[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-dysrhythmia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-dysrhythmia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100554927","picu-related-sleep-and-circadian-dysregulation-pilot-study-100554927",false,"NCT06505447","PICU-related Sleep and Circadian Dysregulation Pilot Study","A Three-phase Pilot Study of the Feasibility of the Measurement and Promotion of Sleep and the Circadian Rhythm in a Pediatric Intensive Care Unit","Inclusion Criteria:\n\n1. Child age 3 to 6 years old on the day of PICU admission\n2. English-speaking parent at the bedside\n3. Child expected to remain in the PICU over 24 to 48 hours\n\nExclusion Criteria:\n\n1. Child is in end-of-life care\n2. The child is receiving neuromuscular blockade for any reason\n3. Caregiver or parent not at the bedside","ALL","3 Years","6 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old. This study will also measure the feasibility of providing daytime light exposure as well as restricting all provided nutrition to during daytime hours.",[27,28,29,30],"Circadian Dysrhythmia","Sleep Disturbance","Critical Illness","Children, Only",[32,33,34,35],"Sleep disruption","circadian rhythm","critical care","pediatrics","RECRUITING","2026-03-18",{"date":39,"type":40},"2026-03-23","ACTUAL",{"date":42,"type":40},"2024-12-06",{"date":44,"type":21},"2027-01-01",{"name":46,"class":47},"State University of New York at Buffalo","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100501278","stabilization-of-circadian-rhythms-in-delirious-icu-patients-through-light-intervention-100501278","NCT05807178","Stabilization of Circadian Rhythms in Delirious ICU Patients Through Light Intervention","Inclusion Criteria:\n\n* Patient capable of giving consent or additionally existing legal caregiver or authorized\u002Fspouse representative in case of non-consenting patients in the intensive care unit\n* Male and female patients with age ≥ 18 years\n* Expected intensive care unit stay ≥ 2 days\n* Positive delirium during and up to a maximum of 30 days after study inclusion (determined by CAM-ICU, at least once per shift)\n\nExclusion Criteria:\n\n* Participation in other clinical studies during the study period and ten days before\n* Previous ICU treatment during the current hospital stay\n* Patients with psychiatric diseases\n* Patients with a history of stroke and known severe residual cognitive deficits\n* Patients with a history of cardiopulmonary arrest or pulseless electric activity with cardiopulmonary resuscitation followed by therapeutic hypothermia during entire hospital stay\n* Amaurosis\n* History of sleep-related breathing disorders\n* History or suspicion of hypoxic brain damage\n* History or suspicion of elevated intracranial pressure in the last 7 days before study inclusion\n* Patient has a power of attorney or patient's provision, where he\u002Fshe refuses participation in any clinical trial\n* The informed consent of the patient or the subject's legally acceptable representative can't be obtained in time\n* History of photoallergic reactions or history of visually triggered seizures\n* Severe eye diseases (e.g. retinopathy, glaucoma) or high sensitivity to bright light\n* Patients with liver cirrhosis\n* Patients with a probability of survival \\\u003C24h\n* Optic neuritis within the last 3 months\n* Travel across two time zones within 3 months prior to study screening\n* Women who are pregnant, have a positive pregnancy test, are breastfeeding or plan to become pregnant during the course of this clinical trial\n* Therapy-refractory blood coagulation disorder and inability to consent are exclusion criteria for a muscle biopsy","18 Years",{"count":57,"type":21},40,[24],"The investigators will examine the effects of dynamic light therapy on circadian rhythms in delirious intensive care unit (ICU) patients. In a randomized controlled trial (RCT), they will investigate the effects of a specific light algorithm on rhythms of serum melatonin, clock gene expression, the proteome, and metabolome, compared to standard hospital lighting, supported by the data science algorithms to improve vital-based algorithms with light interventions.",[27],"2026-01-22",{"date":63,"type":40},"2026-01-23",{"date":65,"type":40},"2026-01-20",{"date":67,"type":21},"2027-09-30",{"name":69,"class":47},"Charite University, Berlin, Germany",2,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100547714","a-multi-modal-combination-intervention-to-promote-cognitive-function-in-older-intensive-care-unit-survivors-100547714","NCT06411561","A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors","SLEEP-COG","Inclusion Criteria:\n\n* Age greater than or equal to 60 years old\n* Current hospitalization at University of Washington Medical Center or Harborview Medical Center\n* Intensive care unit (ICU) length of stay greater than 24 hours\n* Recovery from critical care status to acute care status, and\u002For discharge out of ICU\n* Fluent in English or Spanish\n* Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)\n\nExclusion Criteria:\n\n* Documented history or suspicion of Alzheimer's disease or dementia, or current prescription of anti-dementia medication\n* Documented history of bipolar disorder or schizophrenia\n* Documented acute stroke or traumatic brain injury\n* Severe vision impairment\n* Severe hearing impairment\n* Severe paralysis or dominant arm paresis\n* Transfer from skilled nursing care facility or inpatient rehabilitation facility","60 Years",{"count":80,"type":21},100,[24],"Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.",[29,84,85,86,87,88,27,28],"Delirium","Cognitive Impairment","Cognitive Decline","Alzheimer's Disease","Dementia","2025-07-16",{"date":91,"type":40},"2025-07-20",{"date":93,"type":40},"2024-12-26",{"date":95,"type":21},"2027-05-31",{"name":97,"class":47},"University of Washington"]