[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-subjective-tinnitus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-subjective-tinnitus":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644250","trial-of-management-of-chronic-tinnitus-by-sound-therapy-and-cognitive-behavioral-therapy-100644250",false,"NCT07665385","Trial of Management of Chronic Tinnitus by Sound Therapy and Cognitive Behavioral Therapy","Efficacy of Sound Therapy, Cognitive Behavioral Therapy and Their Combination in Management of Chronic Tinnitus","Inclusion Criteria:\n\n* o Age: 18-65 years.\n\n  * Hearing level: Patients with normal hearing or mild to moderate sensorineural hearing loss (to ensure homogeneity of the sample) (National Institute for Health and Care Excellence, 2020)\n  * Complaint: patients with chronic subjective tinnitus (\\> 3 months).\n  * Psychological state: Patients with stable general and psychological condition.\n\nExclusion Criteria:\n\n* o Age: \\\u003C18, \\>65 years\n\n  * Hearing level: Patients with severe hearing loss not suitable for sound therapy\n  * Complaint: Objective tinnitus (vascular or muscular origin)\n  * Psychological state: Patients with active psychiatric disorders requiring immediate intervention.\n  * Active middle or external ear disease","ALL","18 Months","65 Months",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","clinical trial: The main aim of this study is to compare the effectiveness of Cognitive Behavioral Therapy (CBT) and Sound Therapy, both individually and in combination, in the management of patients with chronic subjective tinnitus and to evaluate their impact on decreasing tinnitus severity, psychological wellbeing and quality of life.\n\nPatients will be randomly divided into three groups:\n\n* Group A: patients will receive Sound Therapy.\n* Group B: patients will receive Cognitive Behavioral Therapy (CBT).\n* Group C: patients will receive Combined CBT + Sound Therapy.",[27],"Chronic Subjective Tinnitus",[29,30,31,32,33],"Sound Therapy","Cognitive Behavioral Therapy","Chronic Tinnitus","Subjective Tinnitus","Tinnitus","NOT_YET_RECRUITING","2026-06-26",{"date":37,"type":38},"2026-06-30","ACTUAL",{"date":40,"type":21},"2026-06-10",{"date":42,"type":21},"2026-12-10",{"name":44,"class":45},"Sohag University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":46},"100629078","transcutaneous-auricular-vagus-nerve-stimulation-combined-with-tailor-made-notched-music-training-therapy-for-chronic-subjective-tinnitus-100629078","NCT07469969","Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Training Therapy for Chronic Subjective Tinnitus","Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Training Therapy for Chronic Subjective Tinnitus: A Multicenter, Randomized, Controlled, Open-label Trial","Inclusion Criteria:\n\n1. Patients whose primary complaint is tinnitus and who seek medical care for this reason\n2. Patients diagnosed with chronic tinnitus for more than 6 months\n3. Age between 18 and 70 years\n4. Tinnitus frequency within the range of 125-8000 Hz\n5. Hearing threshold not exceeding 70 dB HL\n6. Tinnitus Handicap Inventory (THI) score ≥ 38 points.\n\nExclusion Criteria:\n\n1. Patients with conductive hearing loss, history of middle ear surgery, pulsatile tinnitus due to vascular malformations, or tinnitus associated with Meniere's disease\n2. History of head trauma, central nervous system disorders, psychiatric disorders, or substance abuse\u002Fdependence\n3. Patients unwilling or unable to comply with the study protocol requirements\n4. Patients with space-occupying lesions in the peripheral auditory pathway or central nervous system (e.g., acoustic neuroma, middle ear cholesteatoma, meningioma) as identified by imaging studies.","18 Years","70 Years",{"count":57,"type":21},386,[24],"This study is a prospective, multicenter, randomized, controlled, open-label clinical trial designed to evaluate the superiority of transauricular vagus nerve microcurrent stimulation (taVNS) combined with Tailor-Made Notched Music Training (TMNMT) compared with Tinnitus Retraining Therapy (TRT) in patients with chronic subjective tinnitus. A total of 386 participants aged 18-70 years with a tinnitus duration of at least 6 months and a Tinnitus Handicap Inventory (THI) score ≥38 will be enrolled, excluding individuals with severe hearing loss, organic cranial diseases, or other contraindications. Eligible participants will be randomly assigned in a 1:1 ratio to either the experimental group or the control group. The control group will receive standardized TRT, including habituation sound therapy and structured educational counseling, while the experimental group will receive TMNMT combined with taVNS (0.1 Hz pulse-train stimulation, sub-pain threshold intensity of 0.5-10 mA). Although the trial is open-label, outcome assessors and statisticians will remain blinded to group allocation. Baseline and follow-up assessments include THI, visual analog scale (VAS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), audiological evaluations, and multimodal neuroimaging using EEG and fMRI. The primary outcome is the tinnitus improvement response rate at 3 months after treatment initiation, defined as a reduction of more than 7 points in the THI score from baseline. Secondary outcomes include treatment response rates at 6 and 12 months, changes in tinnitus severity and tinnitus-related comorbid symptoms, and neuroplasticity-related changes in central neural mechanisms.",[27],"2026-03-09",{"date":63,"type":38},"2026-03-13",{"date":65,"type":21},"2026-04-01",{"date":67,"type":21},"2030-03-31",{"name":69,"class":45},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]