[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-rhythm-disruption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-rhythm-disruption":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100624538","self-acupressure-and-social-jet-lag-in-female-health-sciences-students-100624538",false,"NCT07410936","Self-Acupressure and Social Jet Lag in Female Health Sciences Students","Effects of Self-Acupressure on Social Jet Lag, Sleep Patterns, and Sleep Quality in Female Health Sciences Students: A Sham-Controlled Randomized Trial","Inclusion Criteria:\n\n* Female undergraduate students enrolled in midwifery or medical programs\n* Age 18 to 25 years\n* Regular academic schedule (work\u002Fschool days and free days identifiable)\n* Willingness to participate and provide written informed consent\n* Ability to comply with daily self-acupressure practice for 12 weeks\n* Ability to complete sleep questionnaires and sleep diary\n\nExclusion Criteria:\n\n* Current diagnosis of a sleep disorder requiring medical treatment (e.g., obstructive sleep apnea, narcolepsy)\n* Use of medications known to significantly affect sleep or circadian rhythms (e.g., hypnotics, stimulants)\n* Shift work or night work during the study period\n* Transmeridian travel (≥2 time zones) within the past 4 weeks or planned during the study period\n* Chronic medical or psychiatric condition that may significantly affect sleep\n* Current pregnancy",true,"FEMALE","18 Years","25 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on social jet lag, sleep patterns, and sleep quality in female health sciences students. Participants will be randomly assigned to either a self-acupressure intervention group or a sham self-acupressure control group. The intervention will be performed daily for 12 weeks. Outcomes will be assessed at baseline and at the end of the intervention period, with the primary outcome being the change in social jet lag. Secondary outcomes include changes in sleep quality, daytime sleepiness, and participant blinding assessment.",[28,29,30,31],"Social Jet Lag","Sleep Disturbance","Sleep Quality","Circadian Rhythm Disruption",[33,34,35,36,37,38,39],"Self-acupressure","Social jet lag","Sleep quality","Sleep patterns","Circadian rhythm","University students","Sham-controlled trial","RECRUITING","2026-05-30",{"date":43,"type":44},"2026-06-02","ACTUAL",{"date":46,"type":44},"2026-04-24",{"date":48,"type":22},"2026-08-15",{"name":50,"class":51},"Nigde Omer Halisdemir University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":16,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":52},"100640692","circadian-clock-proteins-in-gingival-crevicular-fluid-of-individuals-with-and-without-circadian-rhythm-disruption-100640692","NCT07592052","Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption","Investigation of Circadian Clock Gene\u002FProteins in Individuals With and Without Disrupted Circadian Rhythm: A Prospective Cross-Sectional Clinical Study","Nursma-CIRC-HG","Inclusion Criteria:\n\n* Aged between 20 and 50 years\n* Systemically healthy\n* Diagnosed as periodontally healthy or with gingivitis based on clinical periodontal examination\n* Having at least 20 natural teeth in the oral cavity\n* Willing to provide written informed consent\n* Agreeing to participate in circadian rhythm assessment and completing the Morningness-Eveningness Questionnaire (MEQ) and Munich Chronotype Questionnaire (MCTQ)\n* Sleep duration of 6-9 hours per day\n* For periodontally healthy: PD \\\u003C=3 mm, BOP \\\u003C10%, CAL=0, no radiographic bone loss\n* For gingivitis: PD \\\u003C=3 mm, 10%\\\u003C=BOP\\\u003C=30%, CAL=0, no radiographic bone loss\n* For circadian rhythm disruption group: being a night-shift worker\n\nExclusion Criteria:\n\n* Use of antioxidant or melatonin supplements\n* Presence of any systemic disease\n* Use of antibiotics, anti-inflammatory drugs, or immunosuppressants within the past 3 months\n* Having received periodontal treatment within the past 6 months\n* Pregnancy or lactation\n* Use of tobacco or tobacco products\n* Presence of acute oral infection, abscess, or advanced periodontal disease\n* Currently undergoing orthodontic treatment or having fixed orthodontic appliances\n* Inability to comply with study procedures or refusal to provide informed consent\n* Self-reported sleep duration less than 6 hours or greater than 9 hours per day","ALL","20 Years","50 Years",{"count":65,"type":22},116,"OBSERVATIONAL","This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and anti-inflammatory (IL-10) cytokine levels in gingival crevicular fluid (GCF) of individuals with and without circadian rhythm disruption.\n\nParticipants aged 20-50 years will be classified into four groups based on their circadian rhythm status (disrupted\u002Fnormal) and gingival health status (gingivitis\u002Fhealthy). Clinical periodontal parameters including plaque index, gingival index, bleeding on probing, and probing depth will be assessed. Circadian rhythm status will be determined using validated questionnaires (Morningness-Eveningness Questionnaire and Munich Chronotype Questionnaire). Night-shift workers will represent the circadian rhythm disruption group.\n\nGCF samples will be analyzed for circadian clock proteins (BMAL-1, CLOCK, PER-1, PER-2, PER-3, CRY-1, CRY-2, REV-ERB-beta, MTNR1B) and cytokines (IL-1beta, IL-10) using ELISA. Serum cortisol and melatonin levels will be measured for biochemical verification of circadian rhythm status.\n\nGingivitis groups will receive standard periodontal treatment and be re-evaluated at 2 weeks post-treatment. A total of 116 participants (29 per group) are planned for enrollment.",[69,31,70,71],"Gingivitis","Periodontal Inflammation","Circadian Rhythm Sleep Disorder, Shift Work Type",[37,73,69,74,75,76,77,78,79,80],"Periodontal health","Gingival crevicular fluid","Clock genes","BMAL1","Night shift work","IL-1beta","IL-10","Chronotype","NOT_YET_RECRUITING","2026-05-11",{"date":84,"type":44},"2026-05-18",{"date":86,"type":22},"2026-08-01",{"date":88,"type":22},"2027-03-01",{"name":90,"class":51},"Inonu University"]