[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-variable-sleep-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-variable-sleep-deficiency":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100629165","sleep-light-circadian-central-oxidative-stress-100629165",false,"NCT07471126","Sleep, Light, Circadian, Central Oxidative Stress","Role of Ambien Lighting in Circadian Misalignment in a Chronic Variable Sleep Deficiency Paradigm: Impact on Sleep, Cognition, and Central Oxidative Stress","Inclusion Criteria:\n\n* Healthy participants 18-40 years old.\n\nExclusion Criteria:\n\n1. Volunteers must be drug-free (including caffeine, nicotine, and alcohol) for the entire duration of the study, with no history of drug or alcohol dependency.\n2. Subjects must be free from any significant impairments of the visual system, including color blindness.\n3. Subjects must be ambulatory, have no major visual or auditory handicaps, and be free from any major acute, chronic or debilitating medical conditions.\n4. history of psychiatric illnesses or psychiatric disorders\n5. History of consistent work during the overnight hours for the one year prior to study.\n6. History of transmeridian travel \\>2 times zones, will require a 1 week wash out per hour of time difference from the Eastern Standard\u002FDaylight Time zone.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease. Potential pathways underlying the adverse cognitive function and brain health associated with irregular insufficient sleep include misalignment of sleep from the internal \\~24-hour body clock and brain oxidative stress. This research will investigate these putative pathways and inform future interventions to mitigate the impact of sleep loss on cognition and brain health.",[28,29],"Non-visual Effects of Light","Chronic Variable Sleep Deficiency",[31,32,33,34],"Sleep","Circadian","Light exposure","Oxidative Stress","NOT_YET_RECRUITING","2026-06-09",{"date":38,"type":39},"2026-06-11","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2029-06-30",{"name":45,"class":46},"Beth Israel Deaconess Medical Center","OTHER"]