[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cigarette-smoking-behavior\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cigarette-smoking-behavior":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,72,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100608281","catalyzing-cigarette-smoking-cessation-through-harm-reduction-sampling-among-people-unmotivated-to-quit-100608281",false,"NCT07199517","Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit","Inclusion Criteria:\n\n1. Able to communicate fluently in English (i.e., speaking, writing, and reading)\n2. Male and female smokers who are \\> 21 years of age and self-report smoking at least 5 cigarettes (menthol and\u002For non-menthol) per day for at least the last 6 months.\n3. Have a carbon monoxide (CO) greater than or equal to 10 ppm\n4. Not using any forms of nicotine regularly other than cigarettes.\n5. Not interested in quitting smoking in the next 30 days.\n6. Capable of giving written informed consent, including compliance with the requirements and restrictions listed in the combined consent and HIPAA form\n\nExclusion Criteria:\n\nSmoking Behavior\n\n1. Regular use of nicotine-containing products other than cigarettes (e.g., chewing tobacco, snuff, snus, cigars, e-cigs, IQOS, ONPS, etc.).\n2. Current or impending (during the study period) enrollment or plans to enroll in a smoking cessation program.\n3. Current use of smoking cessation medication.\n4. Provide a CO breath test reading less than 10 ppm at Intake.\n\nAlcohol and Drug\n\n1. History of substance abuse (other than nicotine dependence) in the past 12 months.\n2. Current alcohol consumption that exceeds 20 standard drinks\u002Fweek.\n3. Current use of recreational drugs (other than nicotine and cannabis)\n\nMedical\n\n1. Women, including all individuals assigned as \"female\" at birth, who are pregnant, breastfeeding, or planning a pregnancy over the duration of the study period.\n2. Serious or unstable disease within the past year (e.g. cancer, uncontrolled hypertension, cardiovascular event).\n\nPsychiatric\n\n1\\. Lifetime history of schizophrenia or psychosis.\n\nGeneral Exclusion\n\n1. Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact subject safety, study data, and\u002For the study design as determined by the Principal Investigator.\n2. Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the Principal Investigator. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen.\n3. Significant non-compliance with protocol and\u002For study design as determined by the Principal Investigator and\u002Fo. Subjects may be deemed ineligible at any point throughout the study.",true,"ALL","21 Years",{"count":19,"type":20},472,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national sample of people unmotivated to quit smoking. Participants will be randomized 2:1 to choose one of two harm-reduction products (ECIG, ONP) versus a medicinal nicotine control condition (nicotine patch + lozenge, NPL), receive a 4-week starter product regimen, and then be followed for 6 months to assess use behavior.",[26,27,28],"Cigarette Smoking","Tobacco Use","Cigarette Smoking Behavior",[30,31,32,33],"cigarette smoking","harm reduction","sampling","nicotine replacement","RECRUITING","2026-06-10",{"date":37,"type":38},"2026-06-11","ACTUAL",{"date":40,"type":38},"2026-01-12",{"date":42,"type":20},"2030-07-31",{"name":44,"class":45},"Abramson Cancer Center at Penn Medicine","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100605148","generalized-and-domain-specific-episodic-thinking-for-smoking-cessation-100605148","NCT07158749","Generalized and Domain-Specific Episodic Thinking for Smoking Cessation","Generalized and Domain-Specific Episodic Thinking for Smoking Cessation: An 8-Week Pilot and Feasibility Trial","Inclusion Criteria:\n\n* smoked cigarettes daily for the last 30 days;\n* salivary cotinine \\> 30 ng\u002FmL, consistent with tobacco use;\n* plan to quit smoking in the next 30 days\n\nExclusion Criteria:\n\n* prior diagnosis with a smoking-related illness (e.g., respiratory disease);\n* past 30-day use any smoking cessation treatment;\n* anxiety or mood disorders; and\n* medical contraindications for use of nicotine replacement therapy (e.g. pregnancy).",{"count":55,"type":20},134,[23],"Cigarette smoking remains common, particularly in rural areas, despite ample evidence that smoking causes cancer and respiratory disease. Successful smoking cessation yields the majority of its health benefits (e.g., avoidance of lung cancer) after years of sustained behavioral change; however, people who smoke cigarettes tend to show elevated rates of delay discounting (i.e., devaluation of delayed outcomes) and a bias for immediate gratification. The overall goal of this project is to develop different versions of an episodic future thinking intervention (i.e., visualization of the future) and test their feasibility and efficacy for smoking cessation in rural and urban populations.",[28],[60,61],"Cigarette smoking","episodic future thinking","NOT_YET_RECRUITING","2026-03-25",{"date":65,"type":38},"2026-03-31",{"date":67,"type":20},"2026-05-01",{"date":69,"type":20},"2027-05-01",{"name":71,"class":45},"Virginia Polytechnic Institute and State University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":46},"100596201","effects-of-tobacco-abuse-liability-dependent-taxes-in-the-etm-100596201","NCT07042373","Effects of Tobacco Abuse Liability-dependent Taxes in the ETM","Innovative Policy: Effects of Tobacco Abuse Liability-dependent Taxes in the ETM","Inclusion criteria:\n\n* Provide informed consent\n* Be at least 21 years of age or older\n* Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm)\n* Smoke at least 10 cigarettes daily\n* Use other tobacco products less than weekly\n\nExclusion criteria:\n\n* Have uncontrolled physical or mental health conditions\n* Use of smoking cessation medications (e.g., nicotine replacement, bupropion, varenicline) in the past 30 days\n* Report concrete, immediate plans to alter\u002Fquit using their usual tobacco products in the next 30 days\n* If they are pregnant or lactating\n* Have plans to move out of the area during the experiment",{"count":80,"type":20},51,[23],"In a within-subject design, cigarette smokers, stratified by age, will purchase tobacco products under three tax rate conditions based on abuse liability, that is taxes based on: (1) product category score (i.e. score ranging from 0-1 based on abuse liability effect sizes); (2) product category rank (i.e. position of a product relative to all others; e.g. 1st, 5th); and (3) product tiers (i.e. low-, medium-, high abuse liability), as well as a control. In the ETM, the effects of these interventions will be examined on cigarette demand and other products substitution.\n\nThe investigators will use a repeated-measures (within subject) analysis of variance (ANOVA) to test if there are differences between conditions (i.e., tax proposals) independently for each product. The models will include study design parameters for order effects to account for counterbalancing the tax conditions in the ETM. Each tax condition will be compared to the control. All distributional assumptions will be checked prior to analyses and the appropriate transformations will be employed, if needed. For each significant result from the omnibus test, the investigators will perform planned contrasts to test the proposed hypotheses previously described. Note that the omnibus test can result in a significant finding while the contrasts of interest may be non-significant. In this case, the investigators will only report the results from the planned contrasts.\n\nAdditional analyses might be conducted.",[28],[85,86,87],"Cigarettes","Experimental Tobacco Marketplace","Abuse Liability","2026-03-23",{"date":90,"type":38},"2026-03-24",{"date":92,"type":20},"2026-07-31",{"date":94,"type":20},"2027-04-07",{"name":71,"class":45},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":15,"sex":16,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":110,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":46},"100521665","effect-of-flavored-on-nicotine-pouch-products-on-smoking-behaviors-a-smart-study-100521665","NCT06072547","Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study","Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a Sequential Multiple Assignment Randomized Controlled Trial","Inclusion Criteria:\n\n1. Has signed the Informed Consent Form (ICF) and is able to read and understand the information provided in the ICF.\n2. Healthy adults who smoke cigarettes and are 22 to 65 years of age (inclusive) at screening.\n3. Smokes an average of at least 5 cigarettes per day for the last 12 months.\n4. Does not intend to use an FDA-approved treatment for nicotine dependence within the next 60 days (as assessed at screening).\n5. Interested in replacing combustible cigarettes with a smoke-free tobacco product.\n6. Willing and able to comply with the requirements of the study.\n7. Owns a smart phone with text message and data capabilities compatible with necessary surveys.\n\nExclusion Criteria:\n\n1. Participant enrollment numbers met (in sub-group or entire study).\n2. Participant, or their first-degree relative (e.g., parent, sibling, child, spouse) or household member, is a current or former employee of the tobacco or e-vapor industry.\n3. Participant, or their first-degree relative (e.g., parent, sibling, child, spouse) or household member is a named party or class representative in litigation involving a tobacco or e-vapor company.\n4. Participant, or their first-degree relative (e.g., parent, sibling, child, spouse), or household member, is a current or former employee of a marketing consultant, market research firm, advertising or promotions agency, television or radio station, magazine or newspaper, government regulatory agency or public policy advocacy group, or law firm or legal department of a company.\n5. Participant self-reports being \"in poor health.\"\n6. Participants of childbearing potential (CBP) who have a positive pregnancy test (as assessed at screening) or are nursing or planning to become pregnant during their participation.\n7. Participant has an allergy\u002Fsensitivity to menthol or menthol-containing products or phenylalanine.\n8. Participant has any other self-reported health restrictions.\n9. Participant self-reports cardiovascular disease, cancer, diabetes, or is being treated for high blood pressure.\n10. Participant self-reports periodontal disease, gum disease or bleeding, open mouth sores or ulcers.\n11. Participant self-reports as wanting to stop using tobacco products in the next 60 days.\n12. Participant has participated in one tobacco research study in the past 30 days OR a tobacco research study lasting two weeks or longer in the past 90 days.\n13. Participant is unable to read, speak or understand English.\n14. Participants who ever used at least a pack of nicotine pouch products or currently uses nicotine pouch products.\n15. Participant who smokes marijuana more than once a week.\n16. Heterosexually active participants of CBP (not sterilized by tubal ligation, oophorectomy, hysterectomy, or other surgical methods, or post-menopausal) that do not agree to practice medically appropriate methods of birth control (or remain abstinent) during the course of the trial and for 30 days after the last use of the research product. Medically acceptable methods of birth control include: vasectomy, vaginal diaphragm with spermicide, intrauterine device, hormonal birth control (oral, injected, patch, or implanted), condom with spermicide, or sponge with spermicide.\n17. Taking psychoactive medications (e.g., antipsychotics or mood stabilizers).\n18. Cannot participate in the study for any reason (e.g., medical, psychiatric, and or social reason) as judged by the Investigator or designated medical staff based on all available information from the screening period.","22 Years","65 Years",{"count":106,"type":20},400,[23],"The goal of this clinical trial is to learn about the role of flavored on!® nicotine pouch products (the research products), an oral tobacco-leaf-free product, in the replacement of cigarettes with the use of the research products among adults who smoke cigarettes. The main question it aims to answer is whether flavored (vs. non-flavored) research products generate greater reduction of cigarette smoking among adults who smoke cigarettes.\n\nParticipants will be provided with research products to use for 6 weeks. Researchers will compare the reduction in cigarette smoking between participants with access to a complete flavor profile of research products and participants with access to only the Original (non-flavored) variety of research product to see if reduction in cigarette smoking is greater among those with access to flavored research products.",[28],[111,112],"on! Nicotine Pouches","Reduction in Cigarette Smoking","2024-07-10",{"date":115,"type":38},"2024-07-11",{"date":117,"type":38},"2023-09-11",{"date":119,"type":20},"2025-06",{"name":121,"class":122},"Altria Client Services LLC","INDUSTRY"]