[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cleft-palate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cleft-palate":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,52,84,118,146,168,204,223,248,275,300,327,347],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100642485","perioperative-respiratory-adverse-events-in-cleft-lip-and-palate-surgery-incidence-risk-factors-and-clinical-scoring-100642485",false,"NCT07651904","Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring","Prospective Assessment of Perioperative Respiratory Adverse Events in Pediatric Patients Undergoing Cleft Lip and Palate Surgery: Predictive Risk Factors and the Role of Clinical Airway Scores","Inclusion Criteria:\n\n* Age 0-3 years (infants and toddlers)\n* Scheduled for elective cleft lip and\u002For palate repair surgery\n* General anesthesia planned\n* Written parental\u002Fguardian informed consent obtained\n\nExclusion Criteria:\n\n* Pre-existing respiratory failure or active tracheostomy\n* Emergency surgical procedures\n* Inability to obtain parental\u002Fguardian consent","ALL","0 Years","3 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population. These factors substantially increase the risk of perioperative respiratory adverse events (PRAEs), including laryngospasm, bronchospasm, desaturation, post-extubation stridor, and unanticipated re-intubation.\n\nThis prospective single-center observational cohort study aims to determine the true incidence of PRAEs in pediatric patients undergoing elective cleft lip and\u002For palate repair under general anesthesia, and to identify independent predictive risk factors using standardized airway assessment tools including the Han Mask Ventilation Score and the Intubation Difficulty Score (IDS). No interventions beyond routine clinical practice will be applied. All airway management decisions will remain at the discretion of the attending anesthesiologist.",[25,26,27,28,29,30,31],"Cleft Palate","Cleft Lip","Laryngospasm","Bronchospasm","Airway Obstruction","Postoperative Complications","Difficult Intubation",[33,34,35,36,37,38,39],"cleft lip","cleft palate","pediatric anesthesia","perioperative respiratory adverse events","Han mask ventilation score","micrognathia","intubation difficulty score","NOT_YET_RECRUITING","2026-06-13",{"date":43,"type":44},"2026-06-16","ACTUAL",{"date":46,"type":21},"2026-06-27",{"date":48,"type":21},"2027-12-30",{"name":50,"class":51},"Marmara University Pendik Training and Research Hospital","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100521661","etiological-study-of-persistent-velopharyngeal-insufficiency-in-children-with-operated-velopalatine-cleft-by-analysis-of-velopharyngeal-motor-skills-in-static-and-dynamic-mri-100521661","NCT06072495","Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI","FENTIRM","Inclusion Criteria:\n\n* Children aged 7 to 12 years with Isolated cleft lip\n* isolated velopalatal cleft\n* Without a diagnosis of syndromic cleft or Pierre Robin sequence\n* French speaking, and French is the native language\n* Operated with a cheiloplasty (for cleft lip) or an intravelar Veloplasty (according to Sommerlad) at the Amiens University Hospital\n* Whose follow-up is done at the Amiens University Hospital\n\nExclusion Criteria:\n\n* Refusal of the parents and\u002For the patient\n* With a contraindication to MRI\n* Whose follow-up was initiated in another center and\u002For whose surgery was performed in another center\n* Whose surgical schedule has not been followed\n* Patient with severe neurological or neuropsychiatric disorders or Severe speech and language delay not related to the cleft anatomy\n* Patients treated with fixed, non-removable orthodontic treatment.","7 Years","12 Years",{"count":62,"type":21},30,"INTERVENTIONAL",[65],"NA","Velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. It is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft palate by intravelar veloplasty at 6 months. If rehabilitation by a speech therapist is not successful, a pharyngoplasty can be discussed. In the last ten years, MRI was used in dynamic and static way, to analyzed velopharyngeal muscles, in particular Levator Veli Palatini. MRI could be used to identify the etiology of VPI in those patients, and thus allow personalized rehabilitation and surgical management. The aim of this study is to examine the differences in velopharyngeal motricity as well as velar muscles morphology, positioning, and symmetry of children with repaired cleft palate with different degrees of severity of velopharyngeal insufficiency (VPI), and children with labial cleft (noncleft palate anatomy).",[68,69,25],"Velopharyngeal Insufficiency","Real Time MRI",[68,71,72],"real time MRI","Cleft palate","RECRUITING","2026-06-12",{"date":76,"type":44},"2026-06-15",{"date":78,"type":44},"2024-11-06",{"date":80,"type":21},"2026-06",{"name":82,"class":51},"Centre Hospitalier Universitaire, Amiens",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":63,"phases":96,"briefSummary":98,"conditions":99,"keywords":104,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":83},"100590045","phase-4-optimizing-perioperative-analgesia-to-lower-pain-following-cleft-palate-surgery-100590045","NCT06962306","Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery","Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled Trial","OPAL-Cleft","Inclusion Criteria:\n\n* Age 6 months to 4 years of age\n* Primary cleft palate repair\n* Signed informed consent by parent or legal guardian\n\nExclusion Criteria:\n\n* History of chronic kidney or liver disease\n* Planned admission to the Pediatric Intensive Care Unit (PICU)\n* Additional procedures under general anesthesia for which opioids would be prescribed\n* Any patient ineligible for study participation at the discretion of the investigators","6 Months","4 Years",{"count":95,"type":21},60,[97],"PHASE4","The purpose of this study is to compare the use of short acting opioids (fentanyl\u002Fhydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.",[25,100,101,102,103],"Pain","Postoperative Care","Perioperative Care","Children",[105,106,107,108],"Cleft palate surgery","Perioperative pain management","Analgesia","Methadone","2026-04-10",{"date":111,"type":44},"2026-04-14",{"date":113,"type":44},"2025-06-04",{"date":115,"type":21},"2027-07-04",{"name":117,"class":51},"Duke University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":63,"phases":128,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":142,"leadSponsor":144,"locationsCount":83},"100632469","mri-assessment-of-velopharyngeal-anatomy-after-modified-furlow-buccinator-flap-in-late-primary-palate-repair-100632469","NCT07514091","MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair","MRI Assessment of Velopharyngeal Anatomy in Late Primary Cleft Palate Repair Using Modified Furlow With Buccinator Myomucosal Flap: A Case Series Study","Inclusion Criteria:\n\n* Non-syndromic cleft palate (La Veau I-IV)\n* No prior palatal surgery\n* Consent for MRI and follow-up\n\nExclusion Criteria:\n\n* Syndromic clefts or associated craniofacial anomalies.\n* Systemic co-morbidities\n* Previous palatal surgery.\n* Contraindications to MRI.","5 Years",{"count":127,"type":21},10,[65],"The goal of this case series study is to learn if magnetic resonance imaging (MRI) can show how well the palate and throat muscles work at rest and during speech after late cleft palate repair. The surgery uses a technique in which the muscle from the cheek is used to close the gap and repair the cleft and therefore improve speech. The study will answer the question of whether this technique will provide better closure and improved speech in the participants who have not received early treatment. The participants will have the surgery and then have MRI scans 6 months after surgery while resting and speaking specific sounds. Complete speech assessments will also be done 6 months after surgery.",[25,131,132,133],"Cleft Palate, Unilateral, Complete","Cleft Lip, Cleft Alveolus and Cleft Palate","Cleft Palate Repair",[34,135,136,137],"cleft palate repair","velopharyngeal insufficiency","magnetic resonance imaging","2026-04-05",{"date":140,"type":44},"2026-04-07",{"date":80,"type":21},{"date":143,"type":21},"2027-06",{"name":145,"class":51},"Cairo University",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":153,"maxAge":59,"enrollmentInfo":154,"targetDuration":4,"studyType":63,"phases":155,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":83},"100433763","phase-3-nebulized-bupivacaine-analgesia-for-cleft-palate-repair-100433763","NCT04928352","Nebulized Bupivacaine Analgesia for Cleft Palate Repair","Preemptive Nebulized Bupivacaine for Pain Control After Cleft Palate Repair in Children: A Randomized Double Blind Controlled Trial","Inclusion Criteria:\n\n* Children (age 1-7 years) of American Society of Anaesthesiologists physical status (ASA) I-II\n* Elective cleft palate repair ± cleft lip surgery under general anesthesia .\n\nExclusion Criteria:\n\n* Coronary artery disease\n* Hypertension\n* Developmental delay\n* Allergy to study drug","1 Year",{"count":95,"type":21},[156],"PHASE3","In this study we introduce a potent local anesthetic; bupivacaine 0.5% in 0.5 mg\u002Fkg dose by nebulization as a preemptive analgesia to compare efficacy and safety in children with cleft palate repair.",[25],"2025-12-27",{"date":161,"type":44},"2026-01-02",{"date":163,"type":44},"2021-06-14",{"date":165,"type":21},"2026-09-20",{"name":167,"class":51},"Assiut University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":63,"phases":177,"briefSummary":178,"conditions":179,"keywords":185,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":83},"100609847","early-intervention-in-infants-with-unrepaired-cleft-palate-language-palatal-function-and-articulation-100609847","NCT07219901","Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.","Inclusion Criteria:\n\n* Infants with unrepaired cleft palate (with or without cleft lip)\n* Aged between 6 and 10 months at the time of study commencement\n\nExclusion Criteria:\n\n* Medically fragile status that would preclude participation in this community-based study.\n* Palatoplasty completed.\n* Aged over one year\n* Infants with cleft lip only","12 Months",{"count":176,"type":21},200,[65],"The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills. It will also learn about whether the skills are linked to fewer speech sound difficulties when they start school. The main questions it aims to answer are:\n\nDo standard, early intervention techniques to promote language development, that are used in children who are late talkers, work in infants with cleft palates? Will infants with cleft palates increase the number of sounds they use after targeted intervention? Can infants attempt to make stop sounds, like b and p, after targeted intervention? Can infants with cleft palate learn new words more quickly when they are used with gestures?\n\nParticipants will:\n\nParticipate in a baseline evaluation of speech and language skills, either in person, or via Telehealth.\n\nAttend the clinic for twice-weekly visits, for six weeks, to learn techniques to help their infants develop their speech and language skills, in a group setting with other families of infants with cleft palate.\n\nParticipate in a final evaluation of speech and language skills, either in person, or via Telehealth.",[180,181,182,25,183,184,133],"Cleft Lip and Cleft Palate","Cleft Lip Palate","Cleft Lip and\u002For Palate","Cleft Palate Children","Cleft Palates",[186,187,188,189,190,191,192,193,194],"cleft-type speech","hypernasality","palatal function","compensatory speech patterns","obligatory speech patterns","velopharyngeal dysfunction","communication","language","speech","2025-10-20",{"date":197,"type":44},"2025-10-22",{"date":199,"type":21},"2025-10-21",{"date":201,"type":21},"2027-01-31",{"name":203,"class":51},"Old Dominion University",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":125,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":83},"100581901","effect-of-furlow-palatoplasty-with-buccal-myomucosal-flap-on-the-speech-development-100581901","NCT06856330","Effect of Furlow Palatoplasty With Buccal Myomucosal Flap on the Speech Development","Efficacy of Two Flap Palatoplasty (TFP) Versus Furlow With Buccinator Flap (FPBF) During Primary Palatoplasty on the Speech Development","Inclusion Criteria:\n\n* 3-5 years old childreen with previous treated complete cleft lip and palate, nonsyndromic.\n* lip and palate repair performed by one craniofacial surgeon\n\nExclusion Criteria:\n\n* Patients with syndromic cleft lip.\n* Redu cases\n* Bilateral cleft lip\n* Patient older 5years or younger 3 years.\n* Associated Cardiac anomalies.\n* Any systemic condition",{"count":62,"type":21},"About 20 patient will be collected according to the eligibility criteria and grouped into Group I : 10 patients were treated with furlow with buccinators flap Group II : 10 patients were treated with 2 flap palatoplasty All patients will be examined by an expert Phoniatrician by Recording of speech samples in Arabic language for the children in a soundproof room including repeated syllables, sentences with high-pressure sounds and counting from 1 to 10. The records will be analyzed to assess the degree of hypernasality, speech intelligibility and compensatory speech errors",[25],"2025-07-24",{"date":216,"type":44},"2025-07-28",{"date":218,"type":44},"2025-03-25",{"date":220,"type":21},"2025-07-25",{"name":222,"class":51},"Fayoum University",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":230,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":63,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":83},"100548387","ql-vs-lai-for-palatoplasty-100548387","NCT06420336","QL vs LAI for Palatoplasty","Quadratus Lumborum Block for Pain Control in Unilateral Anterior Iliac Bone Graft Harvesting for Pediatric Patients Undergoing Palatoplasty: a Prospective Randomized Control Trial","Inclusion Criteria\n\n* Patients undergoing palatoplasty with autologous bone graft from the anterior iliac crest.\n* Ages 6-18 years of age\n* Planned admission post-op\n* ASA Status Range: 1-3\n\nExclusion Criteria\n\n* Contraindication to QL blocks or LAI which may include:\n* overlying infection skin at the block needle insertion site\n* coagulopathies\n* known bleeding disorders\n* Allergy to local anesthetic\n* Cognitive or developmental impairment that would limit ability to report pain.\n* Non-English Speaking\u002FWriting\n* Subjects or their parent\u002Fguardian unable or choose to not give informed consent\u002Fassent.","6 Years","18 Years",{"count":233,"type":21},46,[65],"This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting). The patients will be randomized to receive either a unilateral QL block by an anesthesiologist, or local anesthetic infiltration at the surgical incision by the surgeon. The primary aim will be assessing post-operative pain in the first 48 hours after surgery. Secondary outcomes will include pain medication use in the first 48 hours after surgery, block resolution time, and evaluating any complications associated with the QL block or local anesthetic infiltration.",[237,238,25],"Post-operative Pain","Opioid Use","2025-07-01",{"date":241,"type":44},"2025-07-04",{"date":243,"type":44},"2024-06-25",{"date":245,"type":21},"2026-07-30",{"name":247,"class":51},"Medical University of South Carolina",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":16,"minAge":256,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":63,"phases":259,"briefSummary":260,"conditions":261,"keywords":262,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100466696","effects-of-alignbabycleft-abacleft-100466696","NCT05357092","Effects of AlignBabyCleft (ABaCleft)","Evaluation of Presurgical Orthopedics in Patients With Cleft Lip and\u002For Palate, a Randomized Controlled Clinial Trial.","(ABaCleft)","Inclusion Criteria:\n\nPatients selected for the clinical trial must meet these criteria after randomization:\n\n* All patients born at term, without any syndrome associated with CLP, aged between 7 days and one month of life, referred from the different hospitals of the Spanish Health System, will be included in the study.\n* No distinction will be made on the basis of race or ethnic group to which the participants belong.\n* Any patient will be discriminated due to distance from their place of residence.\n* Participants must agree to attend regular check-ups.\n* All patients who agree to be part of the experimental study must previously sign the specific informed consent designed for this purpose.\n\nExclusion Criteria:\n\n* Caregivers who are not fluent in the Spanish language will be excluded in order to understand and assimilate all the instructions provided for treatment compliance.\n* Patients who do not comply with the regimen of visits to the orthodontic department, and for whom a correct control of the evolution of the treatment cannot be guaranteed, will be excluded from the study.\n* Lack of collaboration or non-compliance with the use of the clear aligners will also be considered grounds for exclusion.\n* Patients with soft tissue bands should also be excluded from our study.","7 Days","1 Month",{"count":62,"type":21},[65],"Since the appearance of presurgical infant orthopedic (PSIO) as a treatment for patients with cleft lip and palate ( CLP) , numerous techniques have been described with the aim of aligning the displaced alveolar segments and restoring the position of the lateral cartilage, thus improving the results of primary surgery. Currently, the most used technique in the different protocols is the nasoalveolar molding (NAM) described by Grayson, from which variants and modifications have emerged in order to improve its results and provide greater comfort for both the patient and their caregivers.\n\nHowever, the main drawback of traditional acrylic NAM is the need for sequential addition of acrylic to reduce the size of the indentation. These weekly adjustments consume time and resources for the caregiver and the orthodontist. Likewise, it has been observed that acrylic resin can cause inflammation, irritation and gingival ulceration due to excessive pressure.\n\nPSIO treatment in newborns is a complex procedure that could benefit from simplification through digitization, providing accuracy and precision, avoiding risks such as respiratory obstruction and cyanosis that can be produced by taking impressions with alginates or silicones, most of them needing to be performed under general anesthesia.\n\nUntil now, infant care has been left out of such digitization, despite the fact that the majority of babies who need early orthodontic treatment often suffer from craniofacial disorders. However, in recent years numerous advances have been made in this type of treatment, both in taking records, and in the application of more physiological, lighter and constant forces, providing greater comfort, better acceptance and less pain for the patient . These changes represent a great advance applicable to patients with CLP.",[26,25],[263,264,265],"\"cleft lip\"","\" Cleft palate\"","\"presurgical orthopedics\"","2025-04-22",{"date":268,"type":44},"2025-04-25",{"date":270,"type":21},"2025-11-21",{"date":272,"type":21},"2028-11",{"name":274,"class":51},"Universidad Complutense de Madrid",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":281,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":83},"100388775","neural-network-to-calculate-morphology-of-the-cleft-palate-to-reduce-cleft-lip-and-palate-treatment-burden-100388775","NCT04342234","Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden.","Inclusion Criteria:\n\n* Patients with cleft lip and palate malformation with available routinely performed plaster cast model from palatal impressions, intraoral scans from the palate and corresponding images of the cleft palate (1970 till 2025)\n\nExclusion Criteria:\n\n* Existence of a documented rejection",{"count":282,"type":21},450,"This study is to develop a neural network to compute palatal three dimensional (3D) geometry by using routinely taken intraoral\u002Fpalatal photographs and palatal casts of infants with cleft lip and palate deformity for reducing cleft lip and palate treatment burden. Data of palatal casts and palatal images of cleft patients routinely treated at the University Hospital Basel will be analyzed.The collection of large data helps in developing a neural network that will allow the computation of the 3D geometry from single photographs.",[25,285],"Orofacial Cleft",[26,287,288,289,290],"Neural Network","palatal plate therapy","palatal 3D geometry","palatal shape reconstruction","2025-03-19",{"date":293,"type":44},"2025-03-24",{"date":295,"type":44},"2020-03-05",{"date":297,"type":21},"2025-12",{"name":299,"class":51},"University Hospital, Basel, Switzerland",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":308,"sex":16,"minAge":92,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":63,"phases":312,"briefSummary":313,"conditions":314,"keywords":316,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":83},"100584426","role-of-plasma-rich-growth-factor-in-repair-primary-cleft-palate-100584426","NCT06889181","Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate","Evaluation of the Role of the Plasma-rich Growth Factor (PRGF) with Primary Cleft Palate Repair Versus Primary Cleft Palate Repair in Post-operative Wound Healing and Oronasal Fistula Occurrence, a Randomized Clinical Trial","PRGF","Inclusion Criteria:\n\n* systemically healthy patients (American Society of Anesthesiologists -ASA I and II); not older than 6-18 months\n* Patients with primary non-syndromic isolated cleft palate\n* Apprehensive to be in the study.\n\nExclusion Criteria:\n\n* Patients with recurrent palatal fistula\n* Existence of syndromic cleft palate\n* Blood diseases and platelet disorders (hematological disease)\n* Systematic disease radiotherapy or chemotherapy for malignancy",true,"18 Months",{"count":311,"type":21},36,[65],"Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?",[25,315],"Plasma Rich in Growth Factors",[34,317,318],"plasma rich growth factor","healing","2025-03-16",{"date":321,"type":44},"2025-03-21",{"date":323,"type":21},"2025-04-01",{"date":325,"type":21},"2027-06-30",{"name":145,"class":51},{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":63,"phases":335,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":83},"100552791","velopharyngeal-insufficiency-evaluation-post-cleft-palate-repair-furlow-with-buccinator-myomucosal-flap-versus-two-flap-palatoplasty-100552791","NCT06477679","Velopharyngeal Insufficiency Evaluation Post Cleft Palate Repair. Furlow With Buccinator Myomucosal Flap Versus Two Flap Palatoplasty","Inclusion Criteria:\n\n* •children more than 3 years old\n\n  * Type of cleft: isolated cleft palate\n\nExclusion Criteri\n\n* Complicated cases by fistula or redo,\n* Missed follow up; less than 6 months.",{"count":334,"type":21},50,[65],"Cleft palate is one of the most common congenital abnormalities of the orofacial region throughout the world. This condition can cause facial deformity, feeding problems, frequent middle ear infections, dental defects, speech abnormalities and emotional problems . Early surgical repair of this congenital anomaly prevents the psychological and functional problems associated with the deformity . Patients may develop various complications after primary palatoplasty including palatal fistula and velopharyngeal insufficiency (VPI) which are relatively common .\n\nThe main goal of cleft palate repair is to achieve normal speech and adequate velopharyngeal function with minimal effect on facial growth. The primary objective in the surgical repair of a cleft palate is the development of normal speech. Speech quality remains the most important standard for assessing clinical outcomes and the success of surgical procedures. Many surgical techniques for palate correction have been described determining the most effective technique for the surgical repair of palatal clefts continues to cause controversy .\n\nThe incidence of VPI post cleft palate repair is 20-30% of patients . If there is significant velopharyngeal dysfunction during normal speech development, many children learn to compensate for the lack of intraoral pressure. They produce a hoarse voice because of vocal fold adduction and sudden release. Compared with the adductor vocal fold palsy .",[25],"2024-06-26",{"date":340,"type":44},"2024-06-27",{"date":342,"type":21},"2024-06",{"date":344,"type":21},"2026-02",{"name":346,"class":51},"Sohag University",{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":308,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":356,"conditions":357,"keywords":364,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":83},"100178744","genetics-of-reproductive-disorders-including-kallmann-syndrome-and-cleft-lip-andor-palate-100178744","NCT01601171","Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and\u002For Palate","The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and\u002For Palate","Inclusion Criteria:(any of the following conditions)\n\n* hypogonadotropic hypogonadism\n* Kallmann syndrome\n* adult-onset hypogonadotropic hypogonadism\n* hypothalamic amenorrhea\n* polycystic ovarian syndrome\n* primary gonadal failure\n* precocious puberty\n* cleft lip\u002Fpalate\n* family members of the above groups\n\nExclusion Criteria:\n\n* acute illness\u002Fhospitalization\n* pituitary tumors\n* iron overload (hemochromatosis)\n* infiltrative diseases (sarcoidosis)\n* chronic alcohol abuse\n* illicit drug use\n* anabolic steroid abuse",{"count":355,"type":21},2000,"The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and\u002For palate.",[358,359,360,361,362,363,25,26],"Kallmann Syndrome","Hypogonadotropic Hypogonadism","Hypothalamic Amenorrhea","Polycystic Ovarian Syndrome","Precocious Puberty","Cleft Lip and Palate",[365,366,367,368,33,34,369,370],"GnRH deficiency","hypogonadism","anosmia","infertility","cryptorchidism","microphallus","2022-06-17",{"date":373,"type":44},"2022-06-21",{"date":375,"type":4},"2012-03",{"date":377,"type":21},"2030-03",{"name":379,"class":51},"Centre Hospitalier Universitaire Vaudois"]