[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-rhythm-sleep-disorder-of-shift-work-type\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-rhythm-sleep-disorder-of-shift-work-type":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100558361","impact-of-circulating-and-tissue-specific-lipids-on-vascular-function-and-insulin-sensitivity-in-chronic-night-shift-workers-100558361",false,"NCT06550115","Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers","SHINE","Inclusion Criteria:\n\n* 18-65 years old\n* worked the night shift for the last 1 year or more,\n* habitually sleep 5-9 hours per 24h period (night shift workers typically experience chronic insufficient sleep),\n* body mass index (BMI) of 20.0 - 35.0 kg\u002Fm2 and weight stable (plus or minus 5% of current body weight in the last 6 months); sedentary to mild physical activity level (less than 2 days of planned exercise per week);\n\nExclusion Criteria:\n\n* existing diagnosed sleep or eating disorder (e.g. obstructive sleep apnea \\[OSA\\], periodic limb movements of sleep \\[PLMS\\], narcolepsy, travel more than 1 time zone in 3 weeks before the study; anorexia nervosa, more than one food allergy to maintain flexibility in diet planning);\n* following any TRE (time-restricted eating) or intermittent fasting plan in the last year;\n* following any special diet plan, like paleo, keto, gluten-free or vegan, that can affect the primary lipid outcome measures in the last 6 months; any clinically significant surgical condition within the last year;\n* diagnosed diabetes or cardiovascular disease\n\n  * The prevalence of insomnia in shift workers is fairly high, ranging from 12.8% to 76.4%, which is higher than estimated for the general population. Insomnia itself is associated with elevated neural cardiovascular responsiveness to stress compared to people without insomnia. Thus, since excessive sleepiness and symptoms of insomnia may be present in night shift workers they will not be exclusionary.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D risk are unknown. This project will examine whether elevated plasma lipids are a mechanism by which circadian misalignment impairs vascular function, insulin sensitivity, glucose homeostasis and muscle lipid accumulation, which could be targeted to prevent and treat cardiometabolic disease in people who chronically experience circadian misalignment, which includes more than 20% of the US workforce.",[28,29,30,31],"Circadian Rhythm Sleep Disorder of Shift Work Type","Metabolic Disease","Insulin Sensitivity","Blood Pressure",[33,34,35,36,37,38],"Shift work","Sleep","Blood sugar","Metabolism","Lipids","Blood pressure","RECRUITING","2025-12-15",{"date":42,"type":43},"2025-12-17","ACTUAL",{"date":45,"type":43},"2024-03-01",{"date":47,"type":22},"2029-06",{"name":49,"class":50},"Colorado State University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":51},"100436675","countermeasures-to-circadian-misalignment-100436675","NCT04966351","Countermeasures to Circadian Misalignment","Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment","C2CM","Inclusion Criteria:\n\n1. 18-35 old; men and women; equal numbers of women and men will be included.\n2. Body Mass Index (BMI) between 20.0 and 24.9 (\"normal\" weight).\n3. Physical activity history: inactive to habitual moderate physical activity level\n4. Sleep\u002Fwake history: habitual sleep duration between 7-9.25 hours.\n5. Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.\n\nExclusion Criteria:\n\n1. Any clinically significant medical, psychiatric, or sleep disorder\n2. Use of prescribed medications\u002Fsupplements\u002Fillicit drugs within one month prior to study\n3. History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. \\[NOTE: Subjects can be studied at a later date.\\]\n4. Women with history of prior gynecological pathology, \\\u003C1 year post-partum, breast-feeding and\u002For pregnant.\n5. Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.","35 Years",{"count":62,"type":22},32,[25],"Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.\n\nThis project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.",[28,29,30],[33,34,35,36],"2025-07-21",{"date":69,"type":43},"2025-07-24",{"date":71,"type":43},"2021-07-07",{"date":73,"type":22},"2026-06-30",{"name":49,"class":50}]