[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clbp---chronic-low-back-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clbp---chronic-low-back-pain":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100622663","biologic-injection-for-adults-with-lumbar-disc-herniation-100622663",false,"NCT07386548","Biologic Injection For Adults With Lumbar Disc Herniation","Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial","BMAC","Inclusion Criteria:\n\n* Male or female patients ≥ 18 years of age\n* Clinically and\u002For radiographically (MRI) confirmed diagnosis of degenerative disc disease of the lumbar spine, lumbar disc herniation, and indication for lumbar microdiscectomy surgery\n* Unresponsive to conservative\u002Fnon-operative treatment for \\>3 months\n* Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups and observe the treatment plan\n\nExclusion Criteria:\n\n* Prisoners\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who are not able to clearly understand English\n* Adults with diminished capacity to consent\n* Major cognitive impairment causing to inability to understand and provide informed consent\n* Active malignancy\n* Active chronic or acute infection\n* Autoimmune disorder that impacts the lumbar spine (ankylosing spondylitis, lupus e.g.)\n* Bone marrow-derived or non-bone marrow-derived cancer\n* Low platelet count or clotting disorders\n* Prior surgery at the level to be treated or the adjacent level","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.\n\nThe main questions it aims to answer are:\n\n* Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)?\n* Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone?\n\nParticipants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery.\n\nResearchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit.\n\nParticipants will:\n\n* Have surgery (microdiscectomy) with or without the injection.\n* Complete pain and disability questionnaires at several times over 2 years.\n* Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health.\n* Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.",[27,28,29,30,31,32,33,34,35,36,37],"Degenerative Disc Disease","DDD","Degenerative Disc Disease Lumbar","Degenerative Disc Disease, Lumbar","Lumbar Disc Herniation","Disc Herniation, Lumbar","Bone Marrow Aspirate Concentrate","Intervertebral Disc Displacement","Low Back Pain","Chronic Low Back Pain (CLBP)","CLBP - Chronic Low Back Pain",[39,40,41,42,43],"degenerative disc disease","lumbar disc herniation","bone marrow aspirate concentrate","intervertebral disc displacement","low back pain","NOT_YET_RECRUITING","2026-04-14",{"date":47,"type":48},"2026-04-16","ACTUAL",{"date":50,"type":21},"2026-05-01",{"date":52,"type":21},"2030-12",{"name":54,"class":55},"Weill Medical College of Cornell University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":56},"100621307","transcutaneous-electrical-nerve-stimulation-tens-for-the-treatment-of-low-back-pain-lbp-in-adults-100621307","NCT07368920","Transcutaneous Electrical Nerve Stimulation (TENS) for the Treatment of Low Back Pain (LBP) in Adults","A Prospective, Open-Label, Single-Arm, Self-Controlled Study of Transcutaneous Electrical Nerve Stimulation (TENS) for Adult Low Back Pain","Inclusion Criteria:\n\n1. Adults aged 18-65 years\n2. Diagnosis consistent with myofascial low back pain (localized low back pain with a palpable taut band; referred pain and\u002For sensory changes near a specific trigger point; an identifiable tender spot within the taut band; mild muscle weakness and\u002For some limitation of joint range of motion)\n3. Mild pain intensity at baseline (VAS \\\u003C 4 on a 0-10 scale)\n4. Symptom duration \\> 1 month\n5. Able to understand the study procedures and demonstrate good compliance\u002Fcooperation\n6. Written informed consent provided\n\nExclusion Criteria:\n\n1. Low back pain due to other causes, including but not limited to lumbar disc herniation, lumbar spinal stenosis, ankylosing spondylitis, spinal tumor, spinal tuberculosis, or spinal infection\n2. Received physical therapy, interventional procedures, or medication treatment within 4 weeks prior to enrollment that may affect pain or function assessment\n3. Systemic disease or organ dysfunction\n4. Skin\u002Fsoft tissue breakdown or infection at\u002Fnear the planned treatment area\n5. Use of sedative medications or opioid analgesics within 6 months prior to enrollment, or currently receiving other treatments that may affect study outcomes\n6. Severe psychiatric disorder or inability to cooperate with study procedures\n7. Pregnant or breastfeeding women","65 Years",{"count":66,"type":21},40,[24],"The goal of this clinical trial is to assess the effects and safety of transcutaneous electrical nerve stimulation (TENS) in adults with myofascial low back pain. Eligible participants will receive TENS treatment 5 times per week for 4 weeks. Pain intensity and functional outcomes will be assessed at baseline and weekly during the 4-week treatment period, and adverse events will be recorded.",[35,70,37],"Paraspinal Muscles",[72,73,74],"Low back pain","Transcutaneous electrical stimulation","Self-controlled clinical trial","RECRUITING","2026-03-19",{"date":78,"type":48},"2026-03-20",{"date":80,"type":48},"2026-02-01",{"date":82,"type":21},"2029-01-01",{"name":84,"class":55},"Xijing Hospital",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":64,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":102,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":56},"100619054","phase-1-sodium-aescinate-for-the-treatment-of-low-back-pain-lbp-in-adults-100619054","NCT07339631","Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults","The Safety and Clinical Efficacy of Sodium Aescinate: A Double-Blind, Randomized Controlled Trial for the Treatment of Low Back Pain (LBP) in Adults","Inclusion Criteria:\n\n1. Meets the diagnostic criteria for chronic low back pain (cLBP) recommended by the Clinical Practice Guidelines for Chronic Low Back Pain in China (2024 Edition): the course of disease lasts at least 12 weeks, with pain occurring in the region below the lower costal margin, above the gluteal crease (horizontal gluteal fold), and between the midaxillary lines on both sides, which may be accompanied by pain in one or both lower extremities.\n2. Has moderate to severe pain, with a Visual Analog Scale (VAS) score \\> 4 points.\n3. Aged between 18 and 65 years old.\n4. Has a clear understanding of the study content, good compliance, and high willingness to cooperate.\n5. Has signed a written informed consent form voluntarily.\n\nExclusion Criteria:\n\n1. Is in the acute pain phase or acute exacerbation of chronic pain.\n2. Has low back pain caused by other reasons such as infectious diseases or tumors, including but not limited to spinal tumors, spinal tuberculosis, spinal cord infections, etc.\n3. Has a history of allergy to sodium aescinate.\n4. Suffers from systemic diseases or organ dysfunction.\n5. Has participated in other clinical trials within 1 month before enrollment.\n6. Has severe mental illness or other conditions that prevent cooperation with the study.\n7. Is a pregnant or lactating woman, or a woman planning to become pregnant.\n8. Has metal implants or other conditions that are not suitable for MRI examination.\n9. Is considered by the researcher to have conditions that are unfavorable for completing the study course.",{"count":66,"type":21},[94],"PHASE1","The goal of this clinical trial is to assess the clinical efficacy and safety of sodium aescinate in treating low back pain (LBP) in adult participants.",[35,97,37,98],"Paraspinal Muscle","Non-specific Chronic Low Back Pain",[43,100,101,37],"sodium aescinate tablets","double-blind randomized controlled trial",{"date":78,"type":48},{"date":104,"type":48},"2026-03-01",{"date":106,"type":21},"2029-09-01",{"name":84,"class":55}]