[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-tinnitus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-tinnitus":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,82,102,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100623226","bimodal-electrical-sound-stimulation-and-auditory-training-for-chronic-tonal-tinnitus-100623226",false,"NCT07393880","Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus","Non-Invasively Re-Training the Tinnitus Brain Using Bimodal Electrical-Sound Stimulation (NITESGON-ADT): Protocol for a Prospective, Double-Blind, Randomised Controlled Trial","NITESGON-ADT","Inclusion Criteria:\n\n* Adults aged 18-80 years\n* Continuous subjective tinnitus for \\>3 months and ≤5 years\n* Predominantly tonal tinnitus (unilateral or bilateral)\n* Screening THI score 28-76\n* Minimum Masking Level (MML) 20-80 dB HL\n* No prior tinnitus neuromodulation treatment\n* Able to comply with eight sessions over four weeks and follow-up assessments\n\nExclusion Criteria:\n\n* Objective tinnitus or predominantly somatic tinnitus\n* Pulsatile tinnitus\n* Evidence of conductive hearing loss (abnormal otoscopy or tympanometry)\n* Pure-tone audiometry exclusions: \\>40 dB HL at any frequency 250 Hz-1 kHz OR \\>80 dB HL at any frequency 2-8 kHz in either ear\n* Hearing aid use initiated within the past 90 days\n* Active implantable medical device (e.g., pacemaker, DBS, cochlear implant)\n* LDL \\\u003C30 dB SL at 500 Hz in either ear\n* Diagnosis of temporomandibular joint disorder or occipital neuralgia\n* Severe anxiety (STAI \\>120\u002F160)\n* Cognitive impairment (MMSE \\\u003C25)\n* Severe depressive symptoms (BDI ≥30)\n* Diagnosis of Menière's disease\n* Current pregnancy\n* Involvement in medicolegal cases\n* History of auditory hallucinations\n* Current prescription of central nervous system drugs likely to alter neuromodulatory function (e.g., noradrenergic, dopaminergic, serotonergic, benzodiazepine, cholinergic, or other psychoactive medications)\n* Currently enrolled in another interventional study","ALL","18 Years","80 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study tests whether pairing non-invasive stimulation of the greater occipital nerve (NITESGON) with an attentionally demanding auditory frequency discrimination training task reduces tinnitus loudness and tinnitus-related distress. One hundred adults with chronic tonal tinnitus will be randomised to one of four groups in a 2×2 factorial design: real versus sham NITESGON and active versus passive listening during auditory stimulation. Participants complete eight sessions across four weeks, with outcomes assessed at baseline, end of treatment, 28 days post-treatment, and 6 months post-treatment.",[28,29,30],"Tinnitus, Subjective","Tinnitus","Chronic Tinnitus",[29],"RECRUITING","2026-04-02",{"date":35,"type":36},"2026-04-03","ACTUAL",{"date":38,"type":36},"2026-01-30",{"date":40,"type":22},"2029-01-30",{"name":42,"class":43},"University of Dublin, Trinity College","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":44},"100628951","multimodal-therapy-for-somatosensory-tinnitus-100628951","NCT07468318","Multimodal Therapy for Somatosensory Tinnitus","Multimodal Therapeutic Approach to Tinnitus Treatment With Focus on Somatosensory Components: A Randomised Controlled Trial Integrating Physiotherapy, Structured Exercise Program, and Psychological Intervention","SOMATIN","Inclusion Criteria:\n\n* Age 18-70 years (inclusive)\n* Chronic subjective tinnitus present for ≥6 months\n* Tinnitus Handicap Inventory (THI) score ≥18 points (indicating at least mild tinnitus handicap)\n* Positive somatosensory modulation test: ability to reproducibly modulate tinnitus (change in loudness, pitch, or quality) through at least one of the following manoeuvres:\n* Jaw movements (mouth opening, lateral excursion, protrusion, clenching)\n* Neck movements (flexion, extension, rotation, lateral flexion)\n* Pressure on specific head\u002Fneck muscles\n* Eye movements or shoulder elevation\n* Willing and able to attend all study sessions over 28 weeks\n* Adequate cognitive capacity to understand study procedures and complete questionnaires in the Czech language\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Audiological\u002FENT Exclusions:\n* Objective or pulsatile tinnitus\n* Active ear pathology requiring treatment:\n* Acute otitis media or externa\n* Chronic suppurative otitis media\n* Cholesteatoma\n* Meniere's disease with recent vertigo attacks (\\\u003C3 months)\n* Suspected retrocochlear pathology:\n* Acoustic neuroma (vestibular schwannoma)\n* Cerebellopontine angle tumor\n* Neurological Exclusions:\n* Neurological disease affecting brainstem or auditory pathways:\n* Multiple sclerosis with brainstem involvement\n* Stroke affecting auditory pathways\n* Brain tumor\n* Epilepsy or active seizure disorder\n* Musculoskeletal Exclusions:\n* Contraindications to manual therapy:\n* Severe cervical spine instability\n* Rheumatoid arthritis with atlantoaxial instability\n* Down syndrome\n* Vertebrobasilar insufficiency\n* Severe osteoporosis with fracture risk\n* Recent cervical spine surgery (\\\u003C6 months)\n* Recent head or neck trauma (\\\u003C3 months)\n* Ongoing physiotherapy or manual therapy for temporomandibular joint or cervical spine (\\\u003C3 months prior to enrollment)\n* Psychiatric Exclusions:\n* Severe psychiatric disorder:\n* Active psychosis\n* Severe depression requiring inpatient treatment\n* Acute suicidal ideation (PHQ-9 item 9 score ≥2)\n* Active substance abuse disorder\n* Other Exclusions:\n* Pregnancy (due to modifications needed in physical examination and treatment)\n* Ongoing litigation or compensation claims related to tinnitus or hearing loss\n* Current participation in another interventional clinical trial\n* Expected change of residence or long-term absence (\\>2 weeks) during the study period\n* Unable or unwilling to comply with study procedures and attend all sessions",true,"70 Years",{"count":56,"type":22},160,[25],"Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients. In a substantial proportion of cases, tinnitus is associated with dysfunction of the temporomandibular joint (TMJ) and cervical spine - this subtype is called somatosensory tinnitus.\n\nThis randomised controlled trial investigates the effectiveness of a multimodal intervention combining: (1) physiotherapy targeting TMJ and cervical spine dysfunction, (2) a structured combined exercise program (aerobic + resistance + breathing), and (3) psychological support (cognitive-behavioural psychoeducation) in patients with chronic somatosensory tinnitus.\n\nThe study also examines the acute effects of different types and intensities of physical exercise on tinnitus perception, and performs psychometric validation of Czech-language tinnitus assessment questionnaires.\n\nParticipants (N=160, aged 18-70 years) will be randomly assigned to either the multimodal intervention group (8 weeks, 5 sessions\u002Fweek) or a control group. Follow-up assessments will be conducted at 3, 12, and 24 months. The primary outcome is the change in the Tinnitus Handicap Inventory (THI) score.",[60,61,28,62,63,64,30],"Ear Noise","Tinnitus, Noise Induced","Headache Other","Temporomandibular Dysfunction","Cervical Migraine Syndrome",[66,67,68,69,70,71],"exercise therapy","tinnitus","multimodal therapy","subjective noise","somatosensory tinnitus","physiotherapy","NOT_YET_RECRUITING","2026-03-11",{"date":75,"type":36},"2026-03-12",{"date":77,"type":22},"2027-01-01",{"date":79,"type":22},"2030-12-31",{"name":81,"class":43},"Charles University, Czech Republic",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":44},"100613504","efficacy-analysis-of-personalized-target-transcranial-magnetic-stimulation-tms-in-the-treatment-of-chronic-tinnitus-a-single-center-single-blind-randomized-clinical-trial-100613504","NCT07267455","Efficacy Analysis of Personalized-Target Transcranial Magnetic Stimulation (TMS) in the Treatment of Chronic Tinnitus: A Single-Center, Single-Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* 1.Patients with tinnitus as the main complaint: Patients perceive subjective sounds in the ears or deep within the skull in the absence of internal or external acoustic stimulation.\n\n  2.Patients with chronic tinnitus who meet the conditions including tinnitus duration of more than 6 months, THI (tinnitus handicap inventory) score ≥ 38, and no response to conventional drug treatment.\n\n  3.Outpatients of Sun Yat-sen University Sun Yat-sen Memorial Hospital who can receive continuous 5-day cTBS treatment.\n\n  4.Tinnitus frequency ranges from 125 Hz to 8000 Hz. 5.Aged 18-70 years.\n\nExclusion Criteria:\n\n* 1.Patients with tinnitus associated with the following conditions: conductive hearing loss, a history of middle ear surgery, pulsatile tinnitus caused by vascular malformations, or Meniere's disease.\n\n  2.A history of any of the following: head trauma, central nervous system diseases, psychiatric disorders, or substance abuse.\n\n  3.Pregnancy.",{"count":89,"type":22},116,[25],"The goal of this clinical trial is to evaluate the efficacy and safety of personalized-target transcranial magnetic stimulation (TMS) in the treatment of chronic subjective tinnitus. The study aims to determine whether stimulation at individualized auditory cortex targets, identified by resting-state functional MRI, provides greater therapeutic benefit compared with conventional TMS targets.\n\nA total of 116 patients with chronic tinnitus will be recruited and randomly assigned to receive either personalized-target TMS or traditional-target TMS for five consecutive days.\n\nThe main questions this study aims to answer are:\n\nDoes personalized-target TMS improve tinnitus-related symptoms more effectively than traditional-target TMS?\n\nIs personalized-target TMS a safe and tolerable intervention for patients with chronic tinnitus?\n\nResearchers will compare the changes in tinnitus-related clinical rating scales between the two groups, including the Tinnitus Handicap Inventory (THI), Visual Analog Scale (VAS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI).\n\nParticipants will:\n\nReceive continuous theta burst stimulation (cTBS) targeting the left auditory cortex region showing the strongest functional connectivity with the parahippocampal gyrus, identified through resting-state fMRI.\n\nUndergo three cTBS sessions per day (600 pulses per session, 1,800 pulses total daily) for five days.\n\nComplete follow-up assessments at 1 month and 3 months after treatment to evaluate the durability of clinical effects.\n\nThis study will also assess treatment adherence, safety outcomes, and potential predictors of therapeutic response to personalized-target TMS.",[30],"2025-11-25",{"date":95,"type":36},"2025-12-05",{"date":97,"type":36},"2025-08-01",{"date":99,"type":22},"2030-08",{"name":101,"class":43},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":44},"100607074","internet-based-mindfulness-based-cognitive-therapy-imbct-for-chronic-tinnitus-patients-100607074","NCT07183826","Internet-Based Mindfulness-Based Cognitive Therapy (iMBCT) for Chronic Tinnitus Patients","Internet-Based Mindfulness-Based Cognitive Therapy (iMBCT) for Chronic Tinnitus Patients: a Randomized Controlled Trial Protocol","Inclusion criteria\n\n1. Willingness and ability to participate in online therapy.\n2. Polish language proficiency.\n3. 18 years or older.\n4. Suffering from chronic tinnitus for at least 3 months.\n5. A score of ≥32 on the TFI. Exclusion criteria\n\n1\\) Mentally incapable patients. 2) Patients who have already completed structured mindfulness training.",{"count":110,"type":22},78,[25],"This study tested a 6-week, internet-based Mindfulness-Based Cognitive Therapy (MBCT) program designed to help people experiencing distress related to chronic tinnitus. Tinnitus is condition that can cause anxiety, depression, and negatively impact the quality of life.\n\nThe investigators compare the online MBCT program to a wait-list group. Study aims to measure tinnitus distress, symptoms of anxiety, depression, mindfulness traits, and self-compassion before the program, right after, one month later, and six months later.",[30,114,115],"Anxiety","Depressive",[117,67,118,119,120,121,122,114],"chronic tinnitus","Mindfulness-Based Cognitive Therapy","MBCT","Internet-delivered intervention","Online mental health","Depression","2025-09-20",{"date":125,"type":36},"2025-09-25",{"date":127,"type":36},"2025-04-01",{"date":129,"type":22},"2026-06-19",{"name":131,"class":43},"University of Warsaw",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":44},"100607169","interventional-treatment-of-chronic-tinnitus-with-acoustic-stimulation-100607169","NCT07185061","Interventional Treatment of Chronic Tinnitus With Acoustic Stimulation","Clinical Study on Acoustic Stimulation Intervention in Chronic Tinnitus Patients","Inclusion Criteria:\n\n* Patients with chronic tinnitus lasting over six months (with or without hearing loss), showing no organic lesions in the auditory conduction pathway or temporal bone, and either not receiving any treatment (including medication or traditional Chinese medicine) or having discontinued therapy for over three months. These patients must be mentally alert, mentally stable, and able to provide fluent responses to all questions from the doctor and research team members.\n\nExclusion Criteria:\n\n* Patients with organic lesions in the auditory conduction pathway and temporal bone (e.g., tympanic membrane perforation, ossicular chain disruption), other otological conditions such as Meniere's disease, vertigo, chronic otitis media, middle ear cholesteatoma, or acute\u002Fchronic external otitis, history of head trauma or central nervous system disorders, exposure to ototoxic drugs, use of tinnitus medications or traditional Chinese medicine treatments (within 3 months of discontinuation), inability to cooperate with medical procedures or answer questions, or participants who dropped out or lost contact within 3 months.",{"count":140,"type":22},200,[25],"The《Clinical practice guideline: tinnitus》defines tinnitus as the perception of sound without an external source, with patients lasting six months or longer classified as chronic tinnitus. Epidemiological studies indicate that tinnitus affects up to 25% of the global population. With a worldwide estimated 7.2 billion people affected, which translates to approximately 1.8 billion individuals impacted. Among these, 33% (about 590 million people) experience varying degrees of hearing impairment, and severely disrupting their work, daily life, and social interactions. Furthermore, 10%-15% of patients (approximately 180～270 million) require medical treatment or intervention. Notably, tinnitus prevalence increases with age: it affects about 29.7% of those over 60 and rises to 33% for those aged 65 and above. These statistics demonstrate that tinnitus has become one of the most significant global health challenges.\n\nIn recent years, many studies have proposed an innovative therapeutic approach for tinnitus based on new research advancements in its pathogenesis. The methods termed Active Tinnitus Stimulation Therapy (ATST) and focuses on central mechanisms of tinnitus, abnormal neuronal discharges, and neural plasticity in related brain regions. The therapy tailors acoustic stimulation protocols according to individual hearing loss severity and tinnitus characteristics. Specifically, tailored acoustic signals are converted into electrical impulses in the cochlea, transmitted through auditory pathways to thalamic and auditory cortex nuclei. This process actively modulates auditory pathways, enhances filtering of chaotic signals, and activates auditory neurons. By synchronizing the self-discharge of neurons with nearby captured sound signals, ATST disrupts tinnitus generation and suppresses amplification, thereby reducing patients 'perception of tinnitus sounds. The approach comprehensively analyzes patients' hearing thresholds and tinnitus characteristics to generate personalized acoustic stimuli. Through targeted neuronal stimulation, it regulates neural plasticity, reduces abnormal discharges, and achieves active neuromodulation. Although some studies suggest that long-term periodic acoustic stimulation therapy may weaken tinnitus-related EEG networks, indicating potential improvement in chronic tinnitus, there remains a lack of large-scale clinical evidence confirming the effectiveness of this treatment for chronic tinnitus.",[30],"2025-09-15",{"date":146,"type":36},"2025-09-22",{"date":148,"type":36},"2024-10-01",{"date":150,"type":22},"2027-10-01",{"name":152,"class":43},"The First Affiliated Hospital with Nanjing Medical University"]