[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clinical-burnout\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clinical-burnout":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100621393","feasibility-and-acceptability-of-the-unified-protocol-for-burnout-100621393",false,"NCT07370038","Feasibility and Acceptability of the Unified Protocol for Burnout","Implementing the Unified Protocol for Burnout (UP-B): A Feasibility and Acceptability Study.","UP-B","Inclusion Criteria:\n\n* Participants must score above the moderate burnout threshold on the Burnout Assessment Tool (BAT) to be considered eligible. Those who meet this cutoff will subsequently undergo a structured clinical interview to verify the presence of clinical burnout symptoms. The interview will assess whether the symptom profile is consistent with clinical burnout and will document the onset, progression, and course of symptoms. To be considered eligible for the study, the cause of symptoms must be burnout.\n\nExclusion Criteria:\n\n* Current engagement in psychotherapy, defined as receiving ongoing psychological treatment at the time of screening;\n* Current use of psychotropic medication (e.g., antidepressants, anxiolytics, mood stabilizers);\n* Presence of a diagnosed personality disorder and as determined by the clinical interview;\n* Presence of a psychiatric disorder;\n* Presence or history of a psychotic disorder;\n* Suicidal ideation, as assessed through the clinical interview.","ALL","18 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","The present study has three primary objectives: (1) to evaluate the feasibility of implementing the Unified Protocol for Burnout (UP-B) an intervention derived from the Unified Protocol (Barlow et al., 2018); (2) to assess the acceptability of the intervention among both recipients and psychotherapists; and (3) to examine preliminary signals of the UP-B's efficacy. The main questions it aims to answer are:\n\n1. Is the intervention feasible as indicated by recruitment rates, data collection procedures, and acceptable rates of participant retention and treatment completion?\n2. Is the UP-B acceptable for both participants and psychotherapists considering content, content structure, mode of delivery, and adherence?\n3. Does the UP-B show preliminary evidence of effectiveness (i.e., efficacy signals) in reducing burnout, anxiety, depression, and increasing well-being?",[27],"Clinical Burnout",[29,30,31],"transdiagnostic","cognitive-behavioral intervention","clinical burnout","NOT_YET_RECRUITING","2026-01-18",{"date":35,"type":36},"2026-01-27","ACTUAL",{"date":38,"type":21},"2026-01-20",{"date":40,"type":21},"2026-06-30",{"name":42,"class":43},"West University of Timisoara","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100613886","comparing-act-recuperation-and-act-plus-vocational-support-for-clinical-burnout-100613886","NCT07272421","Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout","A Three-Arm Randomized Controlled Trial Comparing Online ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout","Inclusion Criteria:\n\n* Age 18 years or older\n* Self-reported or clinically verified symptoms consistent with clinical burnout (e.g., pronounced fatigue, cognitive difficulties, and reduced stress tolerance following prolonged psychosocial stress)\n* Currently on ≥25% sick leave and experiencing significant functional impairment in work or daily life due to these symptoms\n* Stable occupation or engagement (employment or studies)\n* Ability to read and write Swedish\n* Daily access to the internet\n\nExclusion Criteria:\n\n* Sick leave \\> 2 years for the current episode\n* Severe acute psychiatric conditions, including: severe depression, bipolar disorder, untreated PTSD, schizophrenia, or other psychotic disorders\n* Current substance abuse\n* Active suicidal ideation (as assessed during clinical evaluation)",{"count":53,"type":21},210,[24],"This study compares three different online psychological treatments for people with clinical burnout (stress-related exhaustion) who are on sick leave or have major difficulties coping at work or in daily life. Many patients with burnout receive broad, recuperation-focused interventions (rest, stress reduction, lifestyle changes), but there is still no clearly evidence-based treatment or agreed clinical model. It is also known that returning to work can be difficult, and there is a need for more structured support.\n\nIn this trial, 210 adults in Sweden with clinical burnout will be randomly assigned to one of three 10-week, internet-based treatments:\n\nOnline Acceptance and Commitment Therapy (ACT) A structured, values-based CBT approach that focuses on helping participants clarify what matters to them, relate differently to difficult thoughts and feelings, and gradually re-engage in meaningful activities despite exhaustion.\n\nOnline Recuperation-focused treatment An active comparison condition that emphasizes rest, recuperation, and healthy daily routines. It provides psychoeducation and practical tools for sleep, relaxation, physical activity, pacing, and balance in everyday life, but does not include ACT-specific methods such as exposure or values work.\n\nOnline ACT plus Vocational Support The same ACT program as in group 1, together with three additional sessions with a licensed psychologist focused on work. These sessions help the participant identify work-related barriers, plan a gradual return-to-work (RTW), and formulate a written RTW plan that can be shared with the employer and treating physician.\n\nAll three treatments are delivered via a secure digital platform. Participants work through weekly online modules, receive written feedback from a therapist, and have three video sessions during the 10-week period. Clinical psychology students in their final semester deliver the ACT and recuperation treatments, and licensed psychologists deliver the ACT + vocational support condition.\n\nThe study has two primary aims:\n\n1. to test whether online ACT reduces self-rated burnout symptoms more than the recuperation-focused treatment at the end of treatment, and\n2. to test whether adding structured vocational support to ACT reduces the total number of registered sick-leave days in the year after treatment, compared with ACT alone.\n\nKey secondary outcomes include perceived stress, depression, anxiety, insomnia, everyday memory problems, quality of life, functional impairment, treatment response and remission, treatment credibility and satisfaction, and cost-effectiveness. Outcomes are measured before treatment, weekly during treatment (for selected measures), immediately after treatment, and at 6- and 12-month follow-ups. Sick-leave data are obtained from the Swedish Social Insurance Agency.\n\nTo be eligible, participants must be 18 years or older, have symptoms consistent with clinical burnout (including pronounced fatigue and reduced stress tolerance after prolonged psychosocial stress), be on at least 25% sick leave or have marked functional impairment due to these symptoms, have a stable occupation or study situation, and be able to read and write Swedish. People with very long sick leave (more than two years), severe psychiatric conditions (such as severe depression, bipolar disorder, untreated PTSD, or psychosis), current substance abuse, or active suicidal ideation will not be included.\n\nPotential risks include temporary increases in distress, fatigue, or symptom awareness when working with emotions, behavior change, or work-related issues. Participants are monitored closely through weekly questionnaires and therapist contact. If risk for self-harm or serious deterioration is detected, a licensed psychologist will perform a risk assessment and, if needed, refer the participant to appropriate health care.\n\nThe hope is that this study will identify effective, scalable, and theory-based online treatments for clinical burnout and clarify whether adding structured vocational support improves long-term work outcomes.",[57,27,58],"Burnout","Exhaustion Disorder",[60,61,57,62,63],"ACT","Online","Return To Work","Recovery","2025-11-26",{"date":66,"type":36},"2025-12-09",{"date":68,"type":21},"2025-12-01",{"date":70,"type":21},"2027-12-31",{"name":72,"class":43},"Uppsala University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100599070","returning-to-work-after-stress-related-sick-leave-an-effectiveness-trial-of-work-focused-treatments-in-primary-care-100599070","NCT07079709","Returning to Work After Stress-Related Sick Leave: An Effectiveness Trial of Work-Focused Treatments in Primary Care","ReWork","Inclusion Criteria:\n\n1. be on sick leave at least 50%\n2. be diagnosed with a primary diagnosis adjustment disorder (F43.2-F.43.9) including exhaustion disorder (F43.8A)\n3. be of working age (18-60 years)\n4. be able to understand verbal and written Swedish or English\n5. give informed consent\n\nExclusion Criteria:\n\n1. other psychiatric conditions that require prioritization for immediate or simultaneous treatment: specifically, a current diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or organic mental disorder; current high risk of suicide; or recent (within 3 months) history of substance use disorder)\n2. other ongoing or recent (within 6 months) psychological treatment for stress-related disorders","60 Years",{"count":82,"type":21},204,[24],"The goal of this clinical trial is to learn if work-focused cognitive behaviour (WCBT) works to treat patients on sick leave due to non-traumatic long-term stress-related disorders. The main questions it aims to answer are:\n\n* Is WCBT more effective in improving work ability compared to standard care?\n* Do participants in WCBT have less sick leave days than those in standard care?\n* Is WCBT more effective in improving health outcomes and function than standard care?\n* Is WCBT a more cost-effective treatment option than standard care? Researchers will compare WCBT to standad care to see if there are differences in effect.\n\nParticipants will participate in:\n\n* WCBT\n* Standard care",[27,58,86],"Adjustment Disorder With Work Inhibition",[88,89,90,91,92],"Work-focused CBT","WCBT","Sick leave","Clinical burnout","Cognitive behaviour therapy","2025-07-14",{"date":95,"type":36},"2025-07-23",{"date":97,"type":21},"2025-08-01",{"date":99,"type":21},"2034-12-01",{"name":101,"class":43},"Karolinska Institutet"]