[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-tic-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-tic-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100536855","modeling-tic-change-during-behavior-therapy-for-tics-100536855",false,"NCT06270251","Modeling Tic Change During Behavior Therapy for Tics","Inclusion Criteria:\n\n* Age 12-21 years at time of enrollment.\n* Current chronic motor and\u002For vocal tics, defined as tics for at least 1 year without a tic-free period of more than 3 consecutive months. Tics must not be due to a medical condition or the direct physiological effects of a substance.\n* At least moderate tic severity, defined as a Yale Global Tic Severity Scale total score\n\n  ≥14 (≥9 for those with motor or vocal tics only).\n* Full scale IQ greater than 70\n* English fluency to ensure comprehension of study measures and instructions.\n\nExclusion Criteria:\n\n* Active suicidality.\n* Previous diagnosis of psychosis or cognitive disability.\n* Substance abuse or dependence within the past year.\n* Concurrent psychotherapy focused on tics.\n* Neuroleptic\u002Fantipsychotic medications.\n* Taking a medication that has not reached stability criterion (same medication and dose for 6 weeks with no planned changes over the intervention period)","ALL","12 Years","21 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, and peer victimization. Chronic tics are the primary symptom of Tourette Syndrome (TS) and Persistent Motor\u002FVocal Tic Disorders.\n\nCBIT is a manualized treatment focused on increasing tic controllability. Its core procedure is competing response training (CRT), in which patients learn to inhibit tics by learning and applying a competing motor action to one tic at a time. CBIT is recommended as a first-line treatment relative to medications and other therapies. However, only 52% of children and 38% of adults show clinically meaningful tic improvement. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients, and meta-analysis shows comparable effect sizes for CBIT and medication. Although increasing tic controllability is the primary goal of CBIT, tic controllability nor its correlates have been examined longitudinally during the intervention.\n\nThe overall objective of this study is to use fine-grained data collection strategies to identify patterns in tic controllability and other relevant related variables that are associated with treatment response to CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Behavioral, psychosocial, and global functioning will be assessed longitudinally to examine predictors and correlates of response. CBIT sessions will be video recorded.",[26],"Chronic Tic Disorder","RECRUITING","2026-03-16",{"date":30,"type":31},"2026-03-19","ACTUAL",{"date":33,"type":31},"2024-03-01",{"date":35,"type":20},"2028-09-01",{"name":37,"class":38},"University of Minnesota","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":39},"100536919","internet-based-behavior-therapy-for-adults-with-tourette-syndrome-100536919","NCT06271083","Internet-based Behavior Therapy for Adults With Tourette Syndrome","A Parallel-group, Randomized Controlled Trial of Internet-based Behavior Therapy for Adults With Tourette Syndrome","TICNET","Inclusion Criteria:\n\n≥ 18 years of age.\n\nPrimary diagnosis of TS\u002FCTD, according to criteria in Diagnostic and Statistical Manual of mental disorders 5th edition.\n\nProvided digital informed consent.\n\nHave a Total Tic Severity Score (TTS) of \\>15, or \\>10 for individuals with motor or vocal tics only, in the past week, as measured by the Yale Global Tic Severity Scale (YGTSS).\n\nBeing willing and able to follow the study procedures and participate in the 10-week treatment program.\n\nBeing fluent in Swedish.\n\nHave regular access to a computer connected to the Internet, sufficient technical skills to use the treatment platform, as well as a mobile phone to receive text messages.\n\nExclusion Criteria:\n\nOngoing or planned psychological treatment for TS\u002FCTD.\n\nPrevious BT for tics of a minimum of 8 sessions with a qualified therapist within 12 months prior to assessment.\n\nAdjustment of medication for tics within the last two months prior to assessment.\n\nSevere psychiatric comorbidities such as organic brain disorders, bipolar disorder, ongoing psychosis, anorexia nervosa or substance use disorders that can interfere with the treatment for TS\u002FCTD.\n\nAcute psychiatric problems such as severe depression or suicidal risk needing immediate psychiatric care.\n\nSevere tics causing immediate risk to the participants themselves or to others and requiring urgent medical attention.","18 Years",{"count":50,"type":20},110,[23],"This study protocol outlines a parallel-group, randomized controlled trial (RCT) designed to evaluate the effectiveness of Internet-delivered behavior therapy (BT) based on exposure with response prevention (ERP) for adults with Tourette syndrome (TS) or chronic tic disorder (CTD). The primary aim is to evaluate the effects of Internet-delivered ERP-based BT on tic severity compared to a control condition offering general psychological support at week 11 counting from the treatment start. The primary outcome measure is the Yale Global Tic Severity Scale - Total Tic Severity subscale (YGTSS-TTS). Secondary outcomes include measures of tics-related impairment, work and social adjustment, rates of responders, self-rated tic severity, symptoms of depression, and quality of life. Long-term maintenance of results will be assessed at week 23 and 14 months after the treatment start. Participants will be recruited nationwide. The intervention group will receive 10 weeks of ERP-based therapy delivered through an online platform, with therapist support. The control group will receive psychoeducational content and general psychological support. Adherence to treatment, adverse events, and patient safety will be closely monitored throughout the trial. The study population will be intent-to-treat and the between-group differences at the primary endpoint will be assessed using an analysis of covariance (ANCOVA) with pre-score of the measure as covariate. A health-economic evaluation will assess the cost-effectiveness of the intervention.",[54,26],"Tourette Syndrome","2024-02-14",{"date":57,"type":31},"2024-02-21",{"date":59,"type":31},"2024-02-02",{"date":61,"type":20},"2028-05",{"name":63,"class":38},"Karolinska Institutet"]