[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-rhythm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-rhythm":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,57,82,112,137,179,201,230,277,311,340,372,397,426,451,474,498,532,562,594,619,648,686,726,751],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100644966","chronotype-alignment-and-time-perception-100644966",false,"NCT07677111","Chronotype Alignment and Time Perception","Circadian Match and Mismatch Effects on Temporal Cognition in Morning- and Evening-Type Adults","Inclusion Criteria:\n\n* Healthy adult, 18-40 years\n* Clear morning-type or evening-type on the Morningness-Eveningness Questionnaire (MEQ-SA); intermediate types excluded (state exact cut-offs, e.g. evening-type 41 or below, morning-type 59 or above)\n* Normal or corrected-to-normal visual acuity\n* Normal colour vision (e.g. Ishihara screening)\n* Fluent in the testing-site language (Danish, Chinese, or English)\n* Able to attend both an early-morning (about 08:00) and a late-evening (about 22:00) session\n\nExclusion Criteria:\n\n* Intermediate chronotype (MEQ in the middle band)\n* Night or rotating shift work in the past 3 months, or recent trans-meridian travel (more than 2 time zones in the past 4 weeks)\n* Diagnosed sleep disorder (e.g. insomnia, sleep apnoea)\n* Current psychiatric or neurological disorder\n* Use of sleep medication or psychoactive or CNS-active drugs\n* Colour-vision deficiency\n* Substance-use disorder",true,"ALL","18 Years","55 Years",{"count":22,"type":23},240,"ESTIMATED","INTERVENTIONAL",[26],"NA","People differ in chronotype - whether they function best in the morning (\"larks\") or the evening (\"owls\"). This study asks whether the match or mismatch between a person's chronotype and the time of day at which they are tested changes how they perceive time.\n\nHealthy morning-type and evening-type adults at three sites (Aarhus, Denmark; Changzhou, China; and Hong Kong) complete the same battery of perception and cognition tasks twice - once in the early morning (about 08:00) and once late in the evening (about 22:00), in counterbalanced order. The primary outcome is the accuracy (signed bias) of time-perception judgements; the key comparison is the interaction between chronotype and time of day (the \"synchrony effect\").\n\nSecondary measures include timing precision, the subjective passage of time, sleepiness, mood, colour perception (with and without blue-blocking glasses) and perceptual decision-making. By testing the same protocol across three cultures and latitudes, the study examines whether circadian match\u002Fmismatch effects on temporal cognition generalise across populations.",[29,30,31,32],"Chronotype","Circadian Rhythm","Sleep","Time Perception",[34,35,36,37,38,39,40,41,42,43],"chronotype","morningness-eveningness","synchrony effect","time perception","temporal cognition","circadian rhythm","time-of-day","duration discrimination","arousal","cross-cultural","RECRUITING","2026-06-29",{"date":47,"type":48},"2026-06-30","ACTUAL",{"date":50,"type":48},"2025-09-01",{"date":52,"type":23},"2028-06-30",{"name":54,"class":55},"The Hong Kong Polytechnic University","OTHER",1,{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":67,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100645046","digital-insomnia-and-circadian-therapy-for-reducing-depression-symptoms-in-college-students-100645046","NCT07677930","Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students","Prevent Worsening of Depressive Symptoms Using Digital Cognitive Behavioral Therapy for Insomnia and Circadian Intervention in College Students","Inclusion Criteria:\n\n* Youths aged between 18-24 years old.\n* Insomnia disorders as determined by DSM-5 criteria with a predominant complaint of difficulty initiating sleep.\n* Presence of an evening chronotype according to the score on the Horne-Östberg Morning-Eveningness Questionnaire (MEQ) and having a late bedtime of 12:00 am\u002Fmidnight or later for at least 3 nights per week in the last 3 months.\n* Presented with at least subclinical depressive symptoms as determined by Patient Health Questionnaire-9 ≥ 10.\n* Accessibility to a smartphone.\n\nExclusion Criteria:\n\n* Having a diagnosed sleep disorder that may potentially contribute to the disruption of sleep quantity and quality other than insomnia and delayed sleep phase syndrome, as ascertained by Structured Diagnostic Interview for Sleep patterns and Disorders (DISP), such as restless leg syndrome and OSA, and narcolepsy.\n* Diagnosed with neuropsychiatric disorders such as major depressive disorder, anxiety disorders, bipolar affective disorders, schizophrenia, moderate or above suicidality.\n* Concurrent, regular use of medications known to affect sleep continuity and quality, including both Western medications (e.g. hypnotics, steroids, antidepressants, antihistamines) and over-the-counter medications (e.g. melatonin).\n* Participate in other psychotherapy (e.g., CBT, mindfulness) currently or in the past three months.","24 Years",{"count":66,"type":23},195,[26],"Depression is a leading cause of global disease burden, poor quality of life, disability and suicide, and commonly occurs in adolescence and early adulthood. Insomnia and circadian factors were regarded as potential targets for preventing worsening of depressive symptoms. Additionally, digital insomnia treatment reduces depressive symptoms but is insufficient for individuals with an evening chronotype. Circadian intervention is an adjunctive treatment for sleep disturbance and depression, but is often overlooked. In this study, we aim to evaluate the effect of guided digital insomnia and circadian intervention (dCBT-I + dCI) in reducing depressive symptoms in college students with insomnia and an evening chronotype compared with digital insomnia intervention alone (dCBT-I) and a health education group (dHE). We also aim to develop and evaluate multimodal prediction models to identify individuals who are more or less likely to respond to the interventions, using clinical, behavioral, circadian, and digital engagement data.",[70,71,30,72],"Eveningness","Insomnia","Depressed Mood",[70,71,72,30],"NOT_YET_RECRUITING",{"date":76,"type":48},"2026-07-01",{"date":76,"type":23},{"date":79,"type":23},"2029-06-30",{"name":81,"class":55},"Chinese University of Hong Kong",{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":93,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":56},"100642932","exercise-interventions-in-obstructive-sleep-apnea-syndrome-100642932","NCT07634029","Exercise Interventions in Obstructive Sleep Apnea Syndrome","The Effect of Exercise Snacks and Aerobic Exercise on Circadian Rhythm and Functional Capacity in Individuals With Obstructive Sleep Apnea Syndrome","Inclusion Criteria:\n\n* Individuals diagnosed with OSAHS (AHI ≥ 15) confirmed by polysomnography, with moderate or severe disease, who have been receiving CPAP therapy for at least 3 months.\n* Adults aged 30-65 years.\n* No participation in any regular exercise program within the last 6 months.\n\nExclusion Criteria:\n\n* Individuals with OSAHS and a body mass index (BMI) \\> 35 kg\u002Fm²\n* Severe chronic pulmonary disease\n* Neurological or musculoskeletal disorders that prevent exercise\n* Unstable cardiovascular conditions\n* Unstable metabolic conditions\n* Severe psychiatric disorders such as bipolar disorder or schizophrenia\n* Pregnancy or breastfeeding\n* Individuals working night shifts or with schedules that may cause jet lag\n* Use of steroid or hormone therapy\n* Use of melatonin or sleep-regulating medications within the last 3 months\n* Presence of acute infection or inflammation","30 Years","65 Years",{"count":92,"type":23},39,[26],"Obstructive Sleep Apnea Syndrome (OSA) is a condition characterized by repeated pauses or reductions in breathing during sleep, which can negatively affect sleep quality, daytime functioning, and physical capacity. Although regular exercise is known to have beneficial effects in OSA, the effects of different exercise approaches on circadian rhythm and functional capacity have not been sufficiently investigated.The primary aim of this study is to compare the effects of exercise snacking and aerobic exercise on circadian rhythm and functional capacity in individuals with OSA, in comparison with a control group. The secondary aim is to evaluate the effects of these exercise interventions on peripheral muscle strength, fatigue level, body composition, quality of life, and physical activity level.Participants will be randomly assigned to three groups: an aerobic exercise group, an exercise snacking group, and a control group. While the exercise groups will follow their respective intervention programs, the control group will continue their routine treatment.This study aims to answer whether exercise snacking, which consists of short bouts of exercise distributed throughout the day, may be an alternative or complementary approach to traditional aerobic exercise in individuals with OSA. In addition, this study aims to be the first randomized controlled trial evaluating the effects of exercise snacking on circadian rhythm and functional capacity in individuals with OSA.",[96,97,98,30,31],"Obstructive Sleep Apnea (OSA)","Exercise Snacks","Physical Activity",[100,101,39,102],"Obstructive Sleep Apnea","exercise training","exercise snacks","2026-06-03",{"date":105,"type":48},"2026-06-08",{"date":107,"type":23},"2026-09-01",{"date":109,"type":23},"2028-02",{"name":111,"class":55},"Istanbul University - Cerrahpasa",{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":17,"sex":18,"minAge":120,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":24,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":56},"100530896","screens-sleep-circadian-rhythms-and-electronics-in-the-evening-study-100530896","NCT06192745","SCREENS: Sleep, Circadian Rhythms, and Electronics in the EveNing Study","Experimental Effects of Light And Content From Evening Screen Media Use On Children's Sleep, Executive Functioning, And Emotion Regulation","SCREENS","Inclusion Criteria:\n\n* children between 8.0 and 11.9 year old\n* Tanner stage 1 and 2\n* live with their parent(s) (biological or legal guardian at least 50% of the time and has a primary role of caring for the child).\n* Children who sleep between 8.5 to 11 hours per night habitually\n* Children must sleep alone most nights\n* parent and child able to communicate and read and write in English\n* The child does not have to have access to a mobile device (tablet or Phone), but if they do, the primary device they use has to be an a) Android OS ≥5.0 either used only by the study child or shared with others, b) Amazon Fire OS ≥5.0 that only the child uses or c) an Apple iOS ≥14.0 that only the child uses.\n* If the child's primary device is a Android or Amazon Fired device, the parent and child agree to install Chronicle App (Android or Amazon). If the child's primary device is an Apple device, the parent and child agree to allow us to gather usage screenshots from the primary iPad or iPhone.\n* Families must live in the greater Houston area.\n\nExclusion Criteria:\n\n* child blindness or colorblindness\n* significant vision problems\n* developmental or cognitive delays\n* diagnosis of a sleep or psychiatric disorder\n* diagnosed cognitive or learning impairment affecting executive functioning (e.g., attention deficit hyperactivity disorder)\n* medical conditions that impact sleep\n* taking medications that impact sleep\n* travel beyond 2 time zones in the month before starting the study","8 Years","11 Years",{"count":123,"type":23},220,[26],"The proposed project aims to disentangle the impact of evening light exposure emitted from tablet devices from the impact of arousing media content on children's sleep regulation, circadian physiology and next-day emotion regulation and executive functioning.",[31,30,127,128],"Executive Function","Emotion Regulation","2026-06-01",{"date":103,"type":48},{"date":132,"type":48},"2025-01-10",{"date":134,"type":23},"2028-08-30",{"name":136,"class":55},"Baylor College of Medicine",{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":24,"phases":148,"briefSummary":149,"conditions":150,"keywords":163,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":56},"100600783","hyperthermia-in-patients-with-chronic-primary-pain---effects-on-thermoregulation-somatosensory-system-and-movement-evoked-pain-100600783","NCT07101978","Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain","Hyperthermia in Healthy and Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System, Movement Evoked Pain (HYPPRI-1)","HYPPRI-1","Inclusion Criteria:\n\npatients:\n\n* Confirmed diagnosis of widespread pain (ICD-11 MG30.01)\n* Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) scale ≥ 5 or WPI) ≥ 3 and SS ≥ 9,\n* Pain \\>= 3 month and VAS \\>= 4,0\n* Body - infrared-A-Bulb Distance \\\u003C 38cm (overweight participants)\n* Signed declaration of consent\n\nhealthy:\n\n* No chronic illnesses\n* No acute infections\n* No regular medication: To avoid interactions\n* BMI ≤ 40kg\u002Fcm2\n* Mental health: No psychiatric diagnoses or psychotropic medication in your medical history\n\nExclusion Criteria:\n\n* Participation in other clinical studies\n* Contraindications for hyperthermia (severe cardiovascular diseases, tumour diseases, acute infections, pregnant and breastfeeding women)\n* Acute and \u002F or feverish microbial infections\n* Participants with severe somatic, rheumatic concomitant endocrine or neurological diseases, in particular neurological diseases associated with cognitive disorders, severe liver or kidney and cardiac diseases\n* participants who are permanently treated with opioids, cannabis, immunosuppressive drugs (e.g. corticoids, immunosuppressants) or alpha\u002Fbeta-A(nta)gonists due to a disease from the group described above\n* participants with pain due to a serious psychiatric illness (bipolar disorder, psychosis, personality disorder, severe depression, substance abuse) and serious systemic or neurological disorders\n* pregnancy or breastfeeding (for women)\n* Intake of medication within 6 weeks that inhibits the reuptake of the neurotransmitter serotonin or binds to receptors of this neurotransmitter group","70 Years",{"count":147,"type":23},60,[26],"This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the movement evoked pain in healthy and patients with chronic primary pain (e.g., fibromyalgia). The intervention lasts 3 weeks with two treatment sessions per week.",[151,152,153,154,155,156,157,158,30,159,160,161,162],"Hyperthermia","Chronic Primary Pain","Widespread Pain","Muscular Disease","Rheumatic Diseases","Musculoskeletal Diseases","Neuromuscular Disease","Fibromyalgia","Body Temperature Changes","Somatosensory Function","Quantitative Sensory Testing","Healthy",[164,165,166,167,168,169],"hyperthermia","widespread pain","chronic primary pain","circadian body temperature","quantitative sensory testing","healthy","2026-05-29",{"date":172,"type":48},"2026-06-02",{"date":174,"type":23},"2026-08-01",{"date":176,"type":23},"2028-12-31",{"name":178,"class":55},"Bern University of Applied Sciences",{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":24,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100618825","circadian-rhythm-monitoring-study-100618825","NCT07336654","Circadian Rhythm Monitoring Study","Evaluation of a Novel Wearable Device for Circadian Rhythm Monitoring in Healthy, OSA, and Insomnia Participants","Inclusion Criteria:\n\n* Adults ≥18 years at screening.\n* Able and willing to provide written informed consent.\n* Belonging to one of three strata: (a) healthy controls without diagnosed sleep disorder, (b) patients with physician-diagnosed OSA, or (c) patients with physician-diagnosed insomnia (based on DSM-5\u002FAASM criteria and ISI ≥15)\n* Capable of using a smartphone for app-based data syncing.\n* Willing to comply with study visits, wearable use, and saliva sampling.\n\nExclusion Criteria:\n\n* • Dermatologic conditions preventing wearable use.\n\n  * Significant psychiatric or neurologic illness that may impair compliance.\n  * Shift work or trans-meridian travel within 2 weeks prior.\n  * Currently pregnant\n  * Use of medications known to significantly alter circadian rhythm (e.g., exogenous melatonin, beta-blockers).",{"count":187,"type":23},30,[26],"This will be a single-center, prospective observational study designed to evaluate the feasibility and accuracy of a new wearable device for non-invasive continuous monitoring of physiological signals to derive circadian rhythm. Melatonin sampling will be included for comparison against wearable-derived measures",[30],"2026-05-17",{"date":193,"type":48},"2026-05-19",{"date":195,"type":23},"2026-07",{"date":197,"type":23},"2026-12",{"name":199,"class":200},"ResMed","INDUSTRY",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":24,"phases":210,"briefSummary":212,"conditions":213,"keywords":217,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":226,"leadSponsor":228,"locationsCount":56},"100630931","phase-4-sleep-loss-and-circadian-misalignment---mechanisms-of-insulin-resistance-100630931","NCT07494084","Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance","Inclusion Criteria:\n\n1. Must be between 18-45 years old.\n2. Has a BMI of 18-25 kg\u002Fm2 stable weight over the previous 6 weeks.\n3. Is physically and psychologically healthy (incl. regular menstrual cycles in women, no clinical disorders and\u002For illnesses). Women will be studied during the follicular phase of their menstrual cycle.\n\n   Menstrual cycle criteria (using PMID 10941950) 18 to 25 years - Cycle variation ≤9 days 26 to 41 years - Cycle variation ≤7 days 42 to 45 years - Cycle variation ≤9 days\n4. No current medical or drug treatment (to include steroids or hormones of any type including contraceptives), as assessed by questionnaire.\n5. Has a negative pregnancy test (women), no clinically significant abnormalities in blood and urine, and free of traces of drugs.\n6. No history of clinically relevant psychiatric illness.\n7. No previous history of drug or alcohol abuse.\n8. Not a current smoker.\n9. No history of brain injury or of learning disability.\n10. No previous adverse reaction to sleep deprivation, jet lag, shift work or any of the drugs to be administered.\n11. Not vision or hearing impairment unless corrected back to normal.\n12. No endocrine disorder (no abnormal thyroid function tests; no abnormal morning blood cortisol; no primary gonadal disease as indicated by serum LH or FSH concentration \\> 10 or \\> 15 IU\u002FL, respectively; and no hyperprolactinemia indicated by prolactin \\> 25 μg\u002FL).\n13. No sleep or circadian disorder.\n14. Has good habitual sleep with regular bedtimes (between 6 and 10 hours in duration).\n15. Not extreme morning- nor extreme evening-type using Horne-Ostberg Morningness-Eveningness criteria.\n16. No travel across time zones within one month of entering the study.\n17. No shift work within three months of entering the study.\n18. No anemia (hematocrit \\\u003C38% in men, \\\u003C34% in women).\n19. No blood donation within the previous 8 weeks.\n20. No concurrent participation in another research study.","45 Years",{"count":209,"type":23},48,[211],"PHASE4","The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress which induces insulin resistance and leads to obesity and type 2 diabetes. Many factors contribute to sleep loss including shift work, environmental disturbances, sleep\u002Fcircadian disorders and comorbid medical and mental health conditions. Sleep loss increases the stress hormone cortisol in the evening and decreases daytime testosterone. Examining these hormones in a controlled laboratory environment under different sleep schedules may help researchers find solutions for adults experiencing negative health consequences related to chronic sleep loss.",[214,30,215,216],"Shift Work Schedule","Insulin Resistance","Circadian Misalignment",[218,219,220,39,221],"Shift work","insulin resistance","sleep","type 2 diabetes","2026-05-12",{"date":224,"type":48},"2026-05-15",{"date":76,"type":23},{"date":227,"type":23},"2029-07",{"name":229,"class":55},"Washington State University",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":17,"sex":237,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":24,"phases":242,"briefSummary":243,"conditions":244,"keywords":260,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":56},"100634052","early-pregnancy-lifestyle-and-glucose-patterns-a-substudy-of-tofffy-100634052","NCT07534670","Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY","Early-Pregnancy Chronobehavioural Profiles and Continuous Glucose Dynamics: A Nested Randomised Pilot Study of TOFFFY","Inclusion Criteria:\n\n* Enrolled in the Towards Optimal Fertility, Fathering and Fatherhood studY (TOFFFY) (NCT06293235)\n* Females who are currently pregnant and with viable intrauterine pregnancy at ≤13 weeks gestation at enrolment\n\nExclusion Criteria:\n\n* Females with pre-existing diabetes mellitus (Type 1 or Type 2) and\u002For chronic medical conditions affecting glucose metabolism\n* Females who are taking medications known to significantly affect glucose metabolism\n* Females with multiple pregnancy (e.g., twins or higher-order gestation)\n* Females who are unable to comply with study procedures, including: Inability to use smartphone-based applications and inability to wear wrist actigraphy device","FEMALE","21 Years","39 Years",{"count":241,"type":23},140,[26],"The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational diabetes mellitus (GDM) in pregnant women without pre-existing diabetes.\n\nThe main questions it aims to answer are:\n\n1. Do early-pregnancy chronobehavioral patterns (e.g., irregular sleep, night eating, and unstable rest-activity rhythms) relate to continuous glucose patterns measured using continuous glucose monitoring (CGM)?\n2. Can early behavioral and CGM-derived measures predict glucose regulation and metabolic outcomes later in pregnancy (24-28 weeks)?\n3. Does real-time self-monitoring using wearable devices and food logging improve glycemic outcomes compared to usual care?\n\nThis study is a prospective, nested randomized pilot trial embedded within the ongoing Towards Optimal Fertility, Fathering and Fatherhood studY (TOFFFY) cohort (NCT06293235) at KK Women's and Children's Hospital, Singapore. A total of 140 pregnant women without pre-existing diabetes, recruited at ≤13 weeks gestation, will be randomized in a 1:1 ratio to either a pilot arm (wearable-based self-monitoring) or a control arm (usual care).\n\nParticipants in the pilot arm (n=70) will undergo intensive behavioral and metabolic monitoring over a 14-day period in early pregnancy, including continuous glucose monitoring using a CGM device, wrist actigraphy to assess sleep-wake and rest-activity patterns, and an AI-supported mobile application to record meal timing and dietary intake. Participants will have real-time access to their glucose data and behavioral feedback, enabling self-monitoring and potential behavioral adjustments.",[245,246,247,248,249,250,251,252,30,31,253,254,255,256,257,258,259],"Continuous Glucose Monitoring","Diabetes, Gestational","Diet During Pregnancy","Meal Time","Actigraphy","Pregnancy","Glucose Intolerance During Pregnancy","Gestational Diabetes Mellitus in Pregnancy","Chronobiology","Wearable Electronic Devices","Mobile Applications","Blood Glucose Profile","Metabolic Diseases","Randomized Controlled Trial","Pilot Study",[261,262,263,264,265,266],"Risk factor","Lifestyle","Early pregnancy","Chrono-disruptive behaviours","Maternal health","Lifestyle intervention","2026-04-22",{"date":269,"type":48},"2026-04-27",{"date":271,"type":23},"2026-05-01",{"date":273,"type":23},"2027-06-30",{"name":275,"class":276},"KK Women's and Children's Hospital","OTHER_GOV",{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":17,"sex":18,"minAge":283,"maxAge":284,"enrollmentInfo":285,"targetDuration":4,"studyType":24,"phases":287,"briefSummary":288,"conditions":289,"keywords":292,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":56},"100633968","chrononutrition-in-preterm-infants-a-randomised-controlled-trial-of-time-matched-breast-milk-feeding-and-its-effects-on-sleep-and-circadian-development-100633968","NCT07533578","Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development","Inclusion Criteria:\n\n* Preterm infants born between 32+0 and 36+6 weeks' gestation\n* Age ≤ 1 month at enrolment\n* Infants routinely receiving expressed breast milk (fully or partially breastfed)\n* Written informed consent obtained from parent(s) or legal representative(s)\n* Ability of caregivers to comply with study procedures including milk labelling and feeding according to study allocation\n\nExclusion Criteria:\n\n* Prenatal exposure to illicit drugs (e.g. cannabis, cocaine, heroin, opiates) or significant alcohol exposure\n* Major congenital malformations or congenital infections\n* Significant underlying disease (excluding transient neonatal conditions such as feeding difficulties, hyperbilirubinaemia, hypoglycaemia, anaemia, respiratory distress syndrome, or apnoea-bradycardia syndrome)","0 Days","1 Month",{"count":286,"type":23},200,[26],"This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.\n\nIn early life, infants produce very little of the hormone melatonin, which plays a key role in regulating sleep and circadian rhythms. Breast milk naturally contains melatonin, and its levels vary across the day, with higher concentrations at night. This variation may provide important biological signals that help infants develop healthy sleep-wake patterns.\n\nHowever, expressed breast milk is often fed without considering the time it was expressed. This may disrupt the transfer of circadian signals from mother to infant.\n\nThe aim of this randomised controlled trial is to determine whether feeding expressed breast milk according to the time of expression (e.g. giving night-time milk at night) improves sleep consolidation and circadian development compared with usual feeding practices.\n\nA total of 200 preterm infants born between 32+0 and 36+6 weeks' gestation who are receiving expressed breast milk will be enrolled and randomly assigned to one of two groups:\n\nIntervention group: preterm infants receive expressed breast milk matched to the time of day it was expressed (day, evening or night)\n\nControl group: preterm infants receive expressed breast milk without regard to timing (usual practice)\n\nThe main outcome is sleep consolidation at 6 months of age, measured objectively using actigraphy (a small wearable device that records sleep and activity). Additional outcomes include sleep patterns over time, circadian development, melatonin exposure, gut microbiota composition, and clinical outcomes such as infections and neurodevelopment.\n\nThe intervention does not involve any medication and uses the infant's usual nutrition. Risks are minimal and mainly relate to the additional effort required for milk labelling and timing.\n\nThis study will provide evidence on whether a simple, low-risk change in feeding practice can support infant sleep and early-life circadian development, with potential benefits for child health and family well-being.",[290,30,291],"Infant Sleep Problems","Neurodevelopment",[293,294,30,295,296,297,298,299,300,253,301,249,258],"Chrononutrition","Breast Milk","Circadian Development","Infant Sleep","Sleep Consolidation","Melatonin","Infant Microbiome","Gut Microbiota","Sleep-Wake Cycle","2026-04-10",{"date":304,"type":48},"2026-04-16",{"date":306,"type":23},"2026-10-01",{"date":308,"type":23},"2031-12-30",{"name":310,"class":55},"Luzerner Kantonsspital",{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":24,"phases":322,"briefSummary":323,"conditions":324,"keywords":326,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":56},"100573214","cannabis-effects-on-sleep-circadian-rhythms-and-light-sensitivity-in-young-adults-100573214","NCT06743373","Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults","Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults (CASCILS)","CASCILS","List the inclusion criteria:\n\n* Age 18-25 years\n* Physically and psychiatrically healthy, as determined by instruments described below\n* Cannabis-Using group only: Regular cannabis use, defined as \"frequent\" (6-29 days\u002Fmonth) or \"daily\" (daily) use over the past 3 months\n* Cannabis-Using group only: Willingness to discontinue cannabis for 4 weeks.\n* Control group only: No cannabis use in the past 3 months. Deny engaging in daily or near-daily cannabis use during the past year. No history of alcohol and\u002For substance use disorders. No current sleep disorders (including insomnia and delayed sleep phase disorder).\n* Provision of written informed consent\n\nList the exclusion criteria:\n\n* Significant or unstable acute or chronic medical conditions. Examples of such conditions include, but are not limited to, central nervous system disorders (e.g., head injury, seizure disorder, multiple sclerosis, tumor), cardiovascular or hemodynamically significant cardiac disease, liver disease (e.g., acute or chronic hepatitis, hepatic insufficiency), migraine or chronic headaches, active peptic ulcer disease, inflammatory bowel disease, renal failure, arthritis, and diabetes and other endocrine disorders. Seizure disorder in particular will be exclusionary due to the increased risk it confers for cannabis withdrawal symptoms. Eye\u002Fretinal conditions such as diabetic retinopathy or glaucoma will be exclusionary, although should be very rare in this population. Individuals with well-controlled health conditions that do not affect sleep, retinal function, and\u002For well-being (e.g., well-controlled thyroid disorders, asthma, or ulcer) will not be excluded. To evaluate these criteria, potential participants will complete a locally-developed Medical History Questionnaire.\n* Past or current DSM-5 bipolar disorder or psychotic disorders. Psychiatric disorders will be evaluated using the Mini International Neuropsychiatric Interview (MINI) and the WHO-DAS 2.0, supplemented by clinical interview. We will not exclude participants for subsyndromal symptoms or disorders in these domains. We will not exclude participants for other psychiatric disorders, particularly given the high comorbidity between cannabis use disorder and major depression and anxiety disorder, as long as severity is in the moderate range or lower based on the WHO-DAS 2.0 (average score \\\u003C4).\n* Daily use of alcohol; regular use of illicit substances. Regular use (as defined above) of illicit substances other than cannabis over the past 3 months will be exclusionary. Substance use will be assessed using the Timeline Follow Back method, as well as a urine drug screen.\n* Past or current substance use disorders other than cannabis use disorder, nicotine use disorder, and mild alcohol use disorder (moderate and severe alcohol use disorder are exclusionary).\n* Current syndromal sleep disorders other than insomnia and delayed sleep phase disorder, including narcolepsy, restless legs syndrome, obstructive sleep apnea, and current night shift work (i.e., any work occurring between the hours of midnight and 6:00 a.m.). We will not exclude for subsyndromal symptoms or disorders in these domains. We will not exclude Cannabis-using participants for insomnia and delayed sleep phase disorder because of their conceptual overlap and high co-occurrence with sleep phenotypes of interest. Sleep disorders will be diagnosed according to criteria in the DSM-5 and the International Classification of Sleep Disorders, 3rd Edition, 2014. These disorders will be evaluated using clinical interview and the locally-developed Structured Clinical Interview for Sleep Disorders. Control participants will be excluded for any current sleep disorders, including insomnia and delayed sleep phase disorder.\n* Travel across 2+ time zones in the past 60 days.\n* Benzodiazepines and non-benzodiazepine hypnotic drugs (\"Z-drugs\"). Other sleep-promoting medications will be permitted, including SSRIs\u002FSNRIs, will be permitted if on stable dose and not in the acute phase of treatment. In order to evaluate medications, participants will complete a listing of current medications, including prescription and over the counter medications, \"natural\" preparations, and nutritional supplements.\n* Individuals with a Pennsylvania Medical Marijuana Card using dispensary-obtained marijuana or other THC products for documented Qualifying Medical Conditions other than those of a mental health nature will be excluded. However, individuals who have been issued a Pennsylvania Medical Marijuana ID card for a mental health condition will not be excluded from the study.\n\nThere will not be any Medical Record review. For most individuals, the Medical History Questionnaire, including medical conditions and medications, will be sufficient for identifying exclusionary medical criteria. For instances where an individual is uncertain about exclusionary or current medical conditions or medications, medical records, prescription records or labeled prescription pill bottles, or a Release of Information to contact the individual's Primary Care Practitioner \\[PCP\\] to clarify the individual's medical status will be obtained.","25 Years",{"count":321,"type":23},180,[26],"The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are:\n\n1. Does cannabis use and discontinuation impact sleep drive?\n2. Does cannabis use and discontinuation impact light sensitivity and circadian phase?",[325,31,30],"Cannabis Use",[327,220,328,329,330],"cannabis","circadian rhythms","photosensitivity","cannabis discontinuation","2026-04-03",{"date":333,"type":48},"2026-04-06",{"date":335,"type":48},"2025-03-13",{"date":337,"type":23},"2029-04-30",{"name":339,"class":55},"University of Pittsburgh",{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":90,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":349,"briefSummary":350,"conditions":351,"keywords":356,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":4},"100631332","the-effects-of-circadian-rhythm-based-progressive-relaxation-exercises-in-hemodialysis-patients-100631332","NCT07499297","THE EFFECTS OF CIRCADIAN RHYTHM-BASED PROGRESSIVE RELAXATION EXERCISES IN HEMODIALYSIS PATIENTS","THE EFFECTS OF CIRCADIAN RHYTHM-BASED PROGRESSIVE RELAXATION EXERCISES ON SYMPTOM MANAGEMENT, SLEEP QUALITY, COMFORT, AND MENTAL WELL-BEING IN HEMODIALYSIS PATIENTS","Inclusion Criteria:\n\n* 18 and 65 years of age,\n* have no mental or physical disabilities that would prevent them from answering the questions,\n* have no problems related to touch, temperature perception, hearing, or vision,\n* are relatively independent in performing daily activities,\n* do not use any pharmacological or non-pharmacological methods to facilitate sleep,\n* have been receiving hemodialysis (HD) treatment for at least 3 months,\n* are able to communicate and cooperate.\n\nExclusion Criteria:\n\n* are bedridden,\n* have physical limitations preventing them from performing relaxation exercises,\n* have been practicing relaxation exercises (such as breathing exercises, meditation, yoga, etc.) within the last 6 months,\n* are classified as intermediate type (neither type) according to the Morningness-Eveningness Questionnaire,\n* engage in regular exercise,\n* have been diagnosed with psychiatric disorders such as depression or schizophrenia,\n* do not consent to participate in the study.",{"count":348,"type":23},75,[26],"The aim of this study is to determine the effect of Progressive Relaxation Exercise (PGE) applied according to the circadian rhythms of hemodialysis (HD) patients on symptom management, sleep quality, comfort and mental well-being levels and to examine the experiences of HD patients regarding PGE application. A sequential mixed method research design will be used in the study. The quantitative part of the study was planned as a randomized controlled double-blind experimental study. The qualitative part will be conducted as a qualitative research to be carried out with individual in-depth interview method in order to examine the opinions of the individuals in the intervention group regarding the 8-week PGE applied according to the circadian rhythm. In the collection of research data, the Introductory Information Form, Morningness-Eveningness Questionnaire (MEQ), Dialysis Symptom Index, Hemodialysis Comfort Scale - Version II, Pittsburg Sleep Quality Index (PSQI), Warwick-Edinburgh Mental Well-Being Scale (WEMIOÖ), Individual Follow-up Form, Progressive Relaxation Exercise Application Guideline (PGEUY) and In-Depth Interview Form with Individuals in the Intervention Group will be used.",[352,353,30,354,355],"Nursing","Hemodialysis Patient","Relaxation Exercise","Symptom Management",[352,357,39,358,359,360,361,362],"hemodialysis","relaxation exercise","symptom management","sleep quality","comfort","mental well-being","2026-04-02",{"date":365,"type":48},"2026-04-08",{"date":367,"type":23},"2026-04-01",{"date":369,"type":23},"2026-09-22",{"name":371,"class":55},"Karamanoğlu Mehmetbey University",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":237,"minAge":207,"maxAge":4,"enrollmentInfo":378,"targetDuration":4,"studyType":24,"phases":380,"briefSummary":381,"conditions":382,"keywords":384,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":396},"100617165","effect-of-esketamine-on-postoperative-sleep-in-postmenopausal-women-100617165","NCT07315074","Effect of Esketamine on Postoperative Sleep in Postmenopausal Women","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) physical status I-III.\n2. Aged ≥ 45 years.\n3. Women with natural menopause (aged ≥ 45 years and postmenopause for more than 12 months without surgical or medical intervention) .\n4. Scheduled to undergo elective lower-limb fracture surgery with an expected duration of more than 60 min under general anesthesia.\n5. Body Mass Index (BMI) between 18 and 28 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Presence of preoperative sleep-related disorders, such as obstructive sleep apnea or restless legs syndrome.\n2. History of drug or alcohol abuse or dependence.\n3. Known contraindications or allergies to esketamine or other anesthetic agents.\n4. Use of psychotropic medications or sex hormones within the past 3 months.\n5. Shift work or taking medications affecting melatonin.\n6. Severe comorbid conditions, including but not limited to uncontrolled hypertension, coronary artery disease, cardiac insufficiency, pulmonary hypertension, intracranial hypertension or elevated intraocular pressure, hyperthyroidism, severe hepatic or renal dysfunction.\n7. History of cerebral infarction, intracerebral hemorrhage, or residual central nervous system deficits.\n8. Impairments of language, hearing, vision, or cognitive function that would prevent completion of questionnaires or cooperation with sleep monitoring.\n9. Active oral pathologies.\n10. Transfer to ICU postoperatively.",{"count":379,"type":23},164,[26],"The prevalence of sleep disturbance among postmenopausal women has been reported to reach 51.6%. Epidemiological studies consistently show that the incidence of sleep disorders increases with age and menopausal transition. Compared with premenopausal women, postmenopausal women demonstrate reduced circadian rhythm stability and a higher prevalence of sleep disturbance. In this population, levels of melatonin, total sleep time, sleep latency, N3 stage sleep, and the circadian amplitude of alertness are all diminished. Sleep disturbance can adversely affect both the mental and physical health of women and significantly impair their social functioning. Poor sleep is associated with decreased cognitive performance and heightened emotional distress, contributing to diminished quality of life.\n\nCircadian rhythms are endogenous physiological and behavioral cycles that oscillate over approximately 24 hours, governing critical processes such as sleep-wake cycles, hormonal fluctuations (e.g., cortisol and melatonin). These rhythms are regulated by the suprachiasmatic nucleus (SCN). Disruptions in circadian rhythms have been associated with sleep disturbances.\n\nEsketamine is the S (+) enantiomer of ketamine and has a higher affinity for the NMDA receptor than the R-enantiomer. Previous studies have demonstrated that intraoperative administration of esketamine can improve postoperative sleep quality and reduce the incidence of postoperative sleep disturbances, through its antidepressant efficacy, anti-inflammatory properties, analgesic efficacy, neurocognitive and anxiolytic effects. However, few studies have investigated whether esketamine can regulate perioperative circadian rhythms and subsequently affect sleep, especially in postmenopausal women.\n\nThe objective of this multi-center, prospective, randomized controlled clinical trial is to investigate the effects of esketamine on postoperative sleep in postmenopausal women.",[30,383],"Postoperative Sleep Disturbance",[385,30,298,383,386],"Esketamine","Postmenopause","2026-03-13",{"date":389,"type":48},"2026-03-17",{"date":391,"type":23},"2026-03-01",{"date":393,"type":23},"2026-12-31",{"name":395,"class":55},"Zhuan Zhang",2,{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":4,"eligibilityCriteria":403,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":404,"targetDuration":4,"studyType":24,"phases":406,"briefSummary":407,"conditions":408,"keywords":413,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":424,"locationsCount":56},"100612156","feasibility-of-wearables-in-dementia-care-in-rural-taiwan-100612156","NCT07249918","Feasibility of Wearables in Dementia Care in Rural Taiwan","Facilitating the Measurement and Treatment of the Behavioral Symptoms of Dementia (BPSD) and Understanding Caregiver Burden Using Wearable Devices in Rural Taiwan - A Dyadic Feasibility Pilot Study","Inclusion Criteria:\n\n* For participants with dementia:\n\n  1. Clinical diagnosis of probable Alzheimer's disease (AD) or mild cognitive impairment (MCI) due to AD, based on established diagnostic criteria.\n  2. Presence of at least one prominent behavioral or psychological symptom of dementia (BPSD), including depression, agitation, apathy, or nighttime sleep disturbance.\n  3. Prominent is defined as:\n\n     NPI single-item score ≥ 4 (severity × frequency), or NPI-Q severity score ≥ 2, or PSQI total score ≥ 5 (if sleep disturbance is the main symptom).\n  4. Stable living arrangement or care environment for at least two weeks before enrollment.\n  5. If receiving any pharmacological or non-pharmacological treatments for BPSD, the dosage and frequency must have remained stable for at least two weeks prior to study participation.\n  6. Able and willing to provide informed consent; for those lacking decision-making capacity, consent must be obtained from a legally authorized representative.\n* For primary caregivers:\n\n  1. Adult primary caregiver of the enrolled participant.\n  2. If receiving treatment for caregiver stress, the dosage and frequency must have been stable for at least two weeks before enrollment.\n  3. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Any medical condition that may increase risk during participation, including:\n\n  1. Retinal disease, active use of photosensitizing medications, recent ocular surgery (within 4 weeks), or photosensitivity disorders (e.g., epilepsy).\n  2. Unstable physical or mental condition deemed unsuitable by investigators, such as acute delirium or active respiratory infection (including COVID-19)",{"count":405,"type":23},20,[26],"Taiwan is becoming a super-aged society, and more older adults are living with Alzheimer's disease. Many people with Alzheimer's experience behavioral and psychological symptoms, such as agitation, sleep problems, or mood changes. These symptoms often lower their quality of life and increase stress for their family caregivers.\n\nThis study will test two wearable devices in people with Alzheimer's and their caregivers. One device, called Geneactiv, is a wristwatch that tracks daily activity and sleep. The other device, called Re-Timer, is a light therapy eyewear that may help improve sleep and mood. Researchers will look at how easy the devices are to use, whether participants are willing to wear them for several weeks, and whether the light therapy helps reduce sleep problems or caregiver stress.\n\nThe study will also compare information from questionnaires with information collected by the devices. The results may help researchers design future studies using wearable tools to better support people living with dementia and their caregivers.",[409,410,411,412,30],"Alzheimer's Dementia","Neuropsychiatric Symptoms Related to Neurodegenerative Disease","Wearable Devices","Caregiver Burden of People With Dementia",[414,415,31,416,417],"Wearable device","behavioural and psychological symptoms of dementia (BPSD)","Alzheimer's dementia","Caregiver Burden","2026-02-09",{"date":420,"type":48},"2026-02-11",{"date":422,"type":48},"2025-11-18",{"date":393,"type":23},{"name":425,"class":55},"China Medical University Hospital",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":17,"sex":237,"minAge":19,"maxAge":89,"enrollmentInfo":433,"targetDuration":4,"studyType":434,"phases":4,"briefSummary":435,"conditions":436,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":4},"100623685","investigating-the-effects-of-time-of-day-and-menstrual-cycle-phase-low-and-high-progesterone-on-females-cognitive-and-strength-performance-100623685","NCT07399847","Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Inclusion Criteria:\n\n* Female (assigned at birth)\n* Aged 18-30 years\n* Tier 2 athlete which requires the participants to identify with a specific sport, train with a purpose to compete, regularly train \\~3 times per week and compete at a local level (for example being a member of a BUCS sport and competing regularly with that sport)\n* Regular menstrual cycle - considered between 21-35-day cycles with at least 9 periods a year.\n\nExclusion Criteria:\n\n* The current\u002Fprevious (in the last 3 months) use of any contraceptive method that alter the menstrual cycle\n* The use of the emergency contraceptive pill either 3 months prior to the study or during the study\n* Diagnosis of menstrual disorders including (but not exclusively) endometriosis and Polycystic Ovary Syndrome (PCOS)\n* A formal diagnosis of sleep disorders such as insomnia\n* Consume \\>400mg\u002Fday of caffeine\n* A musculoskeletal injury in the past 3 months\n* A formal diagnosis of neurological or psychiatric disorders such as Attention-Deficit\u002FHyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Dyslexia or schizophrenia\n* Taking prescribed medication that may affect sleep for example stimulants such as Methylphenidate\n* No regular night shift work\n* No trans-meridian travel within 10 days of their expected participation dates (travel that will cause jetlag)\n* Have given blood in the last 12 weeks - this is not strictly an exclusion; participants will just need to wait until after 12 weeks before taking part in the study",{"count":187,"type":23},"OBSERVATIONAL","This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence performance and expand existing research. This study aims to support more inclusive, effective and personalised approaches to training and competition schedules for female athletes.\n\nThe study will involve two testing days that require a participant to complete a compilation of tests at 07:00, 12:00 and 18:00 hours. The testing days will be arranged for when a participant is in phase 1 (lowest levels of progesterone in the menstrual cycle) and phase 4 (highest level of progesterone in the menstrual cycle). The tests will examine a participant's executive function and physical strength.\n\nThis study will aim to recruit thirty 18-30-year-old females from Lancaster University who identify with a sport that they train \\~3 times a week for with a purpose to compete. The females recruited must have a regular menstrual cycle and no history of sleep disorders.\n\nAim: To investigate the effects of time-of-day and menstrual cycle phase (low and high progesterone levels) on executive function and strength in females.\n\nObjectives:\n\n1. To determine the effects of time-of-day on executive function and strength tests.\n2. To determine the effects of menstrual cycle phase on executive function and strength tests.\n3. To examine if there is an interaction between time-of-day and menstrual cycle phase on executive function and strength tests.",[30,437,438,439,440,441],"Menstrual Cycle Phase","Female Athletes","Executive Function (Cognition)","Eumenorrhea","Strength","2026-02-05",{"date":444,"type":48},"2026-02-10",{"date":446,"type":23},"2026-02",{"date":448,"type":23},"2026-09",{"name":450,"class":55},"Lancaster University",{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":4,"eligibilityCriteria":457,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":458,"enrollmentInfo":459,"targetDuration":4,"studyType":24,"phases":461,"briefSummary":462,"conditions":463,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":56},"100603576","dietary-impact-on-sleep-rhythms-and-related-physiology-100603576","NCT07138313","Dietary Impact on Sleep, Rhythms and Related Physiology","Inverkan av Kost pa Dygnsrytmer Och Amnesomsattning","Inclusion Criteria:\n\n* Age 18-32 yr\n* Healthy (self-reported) and not on chronic medication\n* BMI 18-27 kg\u002Fm2 (and waist circumference \\\u003C102 cm), and weight stable (less than 5% body weight change in the past 6 months)\n* Non-smoker and non-nicotine user\n* Regular sleep-wake pattern, with sleep duration of 7-9.25 hrs per night\n* Regular exercise habits the last 2 months\n* Regular daily meal pattern with 3 main meals\n\nExclusion Criteria:\n\n* Major or chronic illness, e.g. diabetes, renal disease or inflammatory bowel disease\n* Current or history of endocrine or metabolic disorders\n* Psychiatric or neurological disorders (e.g. bipolar disorder, epilepsy)\n* Frequent gastrointestinal symptoms\n* Chronic medication\n* Any sleep disorder (including recent or chronic symptoms of insomnia)\n* Shift work in the preceding three months or for a long duration\n* Extreme chronotype or physical activity patterns\n* Time travel over two time zones in the preceding month\n* Too much weight gain or weight loss in the preceding 6 months (±5% body weight in past 6 months)\n* Any issues with or allergies against the provided food items\n* Recent major dietary changes or adoption of specific dietary regimens\n* Women who are pregnant, breastfeeding, or planning to become pregnant during the study period.\n* Use of illicit drugs or substances of abuse","32 Years",{"count":460,"type":23},24,[26],"Sleep and metabolism are closely interconnected, and emerging evidence suggests that dietary composition may influence both sleep quality and key physiological functions such as glucose regulation, cardiovascular activity, and hormonal signaling. This study aims to investigate how a Western-style unhealthy diet versus a healthier, fiber-rich diet affects objective and subjective sleep measures, 24-hour physiological parameters, and a range of biomarkers related to cardiometabolic, neurodegenerative, and gut microbial function.",[31,464,30],"Diet Interventions","2026-02-03",{"date":467,"type":48},"2026-02-04",{"date":469,"type":48},"2025-09-22",{"date":471,"type":23},"2027-12-31",{"name":473,"class":55},"Uppsala University",{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":145,"enrollmentInfo":481,"targetDuration":4,"studyType":434,"phases":4,"briefSummary":483,"conditions":484,"keywords":487,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":56},"100622840","a-longitudinal-follow-up-study-on-predicting-major-depressive-disorder-from-rest-activity-rhythm-profiles-100622840","NCT07388849","A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles","Can Rest-Activity Rhythm Profiles Predict Major Depressive Disorder? A Longitudinal Follow-up Study","Inclusion Criteria:\n\n* Hong Kong residents aged 18 to 70 years\n* Chinese language fluency\n* Accessibility to an Internet-enabled mobile device\n* A willingness to provide informed consent and comply with the study protocol\n\nExclusion Criteria:\n\n* Severe medical or neurocognitive disorders that make participation unsuitable\n* History of electroconvulsive therapy (ECT)\n* An unstable use of psychotropic drugs (medication use has to remain stable for at least 6 weeks before baseline assessment)\n* Current involvement in any psychological treatment program that targets depression and\u002For sleep problems\n* The investigators will not exclude those with current suicidal risks (i.e., non-fleeting intent or plan), which is a common symptom of MDD. However, if serious suicidal risk (i.e., PHQ-9 Item 9 score \\> 2) is identified, the participant will be referred to the PI (a clinical psychologist) for further assessment and professional mental health services if deemed necessary.\n\nExclusion criteria for actigraphy assessment:\n\n* Shift work, pregnancy, work, family, or other commitments that interfere with regular sleep-wake patterns\n* Presence of other untreated sleep disorders, including narcolepsy, obstructive sleep apnoea (OSA), and restless leg syndrome (RLS)\u002Fperiodic leg movement disorder (PLMD) based on the cut-off scores of individual sections in SLEEP-50 (narcolepsy ≥ 7; OSA ≥ 15; RLS\u002FPLMD ≥ 7)",{"count":482,"type":23},160,"This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions, as well as examine their association over time. The investigators aim to identify distinctive RAR profiles of MDD using the data from the original project and hypothesize that two or more groups will be identified based on individual RAR variables using cluster analysis. The investigators hypothesize that significant differences in depressive symptom severity, sleep quality, and other outcome measures collected in this follow-up will be found between the clustered groups. Individuals exhibiting the most disrupted RAR profiles are hypothesized to have the greatest deterioration in depression symptom severity and other outcome measures. The investigators also hypothesize that people persisting with MDD will exhibit greater disruptions in RAR compared to those without MDD at the follow-up. Furthermore, the investigators will examine whether individual RAR parameters are longitudinally associated with changes in depression symptom severity and other outcome measures.",[485,486,30],"Major Depressive Disorder (MDD)","Sleep Disorders",[249,488,489,490],"Major Depressive Disorder","Rest-activity Rhythm","Longitudinal Study","2026-01-28",{"date":442,"type":48},{"date":494,"type":23},"2026-02-01",{"date":496,"type":23},"2029-02-28",{"name":81,"class":55},{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":506,"enrollmentInfo":507,"targetDuration":4,"studyType":24,"phases":509,"briefSummary":510,"conditions":511,"keywords":520,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":56},"100618258","nighttime-synchrony-of-your-nutrition-and-circadian-health-100618258","NCT07329283","Nighttime Synchrony of Your Nutrition and Circadian Health","Nighttime Synchrony of Your Nutrition and Circadian Health: The N-Sync Study","N-Sync","Inclusion Criteria:\n\n1. Age: 18-35 years old; equal numbers of men and women\n2. Body Mass Index (BMI): 18.5-24.9 kg\u002Fm2\n3. Sleep Habits: habitual self-reported average total sleep time (TST) 7-9 hours per night for prior 6 months\n\nExclusion Criteria:\n\n1. Clinically diagnosed sleep disorder or apnea hypopnea index (AHI) ≥5\n2. Evidence of significant organ system dysfunction or disease (e.g., heart disease, diabetes)\n3. Fasting plasma glucose ≥100 mg\u002FdL\n4. Major psychiatric illness (e.g., major depressive disorder)\n5. Cancer that has been in remission less than 5 years\n6. History of shift-work in prior year\n7. Weight change \\>5% of body weight over prior six months\n8. Currently following a weight-loss program\n9. Menopause\n10. Pregnant\u002Fnursing\n11. Greater than 5-day variation in menstrual cycle length month-to-month\n12. Currently smoking\n13. Alcohol intake \\>14 drinks\u002Fweek or \\>3 drinks\u002Fday.\n14. Use of prescription medications (except oral contraceptives) within one month prior to or during in-lab visits.\n15. Consumption of illegal drugs or \\>500mg per day of caffeine.","35 Years",{"count":508,"type":23},120,[26],"Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.\n\nParticipants will attend 6 to 8 in-person visits to the study clinic, including three overnight stays. People will complete surveys and medical tests. The study will last about 4 to 6 months.",[31,512,30,513,514,515,516,517,216,518,519],"Metabolism Changes","Lifestyle Factors","Sleep Hygiene","Sleep Hygiene, Inadequate","Sleep Deprivation","Insufficient Sleep","Circadian Dysregulation","Light Exposure",[31,519,521,30,522,513,514],"Metabolism","Food Intake","2026-01-20",{"date":525,"type":48},"2026-01-22",{"date":527,"type":48},"2025-12-19",{"date":529,"type":23},"2031-05-31",{"name":531,"class":55},"University of Utah",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":18,"minAge":90,"maxAge":4,"enrollmentInfo":539,"targetDuration":4,"studyType":24,"phases":541,"briefSummary":542,"conditions":543,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":56},"100447554","light-in-frail-elderly---the-effect-of-a-dynamic-light-for-sleep-and-circadian-rhythm-100447554","NCT05107947","Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm","LIFE","Inclusion Criteria:\n\n* Over the age of 65 years\n* Admitted to one of the included study rooms\n\nExclusion Criteria:\n\n* Overdose addictive substance\n* Acute neurological disease\n* Melatonin treatment\n* Probable survival \\\u003C5 days\n* Severe visual impairment that makes reading impossible\n* Age \\\u003C65 years\n* Inability to understand Swedish in speech and writing\n* Inability to consent to participate in the study\n* The patient is on any of the following medicines:\n\n  * Medications for Parkinson's disease\n  * Neuroleptics (including lithium)\n  * Dementia",{"count":540,"type":23},300,[26],"The aim of this project is to evaluate the effect of a dynamic light in order to improve the circadian rhythm, provide a better sleep and well-being, and in the long run an improved recovery. The primary question is whether dynamic artificial light with circadian stimulus can affect the circadian rhythm. The secondary question is whether this also provides better sleep and well-being.\n\nThe group that is particularly interesting to study is a geriatric population that is more sensitive to circadian rhythm disorders, sleep disorders and confusion in connection with hospitalization and that can be of particular benefit from this intervention.",[544,30,545,546,547,548,298,31,549,550,551,552],"Aged","Cognition","Fatigue","Humans","Light","Biocentric","Frailty","Karolinska Sleepiness Score","Inflammation","2026-01-09",{"date":555,"type":48},"2026-01-12",{"date":557,"type":48},"2022-10-31",{"date":559,"type":23},"2028-09",{"name":561,"class":55},"Region Skane",{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":567,"acronym":568,"eligibilityCriteria":569,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":570,"enrollmentInfo":571,"targetDuration":4,"studyType":24,"phases":573,"briefSummary":574,"conditions":575,"keywords":579,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":56},"100617855","chrono-align-a-chronotype-based-chrono-nutrition-intervention-in-post-bariatric-patients-100617855","NCT07324044","Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients","Chrono-ALIGN Trial: The Impact of Chronotype-Based Chrono-Nutrition on Metabolic Health, Gut Microbiota, Appetite, and Circadian Alignment in Post-Bariatric Surgery Patients: A Randomized Controlled Trial","Chrono-ALIGN","Inclusion Criteria:\n\n* Adults aged 18-50 years who underwent Sleeve Gastrectomy (SG) 6 Months prior to enrollment.\n* Have achieved ≥50% of excess weight loss post-surgery (to ensure initial success).\n* Current BMI between 25-40 kg\u002Fm².\n* No major postoperative complications and cleared for a regular diet by their healthcare provider.\n* Participants must be able to align their eating schedule within a daytime window (morning to evening), ensuring that the first meal is consumed in the early part of the day and the last meal is completed before late evening, in accordance with chrono-nutrition guidelines.\n\nExclusion Criteria:\n\n* • Pregnancy or planned pregnancy during the study period, and post menopaused females\n\n  * Current diagnosis of severe psychiatric illness that may interfere with adherence (e.g., untreated major depression, psychosis, severe eating disorders).\n  * Active malignancy or serious chronic disease unrelated to obesity that may confound outcomes (e.g., advanced renal failure, uncontrolled liver disease).\n  * Use of medications known to significantly alter circadian rhythm or metabolism (e.g., corticosteroids, melatonin therapy) within the last 3 months.\n  * Inability to comply with study requirements (dietary interventions, sample collection, or follow-up visits).Participants who have previously undergone revision bariatric surgery.\n  * Individuals following intermittent fasting regimens prior to the study.","50 Years",{"count":572,"type":23},246,[26],"This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in post-bariatric surgery patients. A total of 246 adults who underwent sleeve gastrectomy at least six months earlier will be enrolled at King Saud Medical City. Participants will be randomized to receive either standard post-bariatric nutritional care or personalized chrono-nutrition based on individual chronotype. Outcomes include weight change, metabolic biomarkers, dietary behaviors, sleep patterns, and gut microbiota composition. The study aims to determine whether integrating chrono-nutrition into post-bariatric follow-up can enhance metabolic health and improve long-term health.",[576,577,578,248,29,30],"Obesity (Disorder)","Morbid Obesity","Bariatric Sleeve Gastrectomy",[580,581,582,300,583,584],"chrononutrition","Bariatric Surgery","Gastric Sleeve","Appetite","Meal Timing","2025-12-23",{"date":587,"type":48},"2026-01-07",{"date":589,"type":23},"2026-01-01",{"date":591,"type":23},"2028-12-01",{"name":593,"class":55},"King Saud University",{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":600,"eligibilityCriteria":601,"healthyVolunteers":17,"sex":18,"minAge":602,"maxAge":207,"enrollmentInfo":603,"targetDuration":4,"studyType":24,"phases":605,"briefSummary":606,"conditions":607,"keywords":608,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":617,"locationsCount":56},"100615437","circadian-timing-and-time-perception-in-healthy-adults-100615437","NCT07292597","Circadian Timing and Time Perception in Healthy Adults","How Do Individual Differences in Circadian Rhythms Influence Time Perception?","ChronoTime","Inclusion Criteria:\n\n* Aged 23 to 45 years\n* Able to understand and communicate in Danish\n* Completed at least upper secondary education (e.g., gymnasium)\n* Categorized as either a Morning Type (MT) or Evening Type (ET) based on standardized chronotype assessments:\n\n  * Munich Chronotype Questionnaire (MCTQ):\n\n    * MT: sleep midpoint on free days (MSFsc) ≤ 03:00\n    * ET: sleep midpoint on free days (MSFsc) ≥ 05:00\n  * Morningness-Eveningness Questionnaire (MEQ):\n\n    * One of four defined chronotype categories (definitely morning, moderately morning, moderately evening, definitely evening).\n\nExclusion Criteria:\n\n* Current engagement in shift work, rotating schedules, or other forms of irregular sleep-wake timing\n* Diagnosis of any neurological, psychiatric, or sleep-related disorder (e.g., insomnia, narcolepsy, sleep apnea)\n* Use of medications that affect sleep, alertness, or circadian functioning (e.g., melatonin, stimulants, antidepressants)\n* International travel across time zones within the four weeks preceding study participation\n* Are classified as having an intermediate chronotype based on validated chronotype assessments (MCTQ or MEQ), as this group does not provide the necessary contrast to evaluate circadian alignment effects.","23 Years",{"count":604,"type":23},128,[26],"This study examines how a person's natural daily rhythm (\"chronotype\") affects the way time is experienced and judged. Healthy Danish-speaking adults (23-45 years) who are clearly morning-type or evening-type will complete two lab sessions in a crossover design: one at their preferred time of day (e.g., morning for morning-types) and one at the opposite time (misaligned). In each session, participants do brief computerized tasks that measure time estimation\u002Fproduction, vigilance (psychomotor vigilance task), decision-making, and responses to social information, plus simple color-vision tasks. Short questionnaires about sleepiness, mood, fatigue, and the subjective \"passage of time\" are collected before, during, and after testing. A subset will wear a wrist actigraphy device for one week beforehand to characterize sleep-wake patterns.\n\nTesting is conducted under standardized lab conditions with scheduled breaks. The main goal is to determine whether time judgments and vigilance are less accurate during the misaligned session and whether decision-making and social responses also vary with circadian timing. Risks are minimal and mainly relate to temporary tiredness when tested at a non-preferred time; participants may stop at any time. Participation is voluntary. Data are pseudonymized and handled under GDPR. Participants receive DKK 300 after completing both sessions (pro-rated if they withdraw early). Results will be published regardless of outcome, and de-identified data\u002Fcode will be shared after publication.This study examines how a person's natural daily rhythm (\"chronotype\") affects the way time is experienced and judged. Healthy Danish-speaking adults (23-45 years) who are clearly morning-type or evening-type will complete two lab sessions in a crossover design: one at their preferred time of day (e.g., morning for morning-types) and one at the opposite time (misaligned). In each session, participants do brief computerized tasks that measure time estimation\u002Fproduction, vigilance (psychomotor vigilance task), decision-making, and responses to social information, plus simple color-vision tasks. Short questionnaires about sleepiness, mood, fatigue, and the subjective \"passage of time\" are collected before, during, and after testing. A subset will wear a wrist actigraphy device for one week beforehand to characterize sleep-wake patterns.\n\nTesting is conducted under standardized lab conditions with scheduled breaks. The main goal is to determine whether time judgments and vigilance are less accurate during the misaligned session and whether decision-making and social responses also vary with circadian timing. Risks are minimal and mainly relate to temporary tiredness when tested at a non-preferred time; participants may stop at any time. Participation is voluntary. Data are pseudonymized and handled under GDPR. Participants receive DKK 300 after completing both sessions (pro-rated if they withdraw early). Results will be published regardless of outcome, and de-identified data\u002Fcode will be shared after publication.",[30,32],[34,609,41,610,611],"circadian misalignment","time production","time estimation",{"date":613,"type":48},"2025-12-22",{"date":615,"type":48},"2025-10-25",{"date":273,"type":23},{"name":618,"class":55},"University of Aarhus",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":625,"eligibilityCriteria":626,"healthyVolunteers":17,"sex":18,"minAge":602,"maxAge":207,"enrollmentInfo":627,"targetDuration":4,"studyType":24,"phases":628,"briefSummary":629,"conditions":630,"keywords":632,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":642,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":647,"locationsCount":56},"100615605","circadian-rhythms-and-time-perception-in-healthy-adults-during-constant-wakefulness-100615605","NCT07294781","Circadian Rhythms and Time Perception in Healthy Adults During Constant Wakefulness","CircaTime: Effects of Circadian Rhythms on Time Perception During a 36-Hour Constant Routine in Healthy Adults","CircaTime","Inclusion Criteria:\n\n* Age 23 to 45 years.\n* Able and willing to provide written informed consent.\n* Fluent in Danish and able to understand study procedures and instructions.\n* Generally healthy, as assessed by medical history, screening questionnaires, and basic clinical measures (e.g., blood pressure, heart rate).\n* Self-reported regular sleep-wake schedule for at least 4 weeks prior to the laboratory visit (typically 6.5-9 hours of sleep per night, with usual sleep period between approximately 22:00-01:00 and 06:00-09:00).\n* Body mass index (BMI) within a non-extreme range (for example, approximately 18.5-30 kg\u002Fm²), if required by the study physician.\n* No regular night work or rotating shift work during the 3 months before participation.\n* No travel across more than 2 time zones in the 2 months before the constant-routine session.\n* Willing to abstain from caffeine, nicotine, alcohol, and recreational drugs for the specified washout periods before and during the 36-hour constant-routine session.\n* For participants who can become pregnant: negative pregnancy test at screening\u002Farrival and agreement to use reliable contraception for the duration of participation.\n\nExclusion Criteria:\n\n* Any known or suspected major sleep disorder (e.g., insomnia disorder, obstructive sleep apnoea, restless legs syndrome, narcolepsy), based on self-report or prior diagnosis.\n* Current or past major psychiatric or neurological disorders (e.g., major depressive disorder, bipolar disorder, psychotic disorders, epilepsy), unless considered mild and stable and explicitly approved by the study physician.\n* Chronic medical conditions that could be worsened by prolonged wakefulness or that might confound outcome measures, such as significant cardiovascular disease, uncontrolled hypertension, diabetes mellitus, severe respiratory disease, or other serious systemic illness.\n* Regular use of medications or supplements that may affect sleep, circadian rhythms, melatonin secretion, alertness, or mood (e.g., hypnotics, sedative-hypnotics, melatonin, stimulants, certain antidepressants or beta-blockers), unless a safe washout is possible and approved by the study physician.\n* High habitual caffeine intake (for example, \\>400 mg\u002Fday) or nicotine dependence if the participant is unable or unwilling to abstain for the required washout periods.\n* Current harmful alcohol use or substance use disorder, or frequent use of recreational drugs.\n* Pregnancy or breastfeeding.\n* Previous severe adverse reaction to sleep deprivation, extended wakefulness, or similar laboratory protocols.\n* Claustrophobia or inability to tolerate prolonged stays in a controlled laboratory environment.\n* Any condition or circumstance that, in the judgement of the investigators, would make participation unsafe, interfere with the 36-hour wakefulness protocol, or compromise data quality (e.g., inability to remain awake despite support, strong fear of needles or saliva sampling, or inability to comply with study restrictions).",{"count":187,"type":23},[26],"This study examines how the internal body clock (circadian rhythms) influences the way healthy adults experience time, think, and feel when they stay awake for an extended period. Participants will spend about 36 hours in a controlled sleep laboratory while remaining awake the entire time. Light, posture, food intake, and activity are kept as constant as possible (a \"constant routine\") so that changes over time mainly reflect the body's internal clock and increasing sleepiness, rather than changes in the environment. Every two hours, participants complete a brief test battery that includes ratings of sleepiness and mood, a reaction-time task, and short tasks that assess how fast or slow time seems to pass, how accurately they can estimate time intervals, how they respond to simple decisions, and how they judge colours. Saliva samples are collected repeatedly to measure melatonin, a hormone that indicates circadian phase. By comparing changes in behaviour, perception, and melatonin levels across the 36-hour wake period, the study aims to identify when during the circadian cycle people are most vulnerable to distortions in time perception and reduced alertness. The findings may help improve scheduling of shift work and other activities that require sustained wakefulness.",[516,30,631,32],"Healthy Volunteers",[633,634,635,636,637,638,639,640,641],"Circadian rhythms","Constant routine","Extended wakefulness","Sleep loss","Time perception","Subjective time","Psychomotor vigilance task","Dim light melatonin onset","Healthy adults",{"date":613,"type":48},{"date":644,"type":48},"2025-12-05",{"date":646,"type":23},"2027-12-30",{"name":618,"class":55},{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":4,"eligibilityCriteria":654,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":655,"enrollmentInfo":656,"targetDuration":4,"studyType":24,"phases":658,"briefSummary":659,"conditions":660,"keywords":665,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":684,"locationsCount":56},"100615273","pain-perception-and-exercise-induced-hypoalgesia-across-circadian-rhythms-100615273","NCT07290465","Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms","Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants","Inclusion Criteria:\n\n* Healthy participants\n* age 18 to 40 years\n* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided\n* being categorized as \"moderate\" in the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* inability to report pain intensity reliably\n* consumption of narcotics or tobacco products\n* regularly taking pain medications and analgesics\n* pregnant or planning to get pregnant\n* surgery within the last 12 months\n* acute or chronic pain conditions\n* uncontrolled hypertension\n* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries\n* intolerable pain during the pain perception test\n* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).\n* Severe sleep disorders and circadian rhythm disturbances\n* BMI \\> 30\n* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week","40 Years",{"count":657,"type":23},56,[26],"The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.\n\nThe main questions it aims to answer are:\n\n* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?\n* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?\n\nParticipants will:\n\n* Complete questionnaires\n* Undergo quantitative sensory testing\n* Attend both morning and evening sessions in randomized crossover order",[661,30,662,663,29,664],"Exercise Induced Hypoalgesia","Pain Perception","Healthy Participants","Physical Therapy",[666,662,30,29,663,667,668,669,670,671,672,673,664,674,675,676],"Exercise-Induced Hypoalgesia","High-Intensity Functional Training","Supervised Deep Breathing","Pressure Pain Threshold (PPT)","Pain pressure tolerance threshold (PPTol)","Quantative Sensory Testing","Bony Landmarks","Muscular Landmarks","Randomized Control Trial","Crossover","Pain Management","2025-12-04",{"date":679,"type":48},"2025-12-18",{"date":681,"type":23},"2026-01",{"date":683,"type":23},"2026-04",{"name":685,"class":55},"Medipol University",{"id":687,"slug":688,"hasResults":12,"nctId":689,"briefTitle":690,"officialTitle":691,"acronym":692,"eligibilityCriteria":693,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":506,"enrollmentInfo":694,"targetDuration":4,"studyType":24,"phases":696,"briefSummary":697,"conditions":698,"keywords":703,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":719,"startDateStruct":721,"completionDateStruct":723,"leadSponsor":725,"locationsCount":56},"100610994","resistance-exercise-and-sleep-quality-by-chronotype-100610994","NCT07234812","Resistance Exercise and Sleep Quality by Chronotype","The Effects of Tailored Resistance Exercise on Sleep Quality in Relation to Chronotype","TRE-SLEEP","Inclusion Criteria:\n\n* Age between 18 and 35 years\n* Generally healthy, with mild to moderate sleep disturbance as categorized by the Pittsburgh Sleep Quality Index (PSQI)\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²\n* No physical or organic limitations or diseases that would prevent participation in physical activity\n* Non-smoker and non-alcoholic\n* Caffeine consumption ≤ 2 cups per day (including coffee and energy drinks)\n* Have not participated in more than 60 minutes\u002Fweek of usual moderate-to-vigorous physical activity in the past 6 months, categorized as \"moderate\" on the International Physical Activity Questionnaire-Short Form (IPAQ-SF)\n* No clinically diagnosed sleep apnea or other medical\u002Fpsychiatric disorders responsible for sleep complaints\n* Regular sleep schedule (no night shifts or transmeridian travel) in the 30 days prior to study enrollment\n* Able to speak and write English\n\nExclusion Criteria:\n\n* Current use of medications or psychotherapeutic drugs for insomnia or other psychiatric disorders\n* Use of melatonin or other sleep aids in the past month\n* Currently performing any aerobic or mind-body exercise classes (e.g., yoga, Pilates)\n* Habitual daytime napping\n* History of epilepsy or other convulsive disorders\n* Pregnant individuals\n* Habitual or recent use (within the past 30 days) of illegal drugs, psychotropic drugs, hypnotics, stimulants, or analgesics",{"count":695,"type":23},64,[26],"This study examines whether doing moderate resistance exercises in the morning can improve sleep quality and well-being in young adults. Participants with different daily activity patterns (morning or evening types) will take part in an 8-week online exercise program. The study will compare how exercise affects sleep, mood, and daily rhythm across these groups.",[664,699,700,701,29,30,702],"Resistance Exercise","Sleep Disturbances","Sleep Quality","Health Behavior \u002F Well-Being",[704,705,29,706,707,708,709,710,711,664,712,713,714,715,716,717,718],"sleep disturbance","Sleep quality","Morningness-eveningness","Circadian rhythm","Resistance exercise","Home-based exercise","Sleep and exercise","Physical activity and sleep","Exercise","Telerehabilitation","Munich Chronotype Questionnaire (MCTQ)","Pittsburgh Sleep Quality Index (PSQI)","Mood (BRUMS, DASS-21)","Randomized controlled trial","Physical therapy and rehabilitation",{"date":720,"type":48},"2025-11-20",{"date":722,"type":23},"2025-12",{"date":724,"type":23},"2026-05",{"name":685,"class":55},{"id":727,"slug":728,"hasResults":12,"nctId":729,"briefTitle":730,"officialTitle":731,"acronym":732,"eligibilityCriteria":733,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":570,"enrollmentInfo":734,"targetDuration":4,"studyType":24,"phases":735,"briefSummary":736,"conditions":737,"keywords":741,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":742,"lastUpdatePostDateStruct":743,"startDateStruct":745,"completionDateStruct":747,"leadSponsor":749,"locationsCount":56},"100557212","the-influence-of-sleep-on-cardiovascular-outcomes-100557212","NCT06535178","The Influence of Sleep on Cardiovascular Outcomes","Determining the Influence of Sleep on Cardiovascular Outcomes","DISCO","Inclusion Criteria:\n\n* Ostensibly healthy men and women Subgroup study (chronic pain)\n* Satisfies diagnostic criteria for fibromyalgia according to the Widespread Pain Index - Symptom Severity (WPI-SS) scale with the following three conditions being met:\n\n  1. Widespread pain index (WPI) ≥7 and symptom severity (SS) scale score ≥5 or WPI 3-6 and SS scale score ≥9.\n  2. Symptoms have been present at a similar level for at least 3 months.\n  3. The patient does not have a disorder that would otherwise explain the pain.\n\nExclusion Criteria:\n\n* No history of drug or alcohol dependency.\n* Must be current non-smokers, and are required to have a history of less than 5 pack years of smoking.\n* No history of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study. In addition to this, individuals must not have traveled across more than 1 time zone during the 3 months prior to the study.\n* Chronobiologic and sleep disorders.\n* Diseases of the cardiovascular system.\n* Hypertension. Individuals will be allowed to be normotensive (resting systolic blood pressure of \\\u003C140\u002F90 mmHg, measured on more than one occasion) or uncomplicated stage 1 hypertension (systolic BP between 140 and 159 mmHg or a diastolic BP between 90 and 99 mmHg).\n* Disorders of the respiratory system.\n* Pre-diabetes\u002FDiabetes. For participants who have self-reported pre-diabetes\u002Fdiabetes.\n* Disorders of the kidney and urinary tract.\n* Infectious diseases.\n* Disorders of the gastrointestinal system.\n* Disorders of the immune system.\n* Disorders of the hematopoietic system.\n* Neoplastic diseases.\n* Endocrine and metabolic diseases.\n* Neurologic disorders.\n* Must not be participating in another research study that would influence their safe participation in the study.",{"count":187,"type":23},[26],"The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and vascular health markers. The protocol is a 12-week prospective cohort study that includes both field and in-laboratory data collection in ostensibly healthy male and female adults, aged 18-40years. We will also have a sub-group of individuals with chronic pain to examine the effects of sleep regularity on pain outcomes.",[30,738,739,740],"Cardiometabolic Health","Vascular Health","Pain",[30,738,739,740],"2025-11-05",{"date":744,"type":48},"2025-11-10",{"date":746,"type":48},"2024-07-01",{"date":748,"type":23},"2026-09-30",{"name":750,"class":55},"Oregon Health and Science University",{"id":752,"slug":753,"hasResults":12,"nctId":754,"briefTitle":755,"officialTitle":756,"acronym":757,"eligibilityCriteria":758,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":655,"enrollmentInfo":759,"targetDuration":4,"studyType":24,"phases":761,"briefSummary":762,"conditions":763,"keywords":765,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":742,"lastUpdatePostDateStruct":768,"startDateStruct":769,"completionDateStruct":771,"leadSponsor":773,"locationsCount":56},"100419557","food-and-circadian-timing-100419557","NCT04743271","Food and Circadian Timing","Uncovering the Impact of Diet on the Human Circadian Timing System","FACT","Inclusion Criteria:\n\n* Healthy, lean men and women\n\nExclusion Criteria:\n\n* Major dietary restrictions (such as entirely dairy-free and\u002For meat-free diets)\n* A body mass index (BMI) of 18.5\\\u003C \\[BMI\\] \\\u003C 24.9 kg\u002Fm\\^2 and a waist circumference \\\u003C94\u002F80cm\n* Currently psychiatrically\u002Fpsychologically unsuitable for participation\n* Drug\u002Falcohol use, including smoking\n* Medication\u002Fdrug use, including prescribed and over-the-counter medications\n* History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.\n* Traveled across more than 1 time zone during the 3 months prior to the study\n* Currently consuming a habitual high-fat diet\n* Chronobiologic and sleep disorders\n* Diseases of the Cardiovascular System\n* Metabolic Syndrome; Two or more of these factors will be excluded from the study:\n\n  1. HDL cholesterol of less than 40 mg\u002FdL in men or less than 50 mg\u002FdL in women;\n  2. systolic blood pressure\\>135 mmHg or diastolic blood pressure\\>85 mmHg;\n  3. Fasting blood glucose ≥ 100 mg\u002FdL;\n  4. Triglycerides ≥ 150 mg\u002FdL.\n* Pre-Diabetes\u002FDiabetes\n* Hypertension\n* Disorders of the Respiratory System\n* Disorders of the Kidney and Urinary Tract\n* Infectious Diseases\n* Disorders of the Gastrointestinal System\n* Disorders of the Immune System\n* Disorders of the Hematopoietic System\n* Neoplastic Diseases\n* Endocrine and Metabolic Diseases\n* Neurologic Disorders\n* Subjects must not be currently participating in another research study that would influence their safe participation in our study",{"count":760,"type":23},14,[26],"The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.",[764,30],"Diet, High-Fat",[30,766,767],"High Fat","Diet",{"date":744,"type":48},{"date":770,"type":48},"2022-04-01",{"date":772,"type":23},"2026-03-31",{"name":750,"class":55}]