-function-in-post-stroke-rehabilitation-100598630","NCT07073989","Investigating the Impact of Afferent Stimulation on Proprioceptive Function in Post-Stroke Rehabilitation","Inclusion Criteria:\n\n* For healthy subjects:\n\n  1. No neurological or orthopedic conditions affecting upper limb movement.\n  2. No surgical interventions on the upper limbs within the past 6 months.\n  3. General physical condition adequate to perform the session.\n  4. Cognitive abilities sufficient to understand and carry out the experimental procedure.\n* For stroke survivors:\n\n  1. Ischemic or hemorrhagic stroke resulting in motor impairments in the upper limb.\n  2. Chronic stroke condition.\n  3. Subjects with sufficient cognitive abilities to follow instructions and actively participate in the therapy.\n  4. Mini-Mental State Examination (MMSE) score \\> 24.\n  5. Subjects presenting hemiparesis and mild-to-moderate impairment in the upper limb (score on the Fugl-Meyer Motor Assessment for the upper limb, sections A-D, between 35 and 53 points). The maximum score on the FM scale is 66, with the following severity classifications:\n* 0-15: severe impairment\n* 16-34: moderate-to-severe impairment\n* 35-53: mild-to-moderate impairment\n* 54-66: mild impairment 6. Subjects presenting upper limb hypertonia with a score below 3 on the Modified Ashworth Scale.\n\n  7\\. Subjects who have signed the informed consent document to voluntarily participate in the experiments.\n\nExclusion Criteria:\n\n1. Acute musculoskeletal disorders.\n2. Peripheral vascular diseases.\n3. Acute cardiopulmonary conditions.\n4. Acute neurological disorders.\n5. Restricted mobility of upper limb joints due to any cause.\n6. Pain as a cause of impaired upper limb mobility.",{"count":70,"type":21},[24],"The objective of this study is to assess the functionality of a sensory stimulation device that uses mechanical vibrations and low-intensity electrical currents to deliver proprioceptive feedback to stroke patients regarding their movements.",[454,27],"Healthy Subjects or Volunteers",[456,457],"Afferent stimulation","Proprioception","2025-07-09",{"date":460,"type":32},"2025-07-20",{"date":462,"type":32},"2025-06-17",{"date":464,"type":21},"2025-09",{"name":466,"class":39},"Julio S. Lora Millán",{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":476,"conditions":477,"keywords":480,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":40},"100597961","plantar-sensation-position-sense-and-weight-bearing-asymmetry-related-to-balance-and-mobility-post-stroke-100597961","NCT07065292","Plantar Sensation, Position Sense, and Weight-Bearing Asymmetry Related to Balance and Mobility Post-Stroke","Investigation of the Relationship Between Plantar Sensation, Lower Extremity Position Sense, and Weight-Bearing Asymmetry With Posture, Balance, and Mobility in Individuals With Chronic Stroke","Inclusion Criteria:\n\n* Diagnosis of stroke confirmed by a physician (via official report)\n* Minimum of 6 months since stroke onset\n* Aged 18 years or older\n* Mini-Mental State Examination score ≥ 20\n* Brunnstrom lower extremity stage ≥ 3\n* Ability to complete assessments with or without walking aids\n* Voluntary participation\n\nExclusion Criteria:\n\n* Additional neurological, metabolic, or orthopedic conditions\n* Severe vision or hearing impairments\n* Modified Ashworth Score of 4 in any lower limb muscle",{"count":475,"type":21},22,"This study aims to examine how sensory deficits and weight-bearing asymmetry affect posture, balance, and mobility in individuals with chronic stroke. The research focuses on evaluating the relationships between plantar foot sensation, lower extremity position sense, and asymmetrical weight distribution with functional abilities such as walking and postural control.\n\nParticipants will undergo non-invasive assessments, including sensation tests, mobility and balance evaluations, and postural measurements. A total of 24 individuals with chronic stroke who are receiving physiotherapy at a rehabilitation center in Konya, Türkiye, will be included.\n\nThe results of this observational, cross-sectional study may contribute to a better understanding of the sensory-motor interactions in stroke survivors and support the development of more targeted rehabilitation strategies.",[27,478,479,103],"Sensory Impairments","Postural Control",[27,481,482,160,483],"Somatosensory Function","Plantar Sensation","Weight-Bearing Asymmetry","2025-07-03",{"date":486,"type":32},"2025-07-15",{"date":488,"type":32},"2025-05-20",{"date":490,"type":21},"2026-01-20",{"name":492,"class":39},"Afyonkarahisar Health Sciences University",{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":233,"enrollmentInfo":499,"targetDuration":4,"studyType":22,"phases":500,"briefSummary":501,"conditions":502,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":40},"100476924","vibrotactile-coordinated-reset-for-the-treatment-of-chronic-stroke-100476924","NCT05490277","Vibrotactile Coordinated Reset for the Treatment of Chronic Stroke","Inclusion Criteria:\n\n1. Age at the time of enrollment: 18-80 years\n2. Diagnosis of ischemic or hemorrhagic stroke\n3. Disease period of more than 6 months\n4. Mini Mental State Examination of at least 24 points\n5. No medications that affect balance\n6. Motor deficit\n7. Use of Motricity Arm and Leg index to include impaired individuals with some functioning\n8. Modified Rankin Scale for Neurologic Disability: Scores 3 or 4\n\nExclusion Criteria:\n\n1. Any significant psychiatric problems, including acute confusional state (delirium), ongoing psychosis, or clinically significant depression\n2. Any current drug or alcohol abuse\n3. History of recurrent or unprovoked seizures\n4. Any neurological disorder treatments that involve intracranial surgery or device implantation\n5. Participation in another drug, device or biologic trial concurrently or within the preceding days\n6. Pregnancy, breastfeeding or wanting to become pregnant during the trial\n7. History or presence of other major neurological or orthopedic diseases other than stroke that limits motor functioning or cognitive ability\n8. More than 5 degrees of contracture at shoulder, elbow, wrist, finger, hip, knee, or ankle\n9. Botox, baclofen or any other treatment for spasticity except for bracing or splinting within the previous 3 months\n10. Must be able to communicate with staff\n11. Severe sensory abnormalities of the fingers such as vibratory urticaria",{"count":70,"type":21},[24],"The purpose of our study is to evaluate Vibrotactile Coordinated Reset stimulation (vCR) and its effects on motor ability within stroke patients. vCR will be administered with a device called the Vibrotactile (VT) Brain Glove. vCR is expected to provide patients with a non-invasive therapy to aid in recovery from a stroke. This study will include a dedicated sham arm that will aid in understanding true treatment effects from vCR.",[27],"2025-05-12",{"date":505,"type":32},"2025-05-15",{"date":507,"type":21},"2026-01-15",{"date":509,"type":21},"2028-11-15",{"name":511,"class":39},"Stanford University",{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":4,"eligibilityCriteria":518,"healthyVolunteers":12,"sex":17,"minAge":430,"maxAge":233,"enrollmentInfo":519,"targetDuration":4,"studyType":22,"phases":520,"briefSummary":521,"conditions":522,"keywords":523,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":40},"100590912","blood-flow-restriction-and-transcutaneous-electrical-nerve-stimulation-on-motor-function-in-stroke-100590912","NCT06973590","Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Motor Function in Stroke","Effects of Low-intensity Resistance Training With Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Lower Limb Motor Function in People With Stroke","Inclusion Criteria:\n\n1. are between 50 and 80 years of age;\n2. have had a single stroke more than 6 months and less than 15 years;\n3. have at least 5 degrees of active ankle dorsiflexion in the antigravity position;\n4. are able to walk 10 m independently, with or without a walking aid;\n5. are able to score 6 or higher out of 10 on the abbreviated mental test;\n6. have no skin allergies (e.g. redness or itchiness after application of the electrical stimulation pads) to electrical stimulation or electrodes;\n7. are able to follow instructions and give informed consent.\n\nExclusion Criteria:\n\n1. presence of other comorbidities like varicose veins, peripheral neuropathy, cancer, musculoskeletal injury, lower limb peripheral edema, post-surgical swelling, open wounds, or on a medication that increases blood clotting risk;\n2. resting blood pressure ≥ 160\u002F100 mmHg even after taking medications, cardiovascular comorbidity, heart failure, unstable angina, by-pass surgery, a pacemaker;\n3. administration of botulinum toxin in the lower limb at least 6 months prior to training;\n4. history of epilepsy, cochlear implants, any type of deep brain stimulator and metal implants in the head or neck;\n5. currently not participating in resistance training or high-intensity or long duration cardiovascular exercise;\n6. lack the ability to feel pain (because of paralysis), or other subjects who cannot complain of discomfort.",{"count":235,"type":21},[24],"Stroke commonly results in persistent leg impairments that limit mobility and reduce quality of life. This study investigates whether combining low-intensity resistance training with blood flow restriction (LIRT-BFR) and transcutaneous electrical nerve stimulation (TENS) can effectively improve leg function in stroke survivors.\n\nParticipants with chronic stroke will be randomly assigned to one of four intervention groups: 1) LIRT with simulated BFR and simulated TENS; 2) LIRT with actual BFR and simulated TENS; 3) LIRT with simulated BFR and actual TENS; 4) LIRT with both actual BFR and actual TENS. The resistance training utilizes 20% of each participant's maximum lifting capacity. For blood flow restriction, an automated pressure cuff (SmartCuffs 4.0) will be placed on the upper portion of the affected leg, inflated to 50% of the individual's occlusion pressure during exercises and deflated during rest periods. TENS therapy delivers controlled electrical impulses through electrodes positioned on the anterior thigh.\n\nEach 60-minute session includes a 10-minute warm-up followed by 40 minutes of targeted resistance exercises (leg extensions, leg presses, and weight-bearing squats) and concludes with 10 minutes of stationary cycling. The resistance protocol involves 3 sets of 20 repetitions with standardized rest intervals between sets and exercises. Participants will attend three sessions weekly for six weeks.\n\nAssessments will be conducted at baseline, midpoint (3 weeks), completion (6 weeks), and follow-up (1 month post-intervention). The primary outcome measure is the Fugl-Meyer Assessment for Lower Extremity function, with secondary measures including muscle strength, stiffness, balance, mobility, walking capacity, and gait parameters. To understand the underlying mechanisms, we will measure muscle oxygenation using near-infrared spectroscopy, evaluate muscle structure via ultrasound, and monitor physiological responses including heart rate variability and perceived exertion for safety monitoring.",[27],[524,525,132,526],"blood flow restriction","transcutaneous electrical nerve stimulation","low-intensity resistance training","2025-05-07",{"date":505,"type":32},{"date":530,"type":32},"2024-09-01",{"date":532,"type":21},"2026-12-31",{"name":443,"class":39},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":17,"minAge":540,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":22,"phases":543,"briefSummary":544,"conditions":545,"keywords":546,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":40},"100588729","motor-imagery-training-for-upper-limb-functional-strength-in-chronic-stroke-patients-100588729","NCT06945185","Motor Imagery Training for Upper Limb Functional Strength in Chronic Stroke Patients","Inclusion Criteria:\n\n* Stroke duration 6 months onwards (chronic stroke).\n* age 45 years and above.\n* Both genders.\n* Access cognitive function score \\> 24 on MoCA.\n\nExclusion Criteria:\n\n* Patients with any comorbidity, previous surgery and congenital anomly.\n* Patient with any fracture\u002F MSK disorders.\n* Score 3 or more on Modified Ashworth scale.\n* Patients with hearing impairments","45 Years",{"count":542,"type":21},26,[24],"Stroke is a leading cause of upper extremity deficits worldwide. Persistent upper extremity dysfunction affects many post stroke patients and is strongly associated with decreased activities of daily living and poor quality of life.\n\nThere is accumulating evidence of a cross-over effect with training of one limb that slightly increase strength and coordination in contralateral untrained limb through neurological adaptations.\n\nOne of rehabilitation that is beneficial for stroke patient is motor imagery, a mental rehearsal of a movement that does not include physical movement has been shown to enhance upper limb function.\n\nEvidence demonstrate that MI not only activates motor cortical and subcortical regions but also induces plastic change in motor networks and modulates synaptic activity at spinal level.",[27],[547,189,548,549],"Motor Imagery","Neurorehabilitation","Functional strength","2025-04-24",{"date":552,"type":32},"2025-04-25",{"date":554,"type":32},"2024-09-10",{"date":556,"type":21},"2025-05-30",{"name":558,"class":39},"Foundation University Islamabad",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":565,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":567,"conditions":568,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":573,"leadSponsor":575,"locationsCount":40},"100471357","robotic-rehabilitation-for-stroke-survivors-100471357","NCT05417828","Robotic Rehabilitation for Stroke Survivors","Inclusion Criteria:\n\n* Adults with chronic stroke, which affected their upper limb motor functions\n* Adults could able to understand the verbal cues during the training\n\nExclusion Criteria:\n\n* Adults with chronic stroke, who did not lose their upper limb motor functions",{"count":566,"type":21},40,"Pilot study on the physiological response of robotic rehabilitation therapy for improving the performance of activities of daily living of stroke patients",[27],"2025-03-20",{"date":571,"type":32},"2025-03-21",{"date":366,"type":21},{"date":574,"type":21},"2026-12-05",{"name":576,"class":39},"State University of New York at Buffalo",{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":583,"eligibilityCriteria":584,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":585,"targetDuration":4,"studyType":22,"phases":587,"briefSummary":588,"conditions":589,"keywords":590,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":602,"locationsCount":40},"100584070","robotic-rehabilitation-vs-occupational-therapy-chronic-stroke-upper-limb-rehabilitation-100584070","NCT06884553","Robotic Rehabilitation Vs Occupational Therapy Chronic Stroke Upper Limb Rehabilitation","Effects of Robot-assistED Rehabilitation Versus OccupatIonal Therapy on the Functional Recovery of the Upper Limb in PatiEnts with Chronic STroke: a Randomized Controlled Trial","REDIRECT","Inclusion Criteria:\n\n1. First ischemic or hemorrhagic stroke occurring at least 6 months prior.\n2. Persistent motor deficit in the affected upper limb (Motricity Index between 18 and 77).\n3. Willingness to participate in the study, with the provision of informed consent.\n\nExclusion Criteria:\n\n1. Severe spastic hypertonia at the wrist and fingers (Modified Ashworth Scale equal to or greater than 3).\n2. Orthopedic, rheumatological, and\u002For peripheral nervous system disorders affecting the paretic upper limb.\n3. Neurodegenerative and neuromuscular disorders.\n4. Acute pathologies affecting other body systems.\n5. Severe cognitive, language, and behavioral disorders that significantly limit understanding and participation in the planned activities.",{"count":586,"type":21},72,[24],"The functional recovery of the upper limb represents a critical element in post-stroke rehabilitation; hemiplegic\u002Fhemiparetic patients who achieve optimal recovery are a minority, and incomplete recovery has relevant consequences both on functioning and on quality of life of those who survive a stroke. The project aims to assess the effects on the functional recovery, with manual dexterity as the primary outcome, of a treatment protocol using an innovative tool (Gloreha Sinfonia) that enables assisted execution of three-dimensional tasks combined with Serious Games for cognitive stimulation, targeting the functional recovery of the upper limb in patients with stroke outcomes at least 6 months after the acute event (chronic phase). Patients with residual dysfunction of the upper limb, at least 6 months after the stroke, will be randomly assigned to the Robotic Rehabilitation group (ROBOT), the Occupational Therapy group (OT), focused on the use of the upper limb in functional tasks (task-oriented training), or the control group (CT - prescription of a home exercise program). Patients in the ROBOT and OT groups will undergo a total treatment period of 5 weeks, with 3 sessions per week lasting 1 hour, for a total of 15 sessions\u002Fhours of treatment. Patients assigned to the CT group will undergo an initial functional assessment required for defining the exercise program. All patients will be evaluated at baseline (T0), at a 5-week interval (T1), and 6 months after the end of treatment (T2). Outcome indicators include measures of manual dexterity\u002Fupper limb performance, anxiety\u002Fdepression, cognitive abilities, and patient-perceived outcomes. The analysis of Surface Plasmon Resonance imaging (SPRi) of serum exosome content, detected at T0, T1, and T2, will be correlated with variations in functional measures to verify the hypothesis that induction of neuroplasticity underlies any observed changes. Short- and medium-term effects on functional, psychological outcomes, as well as indicators of neuroinflammation and neural regeneration from serum analysis using innovative SPRi, will be compared among the 3 groups.",[27],[591,592,106,593,594,595],"Robotic rehabilitation","occupational therapy","upper limb impairment","biomarkers","manual dexterity","2025-03-13",{"date":598,"type":32},"2025-03-19",{"date":600,"type":32},"2023-09-19",{"date":417,"type":21},{"name":603,"class":39},"University of Florence",{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":17,"minAge":612,"maxAge":233,"enrollmentInfo":613,"targetDuration":4,"studyType":22,"phases":615,"briefSummary":616,"conditions":617,"keywords":619,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":4},"100571579","vr-and-scrip-training-of-pwa-randomized-controlled-trial-100571579","NCT06722092","VR and Scrip Training of PWA, Randomized Controlled Trial","Can Immersive Virtual Reality Magnify Treatment Outcomes of Script Training on Cantonese Speakers with Chronic Aphasia: a Randomized Controlled Trial","VRSTPWA","Inclusion Criteria:\n\n1. a stroke onset more than six months, with an Aphasia Quotient (AQ) below 96.4, as evaluated by the Cantonese version of Western Aphasia Battery (CAB; Yiu, 1992),\n2. premorbid fluent Cantonese speakers,\n3. aged between 30 and 80 years,\n4. no reported progressive neurogenic disorders such as dementia or Parkinson's disease,\n5. no motor speech disorders of moderate to severe level, and\n6. normal or corrected-to-normal vision and hearing functions\n\nExclusion Criteria:\n\n1. concurrent participation in other aphasia treatment trials, and\n2. incompatibility with immersive VR exposure such as complains of nausea, headache, or other severe discomforts during trial use of a head-mounted device during screening.","30 Years",{"count":614,"type":21},105,[24],"The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes.\n\nThe main research questions are:\n\n1. Can script training promote verbal functional communication of Cantonese-speaking PWA?\n2. Can script training enhance nonverbal cognitive functions of Cantonese-speaking PWA?\n3. Can VR magnify verbal and nonverbal treatment outcomes of script training of PWA?",[618,27],"Aphasia, Acquired",[620,217,621,622,623],"functional communication","script training","immersive reality","aphasia intervention","2025-03-11",{"date":596,"type":32},{"date":627,"type":21},"2025-06",{"date":629,"type":21},"2028-06",{"name":443,"class":39},{"id":632,"slug":633,"hasResults":12,"nctId":634,"briefTitle":635,"officialTitle":636,"acronym":637,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":639,"targetDuration":4,"studyType":22,"phases":641,"briefSummary":642,"conditions":643,"keywords":646,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":655,"leadSponsor":656,"locationsCount":658},"100494949","virtual-physical-activity-seated-exercise---phase-2-100494949","NCT05724823","Virtual Physical Activity Seated Exercise - Phase 2","Assessing a Telehealth Seated Exercise Program on Post-stroke Balance and Mobility: a Mixed-method Design","V-PASE","Inclusion Criteria:\n\nParticipants must meet the following inclusion criteria:\n\n* Adult (as defined by Province)\n* Chronic stroke (more than 6 months post-stroke)\n* Ability to stand up from a chair\n* Mobility impairment of lower extremity (requires a walking aid, with or without close supervision)\n* Able to safely engage in exercise and tolerate 60 minutes of exercises\n* Able to communicate in English\n* Have access to a tablet, computer, or laptop with internet and email access\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following criteria:\n\n* Participating in formal exercise or rehabilitation activities\n* Participating in \\> 30 minutes\u002Fday of physical activity (moderate intensity)\n* Participating in another study that may affect outcomes to this study\n* Severe loss of vision, hearing, speech (including aphasia) or cognition that would preclude use of a computer\u002Ftablet and communication over videoconference software\n* A serious comorbid condition (eg., amputation, Parkinson's disease, active cancer)\n* Clinically diagnosed with acute\u002Fchronic illness or other condition which has known physical activity contraindications or limits their ability to complete each experimental condition (i.e., chronic low back pain aggravated by prolonged sitting)",{"count":640,"type":21},100,[24],"This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility impairment.\n\nParticipants will be allocated to either a 10-week seated exercise program or a delayed 2-week Boot Camp program. All seated exercises sessions and assessments will be conducted virtually.",[189,27,644,645],"Stroke, Ischemic","Stroke Hemorrhagic",[189,647,103,648,649,650],"Seated Exercise","Mobility","Cardiometabolic health","Randomized Controlled Trial","2025-03-05",{"date":653,"type":32},"2025-03-10",{"date":222,"type":32},{"date":279,"type":21},{"name":657,"class":39},"University of British Columbia",5]