[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-misalignment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-misalignment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,74,103,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100643876","aerobic-exercise-as-a-countermeasure-for-night-shift-associated-circadian-misalignment-100643876",false,"NCT07668622","Aerobic Exercise as a Countermeasure for Night Shift Associated Circadian Misalignment","The Impact of Exercise on Cardiometabolic Health During Shiftwork: A Proof of Concept Study","SHIFT-EX","Inclusion Criteria:\n\n* Age 18-40 years\n* Body Mass Index 18.5-\\\u003C40kg\u002Fm\\^2\n* Physically inactive: defined as \\\u003C150 minutes per week of voluntary exercise at moderate intensity or greater and \\\u003C60 min per day of total habitual physical activity (i.e., work related, transportation related) at moderate intensity or greater, over the past 3 months.\n* No plans to relocate within the next 6 months.\n* No plans for extended travel (\\>2 weeks) within the next 3 months.\n* Capable and willing to give informed consent, understand exclusion criteria, and adhere to study conditions.\n* Have a primary care physician (or are willing to establish care with a primary care physician prior to study enrollment) to address medical issues which may arise during screening or study procedures.\n* No contraindications to exercise or limitations on ability to be physically active.\n* Ability to adhere to sleeping, eating, and exercise protocol\n* Willing and able to wear activity\u002Fsleep monitor for 7 consecutive days.\n* For Females:\n* Not currently pregnant or lactating.\n* Not pregnant within the past 6 months.\n* Not planning to become pregnant in the next 6 months\n* Regularly timed menstrual cycles to facilitate measurement of EE in the early follicular phase.\n\nExclusion Criteria:\n\n* Diastolic blood pressure \\>100 mmHG, systolic blood pressure \\>160 mmHG, or resting heart rate \\>100 bpm as measured in duplicate on the screening visit after 5 minutes of rest in a seated position.\n* Diabetes (fasting glucose \\>\u002F=126 mg\u002FdL or Hemoglobin A1C \\>\u002F=6.5%) as measured during the screening visit.\n* Undiagnosed hypo- or hyper-thyroidism (TSH outside of the normal range as measured during the screening visit) or history of uncontrolled thyroid disorder. History of thyroid disease or current thyroid disease treated with a stable medication regimen for at least 6 months is acceptable.\n* Triglycerides \\>400 mg\u002FdL as measured on the screening visit.\n* LDL cholesterol \\>200 mg\u002FdL as measured on the screening visit.\n* Abnormal resting electrocardiogram (ECG) as measured on the screening visit: serious arrhythmias, including multifocal PVC's, frequent PVC's (defined as 10 or more per min), ventricular tachycardia (defined as runs of 3 or more successive PVC's), or sustained atrial tachyarrhythmia; 2nd or 3rd degree A-V block, QTc interval \\> 480 msec or other significant conduction defects.\n* Presence or history of any metabolic or chronic health problems which would affect appetite, food intake, energy metabolism, or ability to participate in exercise: CVD, peripheral vascular disease, cerebrovascular disease, significant cardiac arrhythmias or cardiac valve disease, diabetes, uncontrolled hyper- or hypothyroidism, uncontrolled hypertension, cancer (within the last 5 years, except skin cancer or other cancers considered cured with excellent prognosis), HIV infection, significant renal, musculoskeletal, neurologic, hematologic, or psychiatric disease.\n* Significant gastrointestinal disorders including: chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, Ulcerative Colitis, chronic diarrhea, or active gallbladder disease.\n* Significant pulmonary disorders including: chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, or uncontrolled asthma.\n* Symptoms suggestive of CVD: chest pain, shortness of breath at rest or with mild exertion, syncope.\n* Regular use of prescription or over-the-counter medications known to significantly impact appetite, weight, or energy metabolism (e.g., appetite suppressants, lithium, stimulants, anti-psychotics, tricyclic antidepressants).\n* Regular use of systemic steroids (other than Oral Contraceptive Pills).\n* Regular use of obesity pharmacotherapeutic agents within the last 6 months.\n* Current alcohol or substance abuse.\n* Nicotine use (past 6 months).\n* Current severe depression or history of severe depression within the previous year, based on DSM-IV-TR criteria for Major Depressive Episode. Score \\> 16 on the Center for Epidemiologic Studies Depression Scale (CES-D) will require further assessment by the Study MD to determine if it is appropriate for the subject to participate\n* History of other significant psychiatric illness (e.g., psychosis, schizophrenia, mania, bipolar disorder) which in the opinion of the Study MD would interfere with ability to adhere to the study conditions.\n* Weight loss \\>5% in past 3 months.\n* Currently participating in or planning to participate in any formal weight loss or physical activity programs or clinical trials.\n* Primary sleep disorders including but not limited to insomnia, obstructive sleep apnea, periodic limb movements in sleep, restless leg syndrome.\n* Night-time shiftwork, rotating work, or other circadian disruptions and disorders (e.g., diagnosed delayed sleep-wake phase disorder).\n* Self-reported long (\\>9.25h) or short sleep (\\\u003C7h) that would make adhering the exercise conditions difficult.\n* Regular use of prescription or over-the-counter medications known to affect sleep (e.g., benzodiazepines, doxepin, zolpidem, trazodone, diphenhydramine HCl, etc.).\n* Regular use of melatonin (\\>\u002F=2 days per week).\n* High consumption of caffeine (\\>500 mg\u002Fd) or unwilling to abstain from caffeine consumption during run-in and in-patient protocol.\n* Planned travel \\>1 time zone away 4 weeks prior to study start or at any time during study protocol.","ALL","18 Years","40 Years",{"count":21,"type":22},16,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person's sleep and daily schedule are out of sync with their natural body clock (circadian rhythm).",[28,29],"Healthy","Circadian Misalignment","NOT_YET_RECRUITING","2026-06-19",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":22},"2026-07-01",{"date":38,"type":22},"2028-07-01",{"name":40,"class":41},"University of Colorado, Denver","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":5},"100643653","shift-workers-health-behavior-action-program-across-europe-100643653","NCT07631767","Shift Workers' Health Behavior Action Program Across Europe","SHAPE","Inclusion Criteria:\n\n* Age ≥ 21 years\n* Work ≥ 24 hours per week\n* Shift work duration \\> 3 years and currently doing night shifts\n* Expected to continue night shiftwork for at least 1 year after inclusion\n* On average working ≥ 4 night shifts per month\n* Working generally ≥ 2 consecutive night shifts\n* In possession of a smartphone and willing to download the study application\n\nExclusion Criteria:\n\n* Body Mass Index (BMI) \\\u003C 18.5 or \\> 40 kg\u002Fm2\n* Pregnant or lactating\n* Chronic diseases with ongoing therapy (e.g. renal failure, active hepatitis, cirrhosis, myocardial infarction, chronic obstructive pulmonary disease and cancer)\n* Current or recent use of medications interfering with sleep, including: Central nervous system stimulants (e.g., Ritalin, Adderall, Modafinil or similar); Chronic use of sleep agents (e.g., benzodiazepine, non-hypnotic benzodiaze-pine, first-generation antihistamine, melatonin receptors agonists or similar); Other medications or combinations significantly affecting sleeping patterns\n* Recent or ongoing psychotherapy for sleep disorders\n* Current or recent use of medications affecting appetite or weight regulation, including: Appetite-enhancing\u002Fweight-gain medications (e.g., atypical antipsychotics, cor-ticosteroids such as prednisone, mirtazapine or similar); Appetite-suppressing\u002Fweight-loss medications (e.g., CNS stimulants such as Ritalin, Adderall, GLP-1 receptors agonists or similar); Other medications or combinations significantly influencing appetite or body weight\n* Participation in another human trial, lifestyle program or weight loss intervention within the past 3 months\n* Planned surgical procedure during the study period\n* History of or planned bariatric surgery\u002Ftreatment",true,"21 Years",{"count":53,"type":22},400,[25],"This study evaluates the effects of a Combined Lifestyle Intervention Program (CLIP) on sleep, lifestyle behaviors, obesity risk and health in night-shift workers. The primary objective is to assess the effect of the CLIP on objectively measured sleep duration. Secondary objectives include behavioral outcomes related to sleep, diet, physical activity, and stress, as well as body weight and metabolic outcomes, . It is hypothesized that CLIP participants will show a greater increase in sleep duration than controls, alongside favorable changes in lifestyle and health outcomes.",[57,58,29],"Night Shift Work","Obesity & Overweight",[60,61,62,63,64],"Lifestyle","Stress","Sleep","Diet","Physical Activity","2026-06-01",{"date":67,"type":34},"2026-06-08",{"date":69,"type":22},"2026-05-15",{"date":71,"type":22},"2027-12-01",{"name":73,"class":41},"Wageningen University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":42},"100630931","phase-4-sleep-loss-and-circadian-misalignment---mechanisms-of-insulin-resistance-100630931","NCT07494084","Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance","Inclusion Criteria:\n\n1. Must be between 18-45 years old.\n2. Has a BMI of 18-25 kg\u002Fm2 stable weight over the previous 6 weeks.\n3. Is physically and psychologically healthy (incl. regular menstrual cycles in women, no clinical disorders and\u002For illnesses). Women will be studied during the follicular phase of their menstrual cycle.\n\n   Menstrual cycle criteria (using PMID 10941950) 18 to 25 years - Cycle variation ≤9 days 26 to 41 years - Cycle variation ≤7 days 42 to 45 years - Cycle variation ≤9 days\n4. No current medical or drug treatment (to include steroids or hormones of any type including contraceptives), as assessed by questionnaire.\n5. Has a negative pregnancy test (women), no clinically significant abnormalities in blood and urine, and free of traces of drugs.\n6. No history of clinically relevant psychiatric illness.\n7. No previous history of drug or alcohol abuse.\n8. Not a current smoker.\n9. No history of brain injury or of learning disability.\n10. No previous adverse reaction to sleep deprivation, jet lag, shift work or any of the drugs to be administered.\n11. Not vision or hearing impairment unless corrected back to normal.\n12. No endocrine disorder (no abnormal thyroid function tests; no abnormal morning blood cortisol; no primary gonadal disease as indicated by serum LH or FSH concentration \\> 10 or \\> 15 IU\u002FL, respectively; and no hyperprolactinemia indicated by prolactin \\> 25 μg\u002FL).\n13. No sleep or circadian disorder.\n14. Has good habitual sleep with regular bedtimes (between 6 and 10 hours in duration).\n15. Not extreme morning- nor extreme evening-type using Horne-Ostberg Morningness-Eveningness criteria.\n16. No travel across time zones within one month of entering the study.\n17. No shift work within three months of entering the study.\n18. No anemia (hematocrit \\\u003C38% in men, \\\u003C34% in women).\n19. No blood donation within the previous 8 weeks.\n20. No concurrent participation in another research study.","45 Years",{"count":82,"type":22},48,[84],"PHASE4","The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress which induces insulin resistance and leads to obesity and type 2 diabetes. Many factors contribute to sleep loss including shift work, environmental disturbances, sleep\u002Fcircadian disorders and comorbid medical and mental health conditions. Sleep loss increases the stress hormone cortisol in the evening and decreases daytime testosterone. Examining these hormones in a controlled laboratory environment under different sleep schedules may help researchers find solutions for adults experiencing negative health consequences related to chronic sleep loss.",[87,88,89,29],"Shift Work Schedule","Circadian Rhythm","Insulin Resistance",[91,92,93,94,95],"Shift work","insulin resistance","sleep","circadian rhythm","type 2 diabetes","2026-05-12",{"date":69,"type":34},{"date":36,"type":22},{"date":100,"type":22},"2029-07",{"name":102,"class":41},"Washington State University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":42},"100626871","does-circadian-misalignment-have-sex-specific-effects-on-metabolism-100626871","NCT07441265","Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?","Role of Biological Sex in Metabolic Responses to Night Work","Inclusion Criteria:\n\n* 18-40 years of age\n* Body Mass Index 18.5-24.9 kg\u002Fm2\n* Non-smokers, no current tobacco or e-cigarette use\n* Healthy with no acute or chronic medical and psychiatric disorders\n* Sex assigned at birth consistent with reproductive anatomy at enrollment (per protocol definition)\n\nExclusion Criteria:\n\n* History of drug or alcohol dependency\n* History of psychiatric illness or disorder\n* Pregnant\n* No prior gender-affirming hormone therapy and no gonadectomy",{"count":111,"type":22},36,[25],"This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger\u002Ffullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.",[29,115],"Sex Differences",[94,117,118,119,120],"sex differences","night work","glucose control","appetite regulation","2026-02-23",{"date":123,"type":34},"2026-02-27",{"date":125,"type":22},"2026-10-01",{"date":127,"type":22},"2030-09-30",{"name":129,"class":41},"Brigham and Women's Hospital",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":152,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":42},"100618258","nighttime-synchrony-of-your-nutrition-and-circadian-health-100618258","NCT07329283","Nighttime Synchrony of Your Nutrition and Circadian Health","Nighttime Synchrony of Your Nutrition and Circadian Health: The N-Sync Study","N-Sync","Inclusion Criteria:\n\n1. Age: 18-35 years old; equal numbers of men and women\n2. Body Mass Index (BMI): 18.5-24.9 kg\u002Fm2\n3. Sleep Habits: habitual self-reported average total sleep time (TST) 7-9 hours per night for prior 6 months\n\nExclusion Criteria:\n\n1. Clinically diagnosed sleep disorder or apnea hypopnea index (AHI) ≥5\n2. Evidence of significant organ system dysfunction or disease (e.g., heart disease, diabetes)\n3. Fasting plasma glucose ≥100 mg\u002FdL\n4. Major psychiatric illness (e.g., major depressive disorder)\n5. Cancer that has been in remission less than 5 years\n6. History of shift-work in prior year\n7. Weight change \\>5% of body weight over prior six months\n8. Currently following a weight-loss program\n9. Menopause\n10. Pregnant\u002Fnursing\n11. Greater than 5-day variation in menstrual cycle length month-to-month\n12. Currently smoking\n13. Alcohol intake \\>14 drinks\u002Fweek or \\>3 drinks\u002Fday.\n14. Use of prescription medications (except oral contraceptives) within one month prior to or during in-lab visits.\n15. Consumption of illegal drugs or \\>500mg per day of caffeine.","35 Years",{"count":140,"type":22},120,[25],"Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.\n\nParticipants will attend 6 to 8 in-person visits to the study clinic, including three overnight stays. People will complete surveys and medical tests. The study will last about 4 to 6 months.",[62,144,88,145,146,147,148,149,29,150,151],"Metabolism Changes","Lifestyle Factors","Sleep Hygiene","Sleep Hygiene, Inadequate","Sleep Deprivation","Insufficient Sleep","Circadian Dysregulation","Light Exposure",[62,151,153,88,154,145,146],"Metabolism","Food Intake","RECRUITING","2026-01-20",{"date":158,"type":34},"2026-01-22",{"date":160,"type":34},"2025-12-19",{"date":162,"type":22},"2031-05-31",{"name":164,"class":41},"University of Utah"]